Structure−Activity Relationship Studies on a Series of Novel, Substituted 1-Benzyl-5-phenyltetrazole P2X 7 Antagonists
Structure−Activity Relationship Studies on a Series of Novel, Substituted 1-Benzyl-5-phenyltetrazole P2X 7 Antagonists ...https://www.infona.pl/resource/bwmeta1.element.acs-doi-10_1021_jm051202e
RCSB PDB - 1EET: HIV-1 REVERSE TRANSCRIPTASE IN COMPLEX WITH THE INHIBITOR MSC204 Methods Report Page
3. Synthesis and further structure-activity relationship studies of PETT analogues. ... Structure Solution Method. Refinement High Resolution. Refinement Low Resolution. Cut-off Sigma (I). Cut-off Sigma (F). Number ...http://www.rcsb.org/pdb/explore/materialsAndMethods.do?structureId=1EET
Fenobam - Википедија, слободна енциклопедија
... and structure-activity relationship of benzoxazolones: New potent mglu5 receptor antagonists based on the fenobam structure". ... A structure-activity relationship study of fenobam analogues". Bioorganic & medicinal chemistry letters. 16 (5): 1142-5. PMID ... Integrated Platform of Small Molecules and Biological Activities". Annual Reports in Computational Chemistry. 4: 217-241. doi: ... and noncompetitive mGlu5 receptor antagonist with inverse agonist activity". J. Pharmacol. Exp. Ther. 315 (2): 711-21. PMID ...https://sr.wikipedia.org/wiki/Fenobam
Structure-activity relationship - Wikipedia
The structure-activity relationship (SAR) is the relationship between the chemical or 3D structure of a molecule and its ... Combinatorial chemistry Congener Conformation activity relationship Quantitative structure-activity relationship Sims, Gerald; ... known as quantitative structure-activity relationships (QSAR). A related term is structure affinity relationship (SAFIR). The ... Mani, S.V.; D.W. Connell; R.D. Braddock (1991). "Structure activity relationships for the prediction of biodegradability of ...https://en.wikipedia.org/wiki/Structure%E2%80%93activity_relationship
Quantitative structure-activity relationship - Wikipedia
Some examples are quantitative structure-reactivity relationships (QSRRs), quantitative structure-chromatography relationships ... one can find a mathematical relationship, or quantitative structure-activity relationship, between the two. The mathematical ... While many quantitative structure activity relationship analyses involve the interactions of a family of molecules with an ... Quantitative structure-activity relationship models (QSAR models) are regression or classification models used in the chemical ...https://en.wikipedia.org/wiki/Quantitative_structure%E2%80%93activity_relationship
Truncated Orexin Peptides: Structure-Activity Relationship Studies | RTI
The goal of this study was to further investigate the structure-activity relationships of these peptides and to identify the ... German, N., Decker, A., Gilmour, B., Thomas, B., & Zhang, Y. (2013). Truncated Orexin Peptides: Structure-Activity Relationship ... The goal of this study was to further investigate the structure-activity relationships of these peptides and to identify the ... The conformation of the C-terminus might also be a defining factor in agonist activity and selectivity of the orexin peptides ...https://www.rti.org/publication/truncated-orexin-peptides-structure-activity-relationship-studies
OECD Quantitative Structure-Activity Relationships Project [(Q)SARs] - OECD
... structure-activity relationship [(Q)SAR] models for their use in regulatory assessment of chemical safety. (Q)SARs are methods ... for estimating the toxicity and other properties of a chemical from its molecular structure. ... OECD Quantitative Structure-Activity Relationships Project [(Q)SARs] (Quantitative) Structure-Activity Relationships [(Q)SARs] ... OECD Home Chemical safety and biosafetyTesting of chemicalsOECD Quantitative Structure-Activity Relationships Project [(Q)SARs ...http://www.oecd.org/chemicalsafety/testing/oecdquantitativestructure-activityrelationshipsprojectqsars.htm
Structure-activity relationship of naphthaldehydethiosemicarbazones in melanogenesis inhibition.
Previous Document: Enzymatic transformation of caffeic acid with enhanced cyclooxygenase-2 inhibitory activity.. Next Document: ... It was observed that replacement of either of these hydrogens at N1 or N3 by substituents increases the activity significantly ... In addition, the presence of sulfur in thiosemicarbazone is essential for the activity.. ... a series of analogs 15a-p were synthesized and evaluated for anti-melanogenic activity using melanoma B16 cells under the ...http://www.biomedsearch.com/nih/Structure-activity-relationship-naphthaldehydethiosemicarbazones-in/22217872.html
Molecules | Free Full-Text | Special Issue "Structure-Activity Relationship of Natural Products"
This Special Issue of Molecules deals with the structure-activity relationship of natural compounds which possess some ... Structure-Activity and Lipophilicity Relationships of Selected Antibacterial Natural Flavones and Flavanones of Chilean Flora ... "Special Issue "Structure-Activity Relationship of Natural Products"." Molecules 22, no. 5: 697. ... This Special Issue of Molecules deals with the structure-activity relationship of natural compounds which possess some ...http://www.mdpi.com/1420-3049/22/5/697
Combination Chemistry: Structure-Activity Relationships of Novel Psychoactive Cannabinoids | RTI
... they were replaced with additional synthetic cannabinoids withincreasingly diverse chemical structures. This chapter focuses on ... Originally developed as research tools for use in structure-activity relationship studies, synthetic cannabinoids contributed ... Wiley, J. L., Marusich, J., & Thomas, B. F. (2016). Combination Chemistry: Structure-Activity Relationships of Novel ... Originally developed as research tools for use in structure-activity relationship studies, synthetic cannabinoids contributed ...https://www.rti.org/publication/combination-chemistry-structure%E2%80%93activity-relationships-novel-psychoactive-cannabinoids
Structure-activity relationships for 1',1'-dimethylalkyl-?8-tetrahydrocannabinols | RTI
Huffman, J., Miller, J., Liddle, J., Yu, S., Thomas, B., Wiley, J., & Martin, B. (2003). Structure-activity relationships for 1 ...https://www.rti.org/publication/structure%E2%80%93activity-relationships-11-dimethylalkyl-8-tetrahydrocannabinols
Patent US6691045 - Method for determining discrete quantitative structure activity relationships - Google Patents
... transforming and estimating steps for each of the activity classes; and, developing a probability distribution for the activity ... set of chemical compounds with molecular descriptors consisting of a number of multidimensional vectors with an activity class ... Method for developing a quantitative structure activity relationship that includes obtaining a training ... Function Approximation to Quantitative Structure-Activity Relationships and Quantitative Structure-Property Relationships, J. ...http://www.google.com/patents/US6691045?dq=5,960,411
Antiviral and quantitative structure activity relationship study for dihydropyridones derived from curcumin.
Antiviral and quantitative structure activity relationship study for dihydropyridones derived from curcumin. ... Antiviral and quantitative structure activity relationship study for dihydropyridones derived from curcumin. ... Synthesis and structure-activity relationship of 4-pyridones as potential antimalarials. J. Med. Chem., 51: 2845-2852. DOI: ... Density functional theory based quantitative structure activity relationship study of 2,5-bis(1-aziridinyl)-p-benzoquinones ...http://www.biomedsearch.com/article/Antiviral-quantitative-structure-activity-relationship/283456090.html
Structure-activity relationships in aminocyclopentitol glycosidase inhibitors - Organic & Biomolecular Chemistry (RSC...
Structure-activity relationships in aminocyclopentitol glycosidase inhibitors. Lucas Gartenmann Dickson,a Emmanuel Leroya and ... Structure-activity relationships in aminocyclopentitol glycosidase inhibitors. L. Gartenmann Dickson, E. Leroy and J. Reymond, ... A structure-activity relationship analysis was carried out including data from thirty-five different aminocyclopentitol ... The inhibitory activities observed were generally stronger compared to those of their primary amine. analogs. ...http://pubs.rsc.org/en/Content/ArticleLanding/2004/OB/B315704K
Structure-Activity Relationships of N-Cinnamoyl and Hydroxycinnamoyl Amides on α-Glucosidase Inhibition
... Maya G. Chochkova,1 ... S. Adisakwattana, K. Sookkongwaree, S. Roengsumran et al., "Structure-activity relationships of trans-cinnamic acid derivatives ... In order to investigate the structure-. -glucosidase inhibitory relationships of hydroxycinnamoyl amides, some of the previous ... Inhibition of a-Glucosidase Activity by N-Hydroxycinnamoyl Amides and Cinnamic Acids. The inhibitory effects of synthesized N- ...https://www.hindawi.com/journals/jchem/2017/6080129/
Molecules | Free Full-Text | Antiplasmodial Activity, Cytotoxicity and Structure-Activity Relationship Study of Cyclopeptide...
A qualitative SAR (structure-activity relationship) study indicated that a 13-membered macrocyclic ring is preferable over a 14 ... In addition, QSAR (quantitative structure-activity relationship) models were developed, using PLS (partial least squares ... responsible for the antiplasmodial activity. Additionally, predictions made for interesting structures did not contradict the ... In vitro antiplasmodial activity was shown before for several compounds belonging to this class, and in this paper the ...http://www.mdpi.com/1420-3049/22/2/224
Pyrazolo Derivatives as Potent Adenosine Receptor Antagonists: An Overview on the Structure-Activity Relationships
... Siew Lee ... In this paper, an overview of the structure-activity relationship (SAR) profiles of promising nonxanthine pyrazolo derivatives ... We have emphasized the SAR for some representative structures such as pyrazolo-[4,3-e]-1,2,4-triazolo-[1,5-c]pyrimidines; ...https://www.hindawi.com/journals/ijmc/2011/480652/abs/
Molecules | Free Full-Text | Structure-Activity Relationships of the Antitumor C5-Curcuminoid GO-Y030
... we previously conducted a structure-activity relationship study of C5-curcuminoids and showed that highly active GO-Y030 [1,5- ... Intrigued by the potent antitumor activity of C5-curcumin (2)-related 1,5-bisaryl-1,4-pentadiene-3-ones [bis(arylmethylidene) ... was synthesized to elucidate in detail which moiety of GO-Y030 is significant for antitumor activity. The results confirmed ... structure-activity relationship curcumin; antitumor; Michael reaction; structure-activity relationship ...http://www.mdpi.com/1420-3049/20/8/15374
Oxazolidinone Structure-Activity Relationships Leading to Linezolid - Barbachyn - 2003 - Angewandte Chemie International...
Oxazolidinone Structure-Activity Relationships Leading to Linezolid Authors. *. Michael R. Barbachyn Dr.,. *E-mail address: ... Sang-Hun Oh, Josep Kim, Sung-Yoon Baek, Sang-Eun Chae, Hee-Soo Park, Young-Lag Cho, Jin-Hwan Kwak, In Vitro Activities of LCB ... test case for a general approach to improving whole cell Gram-negative activity., Bioorganic & Medicinal Chemistry Letters, ... synthesis of novel oxazolidino-amides/sulfonamides conjugates and their impact on antibacterial activity, Chemical Papers, 2017 ...http://onlinelibrary.wiley.com/doi/10.1002/anie.200200528/full
Fibers | Free Full-Text | The Role of the Protein Corona in Fiber Structure-Activity Relationships
The Role of the Protein Corona in Fiber Structure-Activity Relationships. Melanie Kucki 1,†. ... "The Role of the Protein Corona in Fiber Structure-Activity Relationships." Fibers 2, no. 3: 187-210. ... The Role of the Protein Corona in Fiber Structure-Activity Relationships. Fibers 2014, 2, 187-210. ... The Role of the Protein Corona in Fiber Structure-Activity Relationships. Fibers. 2014; 2(3):187-210. ...http://www.mdpi.com/2079-6439/2/3/187
"Semi-synthesis and structure-activity relationship studies of Stemona " by Kwankamol Sastraruji
... to prepare rare Stemona alkloids and their analogues for testing as AChE inhibitors and structure-activity relationship (SAR) ... This study led to the revision of the stemoburkilline structure from an E-isomer to a Z-isomer. Chapter 4 of this thesis ... Stemona alkaloids have been reported for their insecticidal activities which may be associated with their ability to inhibit ... Semi-synthesis and structure-activity relationship studies of Stemona alkaloids and related analogues ...http://ro.uow.edu.au/theses/3345/
The role of fluorine substitution in the structure-activity relationships (SAR) of classical cannabinoids | RTI
The role of fluorine substitution in the structure-activity relationships (SAR) of classical cannabinoids. ... The role of fluorine substitution in the structure-activity relationships (SAR) of classical cannabinoids. Bioorganic and ...https://www.rti.org/publication/role-fluorine-substitution-structure-activity-relationships-sar-classical-cannabinoids
RCSB PDB - 4ELH: Structure-activity relationship guides enantiomeric preference among potent inhibitors of B. anthracis...
Structure-activity relationship guides enantiomeric preference among potent inhibitors of B. anthracis dihydrofolate reductase ... Structure-activity relationship for enantiomers of potent inhibitors of B. anthracis dihydrofolate reductase.. Bourne, C.R., ... Structure-activity relationship guides enantiomeric preference among potent inhibitors of B. anthracis dihydrofolate reductase ...https://www.rcsb.org/structure/4ELH
Cannabinoid-Mediated Elevation of Intracellular Calcium: A Structure-Activity Relationship | Journal of Pharmacology and...
6, A-C). Also consistent with the structure-activity relationship observed in the HPB-ALL cells, the time delay to onset of the ... Cannabinoid-Mediated Elevation of Intracellular Calcium: A Structure-Activity Relationship. Gautham K. Rao and Norbert E. ... Cannabinoid-Mediated Elevation of Intracellular Calcium: A Structure-Activity Relationship. Gautham K. Rao and Norbert E. ... Cannabinoid-Mediated Elevation of Intracellular Calcium: A Structure-Activity Relationship. Gautham K. Rao and Norbert E. ...http://jpet.aspetjournals.org/content/317/2/820
Binding of porphyrin to human serum albumin. Structure-activity relationships | Biochemical Journal
Structure-activity relationships. S Cohen, R Margalit. Biochemical Journal Sep 01, 1990, 270 (2) 325-330; DOI: 10.1042/ ... the HVD isomers along the porphyrin-protein affinity sequence gives insight into the relationship of porphyrin structure to ...http://www.biochemj.org/content/270/2/325