As a result of this process there is a rise in the production of reactive oxygen species (ROS), which are capable to trigger a ... Other vitamin E compound, γ-tocopherol, is superior to α-tocopherol in the detoxification of reactive nitrogen oxide species ... NOS2 generates NO at a high rate and for prolonged periods, which favours a shift in the cellular redox potential to a more ... This was accompanied by a reduction in levels of nitric oxide, glutathione, free amino groups and total sulfhydryl groups. ...
... and would thereby establish the prototypic redox-based cellular signaling mechanism in biology. Redox activation of NO would ... Paddock, Catherine (2015-04-13). "Study shows blood cells need nitric oxide to deliver oxygen". Medical News Today. Healthline ... Stamler also identified trans-kingdom SNO signaling (operating between species as a general language between microbiota and ... "Exposure of sulphydryl-containing proteins to nitric oxide and endothelium-derived relaxing factor confers novel bioactivity ...
It is believed that the mechanisms are related to the toxic increase in reactive oxygen species (ROS). Oxidative stress is ... Mercuric mercury compounds, such as mercury salts, result from the combination of mercury with chlorine, sulfur, or oxygen. ... activation through oxidative stress and thiol-redox alterations. They investigated the mechanism of the MeHg-induced PLD ... In addition, because of its high affinity for sulfhydryl groups in tubulin, methylmercury inhibits the organization of ...
The journal publishes majorly in the area(s): Oxidative stress & Reactive oxygen species. It has an ISSN identifier of 0891- ... studies have suggested that the ability to generate reactive oxygen species by redox cycling quinones and related compounds may ... deplete glutathione and protein-bound sulfhydryl groups, resulting in the production of reactive oxygen species as superoxide ... Thus, some mechanisms associated with the toxicities of metal ions are very similar to the effects produced by many organic ...
... the ability to form complex compounds, which may be redox active or not .These redox active complexes having free electrons ... Superoxide is one of the main reactive oxygen species (ROS) in the cell and as such, SOD serves a key antioxidant role. The SOD ... The mechanism is at the Selenocystein site, which is in a Se (-) form as resting state. This is oxidized by the peroxide to ... 1.6.4.2) is an enzyme that reduces glutathione disulfide (GSSG) to the sulfhydryl form GSH, which is an important cellular ...
This suggests that detoxification by LMW-SH such as glutathione is not a general mechanism and that other mechanisms are ... Relationship between oxygen sensitivity and oxygen metabolism of Bifidobacterium species. J Dairy Sci. 1992, 75 (12): 3296-3306 ... and sulfhydryl-functional groups present in compounds of the growth medium and bacteria [4]. According to Lüthi-Peng et al. [27 ... However, the wide range of organisms tested an the multiplicity of oxygen detoxification mechanisms as well as the wide ...
The hydrophilic compound pyridine 2,4-dicarboxylate (2,4-PDCA), designed as a mechanism-based competitive inhibitor of prolyl 4 ... The half-maximal concentration of added Fe2+ for enzyme activity depends on the nature of sulphydryl compounds present in the ... and ascorbate is required as a specific alternative oxygen acceptor in such uncoupled reaction cycles. A number of compounds ... Species cross-reactivity of the antibodies was tested using cultured human, mouse and chick fibroblasts and purified prolyl 4- ...
Schimmel M, Bauer G. Proapoptotic and redox state-related signaling of reactive oxygen species generated by transformed ... since it is a precursor of more reactive oxygen species [28]. The mechanism of oxidative damage to the lens through intraocular ... When NBT reacts with superoxide, a dark-blue, insoluble formazan compound is produced [26]. Superoxide is believed to be the ... One of the earliest changes in nuclear cataractogenesis is the loss of protein sulfhydryl groups. It was postulated that the ...
There is a large body of evidence implicating oxidative stress and radical oxygen species in the mechanism of cataractogenesis ... which plays a role in the hydrophobic compounds as a thioltransferase-like redox regulator [46]. ... It contains a side chain sulfhydryl (-SH) residue that enables it to protect cells against oxidants [48]. Therefore, ... Mechanisms involved in the antiplatelet activity of rutin, a glycoside of the flavonol quercetin, in human platelets. J Agric ...
Sulfhydryl-containing compounds including cysteine (Cys), homocysteine (Hcy), glutathione (GSH) and hydrogen sulfide (H2S) are ... Mitochondrial metabolism acts downstream of mTOR to provoke activation of JNK/c-JUN via reactive oxygen species (ROS). At the ... These response mechanisms were systematically characterized by 1H NMR and Mass spectrometry. Finally, sensor FR could be used ... Besides, I-/I3- redox pairs promote selective H2S oxidation while inhibiting water decomposition, resulting in a 56% reduction ...
Methylmercury has a particular affinity for sulfhydryl compounds, which increases its toxicity. Under saturated conditions, ... Invasive Species. An invasive species has been defined as "a species that is nonnative to the ecosystem under consideration and ... and without vigorous oxygen diffusion aided by plant aerenchyma, oxygen is limiting and anaerobic processes dominate (Brady and ... 1997), and interactions with minerals, many of which are redox sensitive and whose availability and oxidation state may change ...
Ozonides, reactive oxygen species generated by OT such as peroxide species, would also easily oxidize reduced sulfhydryl groups ... and perhaps mimic the pro-oxidant mechanism of immune system defense.. Aerobic cells are designed for redox shuttling and ... Lorizate lamented that compounds which could attack viral lipids lack specificity and are "thus unacceptably toxic." OT, in use ... Once the oxygen radical has reacted with these components, all that remain is oxygen (O2) which in the case of blood plasma, ...
The reactive organosulfur compounds form disulfide bonds with free sulfhydryl groups of enzymes and compromise the integrity of ... The reactive organosulphur compounds form disulphide bonds with free sulfhydryl groups of enzymes and compromise the integrity ... The organosulphur compounds of garlic exhibit a range of antibacterial activities such as bactericidal, anti-biofilm, anti- ... The organosulfur compounds of garlic exhibit a range of antibacterial properties such as bactericidal, antibiofilm, antitoxin, ...
... map of the research on some of the antioxidant compounds with potential for use as wound therapies and basic research on redox ... 2) Methods: A literature search was conducted and included any study that evaluated the effects or mechanisms of antioxidants ... The purpose of this review is to identify the compounds with antioxidant properties that have been tested for wound healing and ... Curcumin, NAC, quercetin and chitosan are the antioxidant compounds that shown some initial evidence of efficacy, but more ...
... is the most abundant element after oxygen on the earth crust surface. It plays essential role in crop production by stimulating ... Dietz KJ, Turkan I, Krieger-Liszkay A (2016) Redox-and reactive oxygen species-dependent signaling into and out of the ... Sharma P, Jha AB, Dubey RS, Pessarakli M (2012) Reactive oxygen species, oxidative damage, and antioxidative defense mechanism ... In these, inorganic As compounds are more lethal to plants as compared to the others. Inorganic As species largely occurs in ...
3. Reducing agents: Compounds that possess lower redox potential than the oxidation substrate in the formulation, thereby ... involve coordination of the lone pair of electron on the nitrogen to oxygen to form N-oxide or free-radical autoxidation mecha- ... Oxidation is frequently catalyzed by transition metal contaminants (e.g., Fe2+/Fe3+ and Cu+/Cu2+). The reacting metal species ... In proteins, several electron-rich functional groups are susceptible to oxidation, such as sulfhy-dryl in cysteine, imidazole ...
Wedege K, Dražević E, Konya D, Bentien A. Organic redox species in aqueous flow batteries: redox potentials, chemical stability ... Proposed redox-mediating mechanisms of electron shuttle-major compositions of catechins (e.g., EGCG, GA, GC) in green tea ... In particular, oxygen is a strong electron acceptor; anaerobic conditions are necessary to guarantee the effective redox- ... sulfhydryl (-SH), and methoxy (-OCH3) carboxyl (-COOH) and sulfo (-SO3H)) groups was tested via CV analysis from − 0.8 to 0.6 V ...
... sulfhydryl and is critical in a variety of cellular defense functions including protection from toxic oxygen species and ... 5. Mechanism Of Altered B-Cell Response Induced By Changes In Dietary Protein Type In Mice. Bounous G., Shenouda N., Kongshavn ... Antioxidants & Redox Signaling. Vol. 10, No. 2, 395-402, 2008.. Oxidative stress plays a role in the tumor-cytotoxic effect of ... normal cell GSH levels has also been investigated as a means to reduce the toxicity associated with a wide variety of compounds ...
In addition, reactive oxygen species have an important role in DXR-induced cardiotoxicity. Besides, it plays an important role ... Molecular mechanism of doxorubicin-induced cardiomyopathy An update. European Journal of Pharmacology 2018; 818: 241-253. 2) L ... CoQ10 (ubiquinone in its oxidized form) is reduced by multiple oxidoreductases to maintain a redox cycle. In its reduced form, ... Mitochondrial GSH plays a critical role in cellular life and regulation of conditions caused by sulphydryl groups and resulting ...
Tongul B, Tarhan L: The effect of menadione-induced oxidative stress on the in vivo reactive oxygen species and antioxidant ... Bioactive compounds and antioxidant activity of crude extracts of brushwood vegetable species. Braz J Food Technol. 2011, 14: ... Antioxidant potential and redox properties of B. virgilioides HEE. To verify the antioxidant potential of B. virgilioides, the ... Breakage of the sarcolemma may also occur [62]. The exact mechanisms involved in muscle damage induced by RT are still not ...
Also provided are compounds according to Formulas I-IV, pharmaceutical compositions, unit dosage forms, and food or feed ... Further provided is an extract obtained from the fruit of Myrciaria cauliflora containing at least one compound of the present ... by administering an effective amount of a composition containing such compounds are also provided. ... supplements containing such compounds. Methods for treating a condition in a mammal and for treating or ameliorating a ...
Reactive Oxygen Species 23% * Glutathione 13% * Sulfhydryl Compounds 8% 15 Scopus citations ... Milne, G. L., Musiek, E. S. & Morrow, J. D., Jan 2005, In: Antioxidants and Redox Signaling. 7, 1-2, p. 210-220 11 p.. Research ... Mechanisms linking circadian clocks, sleep, and neurodegeneration. Musiek, E. S. & Holtzman, D. M., Nov 25 2016, In: Science. ...
... and cell redox homeostasis were the considerable enrichments between Cd stress and NaHS treatment under Cd stress. Kyoto ... Gill SS, Tuteja N. Reactive oxygen species and antioxidant machinery in abiotic stress tolerance in crop plants. Plant Physiol ... C. Cell redox homeostasis (GO:0045454) was enriched in C vs. CS. These data indicated that H2S responds to Cd stress mainly ... The mechanism of H2S function on T. thermophila stressed under Cd was evaluated by phenotypic observation, enzyme and ...
Fleming, J., A. Ghose and P. R. Harrison (2001) Molecular mechanisms of cancer prevention by selenium compounds. Nutr. Cancer ... Selenium is classified in a group VIA of the periodic table of elements which includes the nonmetals, sulfur and oxygen, in the ... Brown, T. and A. Shrift (1981) Exclusion of selenium from proteins of selenium-tolerant Astragalus species. Plant Physiol. 67: ... These reductases can also affect the redox regulation of a variety of factors, including ribonucleotide reductase, the ...
The redox imbalance is a major toxicity mechanism of CTX, which is involved in several antioxidant enzymes (e.g. SOD and CAT) ... Organic compounds are molecules that contain carbon bonded to another element such as hydrogen.. Search. Main menu. Skip to ... Tilapia (oreochromis niloticus) is a global cultured and consumed fish species. It is well-studied as potential animal model to ... The reduced antioxidant capacity may cause accumulation of reactive oxygen radicals (ROS), which leads to cells damage in the ...
Ray PD, Huang BW, Tsuji Y. Reactive oxygen species (ROS) homeostasis and redox regulation in cellular signaling. Cell Signal. ... Pro-oxidants are chemical compounds capable of generating potential toxic oxygen species. Although, a normal cell has an ... reduction of reactive oxygen or even nitrogen species by sulfhydryls enhances transcriptional activation, whereas oxidation ... However, such feedback mechanisms could implicate some unidentifiable regions in the brain playing pro-antioxidant roles to ...
Redox chemistry of Tc(VII)/Tc(IV) in dilute to concentrated NaCl and MgCl2 solutions. Yalcintas, E.; Gaona, X.; Scheinost, A. C ... Solution species and crystal structure of Zr(IV) acetate. Hennig, C.; Weiss, S.; Kraus, W.; Kretzschmar, J.; Scheinost, A. ... Adsorption mechanism of selenium(VI) onto maghemite. Jordan, N.; Ritter, A.; Foerstendorf, H.; Scheinost, A. C.; Weiß, S.; Heim ... Peculiar behavior of (U,Am)O2−δ compounds for high americium contents evidenced by XRD, XAS, and Raman spectroscopy. Lebreton, ...
Sulfhydryl compounds - analysis ; Oxidation-reduction ; Animals. Charakt. formalna: Polska ksi ka. J zyk publikacji: POL. 36/42 ... Reactive oxygen species - metabolism ; Vitamin K - pharmacology. Charakt. formalna: Zagraniczny artyku Charakt. merytoryczna: ... the role of antioxidative mechanisms.. Czasopismo: Toxicology Mechanisms and Methods. Szczeg y: 2003 : 13, 4, s. 301-308. ... Czasopismo: Redox Biology. Szczeg y: 2017 : 12, s. 733-744. e-ISSN: 2213-2317. Afiliacja UMB. Angielskie s owa kluczowe: Cell ...