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*  Cytochrome P450 - Wikipedia
CYP27A1 (bile acid biosynthesis), CYP27B1 (vitamin D3 1-alpha hydroxylase, activates vitamin D3), CYP27C1 (unknown function) ... A subset of cytochrome P450 enzymes play important roles in the synthesis of steroid hormones (steroidogenesis) by the adrenals ... CYP4A11 metabolizes endogenous PUFAs to signaling molecules: it metabolizes AA to 20-HETE and EETs; it also hydroxylates DHA to ... found in the inner mitochondrial membrane of adrenal cortex has steroid 11β-hydroxylase, steroid 18-hydroxylase, and steroid 18 ...
  https://en.m.wikipedia.org/wiki/P450
*  Temporal changes of cytochrome P450 (Cyp) and eicosanoid-related gene expression in the rat brain after traumatic brain injury ...
Cyp17a1, the steroid 17alpha-hydroxylase/17,20-lyase, is one of the key enzymes in glucocorticoid, dehydroepiandrosterone, and ... Zou AP, Fleming JT, Falck JR, Jacobs ER, Gebremedhin D, Harder DR, Roman RJ: 20-HETE is an endogenous inhibitor of the large- ... Ellis EF, Police RJ, Rice LY, Grabeel M, Holt S: Increased plasma PGE2, 6-keto-PGF1 alpha, and 12-HETE levels following ... Camara NO, Martins JO, Landgraf RG, Jancar S: Emerging roles for eicosanoids in renal diseases. Curr Opin Nephrol Hypertens. ...
  https://bmcgenomics.biomedcentral.com/articles/10.1186/1471-2164-14-303
*  Ellagic Acid - DrugBank
Vitamin d 24-hydroxylase activity. Specific Function. Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver ... Steroid hydroxylase activity. Specific Function. Metabolizes several precarcinogens, drugs, and solvents to reactive ... Involved in the renal elimination of endogenous and exogenous organic anions. Functions as organic anion exchanger when the ... VanWert AL, Gionfriddo MR, Sweet DH: Organic anion transporters: discovery, pharmacology, regulation and roles in ...
  https://www.drugbank.ca/drugs/DB08846
*  Lecture - Endocrine Development - Embryology
Enzymes less commonly affected: 17alpha-hydroxylase/17,20-lyase and cholesterol desmolase. ... Alpha - glucagon, mobilizes lipid. * Beta - insulin, increase glucose uptake * Beta cells, stimulate fetal growth, continue to ... Alexander Griekspoor, Wilbert Zwart, Jacques Neefjes, Rob Michalides Visualizing the action of steroid hormone receptors in ... Leptin - polypeptide hormone produced in adipose and many other tissues with also many different roles ...
  https://embryology.med.unsw.edu.au/embryology/index.php/Lecture_-_Endocrine_Development
*  4 Information Related to Biologic Plausibility | Veterans and Agent Orange: Update 2008 | The National Academies Press
Journal of Steroid Biochemistry and Molecular Biology 105(1â 5):150â 158. Lu M, Wang H, Li XF, Lu X, Cullen WR, Arnold LL, ... Roles of cytosolic phospholipase A2 and Src kinase in the early ac- tion of 2,3,7,8-tetrachlorodibenzo-p-dioxin through a ... bHLH proteins are characterized by the presence of a string of basic amino acid residues followed by two alpha helices joined ... In one study, an antioxidant (N-acetylcysteine, vitamin C, or melatonin) and DMAV at 100 ppm were coadministered to F344 rats ...
  https://www.nap.edu/read/12662/chapter/6
*  Vitamin D Deficiency and Related Disorders: Practice Essentials, Background, Pathophysiology
... the minimal amount of vitamin D found in breast milk. In children, vitamin D deficiency can result in rickets, which presents ... Vitamin D deficiency can result from inadequate exposure to sunlight; malabsorption; accelerated catabolism from certain ... The second hydroxylation occurs in the kidney and is performed by the P450 enzyme 25-hydroxyvitamin D-1 alpha-hydroxylase. ... is the vitamin D content adequate to satisfy the dietary requirement for vitamin D?. J Steroid Biochem Mol Biol. 2007 Mar. 103( ...
  https://emedicine.medscape.com/article/128762-overview
*  Vitamin D, Sunlight and Prostate Cancer Risk
"Genistein inhibits vitamin D hydroxylases CYP24 and CYP27B1 expression in prostate cells," The Journal of Steroid Biochemistry ... T. C. Chen, "25-hydroxyvitamin D-1 alpha-hydroxylase (CYP27B1) is a new class of tumor suppressor in the prostate," Anticancer ... its serum concentrations may be correlated with total vitamin D levels from both endogenous production and dietary uptakes [20- ... Many angiogenic and proinflammatory regulators may play crucial roles in prostate tumorigenesis and progression [81-84]. It has ...
  https://www.hindawi.com/journals/apm/2011/281863/
*  Frontiers | The impact of vitamin D in breast cancer: genomics, pathways, metabolism | Physiology
In addition to receptors for classic steroid hormones such as estrogen and progesterone, the nuclear vitamin D receptor (VDR) ... In addition to receptors for classic steroid hormones such as estrogen and progesterone, the nuclear vitamin D receptor (VDR) ... Observational studies suggest that vitamin D deficiency is common in breast cancer patients and that low vitamin D status ... Observational studies suggest that vitamin D deficiency is common in breast cancer patients and that low vitamin D status ...
  https://www.frontiersin.org/articles/10.3389/fphys.2014.00213/full
*  Plus it
X receptor isotype identity directs human vitamin D receptor heterodimer transactivation from the 24-hydroxylase vitamin D ... Ueda A, Hamadeh HK, Webb HK, Yamamoto Y, Sueyoshi T, Afshari CA, Lehmann JM, and Negishi M (2002) Diverse roles of the nuclear ... Furthermore, endogenous expression levels of CAR are likely much less than those achieved in the transfection experiments ... Control of steroid, heme, and carcinogen metabolism by nuclear pregnane X receptor and constitutive androstane receptor. Proc ...
  http://dmd.aspetjournals.org/content/35/3/428
*  Anti-beta Actin antibody [mAbcam 8226] - Loading Control (ab8226) References
Yao L et al. Vitamin D attenuates hyperoxia-induced lung injury through downregulation of Toll-like receptor 4. Int J Mol Med ... Tumini E et al. Roles of human POLD1 and POLD3 in genome stability. Sci Rep 6:38873 (2016). PubMed: 27974823 ... Newman AJ et al. A New Method for Quantitative Immunoblotting of Endogenous a-Synuclein. PLoS One 8:e81314 (2013). WB ; Human ... Sinfield JK et al. p38 MAPK alpha mediates cytokine-induced IL-6 and MMP-3 expression in human cardiac fibroblasts. Biochem ...
  http://www.abcam.com/beta-actin-antibody-mabcam-8226-loading-control-ab8226-references.html
*  24R)-cholest-5-ene-3beta,24-diol,NADPH:oxygen oxidoreductase - WikiVisually
Cholesterol 7 alpha hydroxylase consists of 491 amino acids, which on folding forms 23 alpha helices and 26 beta sheets, ... 2. Vitamin C 3. Goats, like almost all animals, make their own vitamin C. An adult goat, weighing approx. 70 kg, will ... This steroid then makes its way throughout the cell, where it alters the permeability and rigidity of plasma membranes much as ... Regulation of the tone is one of the best known roles of NO in the cardiovascular system. CGMP, in turn, activates protein ...
  https://wikivisually.com/wiki/%2824R%29-cholest-5-ene-3beta%2C24-diol%2CNADPH%3Aoxygen_oxidoreductase
*  Cell proliferation, tumorogenicity, and apoptosis sub-cluster 19
1alpha-hydroxylase and 24R-hydroxylase, and their regulation by TGFbeta1. Basal 1alpha- and 24R-hydroxylase activities were ... Neurotrophins have definitive roles in the growth/maintenance of neuronal populations, but their function in malignant gliomas ... Circulating levels of the active form of vitamin D, 1,25-dihydroxyvitamin D3 (1,25-(OH)2D3) are dependent on activity of the ... The potential cytoprotective effects of the gonadal steroid estrogen, acting via its receptor (ER) on target neurons, are of ...
  http://www.biomedsearch.com/cluster/2/Cell-proliferation-tumorogenicity-and-apoptosis/sub-19-p15.html
*  JoVE | Peer Reviewed Scientific Video Journal - Methods and Protocols
Differential expression and regulation of vitamin D hydroxylases and inflammatory genes in prostate stroma and epithelium by 1, ... Our results suggest that BEP-CE is an endogenous ligand that activates the TLR4/SYK signaling pathway. Because BEP-CE is ... This study both illustrates the value of cell type-specific gene deletions in understanding the cellular roles of signal- ... catalytic subunit alpha, PI(3)K?) mutation. The patient was treated with the PI(3)K? inhibitor BYL719, which achieved a lasting ...
  https://www.jove.com/visualize?author=Dennis%20C%20Ko%20
*  Inflammation and vitamin D: the infection connection | SpringerLink
The influence of vitamin D deficiency on inflammation is being explored but studies have not demonstrated a... ... Haddad J, Vitamin D. Binding protein (Gc-globulin): multiple tasks. J Steroid Biochem Mol Biol. 1996;53(1-6):579-82.Google ... Jones G, Prosser DE, Kaufman M. 25-Hydroxyvitamin D-24-hydroxylase (CYP24A1): Its important role in the degradation of vitamin ... Evidence for extrarenal production of 1 alpha,25-dihydroxyvitamin D in man. J Clin Invest. 1982;69(3):722-5.PubMedPubMedCentral ...
  https://link.springer.com/article/10.1007/s00011-014-0755-z?wt_mc=Internal.Internal.8.CON426.jsc_a_bio3&utm_medium=internal&utm_source=internal&utm_content=jsc_a_bio3&utm_campaign=8_dto3312_jsc_a_bio3
*  A review of the serotonin transporter and prenatal cortisol in the development of autism spectrum disorders | SpringerLink
J Steroid Biochem Mol Biol. 2007, 104: 81-84. 10.1016/j.jsbmb.2006.10.006.PubMedGoogle Scholar ... The authors attributed these findings to low vitamin D levels or diet [254, 255]. These findings did not account for the ... Foley KF, Pantano C, Ciolino A, Mawe GM: IFN-gamma and TNF-alpha decrease serotonin transporter function and expression in ... You JS, Hu SY, Chen B, Zhang HG: Serotonin transporter and tryptophan hydroxylase gene polymorphisms in Chinese patients with ...
  https://link.springer.com/article/10.1186/2040-2392-4-37
*  The role of vitamin D in pulmonary disease: COPD, asthma, infection, and cancer | Respiratory Research | Full Text
The role of vitamin D (VitD) in calcium and bone homeostasis is well described. In the last years, it has been recognized that ... Sasaki J, Miyazaki A, Saito M, Adachi T, Mizoue K, Hanada K, et al: Transformation of vitamin D3 to 1 alpha,25-dihydroxyvitamin ... Sutherland ER, Goleva E, Jackson LP, Stevens AD, Leung DY: Vitamin D Levels, Lung Function and Steroid Response in Adult Asthma ... Genetic evidence that the human CYP2R1 enzyme is a key vitamin D 25-hydroxylase. Proc Natl Acad Sci USA. 2004, 101: 7711-7715. ...
  https://respiratory-research.biomedcentral.com/articles/10.1186/1465-9921-12-31
*  Protocols and Video Articles Authored by Leena Hilakivi-Clarke (Translated to Swedish)
... altered the endometrial expression of 25-hydroxylase, 1α-hydroxylase, and vitamin D receptor in the wild-type and Pten(+/-) ... estrogen receptor alpha (ER-alpha) or cyclin D1 mRNA or protein levels were seen. The mRNA and/or protein levels of BRCA1 and ... The Journal of Steroid Biochemistry and Molecular Biology. *Clinical Cancer Research : an Official Journal of the American ... and understanding their roles may be confounded by their ubiquitous expression and functional redundancy. We have proposed a ...
  https://www.jove.com/author/Leena_Hilakivi-Clarke?language=Swedish
*  3-methylcholanthrene: Topics by WorldWideScience.org
Consistent promoting effect was also observed in BP co-oxidation with adipic acid, ..cap alpha..-naphthoflavon, and vitamin E, ... The basal hydroxylase activity appears to be inherited differently from the aromatic hydrocarbon-inducible hydroxylase activity ... Seventeen laboratories collaborated in this study, and each chemical was tested by three to five laboratories. Comparison ... The expression of CYPs in neuronal and glial cells has suggested their possible association with the endogenous physiology of ...
  https://worldwidescience.org/topicpages/0-9/3-methylcholanthrene.html
*  Russell D. Fernald | Stanford Medicine Profiles
We measured mRNA levels of AR-alpha, AR-beta, ER-alpha, ER-betaa, and ER-betab, gonadotropin-releasing hormone 1 (GnRH1), and ... Further, steroid receptor mRNA levels were positively correlated with circulating steroid levels in males, but negatively ... 3 GONADOTROPIN-RELEASING-HORMONE GENES IN ONE ORGANISM SUGGEST NOVEL ROLES FOR AN ANCIENT PEPTIDE PROCEEDINGS OF THE NATIONAL ... Furthermore, we confirmed in vivo binding of endogenous Puralpha and Purbeta to the upstream region of the GnRH1 gene in A. ...
  https://med.stanford.edu/profiles/russell-fernald
*  Protein Enzyme Kinetics - Olis, Inc.
2009). Critical Roles of Subunit NuoH (ND1) in the Assembly of Peripheral Subunits with the Membrane Domain of Escherichia coli ... 2010). Kinetic Analysis of the Three-step Steroid Aromatase Reaction of Human Cytochrome P450 19A1.. JBC 285, 17734-17743. ... 2007). Interplay of Oxygen, Vitamin E, and Carotenoids in Radical Reactions Following Oxidation of Trp and Try Residues in ... 2000). Influences of Energinization and Nucleotide Binding on the Reaction of Lucifer Yellow Vinyl Sulfone with the alpha- ...
  http://olisweb.com/applications/protein-enzyme-kinetics/
*  Lose Weight By Controlling The Fat Storage Hormone - GUWS Medical
Vitamin B6 Has Several Roles in Metabolism Last Updated on Tue, 10 Mar 2015 , Amino Acids ... In addition, vitamin B6 is important in steroid hormone action where it removes the hormone-receptor complex from DNA binding, ... In the biosynthesis of Cortisol, three hydroxylases, the 17a-, the 21-, and the 11 3-hydroxylases, are required. The conversion ... Physiological Stimuli For Gh Release In Search Of An Endogenous Ligand For Gh Secretagogues Last Updated on Tue, 31 Mar 2015 , ...
  https://www.guwsmedical.info/fat-storage.html
*  IJMS | Free Full-Text | Coactivator Recruitment of AhR/ARNT1 | HTML
In this review, we focus on our recent findings related to the recruitment of steroid receptor coactivator 1 (SRC1/NCoA1) by ... An endogenous tumour-promoting ligand of the human aryl hydrocarbon receptor. Nature 2011, 478, 197-203. [Google Scholar] [ ... Steroid receptor coactivator-1 is a histone acetyltransferase. Nature 1997, 389, 194-198. [Google Scholar] [CrossRef] ... Labrecque, M.P.; Takhar, M.K.; Hollingshead, B.D.; Prefontaine, G.G.; Perdew, G.H.; Beischlag, T.V. Distinct roles for aryl ...
  http://mdpi.com/1422-0067/15/6/11100/htm
*  Dysbiosis of gut microbiota in promoting the development of colorectal cancer, Gastroenterology Report | 10.1093/gastro/gox031 ...
... vitamin biosynthesis, behavioral responses and protection from pathogens [15]. The majority of the endogenous bacteria in ... Multiple roles of toll-like receptor 4 in colorectal cancer. Front Immunol 2014; 5: 334. Google Scholar CrossRef Search ADS ... Bile acids, kinds of steroid acids found in the bile, facilitate cholesterol elimination in the liver and absorption of lipids ... Dietary fiber down-regulates colonic tumor necrosis factor alpha and nitric oxide production in trinitrobenzenesulfonic acid- ...
  https://www.deepdyve.com/lp/ou_press/dysbiosis-of-gut-microbiota-in-promoting-the-development-of-colorectal-AOVoNeNS0I
*  Vitamin D and diabetes | SpringerLink
Vitamin D deficiency predisposes individuals to type 1 and type 2 diabetes, and receptors for its activated form-1α,25- ... Liver 25-hydroxylases and kidney 1α-hydroxylase belong to the large family of cytochrome P450-dependent steroid hydroxylases [ ... Fu GK, Lin D, Zhang MY et al (1997) Cloning of human 25-hydroxyvitamin D-1 alpha-hydroxylase and mutations causing vitamin D- ... Haddad JG, Matsuoka LY, Hollis BW, Hu YZ, Wortsman J (1993) Human plasma transport of vitamin D after its endogenous synthesis ...
  https://link.springer.com/article/10.1007/s00125-005-1802-7
*  Download On The Way To The Web: The Secret History Of The Internet And Its Founders 2008
NoRC fully is download On the way to the Web: the secret history of the Internet and its IRE1 by resulting a alpha(1,4 near the ... Vitamin K catalyses marked from MEKK1 ligand-dependent books as effector and is catalyzed by beta s as responsible. These ... In a insulin glycoprotein of used region, glucosamine of misaligned books units the recycling of normal roles( Baker et al. ... relative download Enrico components, various as Ser114 and Ser633, and steroid transfer are here characterised found, but their ...
  http://fahrschule-schuster-wurzen.de/books/download-On-the-way-to-the-Web%3A-the-secret-history-of-the-Internet-and-its-founders-2008.php