*  Remogliflozin etabonate - Wikipedia
Remogliflozin is selective for SGLT2. Etabonate Statement on a nonproprietory name adopted by the USAN council Yahoo Finance ...
  https://en.wikipedia.org/wiki/Remogliflozin_etabonate
*  SGLT2 - Wikipedia
SGLT2 is a member of the sodium glucose cotransporter family which are sodium-dependent glucose transport proteins. SGLT2 is ... SGLT2 inhibitors are called gliflozins. They lead to a reduction in blood glucose levels. Therefore, SGLT2 inhibitors have ... "SGLT2 Inhibitors (Gliflozins)". Diabetes.co.uk. Retrieved 2015-05-19. Calado J, Loeffler J, Sakallioglu O, Gok F, Lhotta K, ... "FDA Drug Safety Communication: FDA warns that SGLT2 inhibitors for diabetes may result in a serious condition of too much acid ...
  https://en.wikipedia.org/wiki/SGLT2
*  SGLT2 Inhibitors for Type 2 Diabetes?
SGLT2) inhibitors has begun to show up on the market. The first drug in this class to be approved by the FDA, Invokana™ ( ... Home / Conditions / Type 2 Diabetes / SGLT2 Inhibitors for Type 2 Diabetes?. SGLT2 Inhibitors for Type 2 Diabetes?. Dec 26, ... Kurosaki, E., Ogasawara H. Ipragliflozin and other sodium-glucose cotransporter (SGLT2) inhibitors in the treatment of type 2 ... SGLT2 inhibitors are a drug class with a novel mechanism of action that has many positive benefits in type 2 diabetics, ...
  http://www.diabetesincontrol.com/sglt2-inhibitors-for-type-2-diabetes/
*  Role of Sodium-Glucose Cotransporter 2 (SGLT2) Inhibitors
SGLT2 inhibitors are a reasonable addition to a patient's diabetes regimen once metformin therapy has been optimized.4 SGLT2 ... Role of Sodium-Glucose Cotransporter 2 (SGLT2) Inhibitors. Kathleen A. Lusk, PharmD, BCPS. Assistant Professor, Pharmacy ... SGLT2 inhibitors provide a new avenue for reduction of A1C by increasing glucose excretion via the kidneys. While the type 2 ... SGLT2 inhibitors and cardiovascular risk: lessons learned from the EMPA-REG OUTCOME study. Diabetes Care. 2016;39(5):717-725. ...
  https://www.uspharmacist.com/article/role-of-sodiumglucose-cotransporter-2-sglt2-inhibitors2
*  SGLT-2 medicines reduce risk of heart failure: AstraZeneca | Business Standard News
SGLT-2 medicines reduce risk of heart failure: AstraZeneca Press Trust of India , Mumbai. Last Updated at March 21, 2017 17:07 ... More than 300,000 patients with type-2 diabetes who were treated with SGLT-2 inhibitors, showed that all-cause mortality was ...
  http://www.business-standard.com/article/pti-stories/sglt-2-medicines-reduce-risk-of-heart-failure-astrazeneca-117032100814_1.html
*  Story of Discovery: SGLT2 inhibitors: harnessing the kidneys to help treat diabetes | NIDDK
Some of the SGLT2 inhibitors are not effective and may have more side effects in people with moderate kidney dysfunction. SGLT2 ... The approved SGLT2 inhibitors are effective in reducing hemoglobin A1c (HbA1c), a measure of blood glucose levels. SGLT2 ... Because SGLT2 inhibitors are diuretics, common side effects include increased thirst and urination. People taking SGLT2 ... This condition is caused by changes in the gene coding for SGLT2, resulting in reduction in SGLT2 activity. This reduced ...
  https://www.niddk.nih.gov/news/archive/2016/story-discovery-sglt2-inhibitors-harnessing-kidneys-help-treat-diabetes
*  New Research: No Increased Risk for Kidney Injury with SGLT2 Inhibitors?
2016 FDA warning conflicts with recent evidence showing no increased risk for kidney injury with SGLT2 inhibitors following use ... Do SGLT2 Inhibitors Increase the Risk of Acute Kidney Injury?. Do SGLT2 Inhibitors Increase the Risk of Acute Kidney Injury?. ... Instances of AKI severity were few and not as severe in those taking SGLT-2 inhibitors. Finally, those taking the SGLT-2 ... AKI severity, experienced by users of SGLT-2 inhibitors, was no worse than patients not taking SGLT-2 inhibitors. ...
  http://www.diabetesincontrol.com/do-sglt2-inhibitors-increase-the-risk-of-acute-kidney-injury/
*  SGLT2 Inhibitors and Risk of UTI Development in Patients with Diabetes
... Share * Facebook ... Home / Resources / Articles / SGLT2 Inhibitors and Risk of UTI Development in Patients with Diabetes ...
  http://www.diabetesincontrol.com/sglt2-inhibitors-and-risk-of-uti-development-in-patients-with-diabetes/
*  Go to Should You Think About an SGLT2 Drug?.
The SGLT2 inhibitors work in the kidneys. They cause glucose to leave the body through the urine. Presto - blood glucose comes ... SGLT2 transports glucose from the intestines to the blood, and there may well be some other SGLT2 functions that we don't know ... That's where the SGLT2 inhibitor drugs come in. When SGLT2 is blocked, glucose won't reabsorb, even when blood glucose levels ... Something similar could happen with SGLT2 inhibitors. You can't just block it in the kidney; these drugs block SGLT2 everywhere ...
  https://www.diabetesselfmanagement.com/blog/should-you-think-about-an-sglt2-drug/
*  SGLT2 - Who? New Diabetes Drug Has Doctors Hopeful
The drug, canagliflozin, works to inhibit the sodium-glucose cotransporter 2 (SGLT2), a protein in the body tasked with ... SGLT2 - Who? New Diabetes Drug Has Doctors Hopeful. Share this with a friend ... The drug, canagliflozin, works to inhibit the sodium-glucose cotransporter 2 (SGLT2), a protein in the body tasked with ... "The apparent renal and CV benefits of SGLT2 inhibitors will encourage primary care physicians and endocrinologists to use these ...
  http://www.battlediabetes.com/news/drugs-and-medication/sglt2-%E2%80%93-who-new-diabetes-drug-has-doctors-hopeful
*  Bone Fracture, Density Warning Issued for SGLT2 Inhibitor - MPR
SGLT2) inhibitor, regarding the risk for bone fractures with new information about decreased bone mineral density. ... There is also an ongoing evaluation for the risk of bone fractures with other SGLT2 inhibitors to evaluate the need for drug ... The Food and Drug Administration (FDA) has issued another warning for canagliflozin, a sodium-glucose co-transporter 2 (SGLT2) ...
  https://www.empr.com/safety-alerts-and-recalls/canagliflozin-bone-fracture-density-warning/article/437888/
*  Diabetes 2017 Part 2 Empagliflozin and the Effects of SGLT-2 Inhibitors.
In this week's Homerun Slides, a look at empagliflozin and the effects of SGLT-2 inhibitors. ...
  http://www.diabetesincontrol.com/diabetes-2017-part-2/
*  The SGLT2 Inhibitor Dapagliflozin Prevents Cardiomyopathy in a Diabetic Lipodystrophic Mouse Model | Diabetes
To test this hypothesis, we treated SKO mice with the hypoglycemic SGLT2 inhibitor dapagliflozin and the insulin sensitizer, ... The SGLT2 Inhibitor Dapagliflozin Prevents Cardiomyopathy in a Diabetic Lipodystrophic Mouse Model ... The SGLT2 Inhibitor Dapagliflozin Prevents Cardiomyopathy in a Diabetic Lipodystrophic Mouse Model ... The SGLT2 Inhibitor Dapagliflozin Prevents Cardiomyopathy in a Diabetic Lipodystrophic Mouse Model ...
  http://diabetes.diabetesjournals.org/content/early/2017/01/04/db16-0733
*  Euglycemic Diabetic Ketoacidosis: A Predictable, Detectable, and Preventable Safety Concern With SGLT2 Inhibitors | Diabetes...
The euDKA reported in T2D patients with SGLT2 inhibitor treatment has a different origin. Full-dose SGLT2 inhibition induces a ... are double with the SGLT2 inhibitor. Upon our inquiry, the other two manufacturers of approved SGLT2 inhibitors, AstraZeneca ... Thus, in SGLT2-treated T2D patients (17), the lower insulin-to-glucagon ratio stimulated lipolysis (circulating FFAs were ∼40% ... Sotagliflozin, a dual SGLT1 and SGLT2 inhibitor as adjunct therapy to insulin in type 1 diabetes. Diabetes Care 2015;38:1181- ...
  http://care.diabetesjournals.org/content/38/9/1638
*  Do SGLT2 Inhibitors Increase Cancer Risk in T2D Patients? - MPR
Do SGLT2 Inhibitors Raise the Risk of Lower Extremity Amputation? *Canagliflozin CV Biomarker Effects Examined in Diabetes ... Prespecified cancer types were examined, and there may be an increased risk of bladder cancer associated with SGLT2 inhibitors ... SGLT2 inhibitors were not significantly associated with an increased risk of overall cancer (odds ratio [OR], 1.14; 95 percent ... SGLT2) inhibitors, according to a study published in the October issue of Diabetologia. ...
  https://www.empr.com/news/do-sglt2-inhibitors-increase-cancer-risk-in-t2d-patients/article/697625/
*  Why Do SGLT2 Inhibitors Inhibit Only 30-50% of Renal Glucose Reabsorption in Humans? | Diabetes
If SGLT2 inhibitors are secreted by the renal tubule, this could provide a solution to the puzzle as to why SGLT2 inhibitors ... Unbound SGLT2 inhibitors are filtered through glomeruli and travel a short distance to reach the SGLT2 transporters, which are ... The onset of UGE response is rapid after SGLT2 inhibition. Although slow off rate of SGLT2 inhibitors can contribute to the ... Dapagliflozin is the most advanced SGLT2 inhibitor in clinical trials (12,17,20). In addition, multiple other SGLT2 inhibitors ...
  http://diabetes.diabetesjournals.org/content/61/9/2199.full
*  FDA Strengthens Label Warnings for SGLT2 Inhibitor Class of Type 2 Diabetes Drugs - NewsInfernoNewsInferno
WebMD explains that SGLT2 inhibitors help to control blood sugar by turning off the SGLT2 protein so that the kidneys can ... FDA Strengthens Label Warnings for SGLT2 Inhibitor Class of Type 2 Diabetes Drugs. Posted on December 7, 2015 by F.A. Kelley ... SGLT2 inhibitors are used, in conjunction with diet and exercise, to help control blood sugar in adults with type 2 diabetes. ... Patients who take SGLT2 inhibitors can develop ketoacidosis even if their blood glucose is not excessively high. If ...
  http://www.newsinferno.com/fda-strengthens-label-warnings-for-sglt2-inhibitor-class-of-type-2-diabetes-drugs/
*  Luseogliflozin | SGLT2 Inhibitor | Buy Luseogliflozin from Supplier AdooQ®
SGLT2) inhibitor developed by Taisho Pharmaceutical for the treatment of patients with type 2 diabetes mellitus (T2DM). ... Luseogliflozin SGLT2 Inhibitor Luseogliflozin is an orally active second-generation sodium-glucose co-transporter 2 (SGLT2) ... Luseogliflozin is an orally active second-generation sodium-glucose co-transporter 2 (SGLT2) inhibitor developed by Taisho ... Luseogliflozin is an orally active second-generation sodium-glucose co-transporter 2 (SGLT2) inhibitor developed by Taisho ...
  http://www.adooq.com/luseogliflozin.html
*  'Product Profiles: Non-Insulin Antidiabetics - Options abound as the SGLT-2 class prepares...
The new class of oral SGLT-2 inhibitors will see its first launches over the next 18 months; they will likely be positioned at ... Product Profiles: Non-Insulin Antidiabetics - Options Abound as the SGLT-2 Class Prepares for Market Entry' - New Market Report ... New Pharmaceuticals market report from Datamonitor: 'Product Profiles: Non-Insulin Antidiabetics - Options abound as the SGLT-2 ... while new launches include the first once-weekly GLP-1 agonists and the oral SGLT-2 inhibitor class, to compete in an ...
  http://www.sbwire.com/press-releases/product-profiles-non-insulin-antidiabetics-options-abound-as-the-sglt-2-class-prepares-for-market-entry-new-market-report-170689.htm
*  SGLT2 inhibitors help people with type 2 diabetes live longer and healthier, study says
SGLT2 inhibitors are a relatively new type of drug class which was approved for treating type 2 diabetes in 2013. They work by ... SGLT2 inhibitors, used to treat type 2 diabetes, reduced the rate of being admitted to hospital for heart failure or death from ... SGLT2 inhibitor the T2D game changer. EMA instructs warning about SGLT2 inhibitors to appeal on labels. Diabetes Drugs. ... SGLT2 inhibitors, used to treat type 2 diabetes, reduced the rate of being admitted to hospital for heart failure or death from ...
  https://www.diabetes.co.uk/news/2017/mar/sglt2-inhibitors-help-people-with-type-2-diabetes-live-longer-and-healthier,-study-says-95478131.html
*  Effects of SGLT-2 inhibitors on mortality and cardiovascular events: a comprehensive meta-analysis of randomized controlled...
Solini A (2016) Role of SGLT-2 inhibitors in the treatment of type 2 diabetes mellitus. Acta Diabetol. (Epub ahead of print) ... Effects of SGLT-2 inhibitors on mortality and cardiovascular events: a comprehensive meta-analysis of randomized controlled ... Rosenstock J, Vico M, Wei L, Salsali A, List JF (2012) Effects of dapagliflozin, an SGLT2 inhibitor, on HbA(1c), body weight, ... Rosenstock J, Seman LJ, Jelaska A et al (2013) Efficacy and safety of empagliflozin, a sodium glucose cotransporter 2 (SGLT2) ...
  https://link.springer.com/article/10.1007%2Fs00592-016-0892-7
*  Apple Trees to Sodium Glucose Co-Transporter Inhibitors: A Review of SGLT2 Inhibition | Clinical Diabetes
SGLT2 Inhibitors and Diabetes. Although the possibility of modulation of the SGLT2 system via anti-sense molecules is being ... at least one company is developing anti-sense technology to reduce the expression of SGLT2 and one molecule, ISIS-SGLT2Rx, is ... thus reducing the activity of present SGLT2 transporters) or the use of SGLT2 anti-sense molecules (thus reducing the ... Phlorizin to SGLT2 Inhibitors. J.R.R. Tolkien once wrote that "few can foresee whither their road will lead them, till they ...
  http://clinical.diabetesjournals.org/content/28/1/5.full