*  Protein phosphatase 1 - Wikipedia
Protein phosphatase 1 (PP1) belongs to a certain class of phosphatases known as protein serine/threonine phosphatases. This ... This binding to phosphorylase a prevents any phosphatase activity of PP1 and maintains the glycogen phosphorylase in its active ... Also, when other substrates become phosphorylated by protein kinase A, they can bind to the catalytic subunit of PP1 and ... Phosphorylase a serves as a glucose sensor in liver cells. When glucose levels are low, phosphorylase a in its active R state ...
  https://en.wikipedia.org/wiki/Protein_phosphatase_1
*  Dephosphorylation - Wikipedia
Phosphatase Phosphorylation FISCHER, EH; KREBS, EG (Sep 1955). "Conversion of phosphorylase b to phosphorylase a in muscle ... and substrate specificities of phosphoprotein phosphatase(s) from rabbit liver". The Journal of Biological Chemistry. 251 (16 ... Krebs and Edmond Fischer used radiolabeled ATP to determine that phosphate is added to the serine residue of phosphorylase to ... Tau dephosphorylation is catalysed by protein phosphatase-2A and phosphatase-2B. Deficiency or modification of one or both ...
  https://en.wikipedia.org/wiki/Dephosphorylation
*  Fast skeletal muscle transcriptome of the Gilthead sea bream (Sparus aurata) determined by next generation sequencing | BMC...
Protein phosphatase 1 catalytic subunit; PHKG, Phosphorylase b kinase gamma; PHK1-B, Phosphorylase kinase alpha-beta subunit; ... Rac-beta serine/threonine protein kinase 2; AKT3, Rac-beta serine/threonine protein kinase 3; ATG1, Serine/threonine-protein ... and insulin receptor substrate (IRS) (2). The only PI3K/Akt/mTOR pathway component that was not represented in the ... Serine threonine-protein phosphatase. Essential for cell division, and participates in muscle contractility and protein ...
  https://bmcgenomics.biomedcentral.com/articles/10.1186/1471-2164-13-181
*  Phosphoprotein Phosphatases Serine Threonine | China-Mainland | Sigma-Aldrich
Type 1 protein phosphatases (PP1) dephosphorylate the β-subunit of phosphorylase kinase and are inhibited by phospho-inhibitor- ... Prior to the knowledge of their sequence, phosphoserine/threonine phosphatases were classified on the basis of their substrate ... PP2C: Phosphoprotein phosphatase 2C. PPM: Phosphoprotein phosphatase M family. PPP: Phosphoprotein phosphatase P family. RIPP: ... PP: Phosphoprotein phosphatase. PP1: Phosphoprotein phosphatase 1. PP2A: Phosphoprotein phosphatase 2A. PP2B: Phosphoprotein ...
  http://www.sigmaaldrich.com/china-mainland/zh/technical-documents/articles/biology/rbi-handbook/intracellular-signaling-enzymes-receptors/phosphoprotein-phosphatases-serine-threonine.html
*  Protein phosphatase - Wikipedia
Many phosphatases are promiscuous with respect to substrate type, or can evolve quickly to change substrate. An alternative ... The major serine/threonine-specific folds are PPM (PP2C) and PPPL (PPP). The only known histidine phosphatases is in the PHP ... glycogen phosphorylase, and glycogen synthase. This leads to phosphorylase kinase and glycogen phosphorylase's becoming ... Phosphatases can be subdivided based upon their substrate specificity. Protein Ser/Thr phosphatases were originally classified ...
  https://en.wikipedia.org/wiki/Protein_phosphatase
*  Cyclophilin residues that affect noncompetitive inhibition of the protein serine phosphatase activity of calcineurin by the...
... assay to measure inorganic phosphate production using the enzyme purine ribonucleoside phosphorylase and the substrate N7- ... Cyclophilin residues that affect noncompetitive inhibition of the protein serine phosphatase activity of calcineurin by the ... but altered its ability to inhibit the serine phosphatase activity of calcineurin (CN). R69E was 13-fold less effective (Ki = ... The phosphoserine phosphatase reaction catalyzed by CN using unlabeled phosphoserine RII19 peptide was coupled to a continuous ...
  https://www.ncbi.nlm.nih.gov/pubmed/8117697
*  Protein phosphorylation - Wikipedia
... glycogen phosphorylase by assisting in the transfer of the γ-phosphoryl group of ATP to a serine residue on phosphorylase b. ... Protein kinases and phosphatases work independently and in a balance to regulate the function of proteins. The amino acids most ... Holt LJ, Tuch BB, Villén J, Johnson AD, Gygi SP, Morgan DO (2009). "Global Analysis of Cdk1 Substrate Phosphorylation Sites ... The signaling capabilities of FGFR1 at the serine 777 site can be weakened by phosphorylation. Serine 1047 and serine 1048 have ...
  https://en.wikipedia.org/wiki/Protein_phosphorylation
*  Phosphatase - Wikipedia
... but also serine residues. Thus, one phosphatase can exhibit the qualities of multiple phosphatase families. Acid phosphatase ... one phosphatase may recognize many different substrates, and one substrate may be recognized by many different phosphatases. In ... Phosphatase enzymes are not to be confused with phosphorylase enzymes, which catalyze the transfer of a phosphate group from ... Many phosphatases have yet to be discovered, and for numerous known phosphatases, a substrate has yet to be identified. However ...
  https://en.wikipedia.org/wiki/Phosphatase
*  Hydrolase - Wikipedia
Phosphorylase Serine hydrolase Prince, Amanda L.; Antony, Kathleen M.; Chu, Derrick M.; Aagaard, Kjersti M. (2014). "The ... "substrate hydrolase." However, common names are typically in the form "substratease." For example, a nuclease is a hydrolase ... phosphatase) EC 3.2: sugars (DNA glycosylases, glycoside hydrolase) EC 3.3: ether bonds EC 3.4: peptide bonds (Proteases/ ...
  https://en.wikipedia.org/wiki/Hydrolase
*  Phosphorylase kinase - Wikipedia
... to the substrate serine. Phosphorylase kinase is a 1.3 MDa hexadecameric holoenzyme, though its size can vary somewhat due to ... When the cell needs to stop glycogen breakdown, PhK is dephosphorylated by protein phosphatases 1 and 2, returning the α and β ... Phosphorylase kinase (PhK) is a serine/threonine-specific protein kinase which activates glycogen phosphorylase to release ... 1997). "The crystal structure of a phosphorylase kinase peptide substrate complex: kinase substrate recognition". EMBO J. 16 ( ...
  https://en.wikipedia.org/wiki/Phosphorylase_kinase
*  HPr kinase/phosphorylase, C-terminal (IPR011104) | InterPro | EMBL-EBI
This entry represents the C-terminal kinase domain of Hpr Serine/threonine kinase (HprK/P). HprK/P is a bifunctional histidine- ... Structure of the full-length HPr kinase/phosphatase from Staphylococcus xylosus at 1.95 A resolution: Mimicking the product/ ... substrate of the phospho transfer reactions.. Proc. Natl. Acad. Sci. U.S.A. 99 3458-63 2002 ... HPr kinase/phosphorylase, C-terminal (IPR011104). Short name: Hpr_kin/Pase_C ...
  http://www.ebi.ac.uk/interpro/entry/IPR011104
*  KEGG SSDB Best Search Result: mcj:MCON 3086
bpsp:AH67_00360 maltodextrin phosphorylase K00688 817 103 ( -) 29 0.365 74 -, 1 ctae:BGI42_03790 serine phosphatase RsbU, ... cet:B8281_16485 ABC transporter substrate-binding prote K02027 457 117 ( -) 33 0.306 121 ,-, 1 bcm:Bcenmc03_4466 peptidase S8 ... sesp:BN6_61310 Protein serine/threonine phosphatase 461 104 ( -) 30 0.308 120 -, 1 vbr:A6E01_09525 thioredoxin-dependent thiol ... bstg:WT74_17445 sugar ABC transporter substrate-binding K02058 356 104 ( -) 30 0.375 40 ,-, 1 ceu:A7L45_19960 excinuclease ABC ...
  http://www.kegg.jp/ssdb-bin/ssdb_best?org_gene=mcj:MCON_3086
*  Phosphoglucomutase - Wikipedia
After glycogen phosphorylase catalyzes the phosphorolytic cleavage of a glucosyl residue from the glycogen polymer, the freed ... Muscle cells in contrast do not have the enzyme glucose 6-phosphatase, so they cannot share their glycogen stores with the rest ... Substrate-velocity relationships and induced transport tests have revealed that the dephosphorylated enzyme then facilitates ... that the single site in the enzyme that becomes phosphorylated and dephosphorylated is the oxygen of the active-site serine ...
  https://en.wikipedia.org/wiki/Phosphoglucomutase
*  Propagating Differential Gene Expression in Protein Interaction Networks
Based on their substrate specificity, these phosphatases can be divided into several groups e.g. serine/threonine protein ... Serine Threonine protein phosphatases; F) glycogen phosphorylase; G) neuronal voltage-gated/dependent calcium channel neuronal ... Cluster B, E and F are related to protein phosphatases, which dephosphorylate their substrates thereby often abrogating the ... Protein phosphatase-2A is a target of epigallocatechin-3-gallate and modulates p53-Bak apoptotic pathway Jichao Qin, Hi-Ge Chen ...
  http://werner.yellowcouch.org/Papers/proteffect/index.html
*  B for Biology: Signal Transduction Pathway - The cAMP Pathway
These phosphatases remove the phosphate group from tyrosine or serine or threonine residues in the substrate proteins thereby ... phosphorylase kinase. This kinase is phosphorylated on serine residue by PKA; which then activates glycogen phosphorylase. The ... Lets make it more clear by taking the example of protein kinase A. The serine residues of the target proteins (phosphorylase ... which are phosphorylated by PKA are usually dephosphorylated by phosphatase called as protein phosphatase 1. Thus, the levels ...
  http://namrataheda.blogspot.in/2013/02/signal-transduction-pathway-camp-pathway.html
*  Mammalian Receptor Proteins; Related Reagents and Methods - Patent application
For example, these receptors should mediate phosphatase or phosphorylase activities, which activities are easily measured by ... The substrates may be, e.g., solid resin beads or sheets of plastic. [0123]Protein fragments may be joined to other materials, ... serine, threonine; lysine, arginine; and phenylalanine, tyrosine. Homologous amino acid sequences are intended to include ... Substrates may be identified, or conditions for enzymatic activity may be assayed by standard methods, e.g., as described in ...
  http://www.patentsencyclopedia.com/app/20100261273
*  Glycogen synthase - Wikipedia
... structural similarities to glycogen phosphorylase at the catalytic and substrate binding site suggest that the mechanism for ... In a recent study of transgenic mice, an overexpression of glycogen synthase and an overexpression of phosphatase both resulted ... Identification of the third site of phosphorylation as serine-7". Eur. J. Biochem. 115 (2): 405-13. doi:10.1111/j.1432- ... Much research has been done on glycogen degradation through studying the structure and function of glycogen phosphorylase, the ...
  https://en.wikipedia.org/wiki/Glycogen_synthase
*  Gene Report for G00001442 - Genes2Cognition Neuroscience Research Programme
The Tat-associated protein phosphatase (TAPP) is related to the serine/threonine, type 1, protein phosphatase (PP1) family. ... Using substrate screening in various tissues, we uncovered two major substrates, p130 and p85, for MRCKalpha-kinase. p130 is ... While GADD34 inhibited PP1-catalyzed dephosphorylation of phosphorylase a, the GADD34-bound PP1 was an active eIF-2alpha ... We observed that the protein HOX11 interacted with protein serine-threonine phosphatase 2A catalytic subunit (PP2AC), as well ...
  http://www.genes2cognition.org/db/Gene/G00001442
*  Cells | Free Full-Text | The Challenge of Producing Ubiquitinated Proteins for Structural Studies | HTML
It has different effects on the target protein substrate, i.e., it can trigger the degradation of the protein in the proteasome ... used to explore the effect of ubiquitination on calmodulin-mediated regulation of phosphorylase kinase and protein phosphatase ... It has different effects on the target protein substrate, i.e., it can trigger the degradation of the protein in the proteasome ... The solvent-accessible C118 of Ras was mutated to serine to prevent unwanted modifications, while the other two cysteines in ...
  http://www.mdpi.com/2073-4409/3/2/639/htm
*  Vitamin B6 - Wikipedia
Serine racemase which synthesizes the neuromodulator d-serine from its enantiomer is a PLP-dependent enzyme. PLP is a coenzyme ... PLP is a required coenzyme of glycogen phosphorylase, the enzyme necessary for glycogenolysis to occur. PLP can catalyze ... transamination reactions that are essential for providing amino acids as a substrate for gluconeogenesis. PLP is an essential ... phosphate and pyridoxamine phosphate involves their dephosphorylation catalyzed by a membrane-bound alkaline phosphatase. Those ...
  https://en.wikipedia.org/wiki/Vitamin_B6
*  Regulatory enzyme - Wikipedia
Specific inhibitors, analogous to the substrate, will strongly join the enzyme, blocking the substrate to join the enzyme. This ... Serine, Tryptophan and Tyrosine are common amino acids that participate in covalent modifications and are used to control ... Kinase and phosphatases are commonly known enzymes that affect these modifications, which result in shifting of conformational ... regulation of glycogen phosphorylase). Each phosphate group contains two negative charges, so the addition of this group can ...
  https://en.wikipedia.org/wiki/Regulatory_enzyme
*  PYGL - Wikipedia
This protein switches from inactive phosphorylase B to active phosphorylase A by phosphorylation of serine residue 14. Activity ... which is phosphorylated by phosphorylase kinase and dephosphorylated by the phosphatase PP1, and the AMP site, which is ... to bind the substrate glycogen. This cofactor is attached by a covalent Schiff base linkage to Lys-680 in the C-terminal domain ... Glycogen phosphorylase, liver form (PYGL), also known as human liver glycogen phosphorylase (HLGP), is an enzyme that in humans ...
  https://en.wikipedia.org/wiki/PYGL
*  Overview of Protein Phosphorylation - Current Protocols
Mutational analysis of a ser/thr phosphatase. Identification of residues important in phosphatase substrate binding and ... Protein (serine, threonine) phosphate phosphatases. Methods Enzymol. 107:102‐130. Shenolikar, S. and Nairn, A.C. 1991. Protein ... Enzymatic conversion of phosphorylase a to b. J. Biol. Chem. 158:321‐345. ... Protein serine/threonine phosphatases: New avenues for cell regulation. Annu. Rev. Cell Biol. 10:55‐86. ...
  http://www.currentprotocols.com/WileyCDA/CPUnit/refId-ps1301.html
*  GSK-3 - Wikipedia
GSK-3 functions by phosphorylating a serine or threonine residue on its target substrate. A positively charged pocket adjacent ... "Inhibition of GSK-3 selectively reduces glucose-6-phosphatase and phosphatase and phosphoenolypyruvate carboxykinase gene ... Separation from cyclic-AMP-dependent protein kinase and phosphorylase kinase". Eur J Biochem. 107 (2): 519-27. doi:10.1111/j. ... Liberman Z, Eldar-Finkelman H (Feb 2005). "Serine 332 phosphorylation of insulin receptor substrate-1 by glycogen synthase ...
  https://en.wikipedia.org/wiki/GSK-3
*  2nym - Proteopedia, life in 3D
Hsu W, Zeng L, Costantini F. Identification of a domain of Axin that binds to the serine/threonine protein phosphatase 2A and a ... PP2A is the major phosphatase for microtubule-associated proteins (MAPs). PP2A can modulate the activity of phosphorylase B ... The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of ... Categories: Human , Phosphoprotein phosphatase , Chao, Y , Chen, Y , Jeffrey, P D , Lin, Z , Shi, Y , Xing, Y , Xu, Y , Heat ...
  http://proteopedia.org/wiki/index.php/2nym