*  Potential role of protein tyrosine phosphatase nonreceptor type 13 in the control of oocyte meiotic maturation | Development
Liu, X. J., Sorisky, A., Zhu, L. and Pawson, T. (1995). Molecular cloning of an amphibian insulin receptor substrate 1-like ... Twelve hours later, oocyte extracts were prepared and the expression of the two constructs was detected using HA antibodies. (C ... In the functional studies we report here, we found that progesterone-induced oocyte maturation is significantly accelerated by ... Protein tyrosine phosphatase nonreceptor type 13 (PTPN13) is a tyrosine phosphatase with multiple interacting domains that has ...
  http://dev.biologists.org/content/131/20/4987
*  JoVE | Peer Reviewed Scientific Video Journal - Methods and Protocols
Receptor Protein-Tyrosine Kinases, Molecular Targeted Therapy, Therapeutics, novel small molecule inhibitor, receptor tyrosine ... With the increasing prevalence of diabetes, both immune-mediated type 1 and obesity-linked type 2, studies aimed at delineating ... Functional activity is then evaluated using clonogenic assays in methylcellulose or soft agar cultures. Experimental compounds ... phosphoenolpyruvate carboxykinase and glucose-6-phosphatase) were also found to be attenuated in diabetic mice treated with DPM ...
  https://www.jove.com/visualize/abstract/23755289/cooperative-anti-diabetic-effects-deoxynojirimycin-polysaccharide
*  Ready-to-use PCR Mastermixes - MP Biomedicals
Protein Kinase Peptides. *Protein Kinase Substrates. *Protein Kinases. *Protein Phosphatase Substrates. *Protein Synthesis ... Target Type and Drugability. *Functional Genomics. *Target Validation*Knock-out/Knock-in/Gain-of-function, Transgenic Models* ... Anti-Macrophage Scavenger Receptor, Human. *Anti-Melanoma Marker, Human. *Anti-Metalloproteinase 2, Human ... Synthetic Substrates*7-Amino-4-trifluoromethylcoumarin substrates (AFC)*Single Amino Acid Substrate ...
  http://www.mpbio.com/index.php?cPath=2873_1_14_102_503_651&country=223
*  Protein Regulation with Rapid Kinetics - ProteoTuner Systems
Regulation system works post-translationally resulting in rapid changes in protein level. ... Laminin Substrate * Feeder Cell Identification * Cryopreservation Media * Validated Cell Types for STEM-CELLBANKER ... Protein function in pathways *Functional analysis of subunits of a protein complex *Functional analysis of essential proteins ... Phosphatases * Alkaline Phosphatase, Calf Intestinal * Alkaline Phosphatase, E. coli * Alkaline Phosphatase, Shrimp ...
  http://www.clontech.com/US/Products/Inducible_Systems/Inducible_Protein_Stabilization/Plasmid?sitex=10020:22372:US&PROD=-mqMO_omottyNhRVff5dH94j:S&PROD_pses=ZG0B0C9E7B8AFFD7CCF9B59CC789757DCD65B4A1D153D9311E4931197F5C83C873E530352271BF96A31D40F21040EF642A00159932972384B2
*  Plus it
Multiple receptor tyrosine kinase activation attenuates therapeutic efficacy of the fibroblast growth factor receptor 2 ... Functional protein pathway activation mapping of the progression of normal skin to squamous cell carcinoma. Cancer Prev Res ... Curcumin inhibits Akt/mammalian target of rapamycin signaling through protein phosphatase-dependent mechanism. Mol Cancer Ther ... Wild-type (WT) and constitutively active mutants for FGFR2 (FGFR2-WT pcDNA3 and FGFR2-C278F pCDNA) expression plasmids were ...
  http://cancerpreventionresearch.aacrjournals.org/content/9/4/296
*  Mechanisms and functions of p38 MAPK signalling | Biochemical Journal
G-protein-coupled receptor kinase 2; GSK, glycogen synthase kinase; hDlg, human discs large; HePTP, haemopoietic tyrosine ... the interplay with other signalling pathways and the nature of p38 MAPK substrates as a source of functional diversity. Finally ... protein kinase D; PP, protein phosphatase; SAP, synapse-associated protein; SAPK, stress-activated protein kinase; SRCAP, Snf2- ... TNF-receptor-associated factor; TTSS, type III secretion system; Ubc13, ubiquitin-conjugating enzyme 13; USF1, upstream ...
  http://www.biochemj.org/content/429/3/403
*  Extracellular Matrix Elasticity Modulates TGF-β-Induced p38 Activation and Myofibroblast Transdifferentiation in Human Tenon...
Giannone G Sheetz MP . Substrate rigidity and force define form through tyrosine phosphatase and kinase pathways. Trends Cell ... rigid substrate). On the transcriptional level, TGF-β induced SMA only on rigid substrates (Fig. 3A). On the protein level, TGF ... To elucidate whether the effects of substrate elasticity on TGF-β signaling elicit subsequent functional changes, we studied ... Adhesion-dependent receptor localization may have an important role. Integrins govern the localization and internalization of ...
  http://iovs.arvojournals.org/article.aspx?articleid=2187670
*  LEOPARD Syndrome
... a gene encoding the protein tyrosine phosphatase SHP-2 located at band 12q24.1.[2] SHP2 mutations seem to facilitate melanin ... Diversity and functional consequences of germline and somatic PTPN11 mutations in human disease. Am J Hum Genet. 2006 Feb. 78(2 ... Different types of skeletal anomalies have been documented in affected patients, including chest deformity (pectus excavatum, ... Therapeutic regimens include beta-adrenergic receptor or calcium channel blocking agents to reduce outflow tract obstruction ...
  http://misc.medscape.com/pi/android/medscapeapp/html/A1096445-business.html
*  Novel Investigations of Flavonoids as Chemopreventive Agents for Hepatocellular Carcinoma
The type 1 insulin-like growth factor receptor (IGF-1R) belongs to the tyrosine kinase receptor family. When activated by its ... Phosphatase and tensin homolog. CAM-DR:. Cell adhesion mediated drug resistance. DAPK:. Death-associated protein kinase. ... EGCG has also been shown to be involved in the activation of AMPK via the suppression of downstream substrates, such as mTOR ... Journal of Functional Foods, vol. 15, pp. 464-475, 2015. View at Publisher · View at Google Scholar ...
  https://www.hindawi.com/journals/bmri/2015/840542/
*  Most recent papers with the keyword frs2 | Read by QxMD
GRB2-associated binding protein 2 (GAB2), CRK-like protein (CRKL) and fibroblast growth factor receptor substrate 2 (FRS2) in ... Pancreatic Islet Protein Complexes and Their Dysregulation in Type 2 Diabetes.. Helle Krogh Pedersen, Valborg Gudmundsdottir, ... Functional analyses revealed that miR-339 can inhibit proliferation of PASMC Also, miR-339 inhibited FGF2-induced proliferation ... The phosphatase PTPRG controls FGFR1 activity and influences sensitivity to FGFR kinase inhibitors. ...
  https://www.readbyqxmd.com/keyword/105045
*  JCI - Contribution of de novo fatty acid synthesis to hepatic steatosis and insulin resistance: lessons from genetically...
Once activated, the insulin receptor phosphorylates several substrates on their tyrosine residues; among such substrates are ... the L-type pyruvate kinase gene by phosphorylation/dephosphorylation of the carbohydrate response element binding protein. Proc ... Studies by Towle and colleagues have revealed that ChREBP binds as a heterotetramer, together with its functional partner Mlx ( ... and glucose 6-phosphatase (G6Pase) (12) (Figure 1). Insulin-mediated Akt phosphorylation of Foxo1 (13) leads to its nuclear ...
  https://www.jci.org/articles/view/34275
*  JoVE | Peer Reviewed Scientific Video Journal - Methods and Protocols
The type III secretion system (T3SS) is a protein delivery system which is involved in a wide spectrum of interactions, from ... Here, we reveal that the Ret-like receptor tyrosine kinase (RTK), Stitcher (Stit), is required for cell growth and ... Calcineurin is a eukaryotic protein phosphatase important for many signalling and developmental processes in cells. Inhibitors ... and uncommon functional groups (such as isonitrile, dichloroimine, isocyanate, and halogenated functional groups) are ...
  https://www.jove.com/visualize?author=Fergal+O%27Gara
*  Pharmacotherapy for Pulmonary Hypertension: Future Directions
... proliferator-activated receptor gamma ligands inhibit Rho/Rho kinase pathway by inducing protein tyrosine phosphatase SHP-2. ... ET-1 binds with two types of receptor; ETA receptor and ETB receptor.[4] ETA receptor located on SMCs and cardiac myocytes, ... Pulmonary vascular wall remodeling is the result of changes in structural and functional components in the pulmonary arteries. ... increased activity of arginase II leads to the decreased production of NO by competing with NOS for L-arginine substrate. The ...
  https://www.jbclinpharm.org/articles/pharmacotherapy-for-pulmonary-hypertension-future-directions-4158.html
*  JoVE | Peer Reviewed Scientific Video Journal - Methods and Protocols
Here, we report a unique interaction between PICK1 and all three members of the protein kinase C and casein kinase II substrate ... Early radiographic response to epidermal growth factor receptor-tyrosine kinase inhibitor in non-small cell lung cancer ... type F (18.9%, ST5-SCCmecII), type C (18.5%, ST59-SCCmecIV), type B (12.0%, ST239-SCCmecIII) and type D (10.9%, ST59-SCCmecVT/ ... Twelve 45-week-old roosters were allocated into four groups, including control roosters kept at 25 °C, roosters subjected to 38 ...
  https://www.jove.com/visualize?author=Chih-Kuan+Chen
*  CECAD: Publications 2010
Udelhoven M, Pasieka M, Leeser U, Krone W, Schubert M (2010). Neuronal insulin receptor substrate 2 (IRS2) expression is ... Retinal localization of the glutamate receptor GluR2 and GluR2-regulating proteins in diabetic rats. Exp Eye Res. Feb;90(2):244 ... The vascular endothelial growth factor receptor tyrosine kinase inhibitors vatalanib and pazopanib potently induce apoptosis in ... Bonn F, Pantakani K, Shoukier M, Langer T, Mannan AU (2010). Func-tional evaluation of paraplegin mutations by a yeast ...
  http://cecad.uni-koeln.de/Publications-2010.152.0.html?L=1%29
*  Or Gozani | Stanford Medicine Profiles
... and the two proteins interact directly in protein-protein interaction assays. Using UV cross-linking, together with functional ... Thus, novel substrates could be discovered via the identification of KMT interacting proteins. Indeed, we find that SETDB1 ... The PHD finger of the chromatin-associated protein ING2 functions as a nuclear phosphoinositide receptor CELL Gozani, O., ... Furthermore, ASH1L facilitates recruitment of LEDGF and wild-type MLL proteins to chromatin at key leukemia target genes and is ...
  https://med.stanford.edu/profiles/or-gozani
*  JoVE Search Results: Protein Kinase
Tyrosine, Kinase, Leukemia, Chronic Myeloid Leukemia, Myeloid Leukemia, Hydrogen, ATP, Role, Atmosphere, Donors, Human, Kinases ... The cytoplasmic adaptor protein Dok7 activates the receptor tyrosine kinase MuSK via dimerization. Abstract ... A global protein kinase and phosphatase interaction network in yeast. Abstract Levy, David E. New York University School of ... Cell type-specific function of TAK1 in innate immune signaling. Abstract Ladbury, John E. University of Texas MD Anderson ...
  http://labindex.jove.com/group/Protein-Kinase
*  JoVE | Peer Reviewed Scientific Video Journal - Methods and Protocols
Coexpression of a Wnt ligand or a Frizzled receptor alters the distribution of Diversin fused with red fluorescent protein, RFP ... The SH2 domain of Grb2 binds to growth factor receptors at phosphorylated tyrosine residues thus coupling receptor activation ... one may accelerate the identification of functional motifs in proteins and the development of peptide-based inhibitors of ... Examples include myosin light chain kinase10, Ca2+/CaM-dependent kinases (CaMKs)11 and phosphatases (e.g. calcineurin)12, and ...
  https://www.jove.com/visualize/abstract/23990909/suppressor-cytokine-signaling-socs-5-utilises-distinct-domains-for
*  JoVE | Peer Reviewed Scientific Video Journal - Methods and Protocols
Epidermal growth factor receptor (EGFR) is a member of the tyrosine kinase receptor family, which is thought to be involved in ... Non-specific lipid transfer proteins (ns-LTPs), ubiquitously found in various types of plants, have been well-known to transfer ... Because topographically complex substrates are easily fabricated and LC defects are readily reconfigured, this work lays the ... To further understand the plasticity of the hand area, the resting state functional connectivity was investigated between the ...
  https://www.jove.com/visualize?author=Zheng-Duo+Shi
*  Phospholipid composition and a polybasic motif determine D6 PROTEIN KINASE polar association with the plasma membrane and...
2011). Tyrosine phosphorylation controls brassinosteroid receptor activation by triggering membrane release of its kinase ... we also tested the binding of wild-type and mutant proteins in lipid overlay assays. In each but one case, the protein kinases ... as a phosphorylation substrate (Zourelidou et al., 2009). Equal protein amounts (∼0.5 µg) were incubated for 60 min at 28°C in ... PI-kinases and phosphatases determine the abundance of different PI species in different membranes; PI biosensors indicate that ...
  http://dev.biologists.org/content/143/24/4687
*  Plant Sterols the Better Cholesterol in Alzheimer's Disease? A Mechanistical Study | Journal of Neuroscience
BACE1 substrates include proteins with important neuronal functions, like the β2-subunit of the voltage-gated sodium channel ( ... we transfected SH-SY5Y wild-type (wt) cells with secretory alkaline phosphatase (SEAP). SEAP secretion was not significantly ... 2007) Clathrin-mediated endocytosis of a lipid-raft-associated protein is mediated through a dual tyrosine motif. J Cell Sci ... 1997) Functional rafts in cell membranes. Nature 387:569-572, doi:10.1038/42408, pmid:9177342. ...
  http://www.jneurosci.org/content/33/41/16072.full
*  Mre11-Rad50-Nbs1 - BET-bromodomain inhibition research
... although LRRK2 will not seem to possess tyrosine kinase activity [16, 17]. MLKs are area of the mitogen-activated proteins ... Toll-like receptor 9 Mainly, a virus acknowledgement receptor of the natural immune system program, participates in the ... Alkaline phosphatase (AP) yellowing was Tectoridin supplier performed using the Quantitative Alkaline Phosphatase Sera ... presumably because of different proteins sources, assay strategies and substrates found in LX 1606 supplier the kinase assay), ...
  http://healthandwellnesssource.org/category/mre11-rad50-nbs1/
*  Gene organization, evolution and expression of the microtubule-associated protein ASAP (MAP9) | BMC Genomics | Full Text
Lee G, Newman ST, Gard DL, Band H, Panchamoorthy G: Tau interacts with src-family non-receptor tyrosine kinases. J Cell Sci. ... ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage. Science. 2007, 316 (5828): 1160- ... Functional analyses of the domain structure of microtubule-associated protein-4 (MAP-U). J Biol Chem. 1991, 266 (15): 9841-9846 ... Cell-type specific MTs, such as the Sertoli cell MTs and the manchette and flagellum MTs of the spermatids, play essential ...
  https://bmcgenomics.biomedcentral.com/articles/10.1186/1471-2164-9-406
*  Most recent papers with the keyword SLP-76 | Read by QxMD
Here, we identified a novel role of the protein tyrosine phosphatase SHP-1 in the regulation of murine LFA-1-mediated adhesion ... for the T cell receptor ζ chain and the scaffold proteins LAT and SLP-76. We find that ZAP-70 selects its substrates by ... This phosphorylation was dependent on at least one functional ITAM and a functional SH2 domain within SYK. Inhibition of Src- ... The application of concanavalin A (Con A) induces milder hepatitis in these mice than in wild-type B6 mice due to a decreased ...
  https://www.readbyqxmd.com/keyword/61055