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*  Plus it
If sensitive to antibiotics, S. aureus infections can be effectively treated with β-lactam antibiotics, macrolides, and ... In light of the fact that many compounds can inhibit enzyme activity based on redox action, promiscuous aggregation, ... the pharmacological industry achieved development of synthetic compounds that selectively block bacterial replication, thereby ... such compounds may not be associated with the same resistance phenomena as antibiotics with bactericidal activity, a conjecture ...
  http://pharmrev.aspetjournals.org/content/60/1/128
*  Potent Inhibition of Monoamine Oxidase B by a Piloquinone from Marine-Derived Streptomyces sp CNQ-027 | Fenical, William
In culture, 6-HAP selectively inhibited proliferation of tumor lines but did not inhibit primary keratinocytes. Resistance to 6 ... Journal of Antibiotics. 71:609-612. AbstractWebsite. A new 14-membered macrolactam natural product, fluvirucin B6 (1), was ... The microbial metabolites known as the macrolides are some of the most successful natural products used to treat infectious and ... Here, we tested 34 organohalogens from anthropogenic and marine sources to identify compounds active toward ryanodine receptor ...
  http://scrippsscholars.ucsd.edu/wfenical/content/potent-inhibition-monoamine-oxidase-b-piloquinone-marine-derived-streptomyces-sp-cnq-027
*  EMC/Paradigm: College Resource Center: Health Careers: Readings in Subject Area: Complete Glossary
macrolides. a class of bacteriostatic antibiotics that inhibit protein synthesis by combining with ribosomes; used primarily to ... chemical substances that are selectively released from neurons and stimulate or inhibit activity in the target cells New Drug ... compounds that contain the same number and type of atoms but have exactly opposite (mirror image) structures. isotonic solution ... a class of antibiotics that block protein synthesis by binding to ribosomal subunits and may also inhibit the formation of ...
  http://www.emcp.com/college_resource_centers/resourcelist.php?GroupID=7238
*  Inhibition of Mycoplasma pneumoniae growth by FDA-approved anticancer and antiviral nucleoside and nucleobase analogs | BMC...
Mpn is resistant to antibiotics targeting cell wall synthesis such as penicillin, and macrolides are the treatment of choice. ... Sixteen of these compounds inhibited Mpn growth to varying levels, and seven showed strong inhibition (Table 1). The anticancer ... This may explain why 6-MP did not inhibit Mpn growth.. To further investigate the mechanism by which 6-TG inhibited Mpn growth ... differences in target enzymes between bacteria and their host to design and select specific inhibitors that will selectively ...
  https://0-bmcmicrobiol-biomedcentral-com.brum.beds.ac.uk/articles/10.1186/1471-2180-13-184
*  Quinolone antibiotic - Wikipedia
Some compounds in this class have been shown to inhibit the synthesis of mitochondrial DNA. The basic pharmacophore, or active ... First and second generation fluoroquinolones selectively inhibit the topoisomerase II ligase domain, leaving the two nuclease ... Nearly all quinolone antibiotics in modern use are fluoroquinolones, which contain a fluorine atom in their chemical structure ... Skalsky K, Yahav D, Lador A, Eliakim-Raz N, Leibovici L, Paul M (April 2013). "Macrolides vs. quinolones for community-acquired ...
  https://en.wikipedia.org/wiki/Quinolone_antibiotic
*  Pathogen- and Host-Directed Anti-Inflammatory Activities of Macrolide Antibiotics
... antibiotics which inhibit bacterial protein synthesis, particularly macrolides and macrolide-like agents, prevent the release ... Drug delivery problems resulting from acid instability prompted the design of newer macrolides. These compounds include (i) ... These results indicate that macrolides may selectively downregulate inflammatory responses which result from the interaction of ... Macrolides, which are primarily antibiotics, belong to the polyketide group of natural products [1]. They derive their name ...
  https://www.hindawi.com/journals/mi/2012/584262/
*  JCI - Macrolides selectively inhibit mutant KCNJ5 potassium channels that cause aldosterone-producing adenoma
These included 6 series of structurally related compounds. One of these comprised 2 macrolide antibiotics - roxithromycin and ... Macrolides selectively inhibit mutant KCNJ5 potassium channels that cause aldosterone-producing adenoma. Ute I. Scholl,1,2 ... These results demonstrate that specific macrolides selectively and potently inhibit channels harboring mutant forms of KCNJ5. ... and 398 compounds (0.5%) showed at least a 33.3% effect. Upon repeat testing, 92 distinct compounds (0.1% of all compounds from ...
  https://www.jci.org/articles/view/91733
*  micro 520 final Flashcards - Cram.com
They inhibit protein synthesis by blocking the 30S subunit A site. They were one of the first 'broad-spectrum' antibiotics ... The term refers to compounds that are isolated from one living organism that kill or inhibit growth of other organisms. The ... It's the ability of an antimicrobial agent to be selectively more toxic to a microorganism than to animal cells. ... What are macrolides and how do they function? Give some examples. They are lactone rings connected to sugars (sugar moiety). ...
  http://www.cram.com/flashcards/micro-520-final-411808
*  Ototoxicity: Overview, Aminoglycosides, Other Antibiotics
Other Antibiotics. Macrolides. Erythromycin was introduced in 1952 and has seen widespread use in clinical medicine. Generally ... The aminoglycosides are bactericidal antibiotics that bind to the 30S ribosome and inhibit bacterial protein synthesis. They ... Platinum compounds damage the stria vascularis in the scala media and cause outer hair cell death beginning at the basal turn ... A particular form of NADPH oxidase, NOX3, is highly and selectively produced in the inner ear and is an important source of ...
  https://emedicine.medscape.com/article/857679-overview
*  A Myrtus communis extract enriched in myrtucummulones and ursolic acid reduces resistance of Propionibacterium acnes biofilms...
... extract enriched in myrtucummulones and ursolic acid reduces resistance of Propionibacterium acnes biofilms to antibiotics used ... Antibiotics Erythromycin and clindamycin were obtained from Sigma Aldrich (Saint-Quentin Fallavier, France) and were dissolved ... 2013). Many other compounds are able to express antimicrobial activity, like limonene and, above all, myrtucommulones (Fiorini- ... 2009). This is the first report indicating that extract from M. communis was able to inhibit biofilm formation and reduce ...
  https://www.thefreelibrary.com/A+Myrtus+communis+extract+enriched+in+myrtucummulones+and+ursolic+...-a0452289014
*  Quinolone antibiotic - Wikipedia
Some compounds in this class have been shown to inhibit the synthesis of mitochondrial DNA.[61][62][63][64] ... First and second generation fluoroquinolones selectively inhibit the topoisomerase II ligase domain, leaving the two nuclease ... "FDA updates warnings for fluoroquinolone antibiotics". FDA. 26 July 2016.. *^ "Fluoroquinolone Safety Labeling Changes" (PDF). ... Skalsky K, Yahav D, Lador A, Eliakim-Raz N, Leibovici L, Paul M (April 2013). "Macrolides vs. quinolones for community-acquired ...
  https://en.wikipedia.org/wiki/Adverse_effects_of_fluoroquinolones
*  All oral presentations.xls
Targeting the vulnerability of cancer cell mitochondria to selectively induce apoptosis: & compounds - Part II. Evaluating the ... Effectiveness Of Antibiotics In The Management Of Acute Exacerbations Of Chronic Obstructive Pulmonary Disease. Do Antibiotics ... The Proarrhythmic Potential of Macrolides: The Role of Interactions. A Review mechanisms of toxicity - Part II. When Magic ... The Potential of Oxoglaucine, a New Antiviral Compound, to Inhibit Enterovirus Replication When Applied Alone or in Combination ...
  http://healthdrugpdf.com/e/ehrlich2007.org1.html
*  Plus it
Compounds that appear to possess actions that inhibit excessive Na+ transport and trigger Cl− secretion are the triphosphate ... Conversely, it appears that extra liquid added to the airway surface does not expand the PCL layer, but rather is selectively ... 89 who showed that the sensitivity of Pseudomonas to macrolides shifted one to two logs to the left under anaerobic compared ... For example, it has been recently shown that the sensitivity of many antibiotics is very different when bacteria are grown ...
  http://erj.ersjournals.com/content/23/1/146
*  US Patent # 9,642,835. Modulators of GTPase and use in relevant treatment - Patents.com
Compounds according to the present invention may be used to inhibit, reduce the likelihood or treat cancer, including the ... Typical antimicrobial agents/antibiotics include the aminoglycosides, ansamycins, carbacephems, carbapenems, cephalosporins, ... cell permeable molecules that selectively and reversibly regulate Rho GTPases is therefore of high scientific and potentially ... glycopeptides, lincosamides, lipopeptides, macrolides, monobacftams, nitrofurans, penicillins, polypeptides, quinolones, ...
  http://patents.com/us-9642835.html
*  Pharm Flashcards by Cath Y | Brainscape
inhibit topoisomerase IV in gram positive organisms. - bactericidal. - relatively selectively toxic 17 ... Resistant strains of S. aureus bind less antibiotic but there is no cross-resistance with other antibiotics Bacteriostatic ... Not too different from macrolides, just different in structure. Lincosamidine antibiotic. Binds to 50S ribosomal subunit and ... Azotemia (abnormally high levels of nitrogen containing compounds like urea, creatinine, etc in the blood; related to ...
  https://www.brainscape.com/flashcards/pharm-4370236/packs/6541232
*  Drug Coated Stent Having a Surface Treatment and Method of Manufacturing - Patent application
... macrolides, sulfa antibiotics, trimethoprim, fusidic acid and aminoglycosides. Antifungal agents include amphotericin B, azoles ... Selectively masking the abluminal surface of a stent and then dipping or spraying the masked stent is a preferred method of ... 0054]Compounds comprising structure (2) at the 13-carbon position of the core taxane structure may function to alter the ... Rifampin is believed to inhibit bacterial DNA-dependent RNA polymerase activity and is bactericidal in nature. Rifampin is ...
  http://www.patentsencyclopedia.com/app/20090171453
*  Infections in Patients with Cancer - Holland-Frei Cancer Medicine - NCBI Bookshelf
Frequently, this has been attributed to the widespread use of broad-spectrum antibiotics. Bacteria that inhibit the growth of ... The new macrolides azithromycin, roxithromycin, and clarithromycin have activity against T. gondii, but sufficient clinical ... Although these organisms may be susceptible to amphotericin B, the azole compounds appear to be more effective therapeutic ... The human immunodeficiency virus (HIV) selectively ablates the T4 cell, which results in severe immune deficiency. Patients ...
  https://www.ncbi.nlm.nih.gov/books/NBK20904/
*  Antibacterials Lecture | Antimicrobial Resistance | Antibiotics
286:1181) 6. extended-spectrum macrolides and fluoroquinolones .7 million annual visits in the US Antibiotics were prescribed ... Chloramphenicol Binds to the 50 S ribosomal subunit Does not inhibit mammalian 80 S subunit Does inhibit mitochondrial 70 S ... RNA and DNA can continue . so protein and RNA synthesis continue Selectively blocking DNA synthesis is lethal Bacteriostatic if ... Mechanisms of Resistance Proteins modify and inactivate the compounds Resistance is additive Proteins are encoded on plasmids ...
  https://www.scribd.com/document/104609234/Antibacterials-Lecture
*  Pharmacology: Antibiotics Flashcards - Cram.com
Antibiotics at Cram.com. Quickly memorize the terms, phrases and much more. Cram.com makes it easy to get the grade you want! ... macrolides: mechanism of action bind 50-S ribosomal subunit --, inhibit bacterial protein synthesis ... microorgs more selectively inhibited than animal cells. - sulfonamide serves as a "false substrate" for PABA, which is used by ... aerobic bacteria lack reductive pathway needed to produce the cytotoxic compounds. bactericidal ...
  http://www.cram.com/flashcards/pharmacology-antibiotics-433344
*  Patent US6416548 - Antimicrobial annuloplasty ring having a biodegradable insert - Google Patents
... and other like compounds. The antibiotics used in accordance with this invention will generally be selected so as to have ... macrolides (e.g., erythromycin), penicilins (e.g., nafcillin), cephalosporins (e.g., cefazolin), other beta-lactam antibiotics ... Selectively flexible annuloplasty ring. US5263992. Oct 24, 1991. Nov 23, 1993. Bio-Metric Systems, Inc.. Biocompatible device ... To effectively inhibit biofilm bacterial growth, an antimicrobial agent should preferably penetrate the biofilm. To achieve ...
  http://www.google.com/patents/US6416548
*  Patent US5985890 - Rapamycin derivatives - Google Patents
... dihydro-rapamycin derivatives and 32-deoxo-rapamycin compounds. Rapamycin derivatives are disclosed of the formula: ##STR1## ... the compounds of formula I can be used in combination with other anti-infective agents, e.g., anti-viral drugs or antibiotics. ... the compounds of formula I, e.g. the compound of Example 1 or 2, inhibit myointimal proliferation when administered per os at a ... to re-oxidize selectively into carbonyl an undesired side reduction which may occur e.g. in position 9. ...
  http://www.google.com/patents/US5985890?dq=5920316
*  Bastion of Reason: Discussing the Nature and Future of Antibiotics - Part 1
Antibiotics are chemical substances that either inhibit the growth of or terminate bacteria. Typically antibiotics are ... Macrolides:. Macrolides are molecules with a macrolide ring and a standard construct of a linear molecule that later form a ... These compounds also provided effective core/lead compounds that could be slightly manipulated to produce new drugs, which had ... Similar to sulfonamide, trimethoprim selectively inhibits the dihydrofolic acid reductase of bacteria, which converts ...
  http://bastionofreason.blogspot.com/2013/12/discussing-nature-and-future-of.html
*  WO2011034768A1 - Integrated stent retrieval loop adapted for snare removal and/or optimized purse stringing - Google...
ACE) inhibitors including captropril and enalopril, statins and related compounds; and (oo) macrolides such as sirolimus or ... The stent may be selectively made radiopaque at desired areas along the wire or made be fully radiopaque, depending on the ... ii) DNA demethylating drugs such as 5-azacytidine, which is also categorized as a RNA or DNA metabolite that inhibit cell ... Other therapeutic agents include nitroglycerin, nitrous oxides, nitric oxides, antibiotics, aspirins, digitalis, estrogen, ...
  https://patents.google.com/patent/WO2011034768A1/en
*  Pharmacology
Macrolides (50S). Macrolide's are a group of bacteriostatic drugs with a wide spectrum of activity. Macrolide's inhibit ... Raetapamulin is the first clinically available member of a new class of antibiotics called pleuromutilins. These drugs inhibit ... Drugs that bind to physiological receptors and mimic the regulatory effects of the endogenous signaling compounds are termed ... It inhibits bacterial protein synthesis selectively, because it binds to the catalytic site of the transferase in the 50S ...
  http://www.tomhsiung.com/wordpress/category/pharmacology/
*  Methods and Compositions for the Disruption of Biofilms - Patent application
Compounds and compositions according to the invention can be used to prevent or inhibit the growth and proliferation of ... classes of antibiotics with known direct or indirect anti-inflammatory effects, including macrolides (e.g. azithromycin) and ... 0117]An antibody or antigen-binding fragment thereof useful in the present invention selectively binds to a protein and thereby ... along with other compounds, such as anti-microbial compounds, or administered concurrently with other such compounds by a ...
  http://www.patentsencyclopedia.com/app/20080199509