*  British Library EThOS: Pharmacological studies of voltage-gated sodium channel expression in human breast cancer cells :...
The specific aims were threefold, as follows: 1) To test the effects of several types of voltage-gated sodium channel (VGSC) ... Pharmacological studies of voltage-gated sodium channel expression in human breast cancer cells : control of metastatic cell ...
  http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.539266
*  PLOS Computational Biology: Impact of Fast Sodium Channel Inactivation on Spike Threshold Dynamics and Synaptic Integration
Spikes are generated by sodium channels, which inactivate when the neuron is depolarized, raising the threshold for spike ... We found that inactivation properties of sodium channels could indeed cause substantial threshold variability in central ...
  http://journals.plos.org/ploscompbiol/article/comments?id=10.1371/journal.pcbi.1001129&imageURI=info:doi/10.1371/journal.pcbi.1001129.g007
*  Rare Genetic Disorder: Sodium channels
Sodium channels. Voltage-gated sodium channels play a critical role in the generation and conduction of action potentials - so ... that can modulate the kinetics and voltage dependence of channel gating. Till 2007, 9 isoforms of the sodium-channel α subunit ... 4 closely related sodium channels (Nav 1.1, -1.2, -1.3, and -1.7) are encoded by a set of 4 genes (SCN1A, SCN2A, SCN3A, and ... Sodium channels are integral membrane proteins and are comprised of a large α subunit, which forms the voltage-sensitive and ...
  http://raregeneticdisorder.blogspot.com/2012/08/sodium-channels.html
*  Indian Patents. 234877:BIARYL SUBSTITUTED 6-MEMBERED HETEROCYCLES AS SODIUM CHANNEL BLOCKERS
... sodium channels are closed. Following membrane depolarization, sodium channels open rapidly and then inactivate.. Sodium ... Voltage-gated sodium channels represent a multigene family. Nine sodium channel subtypes have been cloned and functionally ... Sodium channel inhibitors will prevent cell depolarization caused by sodium ion movement through agonist-modified sodium ... The identification of inhibitors of the sodium channel is based on the ability of sodium channels to cause cell depolarization ...
  http://www.allindianpatents.com/patents/234877-biaryl-substituted-6-membered-heterocycles-as-sodium-channel-blockers
*  Abstract P081: Voltage-Gated TTX-Sensitive Nav1.1 Brain Sodium Channels Are Important for Cardiac Contractile Function |...
Abstract P081: Voltage-Gated TTX-Sensitive Nav1.1 Brain Sodium Channels Are Important for Cardiac Contractile Function. Susan T ... We tested the functional significance of Nav1.1 sodium channels in the heart by creating a novel knock-in of human epilepsy ... Background: Mutations in voltage gated brain sodium channel Nav1.1 have been linked to many disorders, including Generalized ... Conclusions: Our study demonstrates the importance of voltage gated TTX-sensitive Nav1.1 brain sodium channels in cardiac ...
  http://circres.ahajournals.org/content/109/Suppl_1/AP081
*  SCN3B - Sodium channel subunit beta-3 precursor - Homo sapiens (Human) - SCN3B gene & protein
Inactivates the sodium channel opening more slowly than the subunit beta-1. Its association with NFASC may target the sodium ... channels to the nodes of Ranvier of developing axons and retain these channels at the nodes in mature myelinated axons (By ... Modulates channel gating kinetics. Causes unique persistent sodium currents. ... Modulates channel gating kinetics. Causes unique persistent sodium currents. Inactivates the sodium channel opening more slowly ...
  http://www.uniprot.org/uniprot/Q9NY72
*  Birkbeck Institutional Research Online
Prokaryotic NavMs channel as a structural and functional model for eukaryotic sodium channel antagonism. Bagneris, Claire and ... Prokaryotic NavMs channel as a structural and functional model for eukaryotic sodium channel antagonism. Proceedings of the ... binds and is inhibited by eukaryotic sodium channel blockers in a manner similar to the human Nav1.1 channel, despite millions ... Voltage-gated sodium channels are important targets for the development of pharmaceutical drugs, because mutations in different ...
  http://eprints.bbk.ac.uk/9799/
*  Int J Dev Biol - Dual roles of voltage-gated sodium channels in development and cancer
There are nine ? subunits, Nav1.1-Nav1.9, and four ? subunits, ?1-?4. The ? subunits are multifunctional, modulating channel ... Voltage-gated Na+ channels (VGSCs) are heteromeric protein complexes containing pore-forming ? subunits together with non-pore- ... Dual roles of voltage-gated sodium channels in development and cancer. Faheemmuddeen Patel and William J. Brackenbury* ... There are nine ? subunits, Nav1.1-Nav1.9, and four ? subunits, ?1-?4. The ? subunits are multifunctional, modulating channel ...
  http://www.ijdb.ehu.es/web/paper/150171wb/
*  Epicardial Border Zone Overexpression of Skeletal Muscle Sodium Channel SkM1 Normalizes Activation, Preserves Conduction, and...
Epicardial Border Zone Overexpression of Skeletal Muscle Sodium Channel SkM1 Normalizes Activation, Preserves Conduction, and ... Epicardial Border Zone Overexpression of Skeletal Muscle Sodium Channel SkM1 Normalizes Activation, Preserves Conduction, and ... Epicardial Border Zone Overexpression of Skeletal Muscle Sodium Channel SkM1 Normalizes Activation, Preserves Conduction, and ... Epicardial Border Zone Overexpression of Skeletal Muscle Sodium Channel SkM1 Normalizes Activation, Preserves Conduction, and ...
  http://circ.ahajournals.org/content/early/2008/12/22/CIRCULATIONAHA.108.809301
*  "The Relationship Between Voltage-Gated Sodium Channel Inactivation Fir" by J. F. Atherton, A. J. Gillies et al.
The Relationship Between Voltage-Gated Sodium Channel Inactivation Firing Frequency in the Subthalamic Nucleus Projection ... The Relationship Between Voltage-Gated Sodium Channel Inactivation Firing Frequency in the Subthalamic Nucleus Projection ...
  https://corescholar.libraries.wright.edu/ncbp/637/
*  Nav1.2 - Wikipedia
Sodium channels which contain the Navα1.2 subunit are called Nav1.2 channels. Voltage-gated sodium channels are transmembrane ... Navα1.2, also known as the sodium channel, voltage-gated, type II, alpha subunit is a protein that in humans is encoded by the ... 2003). "Sodium channels SCN1A, SCN2A and SCN3A in familial autism". Mol. Psychiatry. 8 (2): 186-94. doi:10.1038/sj.mp.4001241. ... 2003). "Sodium channel beta4, a new disulfide-linked auxiliary subunit with similarity to beta2". J. Neurosci. 23 (20): 7577-85 ...
  https://en.wikipedia.org/wiki/Nav1.2
*  Nav1.7 - Wikipedia
Nav1.7 is a sodium ion channel that in humans is encoded by the SCN9A gene. It is usually expressed at high levels in two types ... Rush AM, Dib-Hajj SD, Liu S, Cummins TR, Black JA, Waxman SG (May 2006). "A single sodium channel mutation produces hyper- or ... Nav1.7 is a voltage-gated sodium channel and plays a critical role in the generation and conduction of action potentials and is ... Bagal SK, Chapman ML, Marron BE, Prime R, Storer RI, Swain NA (2014). "Recent progress in sodium channel modulators for pain". ...
  https://en.wikipedia.org/wiki/Nav1.7
*  SCN7A - Wikipedia
... in particular a Sodium Channel Nax (also known as NaG, Nav2.1, etc.) It belongs to a family of Sodium Channel known as Voltage- ... and it is the only sodium channel known to be completely un-blockable by TTX (tetrodotoxin). Sodium channel Scn7a is the name ... Sodium channel protein type 7 subunit alpha is a protein that in humans is encoded by the SCN7A gene on the chromosome ... "Entrez Gene: SCN7A sodium channel, voltage-gated, type VII, alpha". Hiyama TY, Watanabe E, Ono K, Inenaga K, Tamkun MM, Yoshida ...
  https://en.wikipedia.org/wiki/SCN7A
*  Sodium channels in cardiac Purkinje cells | SpringerLink
Sodium (Na+) currents are responsible for excitation and conduction in most cardiac cells, but their study has been hampered by ... Bean, B. P., Cohen, C. J., and Tsien, R. W., Block of cardiac sodium channels by tetrodotoxin and lidocaine: Sodium currents ... Aldrich, R. W., Corey, D. P., and Stevens, C. F., A reinterpretation of mammalian sodium channel gating based on single channel ... Colatsky, T. J., and Tsien, R. W., Sodium channels in rabbit cardiac Purkinje fibres. Nature278 (1979) 265-268.PubMedGoogle ...
  https://link.springer.com/article/10.1007/BF01945516
*  Species: Epithelial sodium channel (IPR001873) | InterPro | EMBL-EBI
Species: Epithelial sodium channel (IPR001873). Key Species. Key species. Number of proteins. FASTA. Protein IDs. ...
  http://www.ebi.ac.uk/interpro/entry/IPR001873/taxonomy
*  Voltage-Gated Sodium Channels
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  https://www.noteflight.com/scores/view/86502e9f2f0261a1da1ef92f2c0b8a9cefd2988a
*  Structure of sodium channels different than previously believed | EurekAlert! Science News
New Cambridge research provides fresh and unexpected insight into the structure of sodium channels and, specifically, one of ... Sodium channels are implicated in many serious conditions such as heart disease, epilepsy and pain, making them an important ... its components -- β-subunit molecules -- which are responsible for 'fine-tuning' the activity of the channel. The research is ... and sodium channels play a vital role in this process. The sodium channel lies on the surface of the nerve and muscle cells and ...
  https://www.eurekalert.org/pub_releases/2014-04/uoc-sos041714.php
*  epithelial Sodium Channel gamma: Novus Biologicals
Browse our epithelial Sodium Channel gamma all backed by our Guarantee+. ... epithelial Sodium Channel gamma available through Novus Biologicals. ...
  https://www.novusbio.com/gene-id/6340
*  Voltage gated sodium channel, alpha-11 subunit (IPR028821) | InterPro | EMBL-EBI
Nav1.9 (sodium channel protein type 11 subunit alpha) is a tetrodotoxin-resistant sodium channel isoform [PMID: 10580103, PMID ... Voltage gated sodium channel, alpha subunit (IPR001696) *Voltage gated sodium channel, alpha-11 subunit (IPR028821) ... Nine voltage-gated sodium channels (Navs) are expressed in complex patterns in mammalian nerve and muscle. These channels ... Voltage gated sodium channel, alpha-11 subunit (IPR028821). Short name: Na_channel_a11su ...
  http://www.ebi.ac.uk/interpro/entry/IPR028821
*  An oxygen-sensitive mechanism in regulation of epithelial sodium channel | PNAS
Epithelial sodium channels (ENaCs) are of immense importance, controlling Na+ transport across epithelia and thus playing a ... 2002) Endogenously expressed epithelial sodium channel is present in lipid rafts in A6 cells. J Biol Chem 277:33541-33544. ... An oxygen-sensitive mechanism in regulation of epithelial sodium channel Message Subject (Your Name) has sent you a message ... Epithelial sodium channels (ENaCs), which are expressed primarily in the apical membranes of epithelia lining the distal ...
  http://www.pnas.org/content/106/8/2957
*  Evolution of sodium channels predates the origin of nervous systems in animals | PNAS
Voltage-dependent sodium channels are believed to have evolved from calcium channels at the origin of the nervous system. A ... Sodium channels also have a cytoplasmic loop between their third and fourth domains that swings up and occludes the channel ... 1992) Calcium channel characteristics conferred on the sodium channel by single mutations. Nature 356:441-443. ... 2) and have key molecular signatures of sodium channels (Fig. 3). Others have proposed that Nav channels evolved from an ...
  http://www.pnas.org/content/108/22/9154
*  Frontiers | Propranolol Blocks Cardiac and Neuronal Voltage-Gated Sodium Channels | Pharmacology
Heterologous Expression of Sodium Channels. A recombinant human NaV1.5 sodium channel cDNA in a mammalian expression plasmid ( ... We established that cardiac sodium channels have greater affinity for propranolol than brain sodium channels, that block is not ... These data indicate that brain sodium channels exhibit less sensitivity to R-(+)-propranolol than NaV1.5 channels. Based upon ... Finally, we observed that brain sodium channels exhibited less sensitivity to R-(+)-propranolol than NaV1.5 channels. Our ...
  https://www.frontiersin.org/articles/10.3389/fphar.2010.00144/full
*  Sodium channel gene mutation identified in case of familial epilepsy
"Identifying this novel mutation in a sodium channel gene (SCN1A) on Chromosome 2, which is associated with epilepsy will, in ... Researchers at Emory University have identified a specific mutation in a sodium channel gene (SCN1A) that is associated with ... Sodium channel gene mutation identified in case of familial epilepsy. 28.04.2004 ...
  https://www.innovations-report.com/html/reports/medicine-health/report-28532.html
*  Voltage Gated Sodium Channels | Springer for Research & Development
Ion channel biophysicists have at their disposal a rich and ever-growi ... A number of techniques to study ion channels have been developed since the electrical basis of excitability was first ... These structures, along with those from other channels, give unprecedented insight into the structural basis of sodium channel ... Altered Sodium Channel Gating as Molecular Basis for Pain: Contribution of Activation, Inactivation, and Resurgent Currents ...
  https://rd.springer.com/book/10.1007/978-3-642-41588-3
*  Voltage-Gated Sodium Channels in Neurological Disorders | BenthamScience
Voltage-Gated Sodium Channels in Neurological Disorders. Author(s): Mohamed Chahine, Aurelien Chatelier, Olga Babich, Johannes ... Voltage-gated sodium channels play an essential biophysical role in many excitable cells such as neurons. They transmit ... Abstract: Voltage-gated sodium channels play an essential biophysical role in many excitable cells such as neurons. They ... This review describes the biochemical, biophysical and pharmacological properties of neuronal voltage-gated sodium channels ( ...
  http://www.eurekaselect.com/92595/article