*  MUC1 (EMA) is preferentially expressed by ALK positive anaplastic large cell lymphoma, in the normally glycosylated or only...
... and T cell markers CD3 and CD45RO/UCHL-1. By definition, systemic nodal ALCL, primary cutaneous ALCL, and classic HD were all ... Systemic (nodal) anaplastic large cell lymphoma (ALCL) is a CD30 positive non-Hodgkin's lymphoma of T cell or null cell ... Staining for anti-MUC1 monoclonal antibodies in tumour cells of ALK positive systemic nodal anaplastic large cell lymphoma ... Prognostic significance of anaplastic lymphoma kinase (ALK) protein expression in adults with anaplastic large cell lymphoma. ...
  http://jcp.bmj.com/content/54/12/933
*  Alisertib in Treating Patients With Relapsed or Refractory Peripheral T-Cell Non-Hodgkin Lymphoma - Full Text View -...
Lymphoma, Non-Hodgkin. Lymphoma, T-Cell. Leukemia, T-Cell. Leukemia-Lymphoma, Adult T-Cell. Lymphoma, Large-Cell, Anaplastic. ... Transformed cutaneous T-cell lymphoma (CTCL) to PTCL with systemic involvement (not local skin transformation) ... Anaplastic Large Cell Lymphoma Angioimmunoblastic T-Cell Lymphoma Hepatosplenic T-Cell Lymphoma Mature T-Cell and NK-Cell Non- ... Peripheral T-cell NHL (PTCL) not otherwise specified (NOS). *Anaplastic large cell T-cell lymphoma (ALCL) that is anaplastic ...
  https://clinicaltrials.gov/show/NCT01466881
*  Alisertib in Treating Patients With Relapsed or Refractory Peripheral T-Cell Non-Hodgkin Lymphoma - Full Text View -...
Lymphoma, Non-Hodgkin. Lymphoma, T-Cell. Leukemia, T-Cell. Leukemia-Lymphoma, Adult T-Cell. Lymphoma, Large-Cell, Anaplastic. ... Transformed cutaneous T-cell lymphoma (CTCL) to PTCL with systemic involvement (not local skin transformation) ... Anaplastic Large Cell Lymphoma Angioimmunoblastic T-Cell Lymphoma Hepatosplenic T-Cell Lymphoma Mature T-Cell and NK-Cell Non- ... T-cell, Chronic Adult T-cell Leukemia/lymphoma Extranodal Nasal NK/T Cell Lymphoma Anaplastic Large Cell Lymphoma ...
  https://clinicaltrials.gov/ct2/show/study/NCT01466881?show_locs=Y
*  Initial cutaneous manifestation of lymphomas in children
2. Kadin ME, Carpenter C. Systemic and primary cutaneous anaplastic large cell lymphomas. Semin Hematol. 2003;40:244-56. [ ... Anaplastic large cell lymphomas (ALCL) may be primary to the skin (patient #5) or may be systemic (patient #2). In children, ... Primary cutaneous anaplastic large cell lymphoma in a young child. Eur J Pediatr. 2008;167:111-3. [ Links ]. ... Unlike systemic NHL in which the most com-mon cell lineage is B, cases of PCL are generally T-cell related. Cutaneous T-cell ...
  http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0365-05962011000400031&lng=en&nrm=iso&tlng=en
*  SGN-35 in CD30-positive Lymphoproliferative Disorders (ALCL), Mycosis Fungoides (MF), and Extensive Lymphomatoid Papulosis (LyP...
systemic therapy. cutaneous anaplastic large T cell lymphoma. ALCL. lymphomatoid papulosis. LyP. mycosis fungoides. MF. skin ... CD-30 Positive Anaplastic Large T-cell Cutaneous Lymphoma Lymphoma, Primary Cutaneous Anaplastic Large Cell Lymphomatoid ... Lymphoma, T-Cell, Cutaneous. Lymphoma, Primary Cutaneous Anaplastic Large Cell. Neoplasms by Histologic Type. Neoplasms. ... CD30+ primary cutaneous anaplastic large T-cell lymphoma (pc-ALCL), or CD30+ mycosis fungoides for the phase II trial. There is ...
  https://clinicaltrials.gov/ct2/show?term=SGN-35&rank=6
*  Barry Pizer
Isolated cutaneous anaplastic large cell lymphoma progressing to severe systemic disease with myocardial involvement and ... Anaplastic large-cell lymphoma in a child with type I diabetes and unrecognised coeliac disease.. Authors:. Jemima Sharp Barry ... Roger E Taylor Andrew J Howman Keith Wheatley Elena E Brogden Bridget Large Michael J Gibson Keith Robson Dipayan Mitra Frank ... Anaplastic ependymoma with sclerotic bone metastases.. Authors:. Munir Hussain Conor Mallucci Laurence Abernethy Vidula ...
  https://www.pubfacts.com/author/Barry+Pizer
*  Primary Cutaneous Anaplastic Large Cell Lymphoma disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials
MDX-060 in Patients With Relapsed or Refractory Classic Systemic or Primary Cutaneous Anaplastic Large Cell Lymphoma. Withdrawn ... Primary Cutaneous Anaplastic Large Cell Lymphoma, also known as lymphoma, primary cutaneous anaplastic large cell, is related ... MalaCards integrated aliases for Primary Cutaneous Anaplastic Large Cell Lymphoma:. Name: Primary Cutaneous Anaplastic Large ... Primary cutaneous anaplastic large cell lymphoma simulating an aggressive angiocentric T-cell lymphoma. ( 22458926 ) ...
  https://www.malacards.org/card/primary_cutaneous_anaplastic_large_cell_lymphoma
*  Russo I[au] - PubMed - NCBI
A Case of Angioinvasive Cutaneous Anaplastic Large Cell Lymphoma Completely Regressed After Low-dose Systemic Methotrexate. ... A comparative study of the cutaneous side effects between BRAF monotherapy and BRAF/MEK inhibitor combination therapy in ... TLR7 Gln11Leu single nucleotide polymorphism and susceptibility to cutaneous melanoma.. Elefanti L, Sacco G, Stagni C, ... Livedoid eruption in a patient affected by T-γδ large granular lymphocyte leukaemia. ...
  https://www.ncbi.nlm.nih.gov/pubmed?cmd=search&term=Russo+I%5Bau%5D&dispmax=50
*  Single-Fraction Radiotherapy for CD30+ Lymphoproliferative Disorders
"Complete response of relapsed systemic and cutaneous anaplastic large cell lymphoma using brentuximab vedotin: 2 case reports ... or are associated with other lymphomas such as MF, cutaneous, or nodal anaplastic large-cell lymphoma and Hodgkin's Lymphoma [3 ... J. B. Yu, J. M. McNiff, M. W. Lund, and L. D. Wilson, "Treatment of primary cutaneous CD30+ anaplastic large cell lymphoma with ... H. Fujita, T. Nagatani, M. Miyazawa et al., "Primary cutaneous anaplastic large cell lymphoma successfully treated with low- ...
  https://www.hindawi.com/journals/bmri/2015/629587/
*  Search of: 'Lymphoma large-cell' - List Results - ClinicalTrials.gov
MDX-060 in Patients With Relapsed or Refractory Classic Systemic or Primary Cutaneous Anaplastic Large Cell Lymphoma. *Lymphoma ... A Study of Treatment ALK(+) Systemic Anaplastic Large Cell Lymphoma With Crizotinib. *Systemic Anaplastic Large-Cell Lymphoma ... s Lymphoma or Anaplastic Large Cell Lymphoma'. *Relapsed or Refractory CD30+ Hodgkin's Lymphoma or Anaplastic Large Cell ... for Systemic Anaplastic Large Cell Lymphoma. *Lymphoma, Large-Cell, Anaplastic ...
  https://clinicaltrials.gov/ct2/results?cond=%22Lymphoma+large-cell%22
*  Mycosis fungoides: Systemic implications & complications | Hematology News
Marginal zone lymphoma & primary cutaneous anaplastic large cell lymphoma. Take Quiz. Indolent lymphoma subtypes: Marginal zone ... Cutaneous B-cell lymphoma: Epidemiology & diagnosis. Take Quiz. ... Indolent B-cell lymphoma: Autologous & allogeneic stem cell ... Mycosis fungoides: Systemic implications & complications. Take Quiz. Follicular lymphoma imaging, management, & differential ... Guideline updates for non-Hodgkin lymphomas: Part 2. Take Quiz. Guideline updates for non-Hodgkin lymphomas: Part 1. Take Quiz ...
  https://www.mdedge.com/hematologynews/quiz/5496/indolent-lymphoma/mycosis-fungoides-systemic-implications-complications
*  Brentuximab vedotin | Leukemia and Lymphoma Society
Primary cutaneous anaplastic large cell lymphoma (pcALCL) or CD30- expressing mycosis fungoides (MF) who have received prior ... Systemic anaplastic large cell lymphoma (sALCL) after failure of at least one prior multi-agent chemotherapy regimen ... The Leukemia & Lymphoma Society (LLS) is the world's largest voluntary health agency dedicated to blood cancer. The LLS mission ... Classical Hodgkin lymphoma (HL) after failure of autologous hematopoietic stem cell transplantation (auto-HSCT) or after ...
  https://www.lls.org/treatment/types-of-treatment/chemotherapy-and-other-drug-therapies/drug-listings/brentuximab-vedotin
*  MUC1 - Wikipedia
... from cutaneous anaplastic large-cell lymphoma (usually MUC1-) Adenocarcinomas (breast, colorectal, pancreatic, other) Carcinoid ... marker breast micropapillary carcinoma bladder micropapillary carcinoma Distinguish systemic anaplastic large-cell lymphoma ( ... Anaplastic large-cell lymphoma, diffuse large B cell lymphoma (variable), plasmablastic lymphoma, primary effusion lymphoma ... reticulum cell sarcoma Lung: type II pneumocyte lesions (type II cell hyperplasia, dysplastic type II cells, apical alveolar ...
  https://en.wikipedia.org/wiki/MUC1
*  Perils and Pitfalls Regarding Differential Diagnosis and Treatment of Primary Cutaneous Anaplastic Large-Cell Lymphoma
Nevertheless, PC-ALCL must be distinguished from secondary skin lesions in systemic ALCL, which confer a poor prognosis, and ... Primary cutaneous anaplastic large-cell lymphoma (PC-ALCL), belonging to the CD30+ T-cell lymphoproliferative disorders (PCLPDs ... Perils and Pitfalls Regarding Differential Diagnosis and Treatment of Primary Cutaneous Anaplastic Large-Cell Lymphoma. Michael ... is a rare T-cell lymphoma, presenting on the skin and characterized by very good prognosis and response to treatment in the ...
  https://www.hindawi.com/journals/tswj/2011/350612/abs/
*  Adcetris (Brentuximab Vedotin): Side Effects, Interactions, Warning, Dosage & Uses
Large Cell Lymphoma And CD30-expressingMycosis Fungoides. Randomized Clinical Trial In Primary Cutaneous Anaplastic Large Cell ... Table 6: Adverse Reactions Reported in ≥10% of Patients with Relapsed Systemic Anaplastic Large Cell Lymphoma (Study 2). ... Relapsed Primary Cutaneous Anaplastic Large Cell Lymphoma or CD30-expressing Mycosis Fungoides. 1.8 mg/kg up to a maximum of ... Table 12: Efficacy Results in Patients with Systemic Anaplastic Large Cell Lymphoma (Study 2). N = 58. ...
  https://www.rxlist.com/adcetris-drug.htm
*  SGN-35 in CD30-positive Lymphoproliferative Disorders (ALCL), Mycosis Fungoides (MF), and Extensive Lymphomatoid Papulosis (LyP)
CD-30 Positive Anaplastic Large T-cell Cutaneous Lymphoma, Lymphoma, Primary Cutaneous Anaplastic Large Cell, Lymphomatoid ... 2. Patients with known grade 3 or higher (per CTCAE v.4.0 criteria) active systemic or. cutaneous viral, bacterial or fungal ... cutaneous anaplastic large T-cell lymphoma (pc-ALCL), or CD30+ mycosis fungoides for. the phase II trial. There is no specific ... Cutaneous Anaplastic Large T-cell Lymphoma (ALCL), Mycosis Fungoides, and Extensive Lymphomatoid Papulosis (LyP). Trial Phase: ...
  http://www.knowcancer.com/cancer-trials/NCT01352520/
*  FDA Approval of Brentuximab Vedotin - The ASCO Post
... systemic anaplastic large cell lymphoma (ALCL) after failure of other treatment; and primary cutaneous ALCL after failure of ... Brentuximab vedotin combines an antibody and drug and acts by targeting CD30 on lymphoma cells. ... classical Hodgkin lymphoma after stem cell transplant when a patient is at a high risk of relapse or disease progression; ... FDA Expands Approval of Brentuximab Vedotin in Classical Hodgkin Lymphoma. By The ASCO Post. April 10, 2018. Advertisement ...
  http://ascopost.com/issues/april-10-2018/fda-approval-of-brentuximab-vedotin/
*  Lymphomatoid Papulosis Publications and Abstracts | PubFacts.com
... primary cutaneous anaplastic large T-cell lymphoma, systemic anaplastic large T-cell lymphoma with secondary skin involvement, ... CD30-positive primary cutaneous T-cell lymphoma (CTCL) includes mycosis fungoides, anaplastic large-cell lymphoma and ... and primary cutaneous anaplastic large-cell lymphoma (PCALCL), comprises the second most common group of cutaneous T cell ... primary cutaneous anaplastic large cell lymphoma (pcALCL,= 4), subcutaneous panniculitis-like T-cell lymphoma (SPTCL= 13), and ...
  https://www.pubfacts.com/search/Lymphomatoid+Papulosis
*  A Phase 2 Open Label Trial of Brentuximab Vedotin (SGN-35) for Systemic Anaplastic Large Cell Lymphoma - Tabular View -...
Patients with current diagnosis of primary cutaneous ALCL (patients who have transformed to systemic ALCL are eligible). ... A Phase 2 Open Label Trial of Brentuximab Vedotin (SGN-35) for Systemic Anaplastic Large Cell Lymphoma. This study has been ... A Phase 2 Study of SGN-35 in Treatment of Patients With Relapsed or Refractory Systemic Anaplastic Large Cell Lymphoma (ALCL). ... A Phase 2 Open Label Trial of Brentuximab Vedotin (SGN-35) for Systemic Anaplastic Large Cell Lymphoma. ...
  https://clinicaltrials.gov/ct2/show/record/NCT00866047
*  Brentuximab vedotin - Wikipedia
... who have received prior systemic therapy. This approval is for patients with primary cutaneous anaplastic large cell lymphoma ( ... and systemic anaplastic large cell lymphoma (ALCL). It selectively targets tumor cells expressing the CD30 antigen, a defining ... Safety and efficacy of brentuximab vedotin in patients with Hodgkin lymphoma or systemic anaplastic large cell lymphoma ... be made available more generally for the first-line treatment of relapsed or refractory systemic anaplastic large cell lymphoma ...
  https://en.wikipedia.org/wiki/Brentuximab_vedotin
*  Anaplastic Large Cell Lymphoma - Lymphoma Research Foundation
The mission of LRF is to eradicate lymphoma and serve those touched by this disease. ... organization in the nation devoted exclusively to funding innovative lymphoma research and providing people with lymphoma and ... adults and between 10 percent and 30 percent of all lymphomas in children and can present in either the systemic or cutaneous ... What is anaplastic large cell lymphoma?. Dr. Shustov: Anaplastic large cell lymphoma (ALCL) is a rare type of aggressive T-cell ...
  http://www.lymphoma.org/site/pp.asp?c=bkLTKaOQLmK8E&b=6293639
*  Seattle Genetics' ASH 2012 Presentations Highlight ADCETRIS® And Demonstrate Leadership In The Development Of Antibody-Drug...
... and systemic anaplastic large cell lymphoma (sALCL), as well as in some types of cutaneous T-cell lymphoma (CTCL), B-cell ... the treatment of patients with systemic anaplastic large cell lymphoma (sALCL) after failure of at least one prior multi-agent ... ADCETRIS is currently not approved for use in CTCL, B-cell lymphomas, and front-line treatment of HL or MTCL. ... lymphomas and mature T-cell lymphomas (MTCL). Seattle Genetics is broadly evaluating CD30 expression in many other cancer types ...
  https://www.thestreet.com/story/11757286/1/seattle-genetics8217-ash-2012-presentations-highlight-adcetris174-and-demonstrate-leadership-in-the-development-of-antibody-drug-conjugates-adcs.html
*  Seattle Genetics' Adcetris Gets FDA Nod for Label Expansion - November 13, 2017 - Zacks.com
The drug is approved for relapsed Hodgkin lymphoma and relapsed systemic anaplastic large cell lymphoma (sALCL), and for ... The company announced that the FDA has approved Adcetris for the treatment of primary cutaneous anaplastic large cell lymphoma ... Markedly, primary cutaneous ALCL and MF are the most common subtypes of cutaneous T-cell lymphoma (CTCL) which is blood cancer ... ALCANZA and two phase II investigator-sponsored trials in patients with cutaneous T-cell lymphoma (CTCL). Interestingly, the ...
  https://www.zacks.com/stock/news/282667/seattle-genetics-adcetris-gets-fda-nod-for-label-expansion
*  Genetically Modified Peripheral Blood Stem Cell Transplant in Treating Patients With HIV-Associated Non-Hodgkin or Hodgkin...
AIDS-related Small Noncleaved Cell Lymphoma Anaplastic Large Cell Lymphoma Angioimmunoblastic T-cell Lymphoma Cutaneous B-cell ... AIDS-related Immunoblastic Large Cell Lymphoma AIDS-related Lymphoblastic Lymphoma AIDS-related Peripheral/Systemic Lymphoma ... Precursor Cell Lymphoblastic Leukemia-Lymphoma. Lymphoma, Large B-Cell, Diffuse. Burkitt Lymphoma. Lymphoma, T-Cell. Lymphoma, ... Hodgkin Lymphoma Mycosis Fungoides Sezary Syndrome Cutaneous T-cell Lymphoma Peripheral T-cell Lymphoma Lymphoma, Large-cell ...
  https://clinicaltrials.gov/ct2/show/NCT01769911?term=%22+December+23%2C++2012%22%3A%22+January+22%2C++2013%22%5BFIRST-RECEIVED-DATE%5DAND+HIV%5BCONDITION%5D&rank=11
*  Seattle Genetics Submits Supplemental Biologics License Application to FDA for ADCETRIS® (Brentuximab Vedotin) in Cutaneous T...
... cutaneous anaplastic large cell lymphoma who require systemic therapy and have received one prior systemic therapy. These ... classical Hodgkin lymphoma (HL) and relapsed systemic anaplastic large cell lymphoma (sALCL). Seattle Genetics is also ... approval for the treatment of patients with systemic anaplastic large cell lymphoma (sALCL) after failure of at least one prior ... Cutaneous lymphomas are a category of non-Hodgkin lymphoma that primarily involve the skin. According to the Cutaneous Lymphoma ...
  https://www.enhancedonlinenews.com/news/eon/20170620005552/en