*  A Notch positive feedback in the intestinal stem cell niche is essential for stem cell self‐renewal | Molecular Systems Biology
A Notch positive feedback in the intestinal stem cell niche is essential for stem cell self‐renewal. View ORCID ProfileKai‐Yuan ... The stem cell niche provides a spatial environment that regulates stem cell self‐renewal and differentiation (Lander et al, ... Simulated stochastic cellular events (anoikis, cells leaving stem cell zone, and cell division) with increasing cell ... Functional repair of CFTR by CRISPR/Cas9 in intestinal stem cell organoids of cystic fibrosis patients. Cell Stem Cell 13: 653- ...
  http://msb.embopress.org/content/13/4/927
*  The Difficulty of Targeting Cancer Stem Cell Niches | Clinical Cancer Research
Differentiation-defective stem cells outcompete normal stem cells for niche occupancy in the Drosophila ovary. Cell Stem Cell ... The basic concept of a stem cell niche. Niches are special microenvironments that maintain, or even endow cells with, stem cell ... Donor cell leukemia: insight into cancer stem cells and the stem cell niche. Blood 2007;109:2688-92. ... Stem cell function, self-renewal, and behavioral heterogeneity of cells from the adult muscle satellite cell niche. Cell 2005; ...
  http://clincancerres.aacrjournals.org/content/16/12/3121.long
*  Tumor Microenvironment Network (TMEN) - 1. Regulation and Function of the Vascular Niche in Glioma Pathogenisis
... might negatively affect the tumor stem cell compartment but provoke more EMT and stem-cell-like features in the non-stem cell ... The vascular stem cell niche is a microanatomical unit consisting of distinct cell types and matrices that regulate ... Hypothesis 1: We hypothesize that innate immune cells, recruited to the vascular niche by the tumor, support tumor stem cell ... innate immune cells in the vascular niche are critical cell constituents that regulate angiogenesis and tumor stem cell ...
  https://tmenbrain.ucsf.edu/tmen-research/projects/1-regulation-and-function-of-the-vascular-niche-in-glioma-pathogenisis
*  A Notch positive feedback in the intestinal stem cell niche is essential for stem cell self-renewal. | Sigma-Aldrich
A Notch positive feedback in the intestinal stem cell niche is essential for stem cell self-renewal.. [Kai-Yuan Chen, Tara ... fueled by fast-cycling stem cells. The number and identity of these dividing and migrating stem cells are maintained by a ... Inactivation of the positive feedback by CRISPR/Cas9 mutation of the binding sequence alters the mosaic stem cell niche pattern ... How the underlying regulatory scheme manages this dynamic stem cell niche is not entirely clear. We stimulated intestinal ...
  https://www.sigmaaldrich.com/catalog/papers/28455349
*  JCI - The stem cell niches in bone
Asymmetric division means that stem cells divide into 2 daughter cells; one daughter cell remains in the niche as a stem cell ... The HSC niche and associated stromal cells in bone marrow. A stem cell niche is a specific site in adult tissues where stem ... The stem cell niche is composed of a specialized population of cells that plays an essential role in regulating adult stem cell ... SLAM family receptors distinguish hematopoietic stem and progenitor cells and reveal endothelial niches for stem cells. Cell. ...
  https://www.jci.org/articles/view/JCI28568
*  Stem cell niches and mobiles: where biology and art meet - AR Magazine
Stem cell niches are made of different 'building blocks'. Note for example the blue cells in the stem cell niche of Figure 1 D ... Stem cell niches and mobiles: where biology and art meet. Intestinal stem cell niches of Drosophila (picture by Luis Pedro ... I often use this example to explain one important property of stem cell niches: their dynamism. Stem cell niches transit ... I, on the contrary, study the other kind of stem cells: adult stem cells. In adulthood, our bodies rely on stem cell function ...
  http://magazine.ar.fchampalimaud.org/stem-cell-niches-and-mobiles-where-biology-and-art-meet/
*  Understanding the extracellular matrix in acute myeloid leukemia | Haematologica
The cancer stem cell niche: how essential is the niche in regulating stemness of tumor cells? Cell Stem Cell. 2015;16(3):225- ... Normal and leukemic stem cell niches: insights and therapeutic opportunities. Cell Stem Cell. 2015;16(3):254-267. ... Stem cells and the niche: a dynamic duo. Cell Stem Cell. 2010;6(2):103-115. ... Extracellular Matrix Regulation of Stem Cell Behavior. Curr Stem Cell Rep. 2016;2:197-206. ...
  http://www.haematologica.org/content/102/11/1807
*  Abstract 256: Dysfunctional Cardiac Stem Cell Niches Condition the Aging of the Heart | Circulation Research
Although a niche can include a single stem cell, clusters composed of three or more cardiac stem cells (CSCs) and early lineage ... Abstract 256: Dysfunctional Cardiac Stem Cell Niches Condition the Aging of the Heart. Fumihiro Sanada, Hanqiao Zheng, Donato ... Abstract 256: Dysfunctional Cardiac Stem Cell Niches Condition the Aging of the Heart ... Abstract 256: Dysfunctional Cardiac Stem Cell Niches Condition the Aging of the Heart ...
  http://circres.ahajournals.org/content/111/Suppl_1/A256
*  Osteoclast Function Is Essential in the Hematopoietic Stem Cell Niche - The Arthritis Research UK Centre for Osteoarthritis...
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  https://oacentre.kennedy.ox.ac.uk/publications/223682
*  Untitled Document
The underlying technique our lab is built upon is a hematopoetic/mesenchymal stem cell coculture. In this system we are able to ... and investigate the effects of such manipulations on the niche using fluorescence imaging, flow cytometry, in situ ... Using shRNAi we have individually knocked down thousands of genes in leukemic and healthy hematapoetic cells. By means of this ... acurately recreate the bone marrow niche in-vitro, manipulate the microenvironment, ...
  http://mukherjeelab.com/Techniques.html
*  Osteoclasts promote the formation of hematopoietic stem cell niches in the bone marrow.
... ... and OCLs in the development of the hematopoietic stem cell (HSC) niche. They found that the absence of OCL activity resulted in ... Restoration of OCL activity reversed the defect in HSC niche formation. These data demonstrate that OBLs are required for ... a defective HSC niche, an increased proportion of mesenchymal progenitors, reduced osteoblastic differentiation and impaired ...
  http://www.asbmr.org/publications/field/archive.aspx?cid=8c388fc9-804d-4da2-bcda-ce5d92aa173f
*  Stem cell niche
... An article collection in Stem Cell Research & Therapy.. This collection of articles has not been sponsored and ... Finding a niche: studies from the Drosophila ovary Specialized microenvironments called niches help maintain stem cells in an ... Mobilization of hematopoietic stem cells from the bone marrow niche to the blood compartment The vast majority of hematopoietic ... Dormancy in the stem cell niche Tissues characterized by constant turnover contain post-mitotic, terminally differentiated ...
  https://www.biomedcentral.com/collections/stemcellniche
*  Injury-induced stem-cell niches - Wikipedia
... where transplanted neural stem cells persisted undifferentiated in perivascular areas, also called atypical stem cell niches, ... Injury-induced stem-cell niche are defined as cellular microenvironments that are generated during tissue injury, these ... "Remodelling the injured CNS through the establishment of atypical ectopic perivascular neural stem cell niches". Archives ... "Directed migration of neural stem cells to sites of CNS injury by the stromal cell-derived factor 1α/CXC chemokine receptor 4 ...
  https://en.wikipedia.org/wiki/Injury_induced_stem_cell_niches
*  Biomaterials as Stem Cell Niche | SpringerLink
This book provides the state-of-the-art developments in using biomaterials as artificial niches for engineering ste ... Recent developments in stem cell biology have opened new directions in cell therapy. ... Biomaterial Applications in the Adult Skeletal Muscle Satellite Cell Niche: Deliberate Control of Muscle Stem Cells and Muscle ... Biomaterials Cell Differentiation Cell Signaling Regenerative Medicine Scaffolds Stem Cells Tissue Engineering ...
  https://link.springer.com/book/10.1007%2F978-3-642-13893-5
*  A molecular profile of a hematopoietic stem cell niche | PNAS
The mechanisms that regulate cell fate choices in all stem cell systems have cell-autonomous (stem cell intrinsic) and non-cell ... To generate a sufficient number of stem cells for life-long blood cell production, the hematopoietic stem cell population ... Correlating gene expression and stem cell support. The ability of stromal cell lines to support enriched stem cell populations ... We suggest that the AFT024 cell line represents a component of an in vivo stem cell niche. To determine the molecular signals ...
  http://www.pnas.org/content/99/20/13061.full
*  Paracrine Molecules of Mesenchymal Stem Cells for Hematopoietic Stem Cell Niche
Tian Li and Yaojiong Wu, "Paracrine Molecules of Mesenchymal Stem Cells for Hematopoietic Stem Cell Niche," Bone Marrow ... Paracrine Molecules of Mesenchymal Stem Cells for Hematopoietic Stem Cell Niche. Tian Li and Yaojiong Wu ...
  https://www.hindawi.com/journals/bmr/2011/353878/cta/
*  Scientists wage fight against aging bone marrow stem cell niche | EurekAlert! Science News
In a study published March 2, scientists in Germany and the United States propose rejuvenating the bone marrow niche where HSCs ... Now researchers are reporting in the scientific journal EMBO that the bone marrow niche where HSC's form also ages, ... As people get older so do the hematopoietic stem cells (HSCs) that form their blood, creating an increased risk for compromised ... Scientists wage fight against aging bone marrow stem cell niche Study suggests restoring body's blood factory to boost immunity ...
  https://www.eurekalert.org/pub_releases/2017-03/cchm-swf030117.php
*  Cancer Stem Cell Niche: The Place to Be | Cancer Research
... they have been termed cancer stem cells (CSC). Normal stem cells reside in a "stem cell niche" that maintains them in a stem- ... Cancer Stem Cell Niche: The Place to Be. Tijana Borovski, Felipe De Sousa E Melo, Louis Vermeulen and Jan Paul Medema ... Because of the features that these cells share with somatic stem cells, ... Recent data suggest that CSCs also rely on a similar niche, dubbed the "CSC niche," which controls their self-renewal and ...
  http://cancerres.aacrjournals.org/content/early/2011/01/21/0008-5472.CAN-10-3220
*  Tissue-Specific Stem Cell Niche | Springer for Research & Development
This timely volume explores tissue-derived stem cells, summarizing and evaluating the current body of knowledge. Sixteen ... Tissue-Specific Stem Cell Niche is an ideal complementary volume to Biology of Stem Cell Niche and Adult Stem Cells, Second ... Skeletal Stem Cell Niche of the Bone Marrow Agnieszka A. Janeczek, Edoardo Scarpa, Tracey A. Newman, Richard O. C. Oreffo, ... Erratum to Chapter 10, 'Tendon Stem Cell Niche' Raquel Costa-Almeida, A. I. Gonçalves, P. Gershovich, M. T. Rodrigues, R. L. ...
  https://rd.springer.com/book/10.1007/978-3-319-21705-5
*  Regulation of the Intestinal Stem Cell Niche in Aging
Species about Regulation of the Intestinal Stem Cell Niche in Aging ... Cell Stem Cell 14:292-305. 2014. ..Here we will explore the emerging effects of diet on nutrient-sensing pathways active in ... You are here: Research Grants , K99 , AG , regulation , of , Regulation of the Intestinal Stem Cell Niche in Aging ... Ultimately, an improved understanding of the colon stem cell niche may enable development of novel targeted treatments for ...
  http://labome.org/grant/k99/ag/regulation/of/regulation-of-the-intestinal-stem-cell-niche-in-aging-8560030.html
*  Efficient Transplantation via Antibody-Based Clearance of Hematopoietic Stem Cell Niches | Science
Efficient Transplantation via Antibody-Based Clearance of Hematopoietic Stem Cell Niches Message Subject. (Your Name) has ... Efficient Transplantation via Antibody-Based Clearance of Hematopoietic Stem Cell Niches. By Agnieszka Czechowicz, Daniel Kraft ... Efficient Transplantation via Antibody-Based Clearance of Hematopoietic Stem Cell Niches. By Agnieszka Czechowicz, Daniel Kraft ... Upon intravenous transplantation, hematopoietic stem cells (HSCs) can home to specialized niches, yet most HSCs fail to engraft ...
  http://science.sciencemag.org/content/318/5854/1296
*  Do Increased Doses to Stem-Cell Niches during Radiation Therapy Improve Glioblastoma Survival?
... and clinical studies in all areas of stem cell biology and applications. The journal will consider basic, translational, and ... Stem Cells International is a peer-reviewed, Open Access journal that publishes original research articles, review articles, ... Higher doses to the DG, the second stem-cell niche, did not influence the survival. Targeting the potential cancer stem cells ... However, recent data suggest that tumor cancer stem cells (CSCs) in the stem-cell niches, with self-renewing capacities, might ...
  https://www.hindawi.com/journals/sci/2016/8793462/abs/
*  High-throughput methods to define complex stem cell niches
Keywords: stem cell ; microenvironment ; artificial niche ; microfabrication ; high-throughput ; single-cell analysis ... efficiently mimic the in vivo stem cell microenvironment-or niche-and thus would allow reproducible propagation of stem cells ... These approaches can be readily used to dissect the complex molecular interplay of stem cells and their niche and study single- ... High-throughput methods to define complex stem cell niches. Kobel, Stefan; Lutolf, Matthias ...
  https://infoscience.epfl.ch/record/148369
*  Stem-cell niche - Wikipedia
... called the cancer stem cell niche. The CSC niche is very similar to normal stem cells niche (Embryonic Stem Cell (ESC), Adult ... The GSC niche consists of necessary somatic cells-terminal filament cells, cap cells, escort cells, and other stem cells which ... Several factors are important to regulate stem-cell characteristics within the niche: cell-cell interactions between stem cells ... These ECM factors are equally important when stem cells are grown in vitro. Given a choice between niche cell-stem cell ...
  https://en.wikipedia.org/wiki/Stem-cell_niche
*  A Lesson Plan Developed by - PDF
5.2.1 Recall the cell as the smallest unit of life and identify its major structures (including cell membrane, cytoplasm, ... 42 Ecological Niche: the function a species serves in its ecosystem, including where it lives, what it eats, what eats it, and ... a. Do they both have leaves, stems and roots? b. Do they both have chlorophyll? c. Do they both need light? Why? d. What ... c. When an organism dies and is not eaten by a scavenger, decomposers, such as bacteria or fungi, will cause the cells to break ...
  http://docplayer.net/26089099-A-lesson-plan-developed-by.html