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*  Metal Toxicity in Microorganism: Environment & Agriculture Book Chapter | IGI Global
Reactive Oxygen Species (ROS) Stress: Reactive Oxygen Species (ROS) is referred to oxygen containing reactive molecules and ... Thiol: It is a carbon-bonded sulfhydryl (-C-SH or R-SH) group containing organosulfur compound that has capability to reduce ... Reduction Potential: Reduction potential or redox potential or oxidation/reduction potential (i.e., ORP or pE or e, or E h ) is ... The biochemical and molecular mechanisms of metal toxicity may be helpful to depth metal toxicity study in microbes and other ...
  https://www.igi-global.com/chapter/metal-toxicity-in-microorganism/176456
*  Patent US6359004 - Manipulating nitrosative stress to upregulate nitrosative stress defenses - Google Patents
Redox active catalysts functional to convert NO to species with NO+ activity are heme complexes including myoglobin and ... The term "nitric oxide related compounds is used herein to mean compounds able to transfer NO+, NO− or NO2 + group to ... the endogenous production of reactive oxygen species in the body, e.g., superoxide, hydrogen peroxide, hydroxyl radical, ... It is now appreciated that cells of the immune system (e.g., macrophages, neutrophils, etc.) employ a variety of mechanisms to ...
  http://www.google.com/patents/US6359004?dq=4168396
*  Redox-dependent thiol modifications: implications for the release of extracellular vesicles | Springer for Research &...
Electrophilic compounds that are prone to react with thiolates or thiols include reactive oxygen species (ROS), which can lead ... Sanders DA (2000) Sulfhydryl involvement in fusion mechanisms. Sub-Cell Biochem 34:483-514CrossRefGoogle Scholar ... involvement of reactive oxygen species and stable free radicals in mechanisms of oxidative damage, carcinogenesis and ... Wen X, Wu J, Wang F, Liu B, Huang C, Wei Y (2013) Deconvoluting the role of reactive oxygen species and autophagy in human ...
  https://rd.springer.com/article/10.1007/s00018-018-2806-z
*  Redox Modulations, Antioxidants, and Neuropsychiatric Disorders
Open Access journal that publishes original research and review articles dealing with the cellular and molecular mechanisms of ... Figure 3: Mechanisms of Nrf2 activation and degradation. ROS, reactive oxygen species; RNS, reactive nitrogen species; Nrf2, ... This balance between oxidized and reduced compounds within the cell is known as the redox status [1, 2]. In a healthy cell, ... can react with O2 to produce superoxide and quinones/semiquinones that readily bind to sulfhydryl side chains and deplete the ...
  https://www.hindawi.com/journals/omcl/2016/4729192/
*  IJERPH | Free Full-Text | Cellular and Mitochondrial Effects of Alcohol Consumption | HTML
... effects in several human organs and demonstrates the direct participation of mitochondria as potential target of compounds that ... Antioxidant effects have been described due to that alcoholic beverages contain different compounds, such as polyphenols as ... Ethanol stimulates the production of reactive oxygen species at mitochondrial complexes I and III. Free Radic. Biol. Med 1999, ... Gastric mucosa is rich in protein sulfhydryl groups, which may be the target of ROS. Oxidized protein sulfhydryl groups lead to ...
  https://www.mdpi.com/1660-4601/7/12/4281/htm
*  Toxic Effects of Mercury on the Cardiovascular and Central Nervous Systems
It is believed that the mechanisms are related to the toxic increase in reactive oxygen species (ROS). Oxidative stress is ... Mercuric mercury compounds, such as mercury salts, result from the combination of mercury with chlorine, sulfur, or oxygen. ... R. Brigelius-Flohé, "Glutathione peroxidases and redox-regulated transcription factors," Biological Chemistry, vol. 387, no. 10 ... In addition, because of its high affinity for sulfhydryl groups in tubulin, methylmercury inhibits the organization of ...
  https://www.hindawi.com/journals/bmri/2012/949048/
*  Plus it
Interaction of reactive oxygen species with ion transport mechanisms. Am J Physiol Cell Physiol 275: C1-C24, 1998. ... members of the ENaC/degenerin family of ion channels have been shown to be modulated by redox compounds that act on sulfhydryl ... Ca2+-activated K+ channel inhibition by reactive oxygen species. Am J Physiol Cell Physiol 282: C461-C471, 2002. ... Regulation of ion channel structure and function by reactive oxygen-nitrogen species. Am J Physiol Lung Cell Mol Physiol 285: ...
  http://ajplung.physiology.org/content/305/9/L595
*  Sulfhydryl Redox State Affects Susceptibility to Ischemia and Sarcoplasmic Reticulum Ca2+ Release in Rat Heart | Circulation...
Although the ryanodine receptor might be attacked directly by oxygen free radicals, the activation of indirect mechanisms ... 4 The involvement of sulfhydryl oxidation was suggested by the observation that thiol compounds such as N-2- ... Although DTT may act as a scavenger of free radical species, the effects that we have observed when DTT was infused after the ... Sulfhydryl Redox State and Ischemic Preconditioning. Our findings show that changes in thiol redox state affect cardiac ...
  http://circres.ahajournals.org/content/83/9/908
*  Ephedrine Neurotoxicity
... drug-induced production of reactive oxygen species (ROS) and nitric oxide , (NO). The cellular effects of ROS or NO cannot be ... DA was concurrently oxidized to , produce a threefold increase in free radicals, as measured by the , redox-sensitive dye ... AMPH-evoked LPO was only slightly reduced by these , compounds. It is concluded that AMPH enhances ACH release through ... To define the molecular mechanisms underlying amphetamine (AMPH) , neurotoxicity, primary cultures of dopaminergic neurons were ...
  http://www.bio.net/bionet/mm/neur-sci/2003-May/054567.html
*  Protocols and Video Articles Authored by Vojtech Adam
This is due to high affinity of this protein to any reactive species including metals and reactive oxygen species. The purpose ... Ellipticine and its derivatives are efficient anticancer compounds that function through multiple mechanisms. Formation of ... Redox Status Expressed As GSH:GSSG Ratio As a Marker for Oxidative Stress in Paediatric Tumour Patients Oncology Letters. , ... The content of phytochelatin2, a low molecular mass peptide containing a sulfhydryl group, correlated well with the Se content ...
  https://www.jove.com/author/Vojtech_Adam
*  Free Radicals And Human Disease, a Review
... oxygen species (4~45 ) and often involves redox cycling. The differential toxicity of such agents to tumor cells may depend ... For example, the anti- or pro-oxidant properties of sulfhydryl compounds depend upon pH (29-31), those of beta carotene upon ... Production of activated species by such mechanisms can exceed the capacity of local protective mechanisms and produce tissue ... Figure 3: The Role of Active Oxygen Species in Inflammation FIGURE 3. Role of active oxygen species in inflammation. ...
  http://www.doctorproctor.com/crcpap2.htm
*  898. Butylhydroquinone, tert- (TBHQ) (WHO Food Additives Series 40)
TBHQ also undergoes redox cycling with the corresponding quinone, accompanied by the production of reactive oxygen species. In ... Li, Y. & Trush, M.A. (1994) Reactive oxygen-dependent DNA damage resulting from the oxidation of phenolic compounds by a copper ... as indicators of the mechanisms of chemical toxicity. In vitro Toxicol., 8: 71-85. Peters, A.A., Lau, S.S., Dulik, D., Murphy, ... Effect of sulfhydryl modifying agents. Eur. J. Biochem., 226: 31-39. ...
  http://inchem.org/documents/jecfa/jecmono/v040je02.htm
*  Sauvignon blanc wine: Contribution of ageing and oxygen on aromatic and non-aromatic compounds and sensory composition - A...
... are sulphur-containing compounds possessing a sulfhydryl group (-SH). Various sulphur-containing compounds occur in wine and ... The mechanisms for the formation of the 'reductive' compounds are not fully understood. However, the formation of H2S from a ... Young wines contain high concentrations of oxygen-reactive species, triggering a chain of chemical reactions and consequently ... lower redox potentials, such as other phenolic molecules, SO2 and thiol-containing compounds, including glutathione and amino ...
  http://www.scielo.org.za/scielo.php?script=sci_arttext&pid=S2224-79042015000300012&lng=en&nrm=iso&tlng=en
*  Lactalbumin - Wikipedia
... sulfhydryl and is critical in a variety of cellular defense functions including protection from toxic oxygen species and ... Additional basic research is warranted to examine the exact mechanisms by which milk whey protein protects the heart. ... normal cell GSH levels has also been investigated as a means to reduce the toxicity associated with a wide variety of compounds ... Redox Signaling. Vol. 10, No. 2, 395-402, 2008. ... Reactive oxygen free radical species in the heart were ...
  https://en.wikipedia.org/wiki/Lactalbumin
*  Impairment of intestinal glutathione synthesis in patients with inflammatory bowel disease | Gut
Background-Reactive oxygen species contribute to tissue injury in inflammatory bowel disease (IBD). The tripeptide glutathione ... The sulfhydryl amino acid cysteine is a potent scavenger of hydroxyl radicals and could be readily consumed due to oxidative ... Consequently, the GSH redox status (ratio rGSH/GSSG) dramatically decreased down to 42% in the inflamed ileum. This difference ... This could have major implications on intestinal immune functions in IBD as pro-oxidant mechanisms are known to be involved in ...
  http://gut.bmj.com/content/42/4/485.full
*  Plus it
Compounds with reasonable inhibition, specificity, and mechanisms of inactivation have been uncovered. For these inhibitors to ... Interestingly, compounds that are reactive with sulfhydryl groups, such as methanethiosulfonates, i.e., [2-(trimethylammonium) ... and species (SrtA from B. anthracis). All compounds that showed appreciable inhibition of different sortases but not papain ... In light of the fact that many compounds can inhibit enzyme activity based on redox action, promiscuous aggregation, ...
  http://pharmrev.aspetjournals.org/content/60/1/128
*  S-sulfhydration as a cellular redox regulation | Bioscience Reports
... reactive nitrogen species; ROS, reactive oxygen species; RSS, reactive sulfur species; RSSH, hydropersulfides; SNT, S- ... sulfur-containing compounds additionally confirm that the latter compounds play an essential role in the thiol-based redox ... AND REACTIVE SULFUR SPECIES (RSS). Studies of recent years unravelled in greater depth the biogenesis and regulatory mechanisms ... other sulfhydryl groups, cyanide). Not only enzymes involved in sulfur metabolism, like CSE, MST, Rhd but also proteins ...
  http://www.bioscirep.org/content/36/2/e00304
*  Primary Faculty/Secondary Faculty | Department of Pharmacology
Methods for detection of mitochondrial and cellular reactive oxygen species. Antioxid. Redox Signal [print-electronic]. 2014 ... Münzel T, Mülsch A, Holtz J, Just H, Harrison DG, Bassenge E. Mechanisms of interaction between the sulfhydryl precursor L- ... Interactions of nitroglycerin and sulfhydryl-donating compounds in coronary microvessels. Am. J. Physiol. 1994 Jan; 266(1 Pt 2 ... EDRF: nitrosylated compound or authentic nitric oxide. Basic Res. Cardiol. 1991; 86 Suppl 2: 17-26. PMID: 1953608, ISSN: 0300- ...
  https://medschool.vanderbilt.edu/pharmacology/people/primary-facultysecondary-faculty?vid=harrisdg
*  Benefits of Vine Leaf on Different Biological Systems | IntechOpen
Vine leaves, a waste product from the vine, are also rich source of polyphenols and other therapeutic compounds. In this ... It is well known that these risk factors promote excessive formation of oxygen and nitrogen reactive species and may lead to ... since these compounds undergo redox reactions and hydrogen atoms transfer from the phenolic hydroxyl group to the free radicals ... NI: not informed; CCl4: carbon tetrachloride; MDA: malondialdehyde; NP‐SH: nonprotein sulfhydryl; SOD: superoxide dismutase; ...
  https://www.intechopen.com/books/grape-and-wine-biotechnology/benefits-of-vine-leaf-on-different-biological-systems
*  Scientific Evidence - Autism Canada
Blaylock, R. Interactions of cytokines, excitotoxins, and reactive nitrogen and oxygen species in autism spectrum disorders. J ... Sulfhydryl-reactive metals in autism.J Toxicol Environ Health A. 2007 Apr 15;70(8):715-21. ... Chemical compounds that target thiol-disulfide groups on mononuclear phagocytes inhibit immune mediated phagocytosis of red ... Efficacy of methylcobalamin and folinic acid treatment on glutathione redox status in children with autism.Am J Clin Nutr. 2009 ...
  https://autismcanada.org/research/scientific-evidence/
*  Evidence That Glutathione Depletion Is a Mechanism Responsible for the Anti-Inflammatory Effects of Ethyl Pyruvate in Cultured...
... a compound that is known to be an effective scavenger of reactive oxygen species (ROS) (Adickes and Andresen, 1943; Bunton, ... Janssen-Heininger YM, Poynter ME, and Baeuerle PA (2000) Recent advances towards understanding redox mechanisms in the ... The sulfhydryl group of this critical cysteine residue (Cys62) is essential for DNA-binding activity. Because of the three ... Ethyl pyruvate (EP), an effective scavenger of reactive oxygen species, is also an anti-inflammatory agent in a variety of in ...
  http://jpet.aspetjournals.org/content/308/1/307.long
*  Alkyl Mercury-Induced Toxicity: Multiple Mechanisms of Action | SpringerLink
Collectively, published studies reveal that there are some similarities between the mechanisms of the... ... There are a number of mechanisms by which alkylmercury compounds cause toxic action in the body. ... Halliwell B (1992) Reactive oxygen species and the central nervous system. J Neurochem 59(5):16091623Google Scholar ... There are a number of mechanisms by which alkylmercury compounds cause toxic action in the body. Collectively, published ...
  https://link.springer.com/chapter/10.1007/398_2016_1
*  Detox Supplement - Complete Detoxification Kit - SHOP.COM
... and helps limit liver damage as a result of disrupted oxygen supply. Milk thistle contains a compound called silymarin, a ... Approximately 25 species of schizandra exist, and all are indigenous to Asia except for a rare form of the vine that grows in ... Antioxidants and Redox Signaling. 8(3-4): 395-403, 2006. * Shen, G., et al. Modulation of nuclear factor E2-related factor 2- ... NAC cleaves disulfide bonds by converting them to two sulfhydryl groups. This results in the breakup of mucoproteins in lung ...
  https://www.shop.com/Complete+Detoxification+Kit+-742827918-p+.xhtml
*  Sub-chronic toxicopathological study of lantadenes of Lantana camara weed in Guinea pigs | SpringerLink
... which are essential for endogenous antioxidative defense system to scavenge reactive oxygen species and maintain cellular redox ... Mechanisms of disease: molecular pathogenesis of cholestasis. New Eng J Med. 1998;339:1217-27.CrossRefPubMedGoogle Scholar ... In: Handbook of natural Toxins,Toxicology of plant and fungal compounds R. Keeler, and T. Anthony, eds. Marcel Dekker, Inc. N Y ... Estimation of total, protein-bond and non-protein sulfhydryl groups in tissue with Ellman's reagent. Anal Biochem. 1968;25:192- ...
  https://link.springer.com/article/10.1186/s12917-018-1444-x
*  UNIVERSITA' DEGLI STUDI DI CATANIA
This activation can be through redox-dependent and/or redox-independent mechanisms. DNA Repair Function of APE1/Ref-1 Multiple ... 1990). Moreover, compounds that have the propensity to react with sulfhydryl groups such as diethyl maleate, the ... dual regulation by reactive oxygen species. FASEB J, 2000;14: 1705-1714.  Dianova, II, Bohr VA, and Dianov GL. Interaction of ... Thus, alteration of the cellular redox status due to elevated levels of ROS and electrophilic species and/or a reduced ...
  http://spotidoc.com/doc/21737/universita%E2%80%99-degli-studi-di-catania