*  British Library EThOS: Pharmacological studies of voltage-gated sodium channel expression in human breast cancer cells :...
The specific aims were threefold, as follows: 1) To test the effects of several types of voltage-gated sodium channel (VGSC) ... Pharmacological studies of voltage-gated sodium channel expression in human breast cancer cells : control of metastatic cell ...
  http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.539266
*  PLOS Computational Biology: Impact of Fast Sodium Channel Inactivation on Spike Threshold Dynamics and Synaptic Integration
Spikes are generated by sodium channels, which inactivate when the neuron is depolarized, raising the threshold for spike ... We found that inactivation properties of sodium channels could indeed cause substantial threshold variability in central ...
  http://journals.plos.org/ploscompbiol/article/comments?id=10.1371/journal.pcbi.1001129&imageURI=info:doi/10.1371/journal.pcbi.1001129.g007
*  Rare Genetic Disorder: Sodium channels
Sodium channels. Voltage-gated sodium channels play a critical role in the generation and conduction of action potentials - so ... that can modulate the kinetics and voltage dependence of channel gating. Till 2007, 9 isoforms of the sodium-channel α subunit ... 4 closely related sodium channels (Nav 1.1, -1.2, -1.3, and -1.7) are encoded by a set of 4 genes (SCN1A, SCN2A, SCN3A, and ... Sodium channels are integral membrane proteins and are comprised of a large α subunit, which forms the voltage-sensitive and ...
  http://raregeneticdisorder.blogspot.com/2012/08/sodium-channels.html
*  Omega Research
... tested their effects on the electrophysiology of rat hippocampal CA1 neurons and found that the sodium and calcium ion channels ... the ion channels penetrate the membrane bilayer in juxtaposition with the ion channels rather than directly on the channel ... The PUFAs act by stabilizing electrically every cardiac myocyte by modulating conductance of ion channels in the sarcolemma, ... These PUFAs then allosterically alter the conformation and conductance of the channels. Both potential benefits and possible ...
  http://omega-research.com/researchview.php?ID=2988&catid=8
*  Abstract P081: Voltage-Gated TTX-Sensitive Nav1.1 Brain Sodium Channels Are Important for Cardiac Contractile Function |...
Abstract P081: Voltage-Gated TTX-Sensitive Nav1.1 Brain Sodium Channels Are Important for Cardiac Contractile Function. Susan T ... We tested the functional significance of Nav1.1 sodium channels in the heart by creating a novel knock-in of human epilepsy ... Background: Mutations in voltage gated brain sodium channel Nav1.1 have been linked to many disorders, including Generalized ... Conclusions: Our study demonstrates the importance of voltage gated TTX-sensitive Nav1.1 brain sodium channels in cardiac ...
  http://circres.ahajournals.org/content/109/Suppl_1/AP081
*  SCN3B - Sodium channel subunit beta-3 precursor - Homo sapiens (Human) - SCN3B gene & protein
Inactivates the sodium channel opening more slowly than the subunit beta-1. Its association with NFASC may target the sodium ... channels to the nodes of Ranvier of developing axons and retain these channels at the nodes in mature myelinated axons (By ... Modulates channel gating kinetics. Causes unique persistent sodium currents. ... Modulates channel gating kinetics. Causes unique persistent sodium currents. Inactivates the sodium channel opening more slowly ...
  http://www.uniprot.org/uniprot/Q9NY72
*  Birkbeck Institutional Research Online
Prokaryotic NavMs channel as a structural and functional model for eukaryotic sodium channel antagonism. Bagneris, Claire and ... Prokaryotic NavMs channel as a structural and functional model for eukaryotic sodium channel antagonism. Proceedings of the ... binds and is inhibited by eukaryotic sodium channel blockers in a manner similar to the human Nav1.1 channel, despite millions ... Voltage-gated sodium channels are important targets for the development of pharmaceutical drugs, because mutations in different ...
  http://eprints.bbk.ac.uk/9799/
*  Epicardial Border Zone Overexpression of Skeletal Muscle Sodium Channel SkM1 Normalizes Activation, Preserves Conduction, and...
Epicardial Border Zone Overexpression of Skeletal Muscle Sodium Channel SkM1 Normalizes Activation, Preserves Conduction, and ... Epicardial Border Zone Overexpression of Skeletal Muscle Sodium Channel SkM1 Normalizes Activation, Preserves Conduction, and ... Epicardial Border Zone Overexpression of Skeletal Muscle Sodium Channel SkM1 Normalizes Activation, Preserves Conduction, and ... Epicardial Border Zone Overexpression of Skeletal Muscle Sodium Channel SkM1 Normalizes Activation, Preserves Conduction, and ...
  http://circ.ahajournals.org/content/early/2008/12/22/CIRCULATIONAHA.108.809301
*  "The Relationship Between Voltage-Gated Sodium Channel Inactivation Fir" by J. F. Atherton, A. J. Gillies et al.
The Relationship Between Voltage-Gated Sodium Channel Inactivation Firing Frequency in the Subthalamic Nucleus Projection ... The Relationship Between Voltage-Gated Sodium Channel Inactivation Firing Frequency in the Subthalamic Nucleus Projection ...
  https://corescholar.libraries.wright.edu/ncbp/637/
*  Nav1.2 - Wikipedia
Sodium channels which contain the Navα1.2 subunit are called Nav1.2 channels. Voltage-gated sodium channels are transmembrane ... Navα1.2, also known as the sodium channel, voltage-gated, type II, alpha subunit is a protein that in humans is encoded by the ... 2003). "Sodium channels SCN1A, SCN2A and SCN3A in familial autism". Mol. Psychiatry. 8 (2): 186-94. doi:10.1038/sj.mp.4001241. ... 2003). "Sodium channel beta4, a new disulfide-linked auxiliary subunit with similarity to beta2". J. Neurosci. 23 (20): 7577-85 ...
  https://en.wikipedia.org/wiki/Nav1.2
*  Nav1.7 - Wikipedia
Nav1.7 is a sodium ion channel that in humans is encoded by the SCN9A gene. It is usually expressed at high levels in two types ... Rush AM, Dib-Hajj SD, Liu S, Cummins TR, Black JA, Waxman SG (May 2006). "A single sodium channel mutation produces hyper- or ... Nav1.7 is a voltage-gated sodium channel and plays a critical role in the generation and conduction of action potentials and is ... Bagal SK, Chapman ML, Marron BE, Prime R, Storer RI, Swain NA (2014). "Recent progress in sodium channel modulators for pain". ...
  https://en.wikipedia.org/wiki/Nav1.7
*  SCN7A - Wikipedia
... in particular a Sodium Channel Nax (also known as NaG, Nav2.1, etc.) It belongs to a family of Sodium Channel known as Voltage- ... and it is the only sodium channel known to be completely un-blockable by TTX (tetrodotoxin). Sodium channel Scn7a is the name ... Sodium channel protein type 7 subunit alpha is a protein that in humans is encoded by the SCN7A gene on the chromosome ... "Entrez Gene: SCN7A sodium channel, voltage-gated, type VII, alpha". Hiyama TY, Watanabe E, Ono K, Inenaga K, Tamkun MM, Yoshida ...
  https://en.wikipedia.org/wiki/SCN7A
*  Sodium channels in cardiac Purkinje cells | SpringerLink
Sodium (Na+) currents are responsible for excitation and conduction in most cardiac cells, but their study has been hampered by ... Bean, B. P., Cohen, C. J., and Tsien, R. W., Block of cardiac sodium channels by tetrodotoxin and lidocaine: Sodium currents ... Aldrich, R. W., Corey, D. P., and Stevens, C. F., A reinterpretation of mammalian sodium channel gating based on single channel ... Colatsky, T. J., and Tsien, R. W., Sodium channels in rabbit cardiac Purkinje fibres. Nature278 (1979) 265-268.PubMedGoogle ...
  https://link.springer.com/article/10.1007/BF01945516
*  Species: Epithelial sodium channel (IPR001873) | InterPro | EMBL-EBI
Species: Epithelial sodium channel (IPR001873). Key Species. Key species. Number of proteins. FASTA. Protein IDs. ...
  http://www.ebi.ac.uk/interpro/entry/IPR001873/taxonomy
*  Voltage-Gated Sodium Channels
Noteflight is an online music writing application that lets you create, view, print and hear professional quality music notation right in your web browser.
  https://www.noteflight.com/scores/view/86502e9f2f0261a1da1ef92f2c0b8a9cefd2988a
*  Voltage gated sodium channel, alpha-11 subunit (IPR028821) | InterPro | EMBL-EBI
Nav1.9 (sodium channel protein type 11 subunit alpha) is a tetrodotoxin-resistant sodium channel isoform [PMID: 10580103, PMID ... Voltage gated sodium channel, alpha subunit (IPR001696) *Voltage gated sodium channel, alpha-11 subunit (IPR028821) ... Nine voltage-gated sodium channels (Navs) are expressed in complex patterns in mammalian nerve and muscle. These channels ... Voltage gated sodium channel, alpha-11 subunit (IPR028821). Short name: Na_channel_a11su ...
  http://www.ebi.ac.uk/interpro/entry/IPR028821
*  Frontiers | Propranolol Blocks Cardiac and Neuronal Voltage-Gated Sodium Channels | Pharmacology
Heterologous Expression of Sodium Channels. A recombinant human NaV1.5 sodium channel cDNA in a mammalian expression plasmid ( ... We established that cardiac sodium channels have greater affinity for propranolol than brain sodium channels, that block is not ... These data indicate that brain sodium channels exhibit less sensitivity to R-(+)-propranolol than NaV1.5 channels. Based upon ... Finally, we observed that brain sodium channels exhibited less sensitivity to R-(+)-propranolol than NaV1.5 channels. Our ...
  https://www.frontiersin.org/articles/10.3389/fphar.2010.00144/full
*  Sodium channel gene mutation identified in case of familial epilepsy
"Identifying this novel mutation in a sodium channel gene (SCN1A) on Chromosome 2, which is associated with epilepsy will, in ... Researchers at Emory University have identified a specific mutation in a sodium channel gene (SCN1A) that is associated with ... Sodium channel gene mutation identified in case of familial epilepsy. 28.04.2004 ...
  https://www.innovations-report.com/html/reports/medicine-health/report-28532.html
*  Voltage Gated Sodium Channels | Springer for Research & Development
Ion channel biophysicists have at their disposal a rich and ever-growi ... A number of techniques to study ion channels have been developed since the electrical basis of excitability was first ... These structures, along with those from other channels, give unprecedented insight into the structural basis of sodium channel ... Altered Sodium Channel Gating as Molecular Basis for Pain: Contribution of Activation, Inactivation, and Resurgent Currents ...
  https://rd.springer.com/book/10.1007/978-3-642-41588-3
*  Sodium channels amplify spine potentials - Academic Commons
We tested this by measuring the effect of the sodium channel blocker tetrodotoxin (TTX) on depolarizations generated by two- ... Spine sodium channels could boost synaptic potentials and facilitate action potential backpropagation. ... Past theoretical work and recent experimental evidence have suggested that spines could contain sodium channels. ... from neocortical pyramidal neurons are electrically isolated from the dendrite and indicate that they have sodium channels and ...
  https://academiccommons.columbia.edu/catalog/ac%3A150362
*  Marine Drugs | Free Full-Text | Shellfish Toxins Targeting Voltage-Gated Sodium Channels | Notes
Voltage-gated sodium channels (VGSCs) play a central role in the generation and propagation of action potentials in excitable ...
  http://www.mdpi.com/1660-3397/11/12/4698/notes
*  Frontiers | Regulation of Lung Epithelial Sodium Channels by Cytokines and Chemokines | Immunology
Reabsorption is a two-step process: first, sodium enters via sodium-permeable channels in the apical membranes of alveolar type ... Cytokines and chemokines affect alveolar amiloride-sensitive epithelial sodium channels (ENaC) which play a crucial role in ... via sodium-permeable channels in the apical membranes of alveolar type 1 and 2 cells followed by active extrusion of sodium ... inflammation can have a particularly profound effect on lung sodium transport since they can alter both ion channel and barrier ...
  https://www.frontiersin.org/articles/10.3389/fimmu.2017.00766/full
*  Sodium Channels in Epilepsy > Comprehensive Epilepsy Center | Yale School of...
Sodium Channels in Epilepsy. Sodium channels are crucial for the normal electrical activity of the brain, and subtle ... alterations in sodium channels can cause enhanced excitability and epilepsy. We are studying the role of altered sodium channel ...
  https://medicine.yale.edu/epilepsy/research/basic/sodium.aspx
*  New Insights into the Epithelial Sodium Channel Using Directed Mutagenesis | IntechOpen
New Insights into the Epithelial Sodium Channel Using Directed Mutagenesis , IntechOpen, Published on: 2013-02-05. Authors: ... 32 - S Kellenberger, L Schild, 2002Epithelial sodium channel/degenerin family of ion channels: a variety of functions for a ... 26 - J. D Horisberger, A Chraibi, 2004Epithelial Sodium Channel: A Ligand-Gated Channel? Nephron Physiology 963741 ... 1999Epithelial sodium channel in human epidermal keratinocytes: expression of its subunits and relation to sodium transport and ...
  https://www.intechopen.com/books/genetic-manipulation-of-dna-and-protein-examples-from-current-research/new-insights-into-the-epithelial-sodium-channel-using-directed-mutagenesis/