Loading...
*  Mannose Binding Lectins
The collectins are a family of proteins whose individual chains consist of a C-type lectin domain, attached to a collagen ... The collectins are involved in the innate first wave of immune defense. They bind to microbial surface carbohydrates, inducing ... Study of the collectins in specific disease settings now raises the prospects of developing further therapies exploiting the ... Serum mannose-binding protein (MBP) or mannose-binding lectin initiates the lectin branch of the innate immune response by ...
  https://www.4rhealthproducts.com/Mannose-Binding-Lectins-s/1872.htm
*  Allergic Bronchopulmonary Aspergillosis - The Clinical Advisor
Examples of collectins include surfactant proteins A and D and mannose-binding lectin. Murine models have suggested an ... Additional studies are needed to investigate this finding.. What non-invasive pulmonary diagnostic studies will be helpful in ... Sputum cultures may be helpful in excluding alternate microbial pathogens that may be contributing to symptom exacerbations, ... Polymorphisms in the SP-A protein and mannose-binding lectin have been associated with increased risk of ABPA. ...
  https://www.clinicaladvisor.com/pulmonary-medicine/allergic-bronchopulmonary-aspergillosis/article/625807/
*  IJMS | Free Full-Text | Deleted in Malignant Brain Tumors-1 Protein (DMBT1): A Pattern Recognition Receptor with Multiple...
... surfactant proteins and lactoferrin also bind to DMBT1s through their SRCR domains. The binding motif on the SRCR domains ... All these proteins belong to the scavenger receptor cysteine-rich (SRCR) superfamily of proteins: a superfamily of secreted or ... The SRCR domains play a role in the function of DMBT1s, which is the binding of a broad range of pathogens including cariogenic ... These data demonstrate a role for DMBT1s as pattern recognition molecules containing various peptide and carbohydrate binding ...
  http://www.mdpi.com/1422-0067/11/12/5212/htm
*  Molecular Mechanisms of Microbial Pathogenesis
... mannose-binding lectins), in lung (surfactant proteins A and D), and most likely in other tissues as well and bind to ... Among the microbial adhesins studied in greatest detail are bacterial pili and flagella (Fig. 2-1). Pili or fimbriae are ... accounts for the limited ability of most microbial agents to cause disease.A family of related molecules called collectins, ... Many strains of Escherichia coli isolated from urinary tract infections express mannose- binding type 1 pili, whose binding to ...
  http://www.gkhub.info/molecular-mechanisms-of-microbial-pathogenesis.html
*  Pattern recognition receptor - Wikipedia
Dommett RM, Klein N, Turner MW (September 2006). "Mannose-binding lectin in innate immunity: past, present and future". Tissue ... Studies have been conducted on TLR11 as well, and it has been shown that it recognizes flagellin and profilin-like proteins in ... Some of these proteins recognize endogenous or microbial molecules or stress responses and form oligomers that, in animals, ... Complement receptors, collectins, ficolins, pentraxins such as serum amyloid and C-reactive protein, lipid transferases, ...
  https://en.wikipedia.org/wiki/Pattern_recognition_receptor
*  ASMscience | Interplay between Myeloid Cells and Humoral Innate Immunity
Fluid-phase pattern recognition molecules (PRMs), which include collectins, ficolins, and pentraxins, are key components of the ... Human mannose-binding lectin and L-ficolin function as specific pattern recognition proteins in the lectin activation pathway ... Mannan-binding lectin: structure, oligomerization, and flexibility studied by atomic force microscopy. J Mol Biol 391:246-259. ... Role of collectins in innate immunity against aspergillosis. Med Mycol 43(Suppl 1):S155-S163. [PubMed]. ...
  http://www.asmscience.org/content/journal/microbiolspec/10.1128/microbiolspec.MCHD-0051-2016
*  NE1334: Genetic Bases for Resistance and Immunity to Avian Diseases - NIMSS
DK conducted studies to characterize and examine the function of mannose-binding-lectin (MBL, innate immunity) in ... Studies by NH using an atherosclerosis model also reports differentially-expressed genes and soluble proteins found in aortic ... Direct fed microbial supplementation repartitions host energy to the immune system. J. Anim. Sci. 90:2639-2651. Rasaputra, K. S ... and search for new genetic disease markers in the group of collectins (Ficolin). AR will develop key indices of cellular and ...
  https://www.nimss.org/projects/view/mrp/outline/15096
*  THE SYSTEMIC INFLAMMATORY RESPONSE SYNDROME RELATED TO THE RELEASE OF CYTOKINES FOLLOWING SEVERE ENVENOMATION
MBP is a calcium-dependent sugar binding protein or lectin, a member of collectins family (139). MBP binds to mannose residues ... A study of phospholipase A2 induced edema in rat paw. Eur. J. Pharmacol., 1989, 166, 505-10. [ Links ]. 32 COFFMAN RL., LEBMAN ... and the coordinate stimulation of the acute-plasma proteins (APPs). This involves a shift in the proteins secreted by the liver ... In: WORLD CONGRESS ON ANIMAL, PLANT AND MICROBIAL TOXINS, 12, Cuernavaca-México, 1997, Abstracts... Cuernavaca-México: ...
  http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0104-79301999000100002
*  Acute phase proteins | Hycult Biotech
Another well-characterized APP is mannose-binding lectin (MBL), which activates the lectin complement pathway and is therefore ... Complement and collectins. *Cytokines and chemokines. *Granulocyte and lymphocyte proteins. *LPS and microbial toxins ... Acute phase proteins. Acute phase proteins (APPs) are serum proteins whose levels change in response to inflammation, which ... Examples of the latter are LPS-binding protein (LBP) and serum amyloid A (SAA), both involved in the inflammatory response to ...
  https://www.hycultbiotech.com/products/innate/acutephase?application=62
*  Properdin Binds to Late Apoptotic and Necrotic Cells Independently of C3b and Regulates Alternative Pathway Complement...
... immune pattern recognition collectins surfactant proteins A and D and mannose-binding lectin. J. Biol. Chem. 279: 32728-32736. ... 2 W.X., M.R.D., and C.v.K. designed the study; W.X., N.S., and C.M. performed research; W.X., S.P.B., L.A.T., H.d.B., M.R.D., ... It has been recently suggested that properdin could bind directly to microbial targets (21), which is consistent with a ... and lectin pathway (via mannose-binding lectin (MBL) and ficolin) (10, 11, 12, 13, 14). It has been suggested that the main ...
  http://www.jimmunol.org/content/180/11/7613?ijkey=4c7ecf4340af5dabcca70ddb98a75f3703f2602d&keytype2=tf_ipsecsha
*  Pentraxin 3(PTX 3): An Endogenous Modulator of the Inflammatory Response
PTX3 interacts also with components of the lectin pathway. The mannose binding lectin (MBL) binds PTX3 via its collagen-like ... In their study, prognostic value of PTX3 was superior to that provided by CRP, CK, TnT, and NT-proBNP [25]. Additional studies ... The encounter with the microbial world occurs either on the body's external surface, that is, on the skin, or on its internal ( ... The classical short pentraxins C-reactive protein (CRP) and serum amyloid P component (SAP) are acute-phase proteins in humans ...
  https://www.hindawi.com/journals/mi/2012/920517/
*  David A. Stevens | Stanford Medicine Profiles
Collectins and fungal pathogens: roles of surfactant proteins and mannose binding lectin in host resistance MEDICAL MYCOLOGY ... We recount studies showing the specific hormonal binding of mammalian estrogen to proteins in P. brasiliensis and an action of ... Analysis of the population genetic structure of microbial species is of fundamental importance to many scientific disciplines ... and the serum collectins, mannose binding lectins; the binding of these collectins to pathogen associated molecular patterns or ...
  https://med.stanford.edu/profiles/david-stevens
*  Frontiers | Comparative Evaluation of Heterologous Production Systems for Recombinant Pulmonary Surfactant Protein D |...
... using respiratory distress syndrome as a case study. ... using respiratory distress syndrome as a case study. ... are less effective when pulmonary diseases involve inflammatory complications because two hydrophilic surfactant proteins (A ... These products contain lipids and the hydrophobic surfactant proteins B and C, which help to lower the surface tension in the ... These products contain lipids and the hydrophobic surfactant proteins B and C, which help to lower the surface tension in the ...
  https://www.frontiersin.org/articles/10.3389/fimmu.2014.00623/full
*  Hitchhiker's Guide to the Galaxy on Pattern recognition receptors
Dommett RM, Klein N, Turner MW (September 2006). "Mannose-binding lectin in innate immunity: past, present and future". Tissue ... Some of these proteins recognize endogenous or microbial molecules or stress responses and form oligomers that, in animals, ... other PAMPs have been identifies in studies as targets of CLRs as well e.g. mannose is the recognition motif for many viruses, ... Complement receptors, collectins, ficolins, pentraxins such as serum amyloid and C-reactive protein, lipid transferases, ...
  http://hitchhikersgui.de/Pattern_recognition_receptors
*  Frontiers | NET balancing: a problem in inflammatory lung diseases | Immunology
Innate immune collectins such as pulmonary surfactant protein D (SP-D) binds NETs, and enhances the clearance of dying cells ... Innate immune collectins such as pulmonary surfactant protein D (SP-D) binds NETs, and enhances the clearance of dying cells ... However, recent studies reveal that NETs exert adverse effects in a number of diseases including many lung diseases. Most of ... However, recent studies reveal that NETs exert adverse effects in a number of diseases including many lung diseases. Most of ...
  https://www.frontiersin.org/articles/10.3389/fimmu.2013.00001/full
*  Complement Pathway, Rat, Assay | Hycult Biotech
Mannose binding lectin (MBL), a major component of the lectin pathway, is associated with bacterial, fungal and viral infection ... Complement and collectins. *Cytokines and chemokines. *Granulocyte and lymphocyte proteins. *LPS and microbial toxins ... The Alternative pathway is initiated by binding of C1q to antibody complexes, whereas the alternative and lectin pathway are ... HIT411, Lectin Complement Pathway, Rat. - HIT412, Alternative Complement Pathway, Rat. The innate immune system is important in ...
  https://www.hycultbiotech.com/hit413
*  Frontiers | Hide and Seek: How Lyme Disease Spirochetes Overcome Complement Attack | Immunology
Factor H-related proteins FHR-1, FHR-2, or C4Bp. The latter group of genetically and structurally unrelated proteins has been ... and a CD59-like protein or molecules which indirectly counteract complement activation by binding various complement regulators ... Factor H-related proteins FHR-1, FHR-2, or C4Bp. The latter group of genetically and structurally unrelated proteins has been ... and a CD59-like protein or molecules which indirectly counteract complement activation by binding various complement regulators ...
  https://www.frontiersin.org/articles/10.3389/fimmu.2016.00385/full
*  US5854214A - Therapeutic uses of bactericidal/permeability increasing protein products - Google Patents
Collectins: collagenous C-type lectins of the innate immune defense system. Marra et al. 1992. The role of bactericidal/ ... Human mannose-binding protein US5447913A (en) 1995-09-05. Therapeutic uses of bactericidal/permeability-increasing protein ... Direct binding studies of rBPI23 on the EC cells were performed by harvesting the 10× passaged cells from a confluent flask and ... the cationic/hydrophobic motif of LPS binding/bactericidal molecules and the consensus sequences of heparin binding proteins. ...
  https://patents.google.com/patent/US5854214A/en
*  ASMscience | Allergic Bronchopulmonar
... randomized multicenter studies. Measures which may contribute to remission and/or prevent exacerbation include avoidance of ... Neth, O.,, D. J. Jack,, A. W. Dodds,, H. Holzel,, N. J. Klein, and, M. W. Turner. 2000. Mannose binding lectin binds to a range ... Distinct alleles of mannosebinding lectin (MBL) and surfactant proteins A (SP-A) in patients with chronic cavitary pulmonary ... Madan, T.,, S. Kaur,, S. Saxena,, M. Singh,, U. Kishore,, S. Thiel,, K. B. Reid, and, P. U. Sarma. 2005. Role of collectins in ...
  http://www.asmscience.org/content/book/10.1128/9781555815523.ch26
*  ASMscience | Recognition and Removal
Recent studies have implicated calreticulin as a ligand on apoptotic cells that can be recognized and contributes to their ... immune pattern recognition collectins surfactant proteins A and D and mannose-binding lectin. J. Biol. Chem. 279:32728-32736.. ... Griffin, F. M., Jr.,, J. A. Griffin,, J. E. Leider, and, S. C. Silverstein. 1975. Studies on the mechanism of phagocytosis. I. ... Carrero, J. A.,, and E. R. Unanue. 2006. Lymphocyte apoptosis as an immune subversion strategy of microbial pathogens. Trends ...
  http://www.asmscience.org/content/book/10.1128/9781555816650.ch21
*  Frontiers | Molecular Recognition of Paired Receptors in the Immune System | Microbiology
... the immunoglobulin-like and the C-type lectin-like receptors, and explain how these receptors distinguish self and non-self ... the immunoglobulin-like and the C-type lectin-like receptors, and explain how these receptors distinguish self and non-self ... evidence clearly reveals that the members of cell surface receptor families have very similar extracellular ligand-binding ... evidence clearly reveals that the members of cell surface receptor families have very similar extracellular ligand-binding ...
  https://www.frontiersin.org/articles/10.3389/fmicb.2012.00429/full