Monitoring Epstein-Barr Virus (EBV) Load in Rheumatoid Arthritis Patients Treated With New Immunosuppressive Drugs - Tabular...
Current treatment of RA routinely includes potentially immunosuppressive medications like methotrexate and TNFa inhibitors. New immunosuppressive drugs are at disposal, Orencia* (abatacept) which is a T cell co-stimulation modulator (CTLA4Ig) and RoActemra* (tocilizumab), an antibody against IL6 receptor. In solid organ transplant recipients under immunosuppressants, emergence of lymphoma can be predicted by monitoring EBV load in peripheral blood mononuclear cells (PBMNCs). EBV load above 1000 copies per 500 ng PBMNC DNA is considered a limit above which patients will develop EBV associated post transplant lymphoproliferative disorder, a condition characterized by polyclonal EBV positive B lymphocyte proliferation which can evolve into EBV positive B cell lymphoma .. In a first study, we showed that Rheumatoid arthritis patients have 10 fold systemic EBV overload, very similar to that observed in healthy organ transplant recipients. More recently, we showed that methotrexate tended to ...https://clinicaltrials.gov/ct2/show/record/NCT00947492
Mycophenolate mofetil in the treatment of uveitis in children | British Journal of Ophthalmology
Background: Mycophenolate mofetil (MMF) is a new immunosuppressive agent that effectively controls the intraocular inflammation in adults.. Purpose: To assess the efficacy of MMF in uveitis in children and to analyse the possible side effects.. Participants and methods: A retrospective analysis was carried out on 17 children (32 eyes) with intraocular inflammation treated with MMF and followed up at the University Eye Hospital Tuebingen, Tuebingen, Germany, between 2000 and 2005. All children had chronic non-infectious uveitis and received MMF for at least 6 months. All patients were given steroids or other immunosuppressive agents before initiating treatment with MMF.. Results: 17 children (10 boys and 7 girls) with a mean age of 8 (range 2-13) years at the onset of uveitis were examined. The average duration of follow-up after initiation of MMF was 3 (range 2-5) years. A steroid-sparing effect was achieved in 88% of the patients. The oral prednisolone was successfully ...http://bjo.bmj.com/content/91/2/180
Immunosuppressive compounds - Vertex Pharmaceuticals, Inc.
This invention relates to a novel class of immunosuppressive compounds having an affinity for the FK-506 binding protein (FKBP). Once bound to this protein, the immunosuppressive compounds inhibit thehttp://www.freepatentsonline.com/5192773.html
"Immunosuppressive strategies to avoid complications: The Achilles' hee" by Gregory Smallwood
PURPOSE OF REVIEW: The goal of solid organ transplantation has now evolved into minimizing the long-term consequences of immunosuppression. The consequences of immunosuppression include an increased risk of developing diabetes, renal insufficiency, osteoporosis, malignancies, and viral infections, to name but a few. RECENT FINDINGS: Immunosuppressive protocols that avoid or minimize the use of calcineurin inhibitors hold the promise of better long-term patient outcomes, especially with patients who progress on to dialysis or renal transplantation after organ transplantation. New, aggressive induction protocols have been used in patients with chronic viral infections, such as hepatitis C, without untoward effects on outcomes. SUMMARY: It is important to appreciate that the long-term benefits of new immunosuppressive strategies have yet to stand the test of time when considering long-term graft survival. Follow-ups to these ...https://digitalcommons.pcom.edu/scholarly_papers/1191/
Conventional Immunosuppression is Compatible with Costimulation Blockade-Based, Mixed Chimerism Tolerance Induction - Adams -...
Clinical trials to test the safety and efficacy of costimulation-based strategies in clinical solid organ transplantation will likely involve the concomitant use of conventional immunosuppressive agents. For example, the clinical trial currently in progress to test blockade of the CD28/B7 pathway in renal transplant patients includes concurrent treatment with MMF, steroids, and an anti-CD25 mAb. The design of clinical trials to include conventional agents provides an adequate margin of safety against allograft rejection thus permitting the testing of new, exciting agents in an ethically acceptable manner. As a result, a more basic understanding of the interactions between these agents and costimulation blockade strategies is critical for the design of preclinical nonhuman primate studies and clinical trials.. Blockade of the CD40 and CD28 pathways effectively inhibits rejection responses in rodent and nonhuman primate allograft models. However, when this strategy is combined with calcineurin ...http://onlinelibrary.wiley.com/doi/10.1034/j.1600-6143.2003.00155.x/full
A PHARMACOKINETIC POPULATION MODEL FOR CYCLOSPORIN A IN RENAL TRANSPLANT RECIPIENTS : Development of a model for whole blood-...
ABSTRACT. Background: Cyclosporine A (CsA) has since its introduction in the 1980's played a substantial part of the success in solid organ transplantation. Like many other immunosuppressive drugs, CsA has a narrow therapeutic window and a large inter-individual variability. Drug exposure above the therapeutic window is associated with adverse events like nephrotoxicity, infection and cancer while drug exposure below will yield a lack of effect and increased risk for acute rejection episodes. Obtaining an optimal drug concentration will prevent acute organ rejections and optimize survival of the grafts and ultimately the patients.. The primary aim of this study is to implement a T-cell compartment to an already existing whole blood model. Another goal was to further develop the basic whole blood model after the inclusion of 20 new patients followed for at least 8 weeks, by re-evaluating for relevant covariates and include estimation of ...https://www.duo.uio.no/handle/10852/12276
Renal Function Optimization With Mycophenolate Mofetil (MMF) Immunosuppressor Regimes (ALHAMBRA) - Full Text View -...
The study population characteristics raise the need to establish a treatment regime that assures suitable intensity immunosuppression to avoid the appearance of rejection episodes, but minimizes the doses to prevent over-immunosuppression in a population with a theoretic minor immune response.. On the other hand, the delay in the introduction of calcineurin inhibitors will prevent increasing the risk of early graft dysfunction allowing the highest post-transplant renal recovery in organs with less operative mass and greater sensibility to the nephrotoxic effect of these drugs.. The results of several studies confirm the goodness of regimes that include low doses of calcineurin inhibitors, delay their introduction or avoid them.. Nevertheless, although it is standard practice to evaluate the effectiveness of the regimes for a time to assure, with certainty, the response to the treatments, these follow-ups are still relatively ...https://clinicaltrials.gov/ct2/show/NCT00290069
Cellcept: A Promising New Immunosuppressive Drug | Pemphigus Pemphigoid Foundation (IPPF)
By Grant J. Anhalt, M.D. and Hossein Nousari, M.D.Johns Hopkins University, School of Medicine In February 1997, the FDA approved a new drug, mycophenolatehttp://www.pemphigus.org/cellcept-a-promising-new-immunosuppressive-drug-2/
Immunosuppressive Medications for Participants in ITN005CT (NCT00014911) - Full Text View - ClinicalTrials.gov
Study acronym: EXIIST - Extended Immunosuppression in Islet Transplantation. Islet transplantation is an experimental therapy in people with difficult to control Type 1 diabetes (T1D). Insulin producing cells (islets) are isolated from a pancreas. After the cells are prepared, the islets are put into the subject's liver. These transplanted islets may produce insulin that the subject's islets can no longer make. In order to help keep up the function of the transplanted islets, immunosuppressive medications must be given indefinitely or for as long as the study doctor determines is necessary. The medications serve to modify the immune system that normally tries to destroy (reject) new islets.. Participants in this study have received up to three islet cell infusions as a previous participant in the ITN005CT (NIS01) protocol. They also received a maintenance immunosuppressive treatment regimen consisting of a combination of orally administered ...https://clinicaltrials.gov/ct2/show/NCT01309022?term=NIAID&recr=Open&no_unk=Y&sntx=
Immunosuppressive Medications for Participants in ITN005CT (NCT00014911) - Full Text View - ClinicalTrials.gov
Study acronym: EXIIST - Extended Immunosuppression in Islet Transplantation. Islet transplantation is an experimental therapy in people with difficult to control Type 1 diabetes (T1D). Insulin producing cells (islets) are isolated from a pancreas. After the cells are prepared, the islets are put into the subject's liver. These transplanted islets may produce insulin that the subject's islets can no longer make. In order to help keep up the function of the transplanted islets, immunosuppressive medications must be given indefinitely or for as long as the study doctor determines is necessary. The medications serve to modify the immune system that normally tries to destroy (reject) new islets.. Participants in this study have received up to three islet cell infusions as a previous participant in the ITN005CT (NIS01) protocol. They also received a maintenance immunosuppressive treatment regimen consisting of a combination of orally administered ...https://clinicaltrials.gov/ct2/show/NCT01309022?type=Expn&rank=36
Renal Fellow Network: How to best design RCTs for new transplant immunosuppressives
All opinions expressed on the website are those of the respective authors and not of their employer. Information provided here is for medical education only. It is not intended as and does not substitute for medical advice. If you are a patient, please see your doctor for evaluation. The appearance of external hyperlinks to other websites does not constitute endorsement. We do not verify, endorse or take responsibility for the accuracy, currency, completeness or quality of the content contained in these sites. There is no real life patient data on this website. The Renal Fellow Network does not profit from any of the material on this website. No advertisements are accepted. The Renal Fellow Network is not funded by any agency or company. Any information collected by our website, such as email addresses, will never be passed on to any third party, unless required by law. The Renal Fellow Network is moderated occasionally and posteriorly. Moderators are volunteers. Internet users posting comments ...http://renalfellow.blogspot.com/2009/10/how-to-best-design-rcts-for-new.html
Phase 1/2 Safety and Efficacy of PLX3397 in Adults With Relapsed or Refractory Acute Myeloid Leukemia (AML) - Tabular View -...
For both Parts 1 and 2, receipt of HSCT within 60 days of the first dose of PLX3397 is an exclusion criterion. Patients on immunosuppressive therapy post HSCT, or with clinically significant graft-versus-host disease are excluded from Part 1. (Use of topical steroids for ongoing skin GVHD is permitted). Patients for Part 1 must have a wash-out period of ≥2 weeks or at least 4 half-lives from their last systemic immunosuppressive treatment for GVHD. Patients for Part 2 may be receiving systemic immunosuppressive treatment for management of GVHD at the time of screening and ...https://clinicaltrials.gov/ct2/show/record/NCT01349049
Sirolimus for rescue and primary immunosuppression in transpla...
Sirolimus for rescue and primary immunosuppression in transplanted children receiving tacrolimus.: SRL and reduced-dose TAC may achieve adequate immunosuppressihttps://www.mysciencework.com/publication/show/sirolimus-rescue-primary-immunosuppression-transplanted-children-receiving-tacrolimus-e93a8435
Primobolan headaches | Side Effects of Steroids - Steroid.com
With simultaneous application of Tacrolimus hexane with other immunosuppressive drugs increases the risk of infections, and lymphoproliferative disorders. The risk of nephrotoxicity with concomitant administration of cyclosporin hexane and drugs suchhttp://mua.stoynev.us/primobolan-headaches.html
Protective Immunity Project 01 - Full Text View - ClinicalTrials.gov
While the benefits of transplantation to society are substantial, the ever-growing population of immunosuppressed recipients poses a unique challenge in development of immunization and containment strategies to protect the population from communicable pathogens and weaponized infectious agents. The immunosuppressive regimens that have allowed the emergence of successful transplant therapy not only inhibit T cell-dependent rejection but also cause systemic immunosuppression, which attenuates the response to vaccines in general and precludes the use of live attenuated vaccines. To date, there has been relatively little detailed systematic study of the immune alterations that accompany either the short- or long-term immunosuppressive regimens used in clinical organ transplantation. Despite the recent development of increasingly effective, but also increasingly complex, regimens using drugs with very distinct ...https://clinicaltrials.gov/ct2/show/NCT00788021
It has become evident that tumor-induced immuno-suppressive elements in the growth | COX-2 contributes to the maintenance of...
It has become evident that tumor-induced immuno-suppressive elements in the growth microenvironment play a main part in suppressing normal features of effector Capital t cells. can promote antitumor results by re-establishing T-cell defenses (for review, discover ref. 6767).65, 68 1MT is anticipated to possess no serious side effects since it prevents IDO while sparing tryptophan dioxygenase, a hepatic enzyme that regulates body tryptophan amounts.69 Style and advancement of more effective IDO inhibitors is underway (for examine, discover ref. 60, 67, 70).60, 67, 70 Arginase and nitric-oxide synthase Change in the path involving the catabolism of L-arginine is linked to the reductions of T-cell expansion. Two essential digestive enzymes included in arginine rate of metabolism are arginase and inducible nitric oxide synthase (iNOS).9 Arginine is used by iNOS as a precursor for the production of nitric oxide (NO). Consequently, raised amounts of arginase and iNOS deplete arginine, an important ...http://lifescienceexec.com/it-has-become-evident-that-tumor-induced-immuno-suppressive-elements-in-the-growth/
The recognition that immune suppression is crucial to promote tumor progression, which might explain the failure of some cancer vaccines, has resulted in a paradigm shift regarding approaches to cancer immunotherapy. It indeed becomes clear that successful cancer immunotherapy will only be achieved when associated with the elimination of suppressive cells (31-33). Two major immunosuppressive cell types are mainly involved in tumor-induced immunosuppression: Tregs and MDSC. The elimination of Treg cells using a low dosage of cyclophosphamide as a metronomic regimen proved its efficacy in many rodent models as well as in humans (25, 26, 30, 34-37). Many strategies have been tested to dampen the immunosuppressive actions of MDSC, including treatments designed to favor their differentiation, or to inhibit their expansion or their inhibitory function (13, 38). However, the most promising results have been obtained with the selective depletion of these cells. Some groups tested ...http://cancerres.aacrjournals.org/content/70/8/3052
Peptides - LIFE SCIENCES - Products
Find here a selection of peptides of various nature such as toxins, immunosuppressives, antibiotics or chromogenic diagnostic peptides.https://www.iris-biotech.de/de/products/life-sciences/peptides.html
glucocorticoid | hormone | Britannica.com
glucocorticoid: Any steroid hormone that is produced by the adrenal gland and known particularly for its anti-inflammatory and immunosuppressive actions. The adrenal gland is an organ situated...https://www.britannica.com/science/glucocorticoid
AID 209943 - In vitro evaluation for immunosuppressive activity against proliferation of antigen stimulated murine splenic T...
BioAssay record AID 209943 submitted by ChEMBL: In vitro evaluation for immunosuppressive activity against proliferation of antigen stimulated murine splenic T cells.https://pubchem.ncbi.nlm.nih.gov/bioassay/209943
"Immunosuppressive properties of purified immune t-interferon." by M A. Lucero, J Wietzerbin et al.
Lucero, M A.; Wietzerbin, J; Stefanos, S; Billardon, C; Falcoff, R; and Fridman, W H., "Immunosuppressive properties of purified immune t-interferon." (1980). Subject Strain Bibliography 1980. 3146 ...https://mouseion.jax.org/ssbb1980/3146/
Composition for the prevention and/or treatment of the cytotoxic effects induced by the use of immunosuppressive agents - Sigma...
A composition is disclosed which is suitable for the prevention and/or treatment of cell and tissue abnormalities of exogenous, toxic or metabolic origin and suitable for reducing the toxic effects ofhttp://www.freepatentsonline.com/7897641.html
JoVE Author Search: Sfriso P
Anakinra, Arthritis, Corticosteroids, Dermatitis, Disease, Eye, Eyes, Family, Gene, Genetics, Immunosuppressive Agents, Joint, Morbidity, Patients, Skin, Syndrome, Therapeutic, Treatment, Uveitishttp://labindex.jove.com/author/Sfriso-P
Basiliximab (Professional Patient Advice) - Drugs.com
Professional guide for Basiliximab. Includes: pharmacology, pharmacokinetics, contraindications, interactions, adverse reactions and more.https://www.drugs.com/ppa/basiliximab.html
... develops tolerogenic vaccines which re-program the immune system. The company's technology has the potential to develop long-acting treatment of anti-drug antibodies as well as autoimmune diseases that currently can not be cured. In addition, Idogen has the potential to change the transplantation market by reducing the need for immunosuppressive therapy after transplantation. Idogen was founded in 2008 based on a fundamental immunological discovery at Lund University.http://news.cision.com/idogen