*  Biochemistry- Enzymes - Flashcards in University Biology
Different enzymes show a different degree of specificity. Some are specific to one substrate, whilst others aren't. Give an ... i.e. substrate binding at one site can affect substrate binding at the next. 2. Small change in [I] can cause a large change in ... has a structure similar to the substrate, and hence occupies the active site instead of the substrate, taking the free enzyme ... It decreases i.e. there is an apparent increase in affinity of substrate to enzyme (but actually substrate release is just ...
  https://getrevising.co.uk/revision-tests/biochemistry_enzymes?game_type=flashcards
*  Analysis of AtZDP substrate specificity
... Valsecchi, Isabel Uppsala University, Disciplinary Domain of Medicine and Pharmacy, ... All substrates were dephosphorylated by AtZDP, assuming that this enzyme could potentially be involved in double-strand DNA ...
  http://uu.diva-portal.org/smash/record.jsf?pid=diva2:172212
*  Substrate specificity of protein kinases - Patent # 5532167 - PatentGenius
The invention also provides peptide substrates for protein kinase A, cell cycle control kinases, src family kinases, the EGF ... peptides within the library which are substrates for the kinase are converted to phosphopeptides and the phosphopeptides are ... When the substrate is a substrate for a protein-serine/threonine kinase, Xaa5 is Ser or Thr, whereas whenthe substrate is a ... This invention pertains to the substrate specificity of protein kinases and to peptides which are substrates for protein ...
  http://www.patentgenius.com/patent/5532167.html
*  Molecular Basis for the Substrate Specificity of Human Catecholamine Sulfotransferase, SULT1A3 | SpringerLink
Dajani R., Hood A. M., and Coughtrie M. W. H., 1998, A single amino acid, Glu146, governs the substrate specificity of a human ... Coughtrie M.W.H., Taskinen J., Hood A.M. (2002) Molecular Basis for the Substrate Specificity of Human Catecholamine ... Molecular modelling and QSAR analysis demonstrate a molecular basis for sulfotransferase substrate specificity. J Biol Chem, ... enzyme superfamily that transfer a sulfuryl moiety from the co-substrate 3′-phopshoadenosine 5′-phosphosulfate (PAPS). In ...
  https://link.springer.com/chapter/10.1007/978-1-4757-3538-3_34
*  Furaldehyde substrate specificity and kinetics of Saccharomyces cerevisiae alcohol dehydrogenase 1 variants
... Laadan, B. ... resulting in Adh1p-variants with different substrate specificities. ... Kinetic characterization with both aldehydes and the in vivo primary substrate acetaldehyde also enabled to correlate the ... of both native and mutated ADH1 genes was performed in order to identify the key amino acids involved in this substrate shift, ...
  http://www.diva-portal.org/smash/record.jsf?pid=diva2:738158
*  Substrate Specificities of Phenylalanine and Tyrosine Hydroxylase: Role of Aspartate 425 of Tyrosine Hydroxylase | SpringerLink
Substrate Specificities of Phenylalanine and Tyrosine Hydroxylase: Role of Aspartate 425 of Tyrosine Hydroxylase. ... Daubner S.C., Melendez J., Fitzpatrick P.F. (2002) Substrate Specificities of Phenylalanine and Tyrosine Hydroxylase: Role of ... These substrate specificities are determined by the C domains (11). The goal of the experiments described here was to identify ... these enzymes differ in their substrate specificities. PheH is very specific for phenylalanine; although it can hydroxylate ...
  https://link.springer.com/chapter/10.1007/978-1-4615-0945-5_21
*  The substrate specificity of the tyrosine decarboxylase of Streptococcus faecalis | Biochemical Journal
The substrate specificity of the tyrosine decarboxylase of Streptococcus faecalis Message Subject (Your Name) has forwarded a ... The substrate specificity of the tyrosine decarboxylase of Streptococcus faecalis. G. H. Sloane-Stanley ...
  http://www.biochemj.org/content/44/3/373
*  Insights into substrate specificity of NlpC/P60 cell wall hydrolases containing bacterial SH3 domains (Journal Article) | DOE...
... and modulate substrate specificity. Two amino acid differences at the domain interface alter the substrate binding specificity ... To avoid cleavage of unintended substrates, these enzymes have very selective substrate specificities. Our biochemical and ... Title: Insights into substrate specificity of NlpC/P60 cell wall hydrolases containing bacterial SH3 domains ... Accepted Manuscript: Insights into substrate specificity of NlpC/P60 cell wall hydrolases containing bacterial SH3 domains ...
  https://www.osti.gov/pages/biblio/1233189-insights-substrate-specificity-nlpc-p60-cell-wall-hydrolases-containing-bacterial-sh3-domains
*  Enzyme activity and substrate specificity of the major cinnamyl alcohol dehydrogenases in sorghum. | Plant Physiology
Enzyme activity and substrate specificity of the major cinnamyl alcohol dehydrogenases in sorghum.. Se-Young Jun, Alexander M ... Enzyme activity and substrate specificity of the major cinnamyl alcohol dehydrogenases in sorghum. ...
  http://www.plantphysiol.org/content/early/2017/06/12/pp.17.00576/tab-figures-data
*  Characterization of HIV-1 Reverse Transcriptase substrate specificity by conformationally sensitive fluorescence
... ... In doing so, we define the role of induced-fit in nucleotide specificity and mismatch discrimination. Additionally, we have ... but provides a signal to monitor changes in enzyme structure that result from conformational changes induced by substrate ... characterized the kinetics governing the specificity and discrimination of several widely administered Nucleotide Reverse ...
  https://repositories.lib.utexas.edu/handle/2152/ETD-UT-2010-12-2154
*  Substrate specificity and rational design of peptidomimetic inhibitors for SARS coronavirus main protease | HKMJ
1. Substrate-specificity of the main protease of SARS coronavirus was systematically profiled at P5 to P3' positions, which ... Substrate specificity and rational design of peptidomimetic inhibitors for SARS coronavirus main protease ... Substrate preferences at P5 to P3 positions were important in enhancing the main protease activity. 'Super-reactive' substrate ...
  http://www.hkmj.org/abstracts/v20n4s4/18.htm
*  Investigating the basis of substrate specificity in butane monooxygenase and chlorinated ethene toxicity in Pseudomonas...
To investigate the fundamental differences in substrate specificity between BMO and MMO, single amino acid substitutions were ... Investigating the basis of substrate specificity in butane monooxygenase and chlorinated ethene toxicity in Pseudomonas ...
  https://ir.library.oregonstate.edu/concern/graduate_thesis_or_dissertations/02870z43h
*  Molecules | Free Full-Text | A Xylenol Orange-Based Screening Assay for the Substrate Specificity of Flavin-Dependent para...
Screening of a small library of VAO and EUGO active-site variants for alterations in their substrate specificity led to the ... Here, we present the development of a screening assay for the substrate specificity of para-phenol oxidases based on the ... This assay provides a quick and efficient method to screen the substrate specificity of para-phenol oxidases, facilitating the ... The assay was used to screen the activity of VAO and EUGO towards a set of twenty-four potential substrates. This led to the ...
  http://mdpi.com/1420-3049/23/1/164
*  Structure Cluster - 1JT2: STRUCTURAL BASIS FOR THE SUBSTRATE SPECIFICITY OF THE FERUL DOMAIN OF THE CELLULOSOMAL...
Structural basis for the substrate specificity of the feruloyl esterase domain of the cellulosomal xylanase Z from Clostridium ... STRUCTURAL BASIS FOR THE SUBSTRATE SPECIFICITY OF THE FERUL DOMAIN OF THE CELLULOSOMAL XYLANASE Z FROM C. THERMOCELLUM. ...
  http://www.rcsb.org/pdb/explore/structureCluster.do?structureId=1JT2
*  Structural Comparison, Substrate Specificity, and Inhibitor Binding of AGPase Small Subunit from Monocot and Dicot: Present...
Structural Comparison, Substrate Specificity, and Inhibitor Binding of AGPase Small Subunit from Monocot and Dicot: Present ... Substrate Specificity, and Inhibitor Binding of AGPase Small Subunit from Monocot and Dicot: Present Insight and Future ...
  https://www.hindawi.com/journals/bmri/2014/583606/cta/
*  DIGITAL.CSIC: The white-rot fungus Pleurotus ostreatus secretes laccase isozymes with different substrate specificities
The white-rot fungus Pleurotus ostreatus secretes laccase isozymes with different substrate specificities. ... When staining with ABTS and guaiacol in native polyacrilamide gels, different specificities were observed for LCC1/LCC2 and ...
  https://digital.csic.es/handle/10261/97404
*  JAIRO | Mechanistic insight into the substrate specificity of 1,2-β-oligoglucan phosphorylase from Lachnoclostridium...
Mechanistic insight into the substrate specificity of 1,2-β-oligoglucan phosphorylase from Lachnoclostridium phytofermentans.. ... Mechanistic insight into the substrate specificity of 1,2-β-oligoglucan phosphorylase from Lachnoclostridium phytofermentans. ... Mechanistic insight into the substrate specificity of 1,2-β-oligoglucan phosphorylase from Lachnoclostridium phytofermentans.. ...
  http://jairo.nii.ac.jp/0083/00250294/en
*  Substrate Specificity of Organic Cation/H+ Exchange in Avian Renal Brush-Border Membranes | Journal of Pharmacology and...
Substrate Specificity of Organic Cation/H+ Exchange in Avian Renal Brush-Border Membranes. A. R. Villalobos and E. J. Braun ... Substrate Specificity of Organic Cation/H+ Exchange in Avian Renal Brush-Border Membranes. A. R. Villalobos and E. J. Braun ... Substrate Specificity of Organic Cation/H+ Exchange in Avian Renal Brush-Border Membranes. A. R. Villalobos and E. J. Braun ... In summary, the substrate specificity of the renal luminal OC/H+ exchanger for a battery of test OCs was evaluated in membranes ...
  http://jpet.aspetjournals.org/content/287/3/944
*  Acquired Mutations in the MXR/BCRP/ABCP Gene Alter Substrate Specificity in MXR/BCRP/ABCP-overexpressing Cells | Cancer Research
Acquired Mutations in the MXR/BCRP/ABCP Gene Alter Substrate Specificity in MXR/BCRP/ABCP-overexpressing Cells. Yasumasa Honjo ... In light of the fact that mutations in Pgp derived from drug selection have been shown to alter substrate specificity (11) , ... Acquired Mutations in the MXR/BCRP/ABCP Gene Alter Substrate Specificity in MXR/BCRP/ABCP-overexpressing Cells ... Acquired Mutations in the MXR/BCRP/ABCP Gene Alter Substrate Specificity in MXR/BCRP/ABCP-overexpressing Cells ...
  http://cancerres.aacrjournals.org/content/61/18/6635
*  To boost our understanding of Taspase1s substrate specificity we used our biosensor assay mixed with positional scanning...
To boost our understanding of Taspase1s substrate specificity we used our biosensor assay mixed with positional scanning ... To boost our understanding of Taspase1s substrate specificity we used our biosensor assay mixed with positional scanning ... Dependent on the initial staurosporine scaffold the organoruthenium complexes have provided marked specificity for the GSK3 and ...
  https://wallinside.com/post-55592345-to-boost-our-understanding-of-taspase1s-substrate-specificity-we-used-our-biosensor-assay-mixed-with-positional-scanning-mutagenesis.html
*  RCSB PDB - 1PJA: The crystal structure of palmitoyl protein thioesterase-2 reveals the basis for divergent substrate...
The crystal structure of palmitoyl protein thioesterase-2 reveals the basis for divergent substrate specificities of the two ... The crystal structure of palmitoyl protein thioesterase-2 reveals the basis for divergent substrate specificities of the two ... The crystal structure of palmitoyl protein thioesterase-2 (PPT2) reveals the basis for divergent substrate specificities of the ... A previous study had suggested that palmitoyl-CoA was the preferred substrate of PPT2. Furthermore, PPT2 did not hydrolyze ...
  https://www.rcsb.org/structure/1pja
*  Combining Substrate Specificity Analysis with Support Vector Classifiers Reveals Feruloyl Esterase as a Phylogenetically...
The diversity of substrate specificities found in the FAE family shows that this family is old enough to have experienced the ... Our approach consists of two analytical steps; (1) an initial unsupervised analysis to cluster the FAEs substrate specificity ... Conclusion/Significance: The good correlation with the FAEs substrate specificities that we have defined via our phylogenetic ... Methodology/Principal Findings: In this study we evaluate the relative activity of FAEs against a variety of model substrates ...
  http://publications.lib.chalmers.se/publication/127931-combining-substrate-specificity-analysis-with-support-vector-classifiers-reveals-feruloyl-esterase-a
*  Substrate specificity, regioselectivity and cryptoregiochemistry of plant and animal ω-3 fatty acid desaturases | Biochemical...
Substrate specificity, regioselectivity and cryptoregiochemistry of plant and animal ω-3 fatty acid desaturases. D. ... Substrate specificity, regioselectivity and cryptoregiochemistry of plant and animal ω-3 fatty acid desaturases ... Substrate specificity, regioselectivity and cryptoregiochemistry of plant and animal ω-3 fatty acid desaturases ... Substrate specificity, regioselectivity and cryptoregiochemistry of plant and animal ω-3 fatty acid desaturases ...
  http://www.biochemsoctrans.org/content/28/6/632
*  The Application of Molecular Modeling for Prediction of Substrate Specificity in Cytochrome P450 1A2 Mutants | Drug Metabolism ...
The Application of Molecular Modeling for Prediction of Substrate Specificity in Cytochrome P450 1A2 Mutants. Youbin Tu, Rahul ... The Application of Molecular Modeling for Prediction of Substrate Specificity in Cytochrome P450 1A2 Mutants. Youbin Tu, Rahul ... The Application of Molecular Modeling for Prediction of Substrate Specificity in Cytochrome P450 1A2 Mutants. Youbin Tu, Rahul ... The Application of Molecular Modeling for Prediction of Substrate Specificity in Cytochrome P450 1A2 Mutants ...
  http://dmd.aspetjournals.org/content/early/2008/08/14/dmd.108.022640
*  DIGITAL.CSIC: Characterisation of the broad substrate specificity 2-keto acid decarboxylase Aro10p of Saccharomyces...
Substrate specificities of SkAro10p were compared with those of S. cerevisiae Aro10p (ScAro10p) by their expression in a 2-keto ... Characterisation of the broad substrate specificity 2-keto acid decarboxylase Aro10p of Saccharomyces kudriavzevii and its ... The activities of SkAro10p towards substrates (except phenylpyruvate) were higher than of those for ScAro10p.. [Conclusions] ... the decarboxylation activities measured in the cell extracts with SkAro10p ranged with all the tested substrates at the same ...
  https://digital.csic.es/handle/10261/131453