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*  Erythromycin - New World Encyclopedia
... but can also be bactericidal (kills bacteria) in high concentrations. Macrolides tend to accumulate within leukocytes, and are ... By binding to the 50S subunit of the bacterial 70S rRNA complex, protein synthesis and subsequently structure/function ... during active phagocytosis, large concentrations of erythromycin are released. ... Erythromycin belongs to a group of drugs known as macrolides. The activity of macrolides stems from the presence of a macrolide ...
  http://www.newworldencyclopedia.org/entry/Erythromycin
*  Pneumococcal infection - Wikipedia
The risk of pneumococcal infection is much increased in persons with impaired IgG synthesis, impaired phagocytosis, or ... and has bactericidal effects against competing bacteria (Haemophilus influenzae, Neisseria meningitidis, Staphylococcus aureus ... There is slight clinical evidence that penicillins may act synergistically with macrolides to improve outcomes. In the 19th ... Polysaccharide capsule-prevents phagocytosis by host immune cells by inhibiting C3b opsonization of the bacterial cells ...
  https://en.wikipedia.org/wiki/Pneumococcal_infection
*  Clindamycin - Wikipedia
It is a bacterial protein synthesis inhibitor by inhibiting ribosomal translocation, in a similar way to macrolides. It does so ... to determine if there is a macrolide-resistant subpopulation of bacteria present. This test is necessary because some bacteria ... Clindamycin is used in cases of suspected toxic shock syndrome, often in combination with a bactericidal agent such as ... 1981). "Potentiation of Opsonization and Phagocytosis of Streptococcus pyogenes following Growth in the Presence of Clindamycin ...
  https://en.wikipedia.org/wiki/Clindamycin
*  Dr.Med - medical on-line is a reference book.: Azithrus
... inhibits protein synthesis and slows the growth and multiplication of bacteria. In high concentrations, has a bactericidal ... Shown that phagocytes deliver azithromycin to the localization of infection sites, where it is released during phagocytosis. ... Broad-spectrum antibiotic of macrolides, azalid.. Valid bacteriostatic. Communicating with the 50S-subunit of ribosomes, ... Azithromycin remains in bactericidal concentrations of inflammation within 5-7 days after receiving the last dose, which ...
  http://drrmed.blogspot.com/2010/06/azithrus.html
*  Bench-to-bedside review: Bacterial pneumonia with influenza - pathogenesis and clinical implications | Critical Care | Full Text
Although other factors that mediate opsonization or phagocytosis of bacteria have been extensively studied for primary ... Fourteen-member macrolides promote the phosphatidylserine receptor-dependent phagocytosis of apoptotic neutrophils by alveolar ... Karlström A, Boyd KL, English BK, McCullers JA: Treatment with protein synthesis inhibitors improves outcomes of secondary ... Depression of monocyte and polymorphonuclear leukocyte oxidative metabolism and bactericidal capacity by influenza A virus. ...
  https://ccforum.biomedcentral.com/articles/10.1186/cc8893
*  Chemotherapeutic agents used in periodontics
Macrolides:. Macrolides are primarily used to control infections caused by Gram-positive bacteria. First macrolide used was ... Synthesis. Bactericidal. Skin rashes (ampicillin and amoxicillin), allergic reaction, diarrhea (ampicillin and amoxicillin). ... they release the drug after they rupture during phagocytosis 7. The drug has a long half-life of 40-60 hours which allows its ... As already stated, macrolides are primarily active against Gram-positive bacteria including Streptococci, Pneumococci, ...
  http://periobasics.com/chemotherapeutic-agents-used-in-periodontics.html
*  Quorum Sensing - CHEMICAL BIOLOGY
... aeruginosa through a possible impact on synthesis and activity of AI molecules. Macrolides like azithromycin also repress the ... while leaving the Gram-negative bacteria unaffected. Although the mechanism of bactericidal activity of this tetramic acid-like ... aeruginosa and also render it sensitive to tobramycin and phagocytosis by polymorphormonuclear leaucocytes (PMN) in a mice ... However, when bacteria reach a critical mass, the secreted AI concentration also reaches a threshold that enables the bacteria ...
  https://schoolbag.info/chemistry/chemical_biology/181.html
*  Infections in Patients with Cancer - Holland-Frei Cancer Medicine - NCBI Bookshelf
... and reduced killing of ingested bacteria. Abnormalities in neutrophil maturation and bactericidal activity have been reported ... The new macrolides azithromycin, roxithromycin, and clarithromycin have activity against T. gondii, but sufficient clinical ... Immunoglobulins promote phagocytosis and destruction of microorganisms by various mechanisms, such as opsonization of organisms ... Chronic administration may result in interference with steroid synthesis, resulting in gynecomastia and decreased testosterone ...
  https://www.ncbi.nlm.nih.gov/books/NBK20904/
*  Exam 4 Flashcards by Michael Renecle | Brainscape
Bactericidal: agent that kills bacteria. - Bacteriostatic: agent that inhibits growth, but doesn't kill the bacteria. ... Inhibits protein synthesis in bacteria. ? about MOA in amebiasis.. c. Abdominal discomfort/diarrhea.. ... Inflammation results in phagocytosis of crystals. Low pH produced by leukocytes leads to increased uric acid crystallization. ... Aminoglycosides are bactericidal. Macrolides are bactericidal at high concentrations.. 32 Aminoglycoside compounds.. a. Names. ...
  https://www.brainscape.com/flashcards/exam-4-4316967/packs/6040369
*  Dental Plaque
The bacteria in biofilms are phenotypically distinct from their genomically-identical planktonic counterparts. Bacteria in ... P.gingivalis secretes a serine phosphatase that inhibits the synthesis of IL-8 127. This process has been termed as "local ... Some antibiotics such as the macrolides, which are positively charged but hydrophobic in nature, are unaffected by this process ... Traditionally, minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) terms have been used to ...
  http://periobasics.com/dental-plaque-2.html
*  Buy Rulide Online
Generic Rulide is used to treat infections in different parts of the body caused by bacteria (acute pharyngitis (sore throat ... The percentage of surviving bacteria after 2 and 4 h incubation was not significantly different between these macrolides at the ... The bactericidal activities of ofloxacin and roxithromycin were evaluated against 15 strains of S. pneumoniae, which were ... Chemotaxis was also impaired by roxithromycin (100 mg/l) but phagocytosis of Klebsiella pneumoniae was unaltered even at high ...
  http://pillsforsale24h.bid/rulide-cheap.html
*  Micro Exam1 Flashcards - Cram.com
intereferes with binding of f-met tRNA; bactericidal and inhibitor of protein synthesis ... bind/associate bacteria, penetrate through the outer membrane and periplasmic space in gram-, interact with PBPs, activate/ ... must avoid being caught in the mucus layer and if in the lower tract must avoid phagocytosis ... inhibition of cell wall synthesis, disruption of plasma membrane, inhibition of protein synthesis and nucleic acids, anti- ...
  http://www.cram.com/flashcards/micro-exam1-465462
*  Anthrax and Microbiology of B. anthracis
Prevention of bacillary phagocytosis: Capsule formation significantly impairs opsonization and phagocytosis of bacilli, whereas ... All of these drugs were bactericidal at 24 hours of incubation and concentrations >4xMIC. Levofloxacin was bactericidal at ... Clindamycin or other protein synthesis inhibitors may be added to impair toxin synthesis. ... Anthrax toxin and secreted neutral proteases facilitate movement of bacteria in and out of the vasculature by inducing vascular ...
  http://www.thecardiologyadvisor.com/infectious-diseases/anthrax-and-microbiology-of-b-anthracis/article/609712/
*  Staphylococcus aureusand Chronic Airway Disease | World Allergy Organization Journal | Full Text
Hollams E, Hales B, Bachert C, Huvenne W, Parsons F, et al: Th2-associated immunity to bacteria in asthma in teenagers and ... Ferrara A, Dos Santos C, Lupi A: Effect of some fractions of alveolar surfactant (phospholipids and SP-A) on the bactericidal ... S. aureus inhibits the production of superoxide in macrophages to evade killing after phagocytosis; this mechanism is TLR2 ... Harvey RJ, Wallwork BD, Lund VJ: Anti-inflammatory effects of macrolides: Applications in chronic rhinosinusitis. Immunol ...
  https://waojournal.biomedcentral.com/articles/10.1097/WOX.0b013e3181ecd8ae
*  Infections Associated with Medical Devices Pathogenesis, Management and Prophylaxis - PDF
153] In a recent study designed to compare the ent bacteria in the biofilms and a further agent with efficacy of caspofungin ... Whereas times less) and lower levels of phagocytosis relative treatment with local or systemic free amikacin had to the levels ... 55] Notably, glycopeptides are (endocarditis, osteomyelitis and other metastatic inpoorly bactericidal against staphylococci. ... additional factors lular adhesin synthesis in S. epidermidis has been may be important in later stages of adherence in cloned ...
  http://docplayer.net/244669-Infections-associated-with-medical-devices-pathogenesis-management-and-prophylaxis.html
*  Streptococcal and Enterococcal Infections
Group C and group G streptococci are â-hemolytic bacteria that occasionally cause human infections similar to those caused by ... In areas with resistance rates exceeding 5-10%, macrolides should be avoided unless results of susceptibility testing are known ... For enterococci resistant to both vancomycin and â-lactams, no established therapies provide uniformly bactericidal activity. ... through its direct action on protein synthesis, clindamycin is more effective in rapidly terminating toxin production than ...
  http://www.gkhub.info/streptococcal-and-enterococcal-infections.html
*  Pathogen- and Host-Directed Anti-Inflammatory Activities of Macrolide Antibiotics
G. Kaiser, "Protein synthesis inhibitors: macrolides mechanism of action animation. Classification of agents Pharmamotion," The ... the high tissue and macrophage/PMNL concentrations attained by macrolides and macrolide-like agents may favour bactericidal ... which enable bacteria to detect and regulate their population density and to upregulate virulence [35]. Gram-negative bacteria ... "Fourteen-member macrolides promote the phosphatidylserine receptor-dependent phagocytosis of apoptotic neutrophils by alveolar ...
  https://www.hindawi.com/journals/mi/2012/584262/
*  Bacillus anthracis - STEP1 Microbiology - Step 1 - Medbullets.com
Although the bacteria are gram-positive (purple), their spores often appear pink on Gram stain.. Incorrect Answers:. Answer 1: ... This impairs protein synthesis in enterocytes, leading to cell death and a syndrome of bloody diarrhea.. Answer 4: ... an exotoxin that binds the Fc portion of immunoglobulin molecules to block opsonization and phagocytosis. S. aureus also ... Bactericidal Antibiotics * Prophylaxis Antibiotics * ID Medications to Avoid in Pregnancy * MNEMONICS * Words That Sound Alike ...
  http://www.medbullets.com/step1-microbiology/4037/bacillus-anthracis