*  A SUMOylated Energy Switch | Science Signaling
KLF5 was subject to posttranslational modification by small ubiquitin-related modifier (SUMO) proteins, and a SUMOylation- ... Their O2 consumption and body temperature were higher and, in skeletal muscle, the expression of genes encoding proteins ... and uncoupling proteins 2 and 3 (UCP2 and UCP3) in C2C12 myotubes. ...
  http://stke.sciencemag.org/content/1/23/ec212
*  PML nuclear bodies in 3D | Journal of Cell Science
... and their relative localisation to small ubiquitin-related modifier 1 (SUMO-1), SUMO2/3, heterochromatin protein 1 (HP1) and ... By contrast, SUMO2/3 is found mainly in the interior of a subset of PML-NBs, where it might control the protein composition and ... First, conjugation of PML and Sp100 proteins to SUMO-1 results in their self-assembly into a spherical shell of 50-100 nm ... Marian Blanca Ramírez from the CSIC in Spain has been studying the effects of LRRK2, a protein associated with Parkinson's ...
  http://jcs.biologists.org/content/123/3/e304
*  SENP6 - Sentrin-specific protease 6 - Homo sapiens (Human) - SENP6 gene & protein
Desumoylates PML and CENPI, protecting them from degradation by the ubiquitin ligase RNF4, which targets polysumoylated ... proteins for proteasomal degradation. Desumoylates also RPA1, thus preventing recruitment of RAD51 to the DNA damage foci to ... SUMO2 and SUMO3 from targeted proteins. Processes preferentially poly-SUMO2 and poly-SUMO3 chains, but does not efficiently ... "Negative modulation of RXRalpha transcriptional activity by small ubiquitin-related modifier (SUMO) modification and its ...
  http://www.uniprot.org/uniprot/Q9GZR1
*  anti-Ulp1 antibody | GeneTex
Covalent modification of cellular proteins by the ubiquitin-like modifier SUMO (small ubiquitin-like modifier) regulates ... This antibody is specific for yeast ULP1 and does not react with ULP1 from related sources including human SENP.. Top ... Once covalently attached to cellular targets, SUMO regulates protein:protein and protein:DNA interactions, as well as ... ULP-1, ubiquitin-like protein-specific protease 1, initially processes Smt3 and also acts as a deconjugating enzyme for Smt3 [ ...
  http://www.genetex.com/Ulp1-antibody-GTX48820.html
*  SUMO2 - Small ubiquitin-related modifier 2 precursor - Bos taurus (Bovine) - SUMO2 gene & protein
This post-translational modification on lysine residues of proteins plays a crucial role in a number of cellular processes such ... Ubiquitin-like protein that can be covalently attached to proteins as a monomer or as a lysine-linked polymer. Covalent ... chains are also susceptible to polyubiquitination which functions as a signal for proteasomal degradation of modified proteins ... sp,P61955,SUMO2_BOVIN Small ubiquitin-related modifier 2 OS=Bos taurus OX=9913 GN=SUMO2 PE=3 SV=1 ...
  http://www.uniprot.org/uniprot/P61955
*  Carbon monoxide induced PPARγ SUMOylation and UCP2 block inflammatory gene expression in macrophages.
... and p38 mitogen-activated protein kinase (MAPK) dependent manner. Previously, we demonstrated that CO inhibits ... Saitoh H,Hinchey J. Year: 2000Functional heterogeneity of small ubiquitin-related protein modifiers SUMO-1 versus SUMO-2/3.J ... Zhou W,Ryan JJ,Zhou H. Year: 2004Global analyses of sumoylated proteins in Saccharomyces cerevisiae. Induction of protein ... 0/Early Growth Response Protein 1; 0/Ion Channels; 0/Mitochondrial Proteins; 0/PPAR gamma; 0/Reactive Oxygen Species; 0/ ...
  http://www.biomedsearch.com/nih/Carbon-Monoxide-Induced-PPAR-SUMOylation/22046279.html
*  The SUMO ligase PIAS1 regulates UV-induced apoptosis by recruiting Daxx to SUMOylated foci | Journal of Cell Science
2007). PIAS proteins as regulators of small ubiquitin-related modifier (SUMO) modifications and transcription. Biochem. Soc. ... 2000). Functional heterogeneity of small ubiquitin-related protein modifiers SUMO-1 versus SUMO-2/3. J. Biol. Chem. 275, 6252- ... The small ubiquitin-like modifier (SUMO) ligase PIAS1 (Protein Inhibitor of Activated Stat-1) has been shown to play a role in ... The small ubiquitin-like modifier (SUMO) proteins regulate the activity, localization and/or stability of various cellular ...
  http://jcs.biologists.org/content/125/23/5819
*  SUMO protein - Wikipedia
Saitoh H, Hinchey J (March 2000). "Functional heterogeneity of small ubiquitin-related protein modifiers SUMO-1 versus SUMO-2/3 ... Small Ubiquitin-like Modifier (or SUMO) proteins are a family of small proteins that are covalently attached to and detached ... "A small ubiquitin-related polypeptide involved in targeting RanGAP1 to nuclear pore complex protein RanBP2". Cell. 88 (1): 97- ... one of a small number of E3 ligating proteins attaches it to the protein. In yeast, there are four SUMO E3 proteins, Cst9, ...
  https://en.wikipedia.org/wiki/SUMO_protein
*  SUMO3 - Wikipedia
Small ubiquitin-related modifier 3 is a protein that in humans is encoded by the SUMO3 gene. SUMO proteins, such as SUMO3, and ... Saitoh H, Hinchey J (March 2000). "Functional heterogeneity of small ubiquitin-related protein modifiers SUMO-1 versus SUMO-2/3 ... Eaton EM, Sealy L (August 2003). "Modification of CCAAT/enhancer-binding protein-beta by the small ubiquitin-like modifier ( ... Su HL, Li SS (August 2002). "Molecular features of human ubiquitin-like SUMO genes and their encoded proteins". Gene. 296 (1-2 ...
  https://en.wikipedia.org/wiki/SUMO3
*  SUMO2 - Wikipedia
Small ubiquitin-related modifier 2 is a protein that in humans is encoded by the SUMO2 gene. This gene encodes a protein that ... Saitoh H, Hinchey J (Mar 2000). "Functional heterogeneity of small ubiquitin-related protein modifiers SUMO-1 versus SUMO-2/3 ... small ubiquitin-like modifier) protein family. It functions in a manner similar to ubiquitin in that it is bound to target ... "In vitro modification of human centromere protein CENP-C fragments by small ubiquitin-like modifier (SUMO) protein: definitive ...
  https://en.wikipedia.org/wiki/SUMO2
*  Circadian rhythm and its role in malignancy
It is a reversible posttranslational modification in which a small ubiquitin-related modifier protein (SUMO) is covalently ... Also, increase in small-intestinal mucosa β-catenin in Per2m/m mice is associated with an increase in MYC protein, again a ... has been shown to interact with the cell cycle checkpoint proteins ATR, CHK1 and ATRIP (ATR-interacting protein). This ... CRY and BMAL1 proteins decreasing their stability and critically regulating the time of action of clock proteins. Similarly, ...
  https://www.jcircadianrhythms.com/articles/10.1186/1740-3391-8-3/
*  Salmonella Secreted Factor L Deubiquitinase of Salmonella typhimurium Inhibits NF-κB, Suppresses IκBα Ubiquitination and...
... heat shock protein; SUMO, small ubiquitin-related modifier; NEDD8, neural precursor cell-expressed developmentally down- ... ubiquitin-AMC), small ubiquitin-related modifier (SUMO)-AMC, or neural precursor cell-expressed developmentally down-regulated ... YopJ is homologous to CE cysteine proteases and was reported to hydrolyze ubiquitin and SUMO (a ubiquitin-like protein) (15, 16 ... The specificity of SseL appears to be highly selective for ubiquitin, as other substrates containing ubiquitin-related ...
  http://www.jimmunol.org/content/180/7/5045
*  CALM modulates theformation of tau-positivetangles in z | Open-i
Small Ubiquitin-Related Modifier Proteins/metabolism. *Transfection. *Vesicle-Associated Membrane Protein 2/metabolism ... Here we show that CALM modulates autophagy and alters clearance of tau, a protein which is a known autophagy substrate and ... Here we show that CALM modulates autophagy and alters clearance of tau, a protein which is a known autophagy substrate and ... Before degeneration,we observed phosphorylation of the transgenic human tau protein at specific serine and threonine residues ( ...
  https://openi.nlm.nih.gov/detailedresult.php?img=PMC4199285_ncomms5998-f10&req=4
*  Mouse Monoclonal anti-SUMO 2 (SUMO2/1199) | Biotium
The small ubiquitin-related modifier (SUMO) proteins, which include SUMO-1, 2 and 3, belong to the ubiquitin-like protein ... The small ubiquitin-related modifier (SUMO) proteins, which include SUMO-1, 2 and 3, belong to the ubiquitin-like protein ... Antibody & Protein Labeling Kits. Protein Labeling Kits , Small Ligand Labeling Mix-n-Stain™ Antibody Labeling Kits ... Like ubiquitin, the SUMO proteins are synthesized as precursor proteins that undergo processing before conjugation to target ...
  https://biotium.com/product/monoclonal-anti-sumo-2-sumo21199/
*  The motor fuction changes between control and PERK-siRN | Open-i
Small Ubiquitin-Related Modifier Proteins/genetics/metabolism. *Spinal Cord/pathology. *Swine. *Swine, Miniature ... Protein levels were measured by immunoblot analysis using antibodies against LC3II and β-actin at each time point of 1 week, 1 ... Protein levels were measured by immunoblot analysis using antibodies against LC3II and β-actin at each time point of 1 week, 1 ...
  https://openi.nlm.nih.gov/detailedresult.php?img=PMC3818370_pone.0076819.g007&req=4
*  Sequestration of a highly reactive intermediate in an evolving pathway for degradation of pentachlorophenol | Proceedings of...
... small ubiquitin-related modifier (SUMO)] from Saccharomyces cerevisiae (54). The sequence of pcpD was verified by DNA ... We therefore decided to produce the closely related protein from S. chlorophenolicum sp. RA2 (18), which differs from PcpD from ... If the latter were the case, then the source of electrons would differ for small molecule substrates and proteins, which seems ... To address the mechanism of reduction of small molecules and protein substrates by PcpD, we constructed PcpD-FeS, which lacks ...
  http://www.pnas.org/content/110/24/E2182
*  Circadian clock - Wikipedia
A small ubiquitin-related modifier protein modification of BMAL1 has also been proposed as another level of post-translational ... also employed a genome-wide small interfering RNA screen in U2OS cell line to identify additional clock genes and modifiers ... Methylation of a protein structure adds a methyl group and regulates the protein function or gene expression and in histone ... Reversible phosphorylation regulates important processes such as nuclear entry, formation of protein complexes and protein ...
  https://en.wikipedia.org/wiki/Circadian_clock
*  Key Step Discovered for Regulating Embryonic Development - Redorbit
The first, Small Ubiquitin-related Modifier, or SUMO, attaches to other proteins to modify their function or physically move ... "Here we've established a new role for SUMOylation, mediating the interaction between protein and protein methylation in ... Their hearts had smaller chambers and thinner walls. Through a series of experiments, the team worked backward from this ... The key actors are members of two tightly associated families of proteins that Yeh and colleagues discovered and continue to ...
  http://www.redorbit.com/news/science/1854399/key_step_discovered_for_regulating_embryonic_development/
*  Protein inhibitor of activated STAT - Wikipedia
Palvimo JJ (December 2007). "PIAS proteins as regulators of small ubiquitin-related modifier (SUMO) modifications and ... Protein inhibitor of activated STAT (PIAS), also known as E3 SUMO-protein ligase PIAS, is a protein that regulates ... PIAS protein entry at the Protein Information Resource (PIR) PIAS Proteins at the US National Library of Medicine Medical ... Attachment of a SUMO protein to the target allows for protein-protein interaction between PIAS and the transcription factor. ...
  https://en.wikipedia.org/wiki/Protein_inhibitor_of_activated_STAT
*  Reactome | phospho-K48PolyUb,SUMO2-K1840,p-5T-MDC1 [nucleoplasm]
Small Ubiquitin-related MOdifier) protein. ... A protein modification that effectively converts an L-threonine ... A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a ... A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a ... A protein modification that effectively converts an L-threonine residue to O-phospho-L-threonine. ...
  https://reactome.org/content/detail/R-MMU-5684074
*  Modification of Small Hepatitis Delta Virus Antigen by SUMO Protein
SUMO (small ubiquitin-related modifier) has been identified as a reversible posttranslational protein modifier (34, 35). The ... A small ubiquitin-related polypeptide involved in targeting RanGAP1 to nuclear pore complex protein RanBP2. Cell 88:97-107. [ ... In this study, we show that S-HDAg is a small ubiquitin-like modifier 1 (SUMO1) target protein. Mapping data showed that ... protein-protein interaction, protein-DNA interaction, and stability and activity of modified proteins (2, 11, 52, 56). ...
  http://pubmedcentralcanada.ca/pmcc/articles/PMC2798338/
*  SUMO Wrestling Cells Reveal New Protective Mechanism Target for Stroke
... involves the attachment of a small protein called Small Ubiquitin-related Modifier (SUMO) to target proteins. This pathway is ... The findings have shown that SUMOylation of a protein called dynamin-related protein 1 (Drp1) is particularly important because ... Two Proteins Dictate Visual System Axon Stabilization News Scientists have made an important discovery concerning the ... Two Proteins Dictate Visual System Axon Stabilization News Dec 11, 2017 Read more ...
  https://www.technologynetworks.com/drug-discovery/news/sumo-wrestling-cells-reveal-new-protective-mechanism-target-for-stroke-210764
*  SUMO2 Gene - GeneCards | SUMO2 Protein | SUMO2 Antibody
Protein Coding), Small Ubiquitin-Like Modifier 2, including: function, proteins, disorders, pathways, orthologs, and expression ... Protein Symbol:. P61956-SUMO2_HUMAN. Recommended name:. Small ubiquitin-related modifier 2 Protein Accession:. P61956. ... SUMO2 (Small Ubiquitin-Like Modifier 2) is a Protein Coding gene. Among its related pathways are Transport of the SLBP ... This gene encodes a protein that is a member of the SUMO (small ubiquitin-like modifier) protein family. It functions in a ...
  http://www.genecards.org/cgi-bin/carddisp.pl?id_type=entrezgene&id=6613
*  SUMO4 - Wikipedia
This family of genes encode small ubiquitin-related modifiers that are attached to proteins and control the target proteins' ... Small ubiquitin-related modifier 4 is a protein that in humans is encoded by the SUMO4 gene. This gene is a member of the SUMO ... "Association of small ubiquitin-like modifier 4 (SUMO4) variant, located in IDDM5 locus, with type 2 diabetes in the Japanese ... "Evidence for the role of small ubiquitin-like modifier 4 as a general autoimmunity locus in the Japanese population". The ...
  https://en.wikipedia.org/wiki/SUMO4