*  HCV (Inhibitors Agonists Modulators Antagonists)-MedChemExpress.com
... whereas NS3 to NS5B are involved in a membrane-associated RNA replicase complex (RC). The NS3 protein is composed of a serine ... R-7128 is a nucleoside inhibitor of the HCV NS5B polymerase that acts as an RNA chain terminator and prevents elongation of RNA ... The HCV RNA-dependent RNA polymerase (RdRp) has long been a prime target for antiviral development because of its critical role ... ABT-333 is a nonnucleoside inhibitor of the RNA-dependent RNA polymerase encoded by the HCV NS5B gene, inhibits recombinant ...
  http://update.medchemexpress.com/Targets/HCV.html
*  RNA Replicase - RNA Dependent RNA Polymerase Summary | CureHunter Mobile
RNA Dependent RNA Polymerase; RNA-Directed RNA Polymerase; RNA Directed RNA Polymerase; RNA Polymerase, RNA-Dependent; RNA ... RNA Replicase (RNA Dependent RNA Polymerase) Summary Description: An enzyme that catalyses RNA-template-directed extension of ... Key Diseases for which RNA Replicase is Relevant. * Infection : 1 outcome 1 study in 56 results ... the 3'- end of an RNA strand by one nucleotide at a time, and can initiate a chain de novo. (Enzyme Nomenclature, 1992, p293). ...
  http://www.curehunter.com/m/keywordSummaryD012324.do
*  "THE ROLE OF TOMBUSVIRUS REPLICASE PROTEINS AND RNA IN REPLICASE ASSEMB" by Zivile Sliesaraviciute Panaviene
Further studies defined RNA motifs within two short DI RNA regions that enhanced active CNV replicase formation. In summary, ... To study the role of RNA during the assembly of functional tombusvirus replicase, recombinant CNV replicase that showed similar ... study showed that the conserved RNA binding motif of the tombusvirus replicase proteins and viral RNA are involved in replicase ... their associated DI RNAs, subgenomic (sg)RNA synthesis and DI RNA recombination in vivo. Experiments using a two-component ...
  https://uknowledge.uky.edu/gradschool_diss/435/
*  Origins of biological function in DNA and RNA hairpin loop motifs from replica exchange molecular dynamics simulation -...
In this article, we explore the possible conformations of DNA and RNA hairpins to better understand the fundamental differences ... RNA) have remarkably similar chemical structures, but despite this, they play significantly different roles in modern biology. ... Origins of biological function in DNA and RNA hairpin loop motifs from replica exchange molecular dynamics simulation ... Origins of biological function in DNA and RNA hairpin loop motifs from replica exchange molecular dynamics simulation J. B. ...
  http://pubs.rsc.org/en/content/articlelanding/2018/cp/c7cp06355e
*  Transgenic resistance in potato plants expressing potato leaf roll virus (PLRV) replicase gene sequences is RNA-mediated and...
... replicase gene sequences is RNA-mediated and suggests the involvement of post-transcriptional gene silencing, Archives of ... Transgenic resistance in potato plants expressing potato leaf roll virus (PLRV) replicase gene sequences is RNA-mediated and ... Transgenic resistance in potato plants expressing potato leaf roll virus (PLRV) replicase gene sequences is RNA-mediated and ... Transgenic resistance in potato plants expressing potato leaf roll virus (PLRV) replicase gene... Vazquez Rovere, C.; Asurmendi ...
  https://www.deepdyve.com/lp/springer_journal/transgenic-resistance-in-potato-plants-expressing-potato-leaf-roll-pIxgeN06sG
*  Table of Contents - July 01, 1966, 153 (3731) | Science
In Vitro Synthesis of an Infectious Mutant RNA with a Normal RNA Replicase ...
  http://science.sciencemag.org/content/153/3731
*  Infectious disease
RNA replicases nor reverse transcriptase, and the presence of these enzymes are characteristic of specific types of viral ...
  http://www.cs.mcgill.ca/~rwest/link-suggestion/wpcd_2008-09_augmented/wp/i/Infectious_disease.htm
*  Patent US6544730 - High density polymorphic genetic locus - Google Patents
RNA replicase-dependent amplification scheme that is unusual in that the probes, rather that the targets, are amplified ... RNA replicase (Lizardi and Kramer. 1991. TIB 9: 53-58), cycling probe reaction (CPR) (Duck et al. 1991. Biotechniques 9: 142- ... When two oligonucleotides differing by a single DNA base are supplied as primers in a reaction containing a single DNA or RNA ... The N-terminus corresponds to the 5′ end of a DNA or RNA strand. The binding characteristics of PNA/DNA facilitate the ...
  http://www.google.com.au/patents/US6544730
*  Transcription (biology) - Wikipedia
This process is catalyzed by a viral RNA replicase.[2]. Contents. *1 Background ... ribosomal RNA (rRNA), transfer RNA (tRNA), or other enzymatic RNA molecules called ribozymes.[1] Overall, RNA helps synthesize ... RNA synthesis by RNA polymerase was established in vitro by several laboratories by 1965; however, the RNA synthesized by these ... RNA sugar-phosphate backbone forms with assistance from RNA polymerase to form an RNA strand. ...
  https://en.wikipedia.org/wiki/Transcription_
*  Bacteriophage - Wikipedia
For RNA-based phages, RNA replicase is synthesized early in the process. Proteins modify the bacterial RNA polymerase so it ... "Complete nucleotide sequence of bacteriophage MS2 RNA: primary and secondary structure of the replicase gene". Nature. 260 ( ... RNA phage such as MS2 have the smallest genomes of only a few kilobases. However, some DNA phages such as T4 may have large ... Of these, only two families have RNA genomes, and only five families are surrounded by an envelope. Of the viral families with ...
  https://en.wikipedia.org/wiki/Phage
*  Transcription (biology) - Wikipedia
... ribosomal RNA (rRNA), transfer RNA (tRNA), or other enzymatic RNA molecules called ribozymes.[1] Overall, RNA helps synthesize ... RNA synthesis by RNA polymerase was established in vitro by several laboratories by 1965; however, the RNA synthesized by these ... RNA sugar-phosphate backbone forms with assistance from RNA polymerase to form an RNA strand. ... "Tentative identification of RNA-dependent RNA polymerases of dsRNA viruses and their relationship to positive strand RNA viral ...
  https://en.m.wikipedia.org/wiki/Transcription_
*  Archive - European
Specific gene suppression mediated by catalytic RNA: comparative analysis of different types of ribozymes and application ...
  http://www.imbb.forth.gr/en/achievements/research-grants/archive-research-grants/archive-european?start=100
*  Transcription (biology) - Wikipedia
This process is catalyzed by a viral RNA replicase. A DNA transcription unit encoding for a protein may contain both a coding ... RNA sugar-phosphate backbone forms with assistance from RNA polymerase to form an RNA strand. Hydrogen bonds of the RNA-DNA ... ribosomal RNA (rRNA), transfer RNA (tRNA), or other enzymatic RNA molecules called ribozymes. Overall, RNA helps synthesize, ... RNA synthesis by RNA polymerase was established in vitro by several laboratories by 1965; however, the RNA synthesized by these ...
  https://en.wikipedia.org/wiki/Transcription_(biology)
*  Jennifer Doudna - Wikipedia
Doudna, Jennifer Anne (1989). Towards the design of an RNA replicase (PhD thesis). Harvard University. OCLC 23230360. Pollack, ... This initial work to solve large RNA structures led to further structural studies on the IRES and protein-RNA complexes like ... The magnesium ions would cluster at the center of the ribozyme and would serve as a core for RNA folding similar to that of a ... Her Ph.D. thesis was on engineering a self-replicating catalytic RNA and was supervised by Jack W. Szostak. From 1989 to 1991, ...
  https://en.wikipedia.org/wiki/Jennifer_Doudna
*  The Synthesis of a Self-Propagating and Infectious Nucleic Acid with a Purified Enzyme (September 1965)
RNA Exhibit Category: RNA Replicase and Spiegelman's 'Little Monster,' 1961-1969 Box Number: 53. Folder Number: 4. Unique ...
  https://profiles.nlm.nih.gov/ps/retrieve/ResourceMetadata/PXBBCZ
*  Red clover necrotic mosaic virus translation enhancer elements - Wikipedia
RNA1 is required in replication as it encodes for RNA replicase components. This RNA contains structural elements within the 3 ... RCNMV contains a genome that encodes for two positive sense RNA strands known as RNA1 and RNA2 and both these RNA strands lack ... RNA. 7 (12): 1743-52. PMC 1370214 . PMID 11780631. Pfingsten JS, Kieft JS (July 2008). "RNA structure-based ribosome ... An, M; Iwakawa, HO; Mine, A; Kaido, M; Mise, K; Okuno, T (Sep 15, 2010). "A Y-shaped RNA structure in the 3' untranslated ...
  https://en.wikipedia.org/wiki/Red_clover_necrotic_mosaic_virus_translation_enhancer_elements
*  Disruption of the ER induces changes in the localizatio | Open-i
We used in situ hybridization to visualize the distribution of tobacco mosaic virus (TMV) viral RNA (vRNA) in infected tobacco ... TMV movement protein (MP) and replicase colocalized with vRNA, suggesting that viral replication and translation occur in the ... We used in situ hybridization to visualize the distribution of tobacco mosaic virus (TMV) viral RNA (vRNA) in infected tobacco ... TMV movement protein (MP) and replicase colocalized with vRNA, suggesting that viral replication and translation occur in the ...
  https://openi.nlm.nih.gov/detailedresult.php?img=PMC2169346_JCB9907022.f8&req=4
*  LIPID MAPS Lipidomics Gateway : Lipidomics Update
Regulation of the hepatitis C virus RNA replicase by endogenous lipid peroxidation. Nat Med. 2014 Aug;20(8):927-35. doi: ...
  http://lipidmaps.org/update/2017/171001/library.html
*  Piet Borst - Wikipedia
Bacteriophage RNA replicase keeps the template and daughter strand separated during RNA synthesis; duplex RNA is not an ... Borst P, Weissmann C. Replication of viral RNA, 8. Studies on the enzymatic mechanism of replication of MS2 RNA. Proc Natl Acad ... RNA splicing is required to make the messenger RNA for a variant surface antigen in trypanosomes. NAR. 1982;10:3591-604. Kooter ... 1977;80:360-4. Heyting C, Meijlink FC, Verbeet MP, Sanders JP, Bos JL, Borst P. Fine structure of the 21S ribosomal RNA region ...
  https://en.wikipedia.org/wiki/Piet_Borst
*  Inhibition of the binding activity of recombinant PB2 w | Open-i
RNA Replicase/chemistry/genetics/metabolism*. *Viral Proteins/chemistry/genetics/metabolism*. *Virus Replication* ... A novel functional site in the PB2 subunit of influenza A virus essential for acetyl-CoA interaction, RNA polymerase activity, ... A novel functional site in the PB2 subunit of influenza A virus essential for acetyl-CoA interaction, RNA polymerase activity, ... or of all 3 residues of the VRG site to alanine significantly reduced the binding ability of PB2 to acetyl-CoA and its RNA ...
  https://openi.nlm.nih.gov/detailedresult.php?img=PMC4155666_zbc0411495550004&req=4
*  New Agent Inhibits HCV Replication in Mouse Models-No Resistance Seen
Inhibition of hepatitis C virus (HCV) replication by specific RNA aptamers against HCV NS5B RNA replicase. J. Virol. June 2013 ... The researchers developed "RNA aptamers" which bind tightly to the part of that protein that performs the catalysis, disabling ... The target protein for the new agents is the NS5B replicase protein, which is the central catalytic enzyme in HCV replication. ... the replicase. Aptamers are short nucleic acids or peptides that provide the same level of recognition and binding ability that ...
  https://www.asm.org/index.php/asm-newsroom/journal-tip-sheets/88-news-room/journal-tipsheets/91691-new-agent-inhibits-hcv-replication-in-mouse-models-no-resistance-seen
*  Boolarra virus - Wikipedia
"Comparisons among the larger genome segments of six nodaviruses and their encoded RNA replicases". Journal of General Virology ... After comparing the RNA genome of this virus with that of other members of the Nodaviridae family, it was found to be different ... The Boolarra virus typically measures around 30 nano-meters and is approximately 21 percent RNA. Boolarra virus is ...
  https://en.wikipedia.org/wiki/Boolarra_virus
*  Ribozyme-catalysed RNA synthesis using triplet building blocks | eLife
... ribozymes can catalyse the copying of structured RNA sequences, allowing self-synthesis by part of a newly evolved symbiotic ... RNA replicase' ribozyme. RNA strands are made of four different letters attached to each other in a specific order. When RNA is ... Yet, although ribozymes can be made to copy straight RNA templates this way, folded RNA templates - including the replicase ... However, RNA catalysis is dependent upon RNA folding, and this yields structures that can block replication of such RNAs. To ...
  https://elifesciences.org/articles/35255
*  Induction of Plant Genes by Compatible and Incompatible Virus-Plant Interactions | Springer for Research & Development
Kumarasamy R, Symons RH (1979) Extensive purification of the cucumber mosaic virus-induced RNA replicase. Virology 96:622-632 ... Fraenkel-Conrat H (1983) RNA-dependent RNA polymerases of plants. Proc Natl Acad Sci USA 80:422-424PubMedCrossRefGoogle Scholar ... The cowpea mosaic virus RNA replication complex and the host-encoded RNA-dependent RNA polymerase-template complex are ... Characterization of the virus encoded subunit of turnip yellow mosaic virus RNA replicase. Virology 152:322-330PubMedCrossRef ...
  https://rd.springer.com/chapter/10.1007/978-3-642-74164-7_20
*  Black beetle virus - Wikipedia
B1 is used as the end terminal for RNA replicase, but the function is to totally clear. B2 is a separate unique protein which ... Because the virus only has 2 initial RNAs, this is the simplest class of virus. It should be noted that there is an RNA 3 that ... RNA1 sequence encodes for the virus' RNA-dependand RNA polymerase which is protein A. Thee virion also contains code for RNA2 ... Once in the cytoplasm, RNA is transcribed within envagininations of the host cell using its own RNA dependent polymerase. To ...
  https://en.wikipedia.org/wiki/Black_beetle_virus