*  Recombinant Anti-T. brucei RNA-editing complex protein MP81 VHH Single Domain Antibody (Nb10) - Creative Biolabs
... brucei RNA-editing complex protein MP81 VHH Single Domain Antibody (Nb10) is available from creative biolabs. ... Entrez Gene ID. 3655547. UniProt ID. Q586L9. For lab research use only, not for diagnostic, therapeutic or any in vivo human ... Specificity. Tested positive against native T. brucei RNA-editing complex protein MP81. ... Anti-RNA-editing complex protein MP81 antibody is a Single domain antibody that binds to an RNA-editing complex protein MP81. ...
  https://www.creativebiolabs.net/Recombinent-Anti-RNA-editing-complex-protein-MP81-VHH-Single-Domain-Antibody-58856.htm
*  Antibodies | Free Full-Text | Selection and Characterization of Single Domain Antibodies Specific for Bacillus anthracis Spore...
... anthracis proteins could be integrated into emerging biosensors to improve specificity in multiplex assays. ... Peripheral blood lymphocytes were used to construct a phage display library from which single domain antibodies (sdAbs) ... Single domain antibodies: Promising experimental and therapeutic tools in infection and immunity. Med. Microbiol. Immunol. 2009 ... Qi, Y.; Patra, G.; Liang, X.; Williams, L.E.; Rose, S.; Redkar, R.J.; DelVecchio, V.G. Utilization of the rpob gene as a ...
  http://www.mdpi.com/2073-4468/2/1/152/htm
*  Discovery Biology News
... or as a new bi-specific antibody therapeutic.. Camelid single domain antibodies are a novel bi-specific antibody platform that ... Single domain antibodies have the advantage of expedited optimization, flexibility of incorporating multiple specificity and ... With our one-stop services, we are determined to be your best partner in antibody drug discovery from gene synthesis to in-vivo ... GenScript has over 5 years' experience in developing novel single domain antibodies as therapeutic agents or tool reagents for ...
  https://www.genscript.com/DiscoveryBiology_news.html
*  IJMS | Free Full-Text | Antibody Phage Display Libraries: Contributions to Oncology | HTML
Examples of such antibodies will be discussed here with emphasis on those used as probes for molecular imaging and other ... Phage display represents a high-throughput technique for screening billions of random fusion antibodies against virtually any ... Robust techniques combining an antibody library displayed on the phage surface and protein microarray allowed the ... antibody libraries displayed on filamentous phage surfaces have been used to identify specific binders for many different ...
  http://www.mdpi.com/1422-0067/13/5/5420/htm
*  Applications filed at Jan 25 2018 | SPECIFIC ANTI-CD38 ANTIBODIES FOR TREATING HUMAN CANCERS | Patents.com
TREATMENT OF AUTOIMMUNE DISORDERS WITH CD154 ANTIBODIES , Chemokine receptor binding polypeptides , USE OF CXCR3 INHIBITORS FOR ... PROTECTING AGAINST FETAL WASTAGE , ANTI-PD-L1 ANTIBODIES AND DIAGNOSTIC USES THEREOF , ... conformational single domain antibodies and their uses in particular in the therapeutic... ... The present invention is directed to antibodies and fragments thereof and humanized versions thereof having binding specificity ...
  http://www.patents.com/ap-20180125-p98.html
*  Acceptor framework for CDR grafting - ESBATech
... rabbit antibodies, using a particularly well suited antibody acceptor framework. ... The present invention relates to an antibody acceptor framework and to methods for grafting non-human antibodies, e.g., ... a Fv fragment consisting of the VL and VH domains of a single arm of an antibody, (vi) a single domain antibody such as a Dab ... Methods of making single chain antibodies are well known in the art, e.g., Ho et al. (1989), Gene, 77:51; Bird et al. (1988), ...
  http://www.freepatentsonline.com/9005924.html
*  Antibodies Directed To Alpha V Beta 6 And Uses Thereof - Patent application
... single domain antibodies, generation of peptide therapeutics, αVβ6 binding domains in novel scaffolds, gene therapies, ... antibodies one with a specificity to αVβ6 and another to a second molecule that are conjugated together, (ii) a single antibody ... The antibody ordinarily will be stored in lyophilized form or in solution. Therapeutic antibody compositions generally are ... antibody, a bi-specific antibody, a catalytic antibody, a chimeric antibody, a humanized antibody, a fully human antibody, an ...
  http://www.patentsencyclopedia.com/app/20130202621
*  Antibodies | Free Full-Text | Single Domain Antibody Fragments as Drug Surrogates Targeting Protein-Protein Interactions...
Developing reagents that can specifically interfere with PPI is an important goal for both therapeutic use and as reagents to ... In this review, we discuss our work on single domains as intracellular antibodies and where this work might in the future. ... Our recent technology development has provided a set of simple protocols that allow development of single antibody variable (V ... Antibody fragments can be used for inhibiting PPI. ... Single-chain antibody-mediated gene delivery into ErbB2- ...
  http://mdpi.com/2073-4468/2/2/306/htm
*  JoVE | Peer Reviewed Scientific Video Journal - Methods and Protocols
Single-domain antibodies (sdAbs) derived from human V(H) are considered to be less soluble and prone to aggregate which makes ... Upon TMD-induced dimerization, ToxR binds to the ctx promoter causing up-regulation of the LacZ gene for β-galactosidase. A ... Selected sequences are then run through a fold specificity stage and a binding affinity stage. A rank-ordered list of the ... of the interaction sites between two proteins as well as screening for peptides that bind the target protein for therapeutic ...
  https://www.jove.com/visualize/abstract/22253912/crystal-structure-human-single-domain-antibody-dimer-formed-through-v
*  Patents filed at Nov 14 2017 | Antibody targeting osteoclast-related protein siglec-15 | Patents.com
Antibodies directed against programmed death-1 (PD-1) , Monoclonal antibody STRO-4 , Methods of reducing basophil levels , Use ... which contains at least three functional single domain modules of an... ... The present invention relates to an antibody having specificity for an immunogenic determinant consisting of the ... Controlled gene expression methods. Methods and compositions for controlling gene expression are disclosed. ...
  http://www.patents.com/isd-20171114-p90.html
*  US5055289A - Interferon antibody therapeutic compositions having an extended serum half-life - Google Patents
A complex of alpha-interferon with a monoclonal antibody complexes with the alpha-interferon without impairing its antiviral ... Anti-IL-1R1 Single Domain Antibodies And Therapeutic Uses US20090214565A1 (en) * 2005-02-10. 2009-08-27. Jacques Banchereau. ... Monoclonal antibodies having the desired specificity are further screened to select those that form an antibody:agent complex ... Gap gene sequences EP0367166A1 (en) * 1988-10-31. 1990-05-09. Takeda Chemical Industries, Ltd.. Modified interleukin-2 and ...
  https://patents.google.com/patent/US5055289?oq=flatulence
*  NICBR Forum - Biostabilization - Abstracts
Ellen Goldman and Scott Walper will present a brief introduction to the intrinsically stabile single-domain antibodies (sdAb) ... Although Xoma does not work on biostabilizers per say, they do develop therapeutic antibody formulations that could benefit ... maintaining target specificity and affinity). Current standards for stability of antibody formulations are - 30 C for >3 to 5 ... The technology consists of a genetic recombinant modification of the enzyme's cloned gene which genetically fuses it with an ...
  https://ncifrederick.cancer.gov/events/Biostabilization/abstracts.asp
*  NanoGetic SL - Science Exchange
... antibodies, nanobodies, drugs and sensors) and single-domain antibody libraries fabrication for diagnostic and therapeutic ... named Heavy-chain antibodies (HcAb). The variable domains (VHH) of these HcAbs can be obtained, through recombinant gene ... in the framework-2 maintaining their properties and specificity. ... CAMELID SINGLE DOMAIN ANTIBODY PLATFORM NanoGetic team is ... antibodies, nanobodies, drugs and sensors) and single-domain antibody libraries fabrication for diagnostic and therapeutic ...
  https://www.scienceexchange.com/labs/nanogetic-sl
*  Frontiers | Intracellular Crosslinking of Filoviral Nucleoproteins with Xintrabodies Restricts Viral Packaging | Immunology
By retuning sdAb specificity, the approach of crosslinking highly conserved regions of assembly critical proteins may well be ... likely benefit from transitioning away from intracellular expression of crosslinking sdAb to exogenous delivery of antibody. ... Previously, we had generated sdAb (single-domain antibodies) against Filoviruses that have all targeted highly conserved C- ... Previously, we had generated sdAb (single-domain antibodies) against Filoviruses that have all targeted highly conserved C- ...
  https://www.frontiersin.org/articles/10.3389/fimmu.2017.01197/full
*  Patent US6451983 - Tumor necrosis factor antibodies - Google Patents
The ligand is preferably an antibody, F(ab) fragment, single domain antibody (dABs) single chain antibody or a serum binding ... It is preferred, however, that the ligand is a monoclonal antibody or F(ab) fragment thereof. ... Specificity of Binding of the Selected V-Gene Pairs:. A specificity ELISA with MAb32 and soluble ScFv fragments on a number of ... Assignment of function to such regions would permit the development of MAbs and other ligands of therapeutic use. Polyclonal ...
  http://www.google.co.uk/patents/US6451983
*  Protein scaffold-based molecular probes for cancer molecular imaging
Single domain immunoglobin is a class of protein scaffold present in the human single domain antibody (sdAb) and camelidae ... Nanobodies have demonstrated high target specificity and affinity (Huang et al. 2008). Moreover, camelidae antibody variable ... The protein scaffold-based probes have great potential in diagnosis of disease, in monitoring therapeutic efficacy of new drugs ... 1997). High affinity nanobodies have also made directly from phage display with VHH gene repertoires without immunizing a ...
  http://pubmedcentralcanada.ca/pmcc/articles/PMC2914822/?lang=en-ca
*  Methods for detecting and treating cancer - The General Hospital Corporation
8(10): 1057-1062, 1995), single domain antibodies, single chain antibodies, and antibodies having multiple valencies (e.g., ... Nanobodies have the affinity and specificity of conventional antibodies although they are only half of the size of a single ... is that nanobodies can bind therapeutic targets not accessible to conventional antibodies. Recombinant antibody fragments with ... Genes from the human antibody gene libraries are inserted into a population of phage. Each phage carries the genes for a ...
  http://www.freepatentsonline.com/9885720.html
*  Patent US5766946 - Monoclonal antibodies to glycoprotein P - Google Patents
The monoclonal antibody has a continuous amino acid sequence, and a binding affinity for the P-glycoprotein which manifests in ... A monoclonal antibody that recognises a structurally continuous and extracellularly-located epitope of human P-glycoprotein is ... Specificity of MM4.17 for the human MDR1 gene product. The mdr specificity of the MM4.17 monoclonal is determined by assaying ... Fv fragments and single domain antibodies, and is not limited to products derived from hybridoma cell lines but also includes ...
  http://www.google.com/patents/US5766946?dq=5,870,513
*  Neurodegenerative Diseases | Leaders in Pharmaceutical Business Intelligence (LPBI) Group
Single domain antibodies have the advantage of expedited optimization, flexibility of incorporating multiple specificity and ... Small Molecules in Development of Therapeutic Drugs, Electrophysiology, Gene Regulation, Genetics & Pharmaceutical, Genome ... Single domain antibodies shown to cross blood brain barrier and offers enhanced delivery of therapeutics to CNS targets ... GenScript is fully engaged in single-domain antibody lead generation and optimization. With our one-stop services, we are ...
  https://pharmaceuticalintelligence.com/category/neurodegenerative-diseases/
*  IJMS | Free Full-Text | Bispecific Antibodies as a Development Platform for New Concepts and Treatment Strategies | HTML
The single-chain-based bispecific antibodies usually bridge tumor cells with immune cells and form an immunological synapse ... antibodies that can simultaneously bind to cell surface antigens and payloads are a very ideal delivery system for therapeutic ... Bispecific antibodies in the IgG format include asymmetric bispecific antibodies and homodimerized bispecific antibodies, all ... Bispecific antibodies can also be used to treat hemophilia A by mimicking the function of factor VIII. Bispecific antibodies ...
  http://www.mdpi.com/1422-0067/18/1/48/htm
*  Chromatography Archives - Page 6 of 10 - BioProcess InternationalBioProcess International | Page 6
Examples include Fab, F(ab')2, single-chain (sc) Fv, bis-scFV, diabodies, minibodies, and single-domain antibodies (1). Their ... The resulting specificity provides substantial reduction in impurities such as host cell proteins (HCPs) and DNA (4,5,6,7,8). ... Purifying a Recalcitrant Therapeutic Recombinant Protein with a Mixed-Mode Chromatography Sorbent. by Andrew Lees Andrew ... Advances in Gene Therapy: MiniTEM™ Represents a Paradigm Shift in the Characterization of Viral Vectors. ...
  http://www.bioprocessintl.com/category/downstream-processing/chromatography/page/6/
*  Affibody molecule - Wikipedia
A monoclonal antibody, for comparison, is 150 kDa, and a single-domain antibody, the smallest type of antigen-binding antibody ... These molecules can be used for molecular recognition in diagnostic and therapeutic applications. As with other antibody ... high affinity and specificity makes Affibody molecules suitable alternative as monoclonal antibodies for both molecular imaging ... Ståhl, S; Nygren, P-A (1997). "The use of gene fusions to protein A and protein G in immunology and biotechnology". Pathol. ...
  https://en.wikipedia.org/wiki/Affibody_molecule
*  Plus it
Selection and identification of single domain antibody fragments from camel heavy-chain antibodies. FEBS Lett 1997;414:521-6. ... PCR fragments were inserted 5′ of the α-MMR cl1 gene or the BCII10 gene in the pHEN6 vector. ... Antibodies can be used for tumor imaging or delivering therapeutic agents to tumor cells. However, limitations of conventional ... 2A). Therefore, the α-MMR Nbs have a high in vivo specificity and can efficiently target organs such as the liver and spleen. ...
  http://cancerres.aacrjournals.org/content/72/16/4165
*  Applications filed at Feb 16 2017 | Antibodies, Uses & Methods | Patents.com
ANTIBODY PREPARATION METHOD, AND ANTIBODY AND ANTIBODY LIBRARY THUS PREPARED , ... HEAVY CHAIN ONLY ANTIBODIES TO PDGF , FC-REGION VARIANTS WITH IMPROVED PROTEIN A-BINDING , ... The present invention provides a single domain antibody (sdAb) scaffold comprising one or more than one non-canonical disulfide ... preferably of at least one gene of therapeutic... ... specificity to PDGF and bispecific antibodies with antigen- ...
  http://www.patents.com/ap-20170216-p54.html
*  Transglutaminase for inhibiting angiogenesis - Patent # 7704943 - PatentGenius
USA 85, 5879) and single domain antibodies (dAbs) comprising isolated V domains (Ward et at (1989) Nature341, 544). A general ... Suitable non-viral approaches to gene therapy aredescribed in Ledley (1995) Human Gene Therapy 6, 1129-1144.. The nucleic acid ... In combining two or more binding sites, which in themselves may be of high specificity but low affinity, it will be possible to ... and the therapeutic effect can be achieved using a significantly lower total amount. For example, it may be desirable to ...
  http://www.patentgenius.com/patent/7704943.html