*  Tetrodotoxin | definition of tetrodotoxin by Medical dictionary
... tetrodotoxin explanation free. What is tetrodotoxin? Meaning of tetrodotoxin medical term. What does tetrodotoxin mean? ... Looking for online definition of tetrodotoxin in the Medical Dictionary? ... tetrodotoxin. Also found in: Dictionary, Thesaurus, Acronyms, Encyclopedia, Wikipedia. tetrodotoxin. [tet´ro-do-tok″sin] a ... Tetrodotoxin blocks voltage-gated Na+ channels in excitable tissues.. tetrodotoxin. /tet·ro·do·tox·in/ (tet´ro-do-tok″sin) a ...
  https://medical-dictionary.thefreedictionary.com/tetrodotoxin
*  CDC - The Emergency Response Safety and Health Database: Biotoxin: TETRODOTOXIN - NIOSH
Tetrodotoxin poisoning can be fatal.. * METHODS OF DISSEMINATION: *Indoor Air: Because the natural source of tetrodotoxin is ... Water: Because the natural source of tetrodotoxin is from living organisms, and manufacturing tetrodotoxin artificially in ... Outdoor Air: Because the natural source of tetrodotoxin is from living organisms, and manufacturing tetrodotoxin artificially ... DESCRIPTION: Tetrodotoxin is an extremely potent poison (toxin) found mainly in the liver and sex organs (gonads) of some fish ...
  https://www.cdc.gov/niosh/ershdb/emergencyresponsecard_29750019.html
*  Tetrodotoxin Open-label Efficacy and Safety Continuation Study - Full Text View - ClinicalTrials.gov
Experimental: Tetrodotoxin There is only one arm; active treatment with TTX. Biological: Tetrodotoxin 30 µg twice daily for 4 ... Tetrodotoxin Open-label Efficacy and Safety Continuation Study (TEC-006OL). The safety and scientific validity of this study is ... both tetrodotoxin and placebo-treated) to receive or continue to receive tetrodotoxin treatment. ... Tetrodotoxin (TTX) is a selective blocker of Na+ channels and causes analgesia either by decreasing the propagation of action ...
  https://clinicaltrials.gov/ct2/show/study/NCT00726011?show_desc=Y
*  Traumatic Axonal Injury Induces Calcium Influx Modulated by Tetrodotoxin-Sensitive Sodium Channels | Journal of Neuroscience
Injuries with no treatment were performed using CSS with no modifications (n = 9 wells at 25°C; n = 3 at 37°C). Tetrodotoxin ( ... In axons that were pretreated with the Na+channel blocker tetrodotoxin (TTX; 1 μm) and then injured, we found a complete ... Traumatic Axonal Injury Induces Calcium Influx Modulated by Tetrodotoxin-Sensitive Sodium Channels. John A. Wolf, Peter K. Stys ... 1999) Effects of the sodium channel blocker tetrodotoxin on acute white matter pathology after experimental contusive spinal ...
  http://www.jneurosci.org/content/21/6/1923
*  Effect of diltiazem and tetrodotoxin on development of anoxic contracture of the guinea pig myocardium | SpringerLink
papillary muscle anoxic contracture diltiazem tetrodotoxin Z. Januškevič Research Institute of Physiology and Pathology of the ... Effect of diltiazem and tetrodotoxin on development of anoxic contracture of the guinea pig myocardium. ...
  https://link.springer.com/article/10.1007/BF00842138
*  Tetrodotoxin - Wikipedia
Tetrodotoxin has been used clinically to relieve the headache associated with heroin withdrawal. In the U.S., tetrodotoxin ... "Tetrodotoxin". Guide to Pharmacology. IUPHAR/BPS. Kao, C.Y. (1966). "Tetrodotoxin, saxitoxin and their significance in the ... Tetrodotoxin at the US National Library of Medicine Medical Subject Headings (MeSH) Tetrodotoxin: essential data (1999) ... This is the first reported case in which tetrodotoxin has been found to occur in a venom. "Tetrodotoxin". PubChem. National ...
  https://en.wikipedia.org/wiki/Tetrodotoxin
*  Binding of tetrodotoxin to squid nerve fibers. Two kinds of receptors? | JGP
The effect of tetrodotoxin on the sodium currents of the squid (Doryteuthis plei and Sepioteuthis sepiodea) giant axons was ... Binding of tetrodotoxin to squid nerve fibers. Two kinds of receptors?. C Sevcik ...
  http://jgp.rupress.org/content/68/1/95
*  Toxins | Free Full-Text | Highly Toxic Ribbon Worm Cephalothrix simula Containing Tetrodotoxin in Hiroshima Bay, Hiroshima...
The maximum toxicity in terms of tetrodotoxin (TTX) was 25,590 mouse units (MU) per gram for the whole worm throughout the ... tetrodotoxin), 4epi-TTX (4epi-tetrodotoxin) and 4,9-anhyTTX (4,9-anhydrotetrodotoxin); (D) Distribution of toxicity in the ... tetrodotoxin), 4epi-TTX (4epi-tetrodotoxin) and 4,9-anhyTTX (4,9-anhydrotetrodotoxin); (D) Distribution of toxicity in the ... Kim, Y.-H.; Brown, G.B.; Mosher, H.S.; Furman, F.A. Tetrodotoxin: Occurrence in atelopid frogs of Costa Rica. Science 1975, 189 ...
  http://mdpi.com/2072-6651/5/2/376/htm
*  Pharmacologic Actions of Tetrodotoxin Studied by Direct Perfusion of the Sinus Node | Circulation Research
The effects of tetrodotoxin on sinus node activity were studied by direct perfusion through its nutrient artery. Tetrodotoxin ... Pharmacologic Actions of Tetrodotoxin Studied by Direct Perfusion of the Sinus Node. JOHN C. TOMLINSON, THOMAS N. JAMES ... Tetrodotoxin also produced complete blockade of sinus node response to vagal stimulation. Blockade of sinus node responses to ... In the open-chest anesthetized dog, direct perfusion of the sinus node artery with tetrodotoxin, 1.0 µg/ml, caused immediate ...
  http://circres.ahajournals.org/content/23/4/501
*  Marine Drugs | Free Full-Text | Tetrodotoxin Blockade on Canine Cardiac L-Type Ca2+ Channels Depends on pH and Redox Potential
Tetrodotoxin (TTX) is believed to be one of the most selective inhibitors of voltage-gated fast Na+ channels in excitable ... Keywords: tetrodotoxin; calcium current; dog heart; pH dependence; redox potential tetrodotoxin; calcium current; dog heart; pH ... Tetrodotoxin Blockade on Canine Cardiac L-Type Ca2+ Channels Depends on pH and Redox Potential. Bence Hegyi 1. ... "Tetrodotoxin Blockade on Canine Cardiac L-Type Ca2+ Channels Depends on pH and Redox Potential." Mar. Drugs 11, no. 6: 2140- ...
  http://www.mdpi.com/1660-3397/11/6/2140/xml
*  IJMS | Free Full-Text | Effects of (−)-Gallocatechin-3-Gallate on Tetrodotoxin-Resistant Voltage-Gated Sodium Channels in Rat...
Tetrodotoxin inhibits all Nav isoforms, but Nav1.8 and Nav1.9 are relatively tetrodotoxin-resistant compared to other isoforms ... The percentage block of GCG (1 μM) on tetrodotoxin-resistant Na+ current was 45.1% ± 1.1% in 10 min. In addition, GCG did not ... In this study, the effects of GCG on tetrodotoxin-resistant Na+ currents were investigated in rat primary cultures of dorsal ... We found that 1 μM GCG reduced the amplitudes of peak current density of tetrodotoxin-resistant Na+ currents significantly. ...
  http://mdpi.com/1422-0067/14/5/9779/xml
*  Effects of the Sodium Channel Blocker Tetrodotoxin on Acute White Matter Pathology After Experimental Contusive Spinal Cord...
1993) Noninactivating, tetrodotoxin-sensitive Na+ conductance in rat optic nerve axons. Proc Natl Acad Sci USA 90:6976-6980. ... Focal microinjection of tetrodotoxin (TTX), a potent voltage-gated sodium channel blocker, reduces neurological deficits and ... 1997) Local blockade of sodium channels by tetrodotoxin ameliorates tissue loss and long-term functional deficits resulting ... Effects of the Sodium Channel Blocker Tetrodotoxin on Acute White Matter Pathology After Experimental Contusive Spinal Cord ...
  http://www.jneurosci.org/content/19/14/6122
*  Characterization, identification, and screening for tetrodotoxin production by bacteria associated with the ribbon worm ...
... composition of bacteria associated with the proboscis worm Cephalothrix simulawas studied and screening of the tetrodotoxin ( ... Kanoh, S., Distribution of tetrodotoxin in vertebrates, in Recent Advances in Tetrodotoxin Research, Hashimoto, K., Ed., Tokyo ... Yu, V.C-H., Yu, P.H-F., Ho, K-C., and Lee F.W.-F., Isolation and identification of a new tetrodotoxin-producing bacterial ... A Bacillus species was found to be responsible for tetrodotoxin production in proboscis worm C. simula. Vibrio spp. dominated ...
  https://link.springer.com/article/10.1134%2FS0026261714030059
*  The Purpose of This Study is to Determine if Tetrodotoxin (TTX) is Effective in the Treatment of Pain Resulting From...
Experimental: Max dose Tetrodotoxin (once daily) Max dose Tetrodotoxin injectable (1 ml volume), once a day in the morning for ... Experimental: Low dose Tetrodotoxin (twice daily) Low dose Tetrodotoxin injectable (1 ml volume), twice a day for four ... Experimental: Max dose Tetrodotoxin (twice daily) Max dose Tetrodotoxin injectable (1 ml volume), twice a day for four ... Experimental: Mid-range dose of Tetrodotoxin (twice daily) Mid-range dose Tetrodotoxin injectable (1 ml volume), twice a day ...
  https://clinicaltrials.gov/ct2/show/NCT01655823
*  The reaction between tetrodotoxin and membrane sites at the node of Ranvier: its kinetics and dependence on pH | Philosophical...
The reaction between tetrodotoxin and membrane sites at the node of Ranvier: its kinetics and dependence on pH. W. Ulbricht, H ... The reaction between tetrodotoxin and membrane sites at the node of Ranvier: its kinetics and dependence on pH ... The reaction between tetrodotoxin and membrane sites at the node of Ranvier: its kinetics and dependence on pH. ... The reaction between tetrodotoxin and membrane sites at the node of Ranvier: its kinetics and dependence on pH ...
  http://rstb.royalsocietypublishing.org/content/270/908/353
*  EFFECTS OF ATROPINE, TETRODOTOXIN AND LIDOCAINE ON REBOUND EXCITATION OF GUINEA-PIG SMALL INTESTINE | Journal of Pharmacology...
... tetrodotoxin and lidocaine. Procaine, tetrodotoxin and lidocaine increased the latent period of the poststimulus response, ... EFFECTS OF ATROPINE, TETRODOTOXIN AND LIDOCAINE ON REBOUND EXCITATION OF GUINEA-PIG SMALL INTESTINE. J. D. WOOD and D. R. MARSH ... EFFECTS OF ATROPINE, TETRODOTOXIN AND LIDOCAINE ON REBOUND EXCITATION OF GUINEA-PIG SMALL INTESTINE. J. D. WOOD and D. R. MARSH ... EFFECTS OF ATROPINE, TETRODOTOXIN AND LIDOCAINE ON REBOUND EXCITATION OF GUINEA-PIG SMALL INTESTINE. J. D. WOOD and D. R. MARSH ...
  http://jpet.aspetjournals.org/content/184/3/590
*  Tetrodotoxin Promotion | Alomone Labs
Tetrodotoxin (citrate free). A Classic Blocker of a Subset of Nav Channels ... Tetrodotoxin (citrate). A Classic Blocker of a Subset of NaV Channels ...
  https://www.alomone.com/c/tetrodotoxin-promotion-promos-discounts
*  "Evolutionary Genetics of Tetrodotoxin (TTX) Resistance in Snakes: Trac" by Chris R. Feldman
... atratus possess elevated resistance to tetrodotoxin (TTX), the lethal toxin of their newt prey. I show that TTX resistance has ... Evolutionary Genetics of Tetrodotoxin (TTX) Resistance in Snakes: Tracking a Feeding Adaptation from Populations Through Clades ... Feldman, Chris R., "Evolutionary Genetics of Tetrodotoxin (TTX) Resistance in Snakes: Tracking a Feeding Adaptation from ... atratus possess elevated resistance to tetrodotoxin (TTX), the lethal toxin of their newt prey. I show that TTX resistance has ...
  https://digitalcommons.usu.edu/etd/159/
*  T-Type and Tetrodotoxin-Sensitive Ca2+ Currents Coexist in Guinea Pig Ventricular Myocytes and Are Both Blocked by Mibefradil |...
Well-characterized currents include the T-type Ca2+ current (ICa(T))1 2 and the tetrodotoxin (TTX)-sensitive Na+ current (INa). ... T-Type and Tetrodotoxin-Sensitive Ca2+ Currents Coexist in Guinea Pig Ventricular Myocytes and Are Both Blocked by Mibefradil. ... T-Type and Tetrodotoxin-Sensitive Ca2+ Currents Coexist in Guinea Pig Ventricular Myocytes and Are Both Blocked by Mibefradil ... T-Type and Tetrodotoxin-Sensitive Ca2+ Currents Coexist in Guinea Pig Ventricular Myocytes and Are Both Blocked by Mibefradil ...
  http://circres.ahajournals.org/content/86/6/628
*  tetrodotoxin - Seriously Fish
Glossary: tetrodotoxin. Neurotoxin found in many species of puffer fish. Lethal to humans. ...
  http://www.seriouslyfish.com/glossary/t/tetrodotoxin/
*  Separation of the action potential into a Na-channel spike and a K-channel spike by tetrodotoxin and by tetraethylammonium ion...
The effects of tetrodotoxin (TTX) and of tetraethylammonium ion (TEA+) on such action potentials were studied. The results are ... Separation of the action potential into a Na-channel spike and a K-channel spike by tetrodotoxin and by tetraethylammonium ion ... Separation of the action potential into a Na-channel spike and a K-channel spike by tetrodotoxin and by tetraethylammonium ion ...
  http://jgp.rupress.org/content/76/3/337
*  Short Hairpin RNA-mediated Selective Knockdown of NaV1.8 Tetrodotoxin-resistant Voltage-gated Sodium Channel in Dorsal Root...
Pharmacologically, VGSCs can be broadly classified into those that are blocked by tetrodotoxin (tetrodotoxin sensitive) and ... In the presence of tetrodotoxin, the resulting family of currents represents tetrodotoxin-resistant current flowing mostly ... lentivirus only expressing the EGFP reporter or the pan-tetrodotoxin-sensitive shRNA designed to knock down the tetrodotoxin- ... Pan-TTXs = pan-tetrodotoxin sensitive. ( C ) HEK293-NaV1.8 cell line infected with lentivirus expressing NaV1.8 (6033)-short ...
  http://anesthesiology.pubs.asahq.org/article.aspx?articleid=1923738
*  "Biosynthetic studies of tetrodotoxin and its anticancer activities ass" by Zhe Xiao
Xiao, Zhe, "Biosynthetic studies of tetrodotoxin and its anticancer activities assessment in vitro" (2014). Open Access Theses ... Keywords: Tetrodotoxin (TTX), Bacterial synthesis, Anticancer, VGSCs ...
  https://repository.hkbu.edu.hk/etd_oa/56/
*  Depuration of tetrodotoxin and changes in bacterial communities in Pleurobranchea maculata adults and egg masses maintained in...
Depuration of tetrodotoxin and changes in bacterial communities in Pleurobranchea maculata adults and egg masses maintained in ... Depuration of tetrodotoxin (TTX) was investigated in adult grey side-gilled sea slugs, Pleurobranchaea maculata, maintained in ... Wood, S. A., Casas, M., Taylor, D. I., McNabb, P., Salvitti, L., Ogilvie, S., & Cary, S. C. (2012). Depuration of tetrodotoxin ...
  https://researchcommons.waikato.ac.nz/handle/10289/7065
*  August 1967 - Scientific American
Tetrodotoxin. It is a powerful poison that is found in two almost totally unrelated kinds of animal: puffer fish and newts. It ...
  https://www.scientificamerican.com/magazine/sa/1967/08-01/