Influences of inbreeding and gene... preview & related info | Mendeley
We measured telomere lengths of blood leukocytes in several inbred and outbred mammalian species, using a telomere-specific ... Two common strains of laboratory mice, C57BL/6J and DBA/2J, have telomeres several times longer than most other mammals ... the two inbred laboratory mouse strains display significantly different telomere lengths, suggesting the existence of strain- ... mice between parental strains displaying the phenotype of long and short telomeres. In all F(1) mice assayed, peripheral blood ...https://www.mendeley.com/research-papers/influences-inbreeding-genetics-telomere-length-mice/
Origins of mouse inbred strains deduced from whole-genome scanning by polymorphic microsatellite loci, Mammalian Genome | 10...
"Origins of mouse inbred strains deduced from whole-genome scanning by polymorphic microsatellite loci, Mammalian Genome" on ... of laboratory mice, including A/J, C57BL/6J, CBA/J, DBA/2J, SM/J, SWR/J, NC/Nga, and 129/SvJ, and eight wild-derived inbred ... Origins of mouse inbred strains deduced from whole-genome scanning by polymorphic microsatellite loci. Origins of mouse inbred ... Evidence from mtDNA sequences that common laboratory strains of inbred mice are descended from a single female ...https://www.deepdyve.com/lp/springer_journal/origins-of-mouse-inbred-strains-deduced-from-whole-genome-scanning-by-7X39mtevdC
Abbie Lathrop - Wikipedia
... his own DBA strain was probably derived from her partially inbred silver fawn mice. Karin Knorr Cetina wrote in 2009 that at ... Black 6 became the most frequently used strain of laboratory mouse. While Little patronizingly called Lathrop a "talented pet- ... She bred Japanese waltzing mice as well as fancy mice. The mice had straw bedding and lived in wooden boxes. They were fed a ... Lathrop began developing inbred strains around 1910. Loeb and Lathrop performed experiments at her farm and the pair authored ...https://en.wikipedia.org/wiki/Abbie_Lathrop
Association between P2X7 Receptor Polymorphisms and Bone Status in Mice
Female mice of nine inbred strains (C3H/HeJ, NZB/B1NJ, SJL/J, AKR/J, BALB/cJ, 129X1/SvJ, SWR/J, C57L/J, and DBA/2J) were ... The distribution of the two alleles of the P451L mutation among common strains of laboratory mouse strains was determined in 21 ... Only mice from wild populations, outbred strains and a few of the inbred strains, which included the four major strains, BALB, ... Figure 1: Bone parameters in the 129X1/SvJ, BALB/c, B6, and DBA/2 inbred strains. Significant difference between the strains at ...https://www.hindawi.com/journals/jos/2012/637986/
Chronic Intermittent Ethanol (CIE) Exposure Model | iniastress.org
... as well as other inbred mouse strains including DBA/2J and C3H/Hecr, selectively bred HAP/LAP lines, and and BXD RI lines. Mice ... male C57BL/6J mice obtained from Jackson Laboratories (Bar Harbor, ME). Although experimental parameters have been optimized ... Mice are individually housed in standard polypropylene pans with wood-chip bedding and stainless steel wire lids. The mice are ... mice with consumption in nondependent mice. The general experimental strategy of this model is to first establish the positive ...http://iniastress.org/cie
Mouse genome-wide association study identifies polymorphisms on chromosomes 4, 11, and 15 for age-related cardiac fibrosis,...
"Mouse genome-wide association study identifies polymorphisms on chromosomes 4, 11, and 15 for age-related cardiac fibrosis, ... has been detected in mice of a number of laboratory inbred strains, most commonly C3H/HeJ and DBA/2J. In previous mouse ... has been detected in mice of a number of laboratory inbred strains, most commonly C3H/HeJ and DBA/2J. In previous mouse ... at 12 and 20 months of age and close to natural death in a survey of 28 inbred mouse strains. Eight strains showed cardiac ...https://www.deepdyve.com/lp/springer_journal/mouse-genome-wide-association-study-identifies-polymorphisms-on-Ti4aFFdlRs
Laboratory mouse - Wikipedia
"BALB/c". Inbred Strains of Mice. Jackson Laboratory. Retrieved 2007-04-16. "BALB/cByJ". Jax Mice Data Sheet. Jackson Laboratory ... Together they generated the DBA (Dilute, Brown and non-Agouti) inbred mouse strain and initiated the systematic generation of ... were C57BL/6 laboratory mice. Sequencing of the laboratory mouse genome was completed in late 2002 using the C57BL/6 strain. ... The laboratory is also the world's source for more than 8,000 strains of genetically defined mice and is home of the Mouse ...https://en.wikipedia.org/wiki/Laboratory_mouse
Model organism - Wikipedia
... inbred mouse strain and the systematic generation of other inbred strains. The mouse has since been used extensively as a model ... on mouse genetics in the laboratory of William Ernest Castle in collaboration with Abbie Lathrop led to generation of the DBA ... Mestas, Javier; Hughes, Christopher C. W. (2004-03-01). "Of Mice and Not Men: Differences between Mouse and Human Immunology". ... Hedrich, Hans (ed.). "The house mouse as a laboratory model: a historical perspective". The Laboratory Mouse. Elsevier Science ...https://en.wikipedia.org/wiki/Model_organism
Genetic architecture of neurogenesis in the adult mouse forebrain : insights from quantitative trait locus analyses - UBC...
Kempermann and colleagues were the first to examined hippocampal neurogenesis in various inbred laboratory mouse strains ... where mice of C57BL/6J background exhibited the lowest number of BrdU+ cells in the RMS and other strains such as A/J and DBA/ ... The nine strains are among the most commonly used mouse strains in research. They are considered priority strains in the Mouse ... 2012) Hybrid mouse diversity panel: a panel of inbred mouse strains suitable for analysis of complex genetic traits. Mamm ...https://open.library.ubc.ca/cIRcle/collections/ubctheses/24/items/1.0135556
Genetic Control of Interconnected Neuronal Populations in the Mouse Primary Visual System | Journal of Neuroscience
Standard inbred strains. Standard inbred laboratory strains of mice are derived from domesticated hybrids generated from ... BXD24 is an inbred strain derived from nonmutant parental stock (C57BL/6J and DBA/2J), but this strain also has complete ... Taylor B (1989) Recombinant inbred strains. In: Genetic variants and strains of the laboratory mouse (Lyon MF, Searle AG, eds ... Recombinant inbred strains. For this study, we included 32 of the BXD recombinant inbred strains. The parental strains for all ...http://www.jneurosci.org/content/23/35/11178
Lab mice: Are they limiting our understanding of human disease?
Mark Mattson knows a lot about mice and rats. He's fed them; he's bred them; he's cut their heads open with a scalpel. Over a ... "DBA." This was the first mouse to be successfully inbred, meaning that every new mouse pup had exactly the same genes as its ... After 85 years of laboratory life-with technicians removing all the runts from the gene pool-CD-1, and other strains like it, ... Among the mice, no animal outsells C57BL/6, also known as the "Black-6." A general-purpose mouse used as the base strain for ...http://www.slate.com/articles/health_and_science/the_mouse_trap/2011/11/lab_mice_are_they_limiting_our_understanding_of_human_disease_.html?wpisrc=newsletter_tis
Neurogenetics at UT Health Science Center
The Mouse Brain Library, databases on mouse brain size and structure, and online publications. ... This server is the gateway to The Portable Dictionary of the Mouse Genome (over 20,000 gene loci), ... All the BXD mice were obtained directly from the Jackson Laboratory (Bar Harbor, ME). The AXB, BXA RI strains were produced ... responsible for variation in brain weight between mouse strains using the recombinant inbred (RI) strains, BXD and AXB/BXA, and ...http://www.nervenet.org/papers/Strom99/Chapter3.html
2J inbred mouse strain five times from a C57BL/6J strain because pilot studies in our laboratory showed that female DBA/2J mice ... To characterize the development of obesity in the DBA/2J mouse strain, 6 male and female wild-type DBA/2J mice, raised on a LCD ... Characterization of HCD-induced leptin resistance in DBA/2J mice. Male and female wild-type DBA/2J mice fed an HCD for 10 weeks ... Wild-type and transgenic mice (DBA/2J background strain) were obtained from the University of Otago animal breeding facility ...http://www.jneurosci.org/content/36/27/7142
DNA variation and brain region-specific expression profiles exhibit different relationships between inbred mouse strains:...
Seven-week-old male inbred mice were received from the Jackson Laboratory (Bar Harbor, ME, USA) (A/J, C3H/HeJ, C57BL/6J, DBA/2J ... from six commonly used inbred mouse strains (129S6/SvEvTac, A/J, C3H/HeJ, C57BL/6J, DBA/2J, and FVB/NJ). Replicate gene ... Relationships of inbred mouse strains. (a) A phylogenetic tree based on the fraction of allelic differences across 12,473 loci ... Atchley WR, Fitch W: Genetic affinities of inbred mouse strains of uncertain origin. Mol Biol Evol. 1993, 10: 1150-1169.PubMed ...https://genomebiology.biomedcentral.com/articles/10.1186/gb-2007-8-2-r25
Inbred strain - Wikipedia
The latter project led to the development of the DBA strain of mice, now widely distributed as the two major sub-strains DBA/1 ... "Rules for Nomenclature of Inbred Strains". In Green, Margaret C. Genetic Variants and Strains of the Laboratory Mouse. ... Linebreeding Recombinant inbred strain Coisogenic strain Congenic strain Inbreeding depression Inbreeding Jackson Laboratory ... Such strains are useful in the analysis of variance within an inbred strain or between inbred strains because any differences ...https://en.wikipedia.org/wiki/Inbred_strain
Mixed-strain housing for female C57BL/6, DBA/2, and BALB/c mice: validating a split-plot design that promotes refinement and...
The Jackson Laboratory. Growth curve analysis of 7 inbred strains of mice. MPD:Jaxpheno5. Mouse Phenome Database web site, The ... 20 of each strain) or mixed-strain (n = 20) trios. Mixed-strain trios consisted of one mouse of each strain. Mice were also ... The Jackson Laboratory.: Hematological survey of 11 inbred strains of mice. MPD:22969. Mouse Phenome Database web site, The ... using two inbred strains of mice housed together in conventional cages: C57BL/6 (black) and DBA/2 (brown) . Here, we expand ...https://bmcmedresmethodol.biomedcentral.com/articles/10.1186/s12874-016-0113-7
Cardiovascular Response to Beta-Adrenergic Blockade or Activation in 23 Inbred Mouse Strains
... strains Balb/cByJ, C3H/HeOuJ, CBA/J, and DBA/2J) or from the Jackson Laboratory at Bar Harbor, Maine, USA (strains 129S1/SvImJ ... Mice. Inbred mouse strains were selected from the priority strains list of the Mouse Phenome Database (MPD: http://www.jax.org/ ... We report the characterisation of 27 cardiovascular-related traits in 23 inbred mouse strains. Mice were phenotyped either in ... Cardiovascular Response to Beta-Adrenergic Blockade or Activation in 23 Inbred Mouse Strains. Corinne Berthonneche,#1,2 Bastian ...http://pubmedcentralcanada.ca/pmcc/articles/PMC2722085/?lang=en-ca
Imiquimod has strain-dependent effects in mice and does not uniquely model human psoriasis | Genome Medicine | Full Text
... treatment in both sexes of seven mouse strains (C57BL/6 J (B6), BALB/cJ, CD1, DBA/1 J, FVB/NJ, 129X1/SvJ, and MOLF/EiJ). In ... These findings demonstrate strain-dependent aspects of IMQ dermatitis in mice. We have shown that IMQ does not uniquely model ... Although IMQ-induced expression shifts mirrored psoriasis, responses in BALB/c, 129/SvJ, DBA, and MOLF mice were more ... Nonetheless, our findings suggest that B6 mice provide a better background than other strains for modeling psoriasis disease ...https://genomemedicine.biomedcentral.com/articles/10.1186/s13073-017-0415-3
Spontaneous mutation in the db gene results in obesity and diabetes in CD-1 outbred mice | Regulatory, Integrative and...
The C57BLKS/J inbred strains are a derivative strain of C57BL/6J that was genetically contaminated, probably by DBA/2J (25). ... Michael Festing maintained by the Mouse Genome Informatics Group at the Jackson Laboratories. ... The C57BL/6 inbred mouse strain was established in 1921 from a breeder pair (female 57 and male 52) from Abbie Lathrop's mouse ... History of the Swiss albino mouse. The CD-1 mice, an outbred stock of albino mice, are based on the Swiss mouse colony ...http://ajpregu.physiology.org/content/278/2/R320
MGI - Inbred Strains: C57BL
... though in many ways it seems to be atypical of inbred strains of laboratory mice. In contrast to 36 other standard inbred ... Detection of mouse hepatitis virtus antibody by protein A-ELISA in 6 prevalent inbred strains or outbred stocks of mice. Lab. ... Susceptibility of inbred mice to helminths. II. Development of Opisthorchis felineus in A/He, CBA/Lac, CC57W/Mv, C57BL/6J, DBA/ ... Taylor D. M. and Fraser H. (1973) Hydronephrosis in inbred strains of mice with particular reference to the BRVR strain. Lab. ...http://www.informatics.jax.org/inbred_strains/mouse/docs/C57BL.shtml
Program for Monday, May 21st
... which offers increased genetic and phenotypic diversity over traditional inbred mouse strains. We identified two CC strains ... of D2R knockout mice normalizes their enhanced impulsivity. I will present recent findings obtained in our laboratory in the ... We have confirmed ~4.5 million variants between the DBA/2J and C57BL/6J parents. We have aligned sequences for ,50 samples and ... Our laboratory is using a relatively new eight-way recombinant inbred mouse population, the Collaborative Cross (CC), ...https://easychair.org/smart-program/2018IBANGSMeeting/2018-05-21.html
Example data set for DRG annotation - NIF - CRBS Confluence Wiki
... and DBA/2J (DBA) inbred strains differ substantially in many aspects of their response to drugs of abuse'. Even though the ... they do state that they purchased the mice from Jackson Laboratory and do state the strain in the abstract. Use the preferred ... NIF defines an adult mouse as , 50 day post natal so mice 8-12 weeks of age would be classified as Adult so use the label ' ... 2007) Transcriptional profiling of C57 and DBA strains of mice in the absence and presence of morphine. BMC Genomics. Mar 16;8: ...https://confluence.crbs.ucsd.edu/display/NIF/Example+data+set+for+DRG+annotation
The genomic landscape shaped by selection on transposable elements across 18 mouse strains | Genome Biology | Full Text
In addition, deleterious TEVs present in laboratory mice might have been maintained owing to their artificial inbreeding. It is ... DBA/2J, LP/J, NOD/ShiLtJ and NZO/HiLtJ) and 4 wild-derived (CAST/EiJ, PWK/PhJ, WSB/EiJ and SPRET/EiJ) mouse inbred strains as ... Using whole genome sequencing data from 13 classical laboratory and 4 wild-derived mouse inbred strains, we developed a ... DBA/2J, LP/J, NOD/ShiLtJ and NZO/HiLtJ) and 4 wild-derived mouse inbred strains (CAST/EiJ, PWK/PhJ, WSB/EiJ and SPRET/EiJ), and ...https://genomebiology.biomedcentral.com/articles/10.1186/gb-2012-13-6-r45
Pain modality- and sex-specific effects of COMT genetic functional variants
This can be systematically observed in the results of testing the laboratory inbred mouse strains in a battery of common assays ... There is a growing body of evidence that COMT's effects are sexually dimorphic . In inbred strains of mice, female mice ... and five strains carried the ancestral Comt+ allele: C3H/He, C58, CBA, DBA/2, and RIIIS. ... In recent rodent studies, three independent laboratories have shown that in inbred mouse strains, a Comt allele, ComtB2i, ...http://pubmedcentralcanada.ca/pmcc/articles/PMC3700530/?lang=en-ca
Genetic Evidence for Differential Regulation of Corneal Epithelial and Stromal Thickness | IOVS | ARVO Journals
BXD24b is a recombinant inbred strain of mice derived from C57BL/6J and DBA/2J progenitors27 and contains a spontaneous ... Genetic Variants and Strains of the Laboratory Mouse. 2nd ed. Oxford: Oxford University Press; 1989. ... 28 CAST is an inbred strain originally derived from wild mice trapped in a grain warehouse in Thailand.29 BXD24b × CAST F1 mice ... Based on the demonstration that corneal thickness is continuously distributed among inbred strains of mice,1 we have initiated ...http://iovs.arvojournals.org/article.aspx?articleid=2430903