*  Germline STAT 1 Mutation - Wikipedia
The mutations in these patients caused a complete lack of STAT-1 and resulted in a lack of formation of both GAF and ISGF3. ... Impaired response to interferon-alpha/beta and lethal viral disease in human STAT1 deficiency. Nat Genet. 2003;33(3):388-391.. ... More recently, two patients have been identified with homozygous STAT-1 mutations who developed both post-BCG vaccination ... Impairment of mycobacterial but not viral immunity by a germline human STAT1 mutation. Science. 2001;293(5528):300-303. Dupuis ...
  https://en.wikipedia.org/wiki/Germline_STAT_1_Mutation
*  STAT1 - Wikipedia
STAT1) is a transcription factor which in humans is encoded by the STAT1 gene. It is a member of the STAT protein family. All ... STAT1 loss of function, therefore STAT1 deficiency can have many variants. There are two main genetic impairments that can ... Horvath CM, Stark GR, Kerr IM, Darnell JE (December 1996). "Interactions between STAT and non-STAT proteins in the interferon- ... There are two possible trancripts (due to alternative splicing) that encode 2 isoforms of STAT1 STAT1 is involved in ...
  https://en.wikipedia.org/wiki/STAT1
*  Anti-STAT1 antibody [SM1] (ab3987) | Abcam
Mouse monoclonal STAT1 antibody [SM1] validated for WB, IP, IHC, Flow Cyt and tested in Human and Mouse. Referenced in 5 ... Note=STAT1 deficiency results in impaired immune response leading to severe mycobacterial and viral diseases. In the case of ... Defects in STAT1 are a cause of mendelian susceptibility to mycobacterial disease (MSMD) [MIM:209950]; also known as familial ... In response to type II IFN (IFN-gamma), STAT1 is tyrosine- and serine-phosphorylated. It then forms a homodimer termed IFN- ...
  http://www.abcam.com/stat1-antibody-sm1-ab3987.html
*  Anti-STAT1 alpha antibody [EPYR2154]| KO Validated
Rabbit recombinant monoclonal STAT1 alpha antibody [EPYR2154] validated for WB, IP, Flow Cyt and tested in Human and Mouse. ... ab92506 was shown to specifically react with STAT1 alpha when STAT1 alpha knockout samples were used. Wild-type and STAT1 alpha ... Anti-STAT1 alpha antibody [EPYR2154] (Alexa Fluor® 488) (ab193889) *Anti-STAT1 alpha antibody [EPYR2154] (Alexa Fluor® 647) ( ... Phospho STAT1 protein is revealed by ab109461, anti-STAT1 (phospho S727) antibody. ab92506 is used as pan control which detects ...
  http://www.abcam.com/stat1-alpha-antibody-epyr2154-ab92506.html
*  STAT1 - Antibodies - The Human Protein Atlas
STAT1-002 - ENSP00000376137 [100%] STAT1-003 - ENSP00000376136 [100%] STAT1-011 - ENSP00000386244 [100%] STAT1-001 - ... STAT1-011 - ENSP00000386244 [100%] ANTIGEN VIEWi. The protein browser displays the antigen location on the target protein(s) ... HMC-1. HSkMC. HTCEpi. HTEC/SVTERT24-B. HTERT-HME1. HUVEC TERT2. K-562. Karpas-707. LHCN-M2. MCF7. MOLT-4. NB-4. NTERA-2. PC-3. ... HMC-1. HSkMC. HTCEpi. HTEC/SVTERT24-B. HTERT-HME1. HUVEC TERT2. K-562. Karpas-707. LHCN-M2. MCF7. MOLT-4. NB-4. NTERA-2. PC-3. ...
  http://www.proteinatlas.org/ENSG00000115415-STAT1/antibody
*  Reactome | p-Y701-STAT1 [cytosol]
p-Y701-STAT1 [cytosol] (Homo sapiens) * p-Y701-STAT1:p-Y705-STAT3 [cytosol] (Homo sapiens) * p-Y701-STAT1 [cytosol] (Homo ... FGFR1OP-FGFR1 phosphorylates STAT1 and STAT3 (Homo sapiens) * pY-STAT1,3 [cytosol] (Homo sapiens) * p-Y701-STAT1 [cytosol] ( ... p-Y701-STAT1 dimer,p-Y705-STAT3 dimer,p-Y701-STAT1:p-Y705-STAT3 [cytosol] (Homo sapiens) * p-Y701-STAT1 dimer [cytosol] (Homo ... STAT1 and STAT3 dimers translocate to the nucleus (Homo sapiens) * p-Y701-STAT1 dimer,p-Y705-STAT3 dimer,p-Y701-STAT1:p-Y705- ...
  https://reactome.org/content/detail/R-HSA-3132766
*  STAT1 Antibody (4H9) (NBP1-48011): Novus Biologicals
Mouse Monoclonal Anti-STAT1 Antibody (4H9). Validated: WB, ICC/IF, IHC, IHC-P. Tested Reactivity: Human, Canine, Primate. 100% ... Blogs on STAT1. Check out the latest blog posts on STAT1.. Using a STAT3 antibody in chromatin immunoprecipitation (ChIP). ... STAT1 Antibody (4H9) Summary. Immunogen. Protein expressed in 293T cell transfected with human STAT1 expression vector (NP_ ... Western Blot: STAT1 Antibody (4H9) [NBP1-48011] Analysis of extracts (35ug) from 9 different cell lines by usin g anti-STAT1 ...
  https://www.novusbio.com/products/stat1-antibody-4h9_nbp1-48011
*  Modulation of STAT1-Driven Transcriptional Activity by Histone Deacetylases | SpringerLink
Stark GR, Darnell JE Jr (2012) The JAK-STAT pathway at twenty. Immunity 36:503-514CrossRefPubMedPubMedCentralGoogle Scholar ... STAT1 HDAC HDAC inhibitors Interferons Luciferase gene reporter Springer Nature is developing a new tool to find and evaluate ... Horvai AE, Xu L, Korzus E, Brard G, Kalafus D, Mullen TM et al (1997) Nuclear integration of JAK/STAT and Ras/AP-1 signaling by ... Jove R (2000) Preface: STAT signaling. Oncogene 19:2466-2467CrossRefPubMedGoogle Scholar ...
  https://link.springer.com/protocol/10.1007%2F978-1-4939-6527-4_20
*  STAT 211 : Stat 1 - Rutgers - Page 1 - Course Hero
Stat 1 at Rutgers. Find STAT211 study guides, notes, and practice tests from Rutgers. ... Here is the best resource for homework help with STAT 211 : ... STAT 211 Stat 1 * School:. Rutgers - The State University of ... The folder 'STAT 3503 A3 new questions ' have 3 new questions. The STAT 3503 is about Regression Analysis. The deadline is next ... STAT 211 - Spring 2011 * A One-Way Analysis of Variance is a way to test the equality of three or more means at one time by ...
  https://www.coursehero.com/sitemap/schools/22-Rutgers/courses/711461-STAT211/
*  STAT1 polyclonal antibody - (PAB24881) - Products - Abnova
A synthetic peptide corresponding to STAT1. (PAB24881) - Products - Abnova ... Rabbit polyclonal antibody raised against synthetic peptide of STAT1. ... The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT ... Western blot analysis of HeLa cell lysate with STAT1 polyclonal antibody (Cat # PAB24881). ...
  http://www.abnova.com/products/products_detail.asp?catalog_id=PAB24881
*  JCI - Isocitrate dehydrogenase mutations suppress STAT1 and CD8+ T cell accumulation in gliomas
STAT1, and phosphorylated STAT1 (p-STAT1) by Western blotting (ref. 27 and Figure 5, A and B). Surprisingly, in addition to ... Decreased STAT1 positive cells in IDH-MUT compared with IDH-WT LGG tumor sections. (A) Representative images showing STAT1 ... GL261WT cells transfected with STAT1 shRNA demonstrated decreased Stat1, Cxcl9, and Cxcl10 levels by RT-PCR (Figure 6C) and ... E) ImageJ quantification of Western blot band densities of STAT1, p-STAT1, and IRF1, normalized to β-actin levels for NHA and ...
  https://www.jci.org/articles/view/90644
*  JCI - Glucocorticoid receptor dimers control intestinal STAT1 and TNF-induced inflammation in mice
... it is conceivable that GR dimers block ISGs at the level of STAT1. Activated STAT1/STAT1 homodimers or STAT1/STAT2 heterodimers ... STAT1 is a master regulator of TNF sensitivity. (A) RNA was isolated from IECs of STAT1+/+ (black bars) and STAT1-/- mice ( ... E) Relative STAT1 and p-STAT1 signal intensities were quantified and normalized to ACTIN and STAT1 levels respectively. P ... STAT1 and its responsive genes are master regulators of sensitivity to TNF. STAT1-deficient (STAT1-/-) mice exhibit strong IFN- ...
  https://www.jci.org/articles/view/96636
*  PARP9 and PARP14 cross-regulate macrophage activation via STAT1 ADP-ribosylation
PARP14 induces ADP-ribosylation of STAT1, which is suppressed by PARP9. Mutations at these ADP-ribosylation sites lead to ... PARP14 silencing induces pro-inflammatory genes and STAT1 phosphorylation in M(IFNγ) cells, whereas it suppresses anti- ... "PARP9 and PARP14 cross-regulate macrophage activation via STAT1 ADP-ribosylation." Nature Communications 7 (1): 12849. doi: ... PARP9 silencing suppresses pro-inflammatory genes and STAT1 phosphorylation in M(IFNγ) cells. ...
  https://dash.harvard.edu/handle/1/29626127
*  Ubiquitin-Specific Protease 13 Regulates IFN Signaling by Stabilizing STAT1 | The Journal of Immunology
USP13 may regulate STAT1 protein because the protein level and stability of STAT1 were increased with USP13 overexpression. ... Ubiquitin-Specific Protease 13 Regulates IFN Signaling by Stabilizing STAT1. Hom-Ming Yeh, Chia-Yi Yu, Ho-Chun Yang, Shih-Han ... Ubiquitin-Specific Protease 13 Regulates IFN Signaling by Stabilizing STAT1. Hom-Ming Yeh, Chia-Yi Yu, Ho-Chun Yang, Shih-Han ... Ubiquitin-Specific Protease 13 Regulates IFN Signaling by Stabilizing STAT1. Hom-Ming Yeh, Chia-Yi Yu, Ho-Chun Yang, Shih-Han ...
  http://www.jimmunol.org/content/early/2013/08/10/jimmunol.1300225
*  STAT1, IGF1, RAC1, and MDM2 Are Associated with Recurrence of Giant Cell Tumor of Bone
... Shuxin Chen,1 Zepeng Du,2 Bingli Wu,3 ... Shuxin Chen, Zepeng Du, Bingli Wu, et al., "STAT1, IGF1, RAC1, and MDM2 Are Associated with Recurrence of Giant Cell Tumor of ... 1Department of Orthopedic Surgery, Shantou Central Hospital, Affiliated Shantou Hospital of Sun Yat-sen University, Shantou ... 1 Xueli Qiu,1 Yufeng Zhang,1 Liyan Xu,4 Enmin Li,3 and Zhigang Zhong1 ...
  https://www.hindawi.com/journals/jir/2018/4564328/cta/
*  STAT-1 facilitates the ATM activated checkpoint pathway following DNA damage | Journal of Cell Science
STAT-1 facilitates the ATM activated checkpoint pathway following DNA damage. Paul A. Townsend, Mark S. Cragg, Sean M. Davidson ... STAT-1 facilitates the ATM activated checkpoint pathway following DNA damage. Paul A. Townsend, Mark S. Cragg, Sean M. Davidson ... STAT-1 facilitates the ATM activated checkpoint pathway following DNA damage. Paul A. Townsend, Mark S. Cragg, Sean M. Davidson ... STAT-1 facilitates the ATM activated checkpoint pathway following DNA damage Message Subject (Your Name) has sent you a message ...
  http://jcs.biologists.org/content/128/5/1064.article-info
*  Protein inhibitor of activated STAT-1 | definition of protein inhibitor of activated STAT-1 by Medical dictionary
What is protein inhibitor of activated STAT-1? Meaning of protein inhibitor of activated STAT-1 medical term. What does protein ... Looking for online definition of protein inhibitor of activated STAT-1 in the Medical Dictionary? protein inhibitor of ... redirected from protein inhibitor of activated STAT-1) PIAS1. A gene on 15q that encodes a member of the mammalian PIAS ( ... including the STAT pathway, the p53 pathway and the steroid hormone signalling pathway; it acts in the testis as a nuclear ...
  http://medical-dictionary.thefreedictionary.com/protein+inhibitor+of+activated+STAT-1
*  IL-27 Induces Th17 Differentiation in the Absence of STAT1 Signaling | The Journal of Immunology
IL-27 Induces Th17 Differentiation in the Absence of STAT1 Signaling. Anneli Peters, Kevin D. Fowler, Fanny Chalmin, Doron ... IL-27 Induces Th17 Differentiation in the Absence of STAT1 Signaling. Anneli Peters, Kevin D. Fowler, Fanny Chalmin, Doron ... IL-27 Induces Th17 Differentiation in the Absence of STAT1 Signaling Message Subject (Your Name) has forwarded a page to you ... Our results suggest that the ratio of p-STAT3/p-STAT1 induced by a cytokine or cytokine pairs can be used to predict whether ...
  http://www.jimmunol.org/content/early/2015/09/25/jimmunol.1302246
*  IJMS | Free Full-Text | Interferon-alpha Induces High Expression of APOBEC3G and STAT-1 in Vitro and in Vivo | HTML
The expression levels of STAT-1 and APOBEC3G in the liver of CHB patients with a complete response to IFN-a are significantly ... Moreover, interferon resistance may be related to the down-regulation of STAT-1 expression in the patients who had non-response ... In addition, the differences in STAT-1 and APOBEC3G expression in liver tissues were also observed in patients with different ... Moreover, a corresponding gradual increase in STAT-1 expression levels was also observed. ...
  http://www.mdpi.com/1422-0067/11/9/3501/htm
*  Enhancement of antiproliferative activity of gamma interferon by the specific inhibition of tyrosine dephosphorylation of Stat1...
... in the Stat1 N-terminal domain inhibited Stat1 tyrosine dephosphorylation. The deletion of the Stat1 N-terminal domain resulted ... We report that the N-terminal domain of Stat1, which is highly conserved among all STAT family members, is required for its ... We suggest that the N-terminal domains of STATs are crucial for modulating STAT activities through regulating the tyrosine ... Enhancement of antiproliferative activity of gamma interferon by the specific inhibition of tyrosine dephosphorylation of Stat1 ...
  https://www.ncbi.nlm.nih.gov/pubmed/8756652
*  Dendritic Cells Require STAT-1 Phosphorylated at Its Transactivating Domain for the Induction of Peptide-Specific CTL | The...
... complex also phosphorylates a second STAT, STAT-2, which forms heterodimers with STAT-1 (7). STAT dimers shift their ... Wild-type (wt) C57BL/6N, B6.129P2-Stat1tm1 (STAT-1-ko) (4), B6.129P2-Stat1tm1(S727A) (13), B6.129P2-IFNAR1tm1 (IFNAR1-ko) (39 ... Targeted disruption of the Stat1 gene in mice reveals unexpected physiologic specificity in the JAK-STAT signaling pathway. ... This IFN-I activity is mediated by STAT-4 and may, like IFN-γ production in CD4+ T cells, be negatively regulated by STAT-1. In ...
  http://www.jimmunol.org/content/183/4/2286.long
*  Plus it
STAT1 KO mice show enhanced OD plasticity through an accelerated increase in open-eye responses. To determine the role of STAT1 ... To determine whether STAT1 is regulated by visual experience, we examined STAT1 expression after MD. During the peak of the ... Increased expression of STAT1 after 4 d MD suggests a permissive or regulatory role for STAT1 in OD plasticity. ... We measured developmental changes in the expression of STAT1 protein extracted from V1. The levels of STAT1 increased after eye ...
  http://www.jneurosci.org/content/34/31/10256
*  Macrophages contribute to pathogenesis of visceral leishmaniasis via a STAT1-dependent mechanism (131.10) | The Journal of...
This phenotype was strikingly similar to that seen in infected STAT1-/- mice. Further in vivo studies using an airpouch model ... Macrophages contribute to pathogenesis of visceral leishmaniasis via a STAT1-dependent mechanism (131.10). Heidi M Snider, ... We also found that STAT1 in non-T cells (i.e. macrophages and neutrophils) mediated susceptibility and pathology. The objective ... Taken together, these results demonstrate that macrophages are involved in the pathogenesis of VL, and that STAT1 signaling may ...
  http://www.jimmunol.org/content/182/1_Supplement/131.10
*  Autosomal-Dominant Chronic Mucocutaneous Candidiasis with STAT1-Mutation can be Complicated with Chronic Active Hepatitis and...
STAT) 1 gene mutation, and some of the important complica ... AD-CMC STAT1 hypothyroidism chronic active hepatitis anti-IL-17 ... STAT1 mutations in autosomal dominant chronic mucocutaneous candidiasis. N Engl J Med. 2011;365:54-61.PubMedCrossRefGoogle ... IFNgamma signaling-does it mean JAK-STAT? Cytokine Growth Factor Rev. 2008;19:383-94.PubMedCrossRefGoogle Scholar ... Impairment of mycobacterial but not viral immunity by a germline human STAT1 mutation. Science. 2001;293:300-3.PubMedCrossRef ...
  https://link.springer.com/article/10.1007%2Fs10875-012-9744-6
*  STAT1 as a key modulator of cell death. - Semantic Scholar
Among the members of the STAT family, accumulating evidence now indicates an important role for STAT1 in various forms of cell ... or HDAC have been implicated in the regulation of cell death by STAT1. Furthermore, STAT1 itself is also subject to complex ... which can critically affect STAT1 signaling and STAT1-dependent cell death. Given the reports showing that dysregulation of ... STAT1-dependent regulation of cell death is largely dependent on a transcriptional mechanism such as the activation of death- ...
  https://www.semanticscholar.org/paper/STAT1-as-a-key-modulator-of-cell-death.-Kim-Lee/397c4bb250eb69b97ac623a9932b5539bf766bc7