Gentaur Molecular :Ray Biotech \ Recombinant Human Amyloid P Component \ 228-10064-2
Recombinant Human Amyloid P Component \ 228-10064-2 for more molecular products just contact us ... Serum amyloid P-component, SAP, 9.5S alpha-1-glycoprotein, APCS, PTX2, MGC88159. ... Recombinant Human Amyloid P Component. Related products : Recombinant Human Amyloid P Component ... Serum amyloid P-component, SAP, 9.5S alpha-1-glycoprotein, APCS, PTX2, MGC88159. ...http://www.antibody-antibodies.com/product_det.php?id=1782920&supplier=search&name=Recombinant%20Human%20Amyloid%20P%20Component
Structure Cluster - 1GYK: Serum Amyloid P Component co-crystallised with MOBDG at neutral pH 3D Similarity Report Page
The Structures of Crystalline Complexes of Human Serum Amyloid P Component with its Carbohydrate Ligand, the Cyclic Pyruvate ... Description: SERUM AMYLOID P-COMPONENT protein , Length: 204 No structure alignment results are available for 1GYK.A, 1GYK.B, ...http://www.rcsb.org/pdb/explore/structureCluster.do?structureId=1GYK
A Study to Evaluate the Safety of GSK2398852 When Co-administered With GSK2315698 in Patients With Systemic Amyloidosis - Full...
Therapeutic Clearance of Amyloid by Antibodies to Serum Amyloid P Component. N Engl J Med. 2015 Sep 17;373(12):1106-14. doi: ... GSK2315698 will be administered at variable doses until the concentration of the serum amyloid P component monoclonal antibody ... GSK2315698 will be administered at variable dosed until the concentration of the serum amyloid P component monoclonal antibody ... GSK2315698 will be administered at variable dosed until the concentration of the serum amyloid P component monoclonal antibody ...https://clinicaltrials.gov/ct2/show/NCT01777243?cond=Amyloidosis&rank=14
Amyloid P Component, serum (APCS) Antikörper
... serum amyloid P-component , serum amyloid P component , Serum amyloid P-component , SAP , APCS amyloid P-component serum ... Weitere Antikörper gegen Amyloid P Component, serum Interaktionspartner. Human Amyloid P Component, serum (APCS) ... Am meisten referenzierte anti-Amyloid P Component, serum Antikörper. Show all anti-Amyloid P Component, serum (APCS) Antikörper ... amyloid P component, serum , pentraxin , C-reactive protein , amyloid P component serum , 9.5S alpha-1-glycoprotein , pentaxin- ...http://www.antikoerper-online.de/abstract/Amyloid+P+Component%2C+serum+
PTX3, A Prototypical Long Pentraxin, Is an Early Indicator of Acute Myocardial Infarction in Humans | Circulation
The major acute phase reactants: C-reactive protein, serum amyloid P component and serum amyloid A protein. Immunol Today. 1994 ... CRP belongs to the pentraxin family of proteins (CRP and serum amyloid P component, SAP) conserved during evolution from ... cloning of a new gene related to C-reactive protein and serum amyloid P component. J Biol Chem. 1992;267:22190-22197. ... similarities and differences with the short pentraxins C-reactive protein and serum amyloid P component. J Biol Chem. 1997;272: ...http://circ.ahajournals.org/content/102/6/636
Toxins | Free Full-Text | Impact of the Nature and Size of the Polymeric Backbone on the Ability of Heterobifunctional Ligands...
... serum amyloid P component, of the innate immune system. Effective in vivo protection from Shiga toxin Type 1 (Stx1) is achieved ... serum amyloid P component (SAP, Figure 1), thereby protecting mice from intoxication by Stx1 . SAP is a serum circulating ... serum amyloid P component, of the innate immune system. Effective in vivo protection from Shiga toxin Type 1 (Stx1) is achieved ... Developmental and liver-specific expression directed by the serum amyloid-p component promoter in transgenic mice. J. Biochem. ...http://www.mdpi.com/2072-6651/3/9/1065/htm
Antibodies to human serum amyloid P component eliminate visceral amyloid deposits
Serum amyloid P component (SAP) is selectively concentrated in amyloid deposits by its avid binding to all amyloid fibril types ... Antibodies to human serum amyloid P component eliminate visceral amyloid deposits. Karl Bodin,1,* Stephan Ellmerich,1,* Melvyn ... However, all amyloid deposits contain the normal, non-fibrillar, plasma glycoprotein, serum amyloid P component (SAP)2, 3. Here ... Binding of serum amyloid P component (SAP) by amyloid fibrils. Clin. Exp. Immunol. 1979;38:284-293. [PubMed] ...http://pubmedcentralcanada.ca/pmcc/articles/PMC2975378/?lang=en-ca
Barbara Bottazzi, PhD - 5x1000
Bottazzi B, Fornasari L, Frangolho A, Giudicatti S, Mantovani A, Marabelli F, et al. Multiplexed label-free optical biosensor for medical diagnostics. Journal of biomedical optics. 2014;19(1):17006.. Beghe B, Verduri A, Bottazzi B, Stendardo M, Fucili A, Balduzzi S, et al. Echocardiography, spirometry, and systemic acute-phase inflammatory proteins in smokers with COPD or CHF: an observational study. PloS one. 2013;8(11):e80166.. Job ER, Bottazzi B, Short KR, Deng YM, Mantovani A, Brooks AG, et al. A single amino acid substitution in the hemagglutinin of H3N2 subtype influenza A viruses is associated with resistance to the long pentraxin PTX3 and enhanced virulence in mice. J Immunol. 2014;192(1):271-81.. Mantovani A, Valentino S, Gentile S, Inforzato A, Bottazzi B, Garlanda C. The long pentraxin PTX3: a paradigm for humoral pattern recognition molecules. Ann N Y Acad Sci. 2013;1285(1):1-14.. Latini R, Gullestad L, Masson S, Nymo SH, Ueland T, Cuccovillo I, et al. Pentraxin-3 in chronic heart ...http://5x1000.humanitas.it/news/bottazzi-barbara/
Serum amyloid P and CPHPC complex - Stock Image C026/2733 - Science Photo Library
Serum amyloid P and CPHPC complex. Molecular model showing 5 molecules of the anti-amyloid drug CPHPC (spheres) bound to a serum amyloid P (SAP) molecule (shown here as both ribbons and spacefilled models, colourful). CPHPC is a small molecule able to strip amyloid P (AP) from deposits by reducing levels of circulating SAP. It can be used to help treat amyloidosis, a disease caused by a build-up of amyloid (insoluble fibrous protein aggregates) in body tissues that leads to organ failure. The symmetrical nature of CPHPC allows it to bind to two SAP subunits from different SAP molecules. This allows five molecules of CPHPC to bind two SAP pentamers together and it is this mechanism of action that potently removes SAP from amyloid deposits in the tissues. This behaviour may also provide a new approach for treating both systemic amyloidosis and ...http://www.sciencephoto.com/media/680607/view
Amyloid P Component - Medical Dictionary online-medical-dictionary.org
Amyloid P component is a small, non-fibrillar Glycoprotein found in normal Serum and in all Amyloid Deposits. It has a pentagonal (pentaxin) structure. It is an Acute Phase Protein, modulates immunologic responses, inhibits Elastase, and has been suggested as an indicator of Liver Disease ...http://www.online-medical-dictionary.org/definitions-a/amyloid-p-component.html
HELP LDL Apheresis Reduces Plasma Pentraxin 3 in Familial Hypercholesterolemia - pdf descargar
HELP LDL Apheresis Reduces Plasma Pentraxin 3 in Familial Hypercholesterolemia. . Biblioteca virtual para leer y descargar libros, documentos, trabajos y tesis universitarias en PDF. Material universiario, documentación y tareas realizadas por universitarios en nuestra biblioteca. Para descargar gratis y para leer online.http://libros.duhnnae.com/2017/jun8/14983922095-HELP-LDL-Apheresis-Reduces-Plasma-Pentraxin-3-in-Familial-Hypercholesterolemia.php
Toxins | Free Full-Text | Impact of the Nature and Size of the Polymeric Backbone on the Ability of Heterobifunctional Ligands...
Inhibition of AB5-type bacterial toxins can be achieved by heterobifunctional ligands (BAITs) that mediate assembly of supramolecular complexes involving the toxin's pentameric cell membrane-binding subunit and an endogenous protein, serum amyloid P component, of the innate immune system. Effective in vivo protection from Shiga toxin Type 1 (Stx1) is achieved by polymer-bound, heterobifunctional inhibitors-adaptors (PolyBAITs), which exhibit prolonged half-life in circulation and by mediating formation of face-to-face SAP-AB5 complexes, block receptor recognition sites and redirect toxins to the spleen and liver for degradation. Direct correlation between solid-phase activity and protective dose of PolyBAITs both in the cytotoxicity assay and in vivo indicate that the mechanism of protection from intoxication is inhibition of toxin binding to the host cell membrane. The polymeric scaffold influences the activity not only by clustering active binding ...http://www.mdpi.com/2072-6651/3/9/1065
Pitavastatin Improves Plasma Pentraxin 3 and Arterial Stiffness in Atherosclerotic Patients with Hypercholesterolemia
Results: Significant improvement of the LDL-C/HDL-C and log (TG/HDL-C) ratios began to be observed from 1 month after using pitavastatin. Significant correlation of the initial PTX3 value was observed with the initial plaque score (PS) (p=0.038, r=0.246), but not between the hsCRP and plasma PTX3 or PS. When patients were divided into 3 groups based on the initial PTX3 values, a significant decrease of the plasma PTX3 was obtained in the highest PTX3 group alone (p=0.034). The change in the plasma PTX3 value (ΔPTX3) was significantly correlated with the Δ mean IMT during the study period (p=0.008, r=0.456 ...https://www.jstage.jst.go.jp/article/jat/16/4/16_No613/_article
Long Pentraxin 3, a Key Component of Innate Immunity, Is Modulated by High-Density Lipoproteins in Endothelial Cells |...
Our study shows that HDL3 induce the expression of PTX3 in vitro and in vivo. This effect is dependent on the activation by lysosphingolipids of a G-coupled receptor belonging to S1P-receptors family and the subsequent activation of the PI3K/Akt pathway. Our data add new insights suggesting a further mechanism by which HDL3 may play an atheroprotective effect through the modulation of a key component of the humoral arm of innate immunity.. PTX3 has been initially described as an early marker for primary local activation of innate immunity and inflammatory response24-26 and is highly expressed in the heart during inflammatory reactions, in atherosclerotic lesions, in plasma in patients with arterial inflammation, particularly with unstable angina pectoris, and in vascular cells in response to inflammatory stimuli and to oxLDL.27-30. Whether PTX3 plays a role in the pathogenesis of vascular diseases, however, is unclear. The in vivo role of PTX3 in inflammatory conditions has been investigated ...http://atvb.ahajournals.org/content/28/5/925
Abstract 149: Effect of Pentraxin 3 on Pressure Overload--Induced Left Ventricular Hypertrophy | Circulation Research
Backgrounds: Left ventricular (LV) adverse remodeling is enhanced by inflammatory cytokines. Pentraxin 3 (PTX3), which is one of the pentraxin superfamily same as C-reactive protein, is rapidly produced in response to inflammatory signals, and plasma PTX3 levels are increased in patients with heart failure. Previously we reported that PTX3 deficient mice demonstrated the suppression of hypertrophic cardiac remodeling after pressure overload. This study aimed to examine the cardiac specific influence of PTX3 on LV hypertrophy and dysfunction in response to pressure overload.. Methods and Results: We created transgenic (TG) mice with cardiac-specific overexpression of PTX3 using alpha-myosin heavy chain promoter. We performed transverse aortic constriction (TAC) or sham operation on TG and wild type (WT) littermate mice. Expression of PTX3 was increased after TAC in WT mice, and immunohistochemistry proved that PTX3 was produced mainly from the interstitial tissue of the heart and infiltrating ...http://circres.ahajournals.org/content/111/Suppl_1/A149
APCS Gene - GeneCards | SAMP Protein | SAMP Antibody
Complete information for APCS gene (Protein Coding), Amyloid P Component, Serum, including: function, proteins, disorders, pathways, orthologs, and expression. GeneCards - The Human Gene Compendiumhttp://www.genecards.org/cgi-bin/carddisp.pl?gene=APCS
Establishment of a High Sensitivity Plasma Assay for Human Pentraxin3 as a Marker for Unstable Angina Pectoris |...
Thank you for your interest in spreading the word on Arteriosclerosis, Thrombosis, and Vascular Biology.. NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address. ...http://atvb.ahajournals.org/content/early/2006/11/09/01.ATV.0000252126.48375.d5
Mucosal pentraxin elisa and antibody
Shop Mucosal pentraxin ELISA Kit, Recombinant Protein and Mucosal pentraxin Antibody at MyBioSource. Custom ELISA Kit, Recombinant Protein and Antibody are available.https://www.mybiosource.com/protein_family.php?root=mucosal-pentraxin
Association of serum markers with improvement in clinical response measures after treatment with golimumab in patients with...
In this study, we evaluated an array of 107 serum proteins and showed that golimumab treatment with or without MTX is effective in modulating certain acute phase reactants (CRP, α1-antitrypsin, von Willebrand factor, and haptoglobin), inflammatory markers (IL-6 and ENRAGE), and other selected proteins (bFGF, apoliprotein C3, and serum amyloid P) in two separate datasets from the same study of patients with inadequate responders to MTX. The robustness of the analyses can be attributed to the minimal variability observed between the different platforms used for testing levels of these proteins (Rules-Based Medicine, Luminex, and ELISA). Thus, this provided us with a high level of confidence in the reproducibility of the changes and associations observed.. In the golimumab-treated patients, ACR 20 and ACR 50 responders displayed a distinct serum protein signature as compared with nonresponders, which confirms the importance of the significant ...https://arthritis-research.biomedcentral.com/articles/10.1186/ar3188
Alexandra María Ogando Vélez | NEUROID
Mentor: Dr. Loyda Meléndez; University of Puerto Rico, Medical Sciences Campus. Project: Characterizing cathepsin B/serum amyloid p complex-induced neuronal dysfunction in a mouse model of HIV-associated encephalitis. ...http://neuroid.uprrp.edu/index.php/team/454/
SAP30 purified MaxPab mouse polyclonal antibody (B01P) - (H00008819-B01P) - Products - Abnova
Mouse polyclonal antibody raised against a full-length human SAP30 protein. SAP30 (NP_003855.1, 1 a.a. ~ 220 a.a) full-length human protein. (H00008819-B01P) - Products - Abnovahttp://www.abnova.com/products/products_detail.asp?catalog_id=H00008819-B01P
The Neuronal Pentraxin-2 Pathway Is an Unrecognized Target in Human Neuroblastoma, Which Also Offers Prognostic Value in...
Sigma-Aldrich offers abstracts and full-text articles by [Alice Bartolini, Daniela Di Paolo, Alessio Noghero, Daniele Murgia, Angela R Sementa, Michele Cilli, Renata Pasqualini, Wadih Arap, Federico Bussolino, Mirco Ponzoni, Fabio Pastorino, Serena Marchiò].https://www.sigmaaldrich.com/catalog/papers/26294210
Qingres-An academic Publisher
The association of obesity with critical chronic diseases including CVD is well-confirmed. PTX3 may act as a cardioprotective biomarker by decreasing inflammation in cardiovascular bed[2, 28]. However, it may also contribute to atherogenic process. These contradictory findings make PTX3 an important parameter to be investigated. Negative correlations between PTX3 and IR as well as TRG were reported in some studies[3-5, 29] however, such a relation couldn't be found in the others [4, 9] including our study.. There are reports explaining that PTX3 was reduced during obesity[30-32]. Our results agree with the results obtained in these studies. Plasma PTX3 showed a nonsignificant trend towards lower levels in MO group as in one of the above studies.. No correlations were found between this parameter and IR, most probably because our study population is composed of prepubertal children. PTX3 can not be described as a cardiovascular biomarker in this period.. While ANGPTL4 plays antilipotoxic ...http://mo.qingres.com/htmls/Mo_943_Detail.html
Page contains details about PEI-PDHA/PEG-PDHA/PTX/siSna/siTwi . It has composition images, properties, Characterization methods, synthesis, applications and reference articles : nano.nature.comhttp://nano.nature.com/nano/GR-M4761587