*  SUMO2 - Small ubiquitin-related modifier 2 precursor - Bos taurus (Bovine) - SUMO2 gene & protein
This post-translational modification on lysine residues of proteins plays a crucial role in a number of cellular processes such ... Ubiquitin-like protein that can be covalently attached to proteins as a monomer or as a lysine-linked polymer. Covalent ... chains are also susceptible to polyubiquitination which functions as a signal for proteasomal degradation of modified proteins ... sp,P61955,SUMO2_BOVIN Small ubiquitin-related modifier 2 OS=Bos taurus OX=9913 GN=SUMO2 PE=3 SV=1 ...
  http://www.uniprot.org/uniprot/P61955
*  Sumo1 - Small ubiquitin-related modifier 1 precursor - Rattus norvegicus (Rat) - Sumo1 gene & protein
This post-translational modification on lysine residues of proteins plays a crucial role in a number of cellular processes such ... Involved for instance in targeting RANGAP1 to the nuclear pore complex protein RANBP2. Covalently attached to the voltage-gated ... Ubiquitin-like protein that can be covalently attached to proteins as a monomer or a lysine-linked polymer. Covalent attachment ... chains are also susceptible to polyubiquitination which functions as a signal for proteasomal degradation of modified proteins ...
  https://www.uniprot.org/uniprot/Q5I0H3
*  Tripartite Motif-Containing Protein 28 Is... & related info | Mendeley
Tripartite Motif-Containing Protein 28 Is a Small Ubiquitin-Related Modifier E3 Ligase and Negative Regulator of IFN Regulatory ... Modification of IRF7 by small ubiquitin-related modifiers (SUMOs) has been shown to regulate IFN expression and antiviral ... Unlike the common SUMO E3 ligase, protein inhibitor of activated STAT1, the E3 activity of TRIM28 is specific to IRF7, because ... As reported in this article, we have identified the tripartite motif-containing protein 28 (TRIM28) as a binding partner of ...
  https://www.mendeley.com/research-papers/tripartite-motifcontaining-protein-28-small-ubiquitinrelated-modifier-e3-ligase-negative-regulator-i/
*  Sumoylation as a Signal for Polyubiquitylation and Proteasomal Degradation | SpringerLink
... is a versatile cellular tool to modulate a protein's function. SUMO modification is a reversible process analogous to ... The small ubiquitin-related modifier (SUMO) is a versatile cellular tool to modulate a protein's function. SUMO modification is ... Saitoh H, Hinchey J. Functional heterogeneity of small ubiquitin-related protein modifiers SUMO-1 versus SUMO-2/3. J Biol Chem ... A small ubiquitin-related polypeptide involved in targeting RanGAP1 to nuclear pore complex protein RanBP2. Cell 1997; 88:97- ...
  https://link.springer.com/chapter/10.1007/978-1-4419-6676-6_16
*  Bhattacharya S[au] - PubMed - NCBI
Mechanical Softening of a Small Ubiquitin-related Modifier Protein (SUMO2) Due to Temperature Induced Flexibility at the Core. ... Calcium-binding protein EhCaBP3 is recruited to the phagocytic complex of Entamoeba histolytica by interacting with Arp2/3 ... Translational proteomic study to address host protein changes during aspergillosis.. Desoubeaux G, Chauvin D, Piqueras MDC, ... Allosteric Activation of Striatal-Enriched Protein Tyrosine Phosphatase (STEP, PTPN5) by a Fragment-like Molecule. ...
  https://www.ncbi.nlm.nih.gov/pubmed?cmd=search&term=Bhattacharya+S%5Bau%5D&dispmax=50
*  Polymorphisms in the UBC9 and PIAS3 genes of the SUMO-conjugating system and breast cancer risk | Springer for Research &...
SUMOylation consists in the covalent conjugation of small ubiquitin-related modifiers to target proteins. SUMOylation ... SUMOylation consists in the covalent conjugation of small ubiquitin-related modifiers to target proteins. SUMOylation ... Muller S, Matunis MJ, Dejean A (1998) Conjugation with the ubiquitin-related modifier SUMO-1 regulates the partitioning of PML ... Covalent modification of the Werner's syndrome gene product with the ubiquitin-related protein, SUMO-1. J Biol Chem 275:20963- ...
  https://rd.springer.com/article/10.1007/s10549-009-0530-y
*  Carbon monoxide induced PPARγ SUMOylation and UCP2 block inflammatory gene expression in macrophages.
... and p38 mitogen-activated protein kinase (MAPK) dependent manner. Previously, we demonstrated that CO inhibits ... Saitoh H,Hinchey J. Year: 2000Functional heterogeneity of small ubiquitin-related protein modifiers SUMO-1 versus SUMO-2/3.J ... Zhou W,Ryan JJ,Zhou H. Year: 2004Global analyses of sumoylated proteins in Saccharomyces cerevisiae. Induction of protein ... 0/Early Growth Response Protein 1; 0/Ion Channels; 0/Mitochondrial Proteins; 0/PPAR gamma; 0/Reactive Oxygen Species; 0/ ...
  http://www.biomedsearch.com/nih/Carbon-Monoxide-Induced-PPAR-SUMOylation/22046279.html
*  The SUMO ligase PIAS1 regulates UV-induced apoptosis by recruiting Daxx to SUMOylated foci | Journal of Cell Science
2007). PIAS proteins as regulators of small ubiquitin-related modifier (SUMO) modifications and transcription. Biochem. Soc. ... 2000). Functional heterogeneity of small ubiquitin-related protein modifiers SUMO-1 versus SUMO-2/3. J. Biol. Chem. 275, 6252- ... The small ubiquitin-like modifier (SUMO) ligase PIAS1 (Protein Inhibitor of Activated Stat-1) has been shown to play a role in ... The small ubiquitin-like modifier (SUMO) proteins regulate the activity, localization and/or stability of various cellular ...
  http://jcs.biologists.org/content/125/23/5819
*  SUMO protein - Wikipedia
Saitoh H, Hinchey J (March 2000). "Functional heterogeneity of small ubiquitin-related protein modifiers SUMO-1 versus SUMO-2/3 ... Small Ubiquitin-like Modifier (or SUMO) proteins are a family of small proteins that are covalently attached to and detached ... "A small ubiquitin-related polypeptide involved in targeting RanGAP1 to nuclear pore complex protein RanBP2". Cell. 88 (1): 97- ... one of a small number of E3 ligating proteins attaches it to the protein. In yeast, there are four SUMO E3 proteins, Cst9, ...
  https://en.wikipedia.org/wiki/SUMO_protein
*  SUMO3 - Wikipedia
Small ubiquitin-related modifier 3 is a protein that in humans is encoded by the SUMO3 gene. SUMO proteins, such as SUMO3, and ... Saitoh H, Hinchey J (March 2000). "Functional heterogeneity of small ubiquitin-related protein modifiers SUMO-1 versus SUMO-2/3 ... Eaton EM, Sealy L (August 2003). "Modification of CCAAT/enhancer-binding protein-beta by the small ubiquitin-like modifier ( ... Su HL, Li SS (August 2002). "Molecular features of human ubiquitin-like SUMO genes and their encoded proteins". Gene. 296 (1-2 ...
  https://en.wikipedia.org/wiki/SUMO3
*  SUMO2 - Wikipedia
Small ubiquitin-related modifier 2 is a protein that in humans is encoded by the SUMO2 gene. This gene encodes a protein that ... Saitoh H, Hinchey J (Mar 2000). "Functional heterogeneity of small ubiquitin-related protein modifiers SUMO-1 versus SUMO-2/3 ... small ubiquitin-like modifier) protein family. It functions in a manner similar to ubiquitin in that it is bound to target ... "In vitro modification of human centromere protein CENP-C fragments by small ubiquitin-like modifier (SUMO) protein: definitive ...
  https://en.wikipedia.org/wiki/SUMO2
*  2013: School of Biochemistry | News | University of Bristol
... involves the attachment of a small protein called Small Ubiquitin-related Modifier (SUMO) to target proteins. This pathway is ... The findings have shown that SUMOylation of a protein called dynamin-related protein 1 (Drp1) is particularly important because ... SENP3-mediated deSUMOylation of dynamin-related protein 1 promotes cell death following ischaemia' by Chun Guo, Keri L Hildick ... The European Research Council-funded study, entitled 'SENP3-mediated deSUMOylation of dynamin-related protein 1 promotes cell ...
  http://www.bris.ac.uk/news/2013/9390.html
*  SIZ1 Small Ubiquitin-Like Modifier E3 Ligase Facilitates Basal Thermotolerance in Arabidopsis Independent of Salicylic Acid |...
Saitoh H, Hinchey J (2000) Functional heterogeneity of small ubiquitin-related protein modifiers SUMO-1 versus SUMO-2/3. J Biol ... The small ubiquitin-like modifier (SUMO) protein modification system in Arabidopsis: accumulation of SUMO 1 and -2 conjugates ... A small heat shock protein cooperates with heat shock protein 70 systems to reactivate a heat-denatured protein. Plant Physiol ... SIZ1 Small Ubiquitin-Like Modifier E3 Ligase Facilitates Basal Thermotolerance in Arabidopsis Independent of Salicylic Acid. ...
  http://www.plantphysiol.org/content/142/4/1548.full
*  SUMOylation in Trypanosoma brucei [PeerJ]
We here show that Trypanosoma brucei SUMO (Tb927.5.3210) modifies many proteins. The levels of SUMOylation were unaffected by ... proteins are involved in many processes in eukaryotes. ... heterogeneity of small ubiquitin-related protein modifiers SUMO ... Small ubiquitin like modifier (SUMO) proteins have been found in almost all eukaryotes. Conjugation of SUMO to target proteins ... Small ubiquitin like modifier (SUMO) proteins are involved in many processes in eukaryotes. We here show that Trypanosoma ...
  https://peerj.com/articles/180/
*  Circadian rhythm and its role in malignancy
It is a reversible posttranslational modification in which a small ubiquitin-related modifier protein (SUMO) is covalently ... Also, increase in small-intestinal mucosa β-catenin in Per2m/m mice is associated with an increase in MYC protein, again a ... has been shown to interact with the cell cycle checkpoint proteins ATR, CHK1 and ATRIP (ATR-interacting protein). This ... CRY and BMAL1 proteins decreasing their stability and critically regulating the time of action of clock proteins. Similarly, ...
  https://www.jcircadianrhythms.com/articles/10.1186/1740-3391-8-3/
*  Salmonella Secreted Factor L Deubiquitinase of Salmonella typhimurium Inhibits NF-κB, Suppresses IκBα Ubiquitination and...
... heat shock protein; SUMO, small ubiquitin-related modifier; NEDD8, neural precursor cell-expressed developmentally down- ... ubiquitin-AMC), small ubiquitin-related modifier (SUMO)-AMC, or neural precursor cell-expressed developmentally down-regulated ... YopJ is homologous to CE cysteine proteases and was reported to hydrolyze ubiquitin and SUMO (a ubiquitin-like protein) (15, 16 ... The specificity of SseL appears to be highly selective for ubiquitin, as other substrates containing ubiquitin-related ...
  http://www.jimmunol.org/content/180/7/5045
*  CALM modulates theformation of tau-positivetangles in z | Open-i
Small Ubiquitin-Related Modifier Proteins/metabolism. *Transfection. *Vesicle-Associated Membrane Protein 2/metabolism ... Here we show that CALM modulates autophagy and alters clearance of tau, a protein which is a known autophagy substrate and ... Here we show that CALM modulates autophagy and alters clearance of tau, a protein which is a known autophagy substrate and ... Before degeneration,we observed phosphorylation of the transgenic human tau protein at specific serine and threonine residues ( ...
  https://openi.nlm.nih.gov/detailedresult.php?img=PMC4199285_ncomms5998-f10&req=4
*  WikiGenes - Protein Processing, Post-Translational
Small ubiquitin-related modifier (SUMO) family proteins function by becoming covalently attached to other proteins as post- ... Psychiatry related information on Protein Processing, Post-Translational. *High impact information on Protein Processing, Post- ... Psychiatry related information on Protein Processing, Post-Translational. *Glycosylation of microtubule-associated protein tau ... Structure, expression, and evolution of a gene encoding the precursor of nisin, a small protein antibiotic. Buchman, G.W., ...
  http://www.wikigenes.org/e/mesh/e/206.html
*  Mouse Monoclonal anti-SUMO 2 (SUMO2/1199) | Biotium
The small ubiquitin-related modifier (SUMO) proteins, which include SUMO-1, 2 and 3, belong to the ubiquitin-like protein ... The small ubiquitin-related modifier (SUMO) proteins, which include SUMO-1, 2 and 3, belong to the ubiquitin-like protein ... Antibody & Protein Labeling Kits. Protein Labeling Kits , Small Ligand Labeling Mix-n-Stain™ Antibody Labeling Kits ... Like ubiquitin, the SUMO proteins are synthesized as precursor proteins that undergo processing before conjugation to target ...
  https://biotium.com/product/monoclonal-anti-sumo-2-sumo21199/
*  Circadian clock - Wikipedia
A small ubiquitin-related modifier protein modification of BMAL1 has also been proposed as another level of post-translational ... also employed a genome-wide small interfering RNA screen in U2OS cell line to identify additional clock genes and modifiers ... Methylation of a protein structure adds a methyl group and regulates the protein function or gene expression and in histone ... Reversible phosphorylation regulates important processes such as nuclear entry, formation of protein complexes and protein ...
  https://en.wikipedia.org/wiki/Circadian_clock
*  The motor fuction changes between control and PERK-siRN | Open-i
Small Ubiquitin-Related Modifier Proteins/genetics/metabolism. *Spinal Cord/pathology. *Swine. *Swine, Miniature ... Protein levels were measured by immunoblot analysis using antibodies against LC3II and β-actin at each time point of 1 week, 1 ... Protein levels were measured by immunoblot analysis using antibodies against LC3II and β-actin at each time point of 1 week, 1 ...
  https://openi.nlm.nih.gov/detailedresult.php?img=PMC3818370_pone.0076819.g007&req=4
*  Sequestration of a highly reactive intermediate in an evolving pathway for degradation of pentachlorophenol | Proceedings of...
... small ubiquitin-related modifier (SUMO)] from Saccharomyces cerevisiae (54). The sequence of pcpD was verified by DNA ... We therefore decided to produce the closely related protein from S. chlorophenolicum sp. RA2 (18), which differs from PcpD from ... If the latter were the case, then the source of electrons would differ for small molecule substrates and proteins, which seems ... To address the mechanism of reduction of small molecules and protein substrates by PcpD, we constructed PcpD-FeS, which lacks ...
  http://www.pnas.org/content/110/24/E2182
*  Protein inhibitor of activated STAT - Wikipedia
Palvimo JJ (December 2007). "PIAS proteins as regulators of small ubiquitin-related modifier (SUMO) modifications and ... Protein inhibitor of activated STAT (PIAS), also known as E3 SUMO-protein ligase PIAS, is a protein that regulates ... PIAS protein entry at the Protein Information Resource (PIR) PIAS Proteins at the US National Library of Medicine Medical ... Attachment of a SUMO protein to the target allows for protein-protein interaction between PIAS and the transcription factor. ...
  https://en.wikipedia.org/wiki/Protein_inhibitor_of_activated_STAT
*  Key Step Discovered for Regulating Embryonic Development - Redorbit
The first, Small Ubiquitin-related Modifier, or SUMO, attaches to other proteins to modify their function or physically move ... "Here we've established a new role for SUMOylation, mediating the interaction between protein and protein methylation in ... Their hearts had smaller chambers and thinner walls. Through a series of experiments, the team worked backward from this ... The key actors are members of two tightly associated families of proteins that Yeh and colleagues discovered and continue to ...
  http://www.redorbit.com/news/science/1854399/key_step_discovered_for_regulating_embryonic_development/
*  SUMO4 - Wikipedia
This family of genes encode small ubiquitin-related modifiers that are attached to proteins and control the target proteins' ... Small ubiquitin-related modifier 4 is a protein that in humans is encoded by the SUMO4 gene. This gene is a member of the SUMO ... "Association of small ubiquitin-like modifier 4 (SUMO4) variant, located in IDDM5 locus, with type 2 diabetes in the Japanese ... "Evidence for the role of small ubiquitin-like modifier 4 as a general autoimmunity locus in the Japanese population". The ...
  https://en.wikipedia.org/wiki/SUMO4