*  Fuse-It-siRNA - ibidi
This is because the transferred siRNA is immediately incorporated into the RISC complex without the interfering processes of ... Small amount of siRNA is sufficient for effective knockdown. *Excellent biocompatibility because of low cytotoxicity ... Fusogenic Liposomes for Transferring RNA into Cells. *Controlling O2 in Physiological Experiments ...
  https://ibidi.com/fuse-it-membrane-fusion/198-fuse-it-sirna.html
*  Antitumor Activity of Small Interfering RNA/Cationic Liposome Complex in Mouse Models of Cancer | Clinical Cancer Research
Although the RNA interference effect, which is mediated by small interfering RNA (siRNA) or micro-RNA, has potential ... Small interfering RNAs (siRNAs), which are small double-stranded RNA (dsRNA) oligonucleotides with or without overhangs, are ... Small interfering RNA functions by binding to RNA-induced silencing complex in the cytosol, so that the delivery of siRNA ... Vickers TA, Koo S, Bennet CF, et al Efficient reduction of target RNAs by small interfering RNA and RNase H-dependent antisense ...
  http://clincancerres.aacrjournals.org/content/10/22/7721
*  OPUS 4 | Search
Small interfering RNAs (siRNAs) are now established as the preferred tool to inhibit gene function in mammalian cells yet ... The use of chemically synthesized short interfering RNAs (siRNAs) is currently the method of choice to manipulate gene ... that siRNA activity is primarily enhanced by favouring the incorporation of the intended antisense strand during RNA-induced ...
  http://publikationen.ub.uni-frankfurt.de/solrsearch/index/search/searchtype/authorsearch/author/Jyoti+Chattopadhyaya
*  Sirna Therapeutics - Venrock
Idun Pharmaceuticals lead the discovery of small molecule drugs that interfere with the programmed cell death processes for the ... Sirna Therapeutics focuses on developing therapeutics based on RNA interference (RNAi) technology. ... Private Healthcare, Therapeutics-Small Molecules Investment Status. Public (NASDAQ: IRWD) Year Funded. 1999. ... Memory Pharmaceuticals develops small molecule therapeutics for memory-related neurological diseases and for psychiatric ...
  http://www.venrock.com/investment/sirna-therapeutics/
*  nanoUDLA: DNA Computer Works in Human Cells
The system runs on a process called RNA interference (RNAi) in which small molecules of RNA prevent a gene from producing ... Cells produce what are known as short interfering RNA (siRNA) molecules, which recognize corresponding DNA sequences in genes ...
  http://nanoudla.blogspot.com/2007/09/dna-computer-works-in-human-cells.html
*  The time course of lipophilic siRNA accumulation in KB- | Open-i
RNA Interference*. *RNA, Small Interfering/chemical synthesis/chemistry*/metabolism. Minor. *Biological Transport ...
  https://openi.nlm.nih.gov/detailedresult.php?img=PMC3299988_gkr1002f3&req=4
*  Bio-inspired pulmonary surfactant-modified nanogels: a promising siRNA delivery system
DRUG-DELIVERY, EXOGENOUS SURFACTANT, LUNG, THERAPEUTICS, THERAPIES, SMALL-INTERFERING RNA, LOADED DEXTRAN NANOGELS, POLYMER ... SMALL-INTERFERING RNA,LOADED DEXTRAN NANOGELS,POLYMER HYBRID NANOPARTICLES,Targeted delivery,Pulmonary surfactant,siRNA ...
  https://biblio.ugent.be/publication/5993109
*  Rescue effect of siRNA-resistant form of GGTβ. A) Repr | Open-i
Inhibition or down-regulation of GGT using small interference RNA (siRNA) inhibited dendritic development of PCs. In contrast, ... Inhibition or down-regulation of GGT using small interference RNA (siRNA) inhibited dendritic development of PCs. In contrast, ... such as Rho family small GTPase Rac1, which has been shown to be involved in neuronal morphogenesis. Here we show that GGT ... such as Rho family small GTPase Rac1, which has been shown to be involved in neuronal morphogenesis. Here we show that GGT ...
  https://openi.nlm.nih.gov/detailedresult.php?img=PMC2902468_1756-6606-3-18-5&req=4
*  MISSION™ shRNA Library: Next Generation RNA Interference | China-Mainland | Sigma-Aldrich
Key rules and parameters for use of small interfering RNAs (siRNAs) less than 30 base pairs (bp) were developed that allow use ... Hannon, G.J., RNA Interference. Nature, 418, 244-251 (2002). *Elbashir, S.M., et al., Duplexes of 21-nucleotide RNAs mediate ... interfered with gene function. This discovery was called RNA interference or RNAi. ... The technology of RNA interference emerged in its earliest form following a 1998 study in Caenorhabditis elegans1 and has since ...
  https://www.sigmaaldrich.com/china-mainland/zh/technical-documents/articles/life-science-innovations/mission-shrna-library0.html
*  Small interfering RNA - Wikipedia
Small interfering RNA (siRNA), sometimes known as short interfering RNA or silencing RNA, is a class of double-stranded RNA ... Jensen, Kirsty; Anderson, Jennifer A.; Glass, Elizabeth J. (2014-04-15). "Comparison of small interfering RNA (siRNA) delivery ... Li LC (2008). "Small RNA-Mediated Gene Activation". RNA and the Regulation of Gene Expression: A Hidden Layer of Complexity. ... Dicer cuts the long dsRNA to form short interfering RNA or siRNA; this is what enables the molecules to form the RNA-Induced ...
  https://en.wikipedia.org/wiki/Small_interfering_RNA
*  Poly(Ester Amine)-Mediated, Aerosol-Delivered Akt1 Small Interfering RNA Suppresses Lung Tumorigenesis - Redorbit
Poly(ester amine) carrier may serve as an effective carrier, and aerosol delivery of Akt1 small interfering RNA may be a ... Poly(Ester Amine)-Mediated, Aerosol-Delivered Akt1 Small Interfering RNA Suppresses Lung Tumorigenesis. by Sam Savage ... were used for in vivo effects of aerosol-delivered Akt1 small interfering RNA (siRNA) in lung tumorigenesis. In K-ras^sup LA1^ ... To demonstrate the feasibility and emphasize the importance of noninvasive aerosol delivery of Akt1 small interfering RNA ( ...
  http://www.redorbit.com/news/health/1459846/polyester_aminemediated_aerosoldelivered_akt1_small_interfering_rna_suppresses_lung_tumorigenesis/
*  Testing Novel Compounds for Noninvasive Delivery of Small Interfering RNA into CNS | Parkinson's Disease
Small interfering RNA (siRNA) molecules have been successfully used to target specific genes in cell culture. However, the lack ... Testing Novel Compounds for Noninvasive Delivery of Small Interfering RNA into CNS. Rapid Response Innovation Awards, 2011. ... Gene expression can be specifically modulated by molecules named small interfering RNAs (siRNAs). Although siRNAs have emerged ... Recently, we have designed non-viral vectors that can deliver functional small interfering siRNAs specifically into cultured ...
  https://www.michaeljfox.org/foundation/grant-detail.php?grant_id=929
*  IJMS | Free Full-Text | Prevention of Tendon Adhesions by ERK2 Small Interfering RNAs | HTML
Using a chicken model, we have examined the effects of a small interfering RNA (siRNA) targeting ERK2 delivered by a lentiviral ... RNA interference (RNAi) is an evolutionarily conserved process in which cells employ small interfering RNA (siRNA) duplexes to ... Prevention of Tendon Adhesions by ERK2 Small Interfering RNAs. Hongjiang Ruan †, Shen Liu †, Fengfeng Li, Xujun Li and Cunyi ... Using a chicken model, we have examined the effects of a small interfering RNA (siRNA) targeting ERK2 delivered by a lentiviral ...
  http://www.mdpi.com/1422-0067/14/2/4361/htm
*  IJMS | Free Full-Text | Prevention of Tendon Adhesions by ERK2 Small Interfering RNAs | Notes
Using a chicken model, we have examined the effects of a small interfering RNA (siRNA) targeting ERK2 delivered by a lentiviral ... Small Regulatory RNAs in the Control of Motility and Biofilm Formation in E. coli and Salmonella ...
  http://www.mdpi.com/1422-0067/14/2/4361/notes
*  Combined Small Interfering RNA Therapy and In Vivo Magnetic Resonance Imaging in Islet Transplantation | Diabetes
Combined Small Interfering RNA Therapy and In Vivo Magnetic Resonance Imaging in Islet Transplantation. ... Combined Small Interfering RNA Therapy and In Vivo Magnetic Resonance Imaging in Islet Transplantation ... Combined Small Interfering RNA Therapy and In Vivo Magnetic Resonance Imaging in Islet Transplantation ... Combined Small Interfering RNA Therapy and In Vivo Magnetic Resonance Imaging in Islet Transplantation ...
  http://diabetes.diabetesjournals.org/content/60/2/565
*  Systematic coarse-grained modeling of complexation between small interfering RNA and polycations (Journal Article) | SciTech...
Here, we systematically develop such a model for the complexation of small interfering RNA (siRNA) and grafted ... Journal Article: Systematic coarse-grained modeling of complexation between small interfering RNA and polycations ... Title: Systematic coarse-grained modeling of complexation between small interfering RNA and polycations ...
  https://www.osti.gov/scitech/biblio/22493384-systematic-coarse-grained-modeling-complexation-between-small-interfering-rna-polycations
*  Inhibition of HIV-1 Infection by Small Interfering RNA-Mediated RNA Interference | The Journal of Immunology
Inhibition of HIV-1 Infection by Small Interfering RNA-Mediated RNA Interference. John Capodici, Katalin Karikó and Drew ... Inhibition of HIV-1 Infection by Small Interfering RNA-Mediated RNA Interference ... Inhibition of HIV-1 Infection by Small Interfering RNA-Mediated RNA Interference ... Inhibition of HIV-1 Infection by Small Interfering RNA-Mediated RNA Interference ...
  http://www.jimmunol.org/content/169/9/5196
*  Characterization and evaluation of amphipathic, cationic peptides for small interfering RNA delivery
... ... Baoling Chen (2015). Characterization and evaluation of amphipathic, cationic peptides for small interfering RNA delivery. ... which can be triggered by small interfering RNA. The efficiency and specificity of this process makes siRNA a powerful tool for ... In the human non-small cell lung tumor xenograft model, the STR-HK-siRNA complexes induced the highest tumor inhibition rate ( ...
  https://uwspace.uwaterloo.ca/handle/10012/9447
*  A Theranostic Small Interfering RNA Nanoprobe Protects Pancreatic Islet Grafts From Adoptively Transferred Immune Rejection |...
Combined small interfering RNA therapy and in vivo magnetic resonance imaging in islet transplantation. Diabetes 2011;60:565- ... A Theranostic Small Interfering RNA Nanoprobe Protects Pancreatic Islet Grafts From Adoptively Transferred Immune Rejection. ... A Theranostic Small Interfering RNA Nanoprobe Protects Pancreatic Islet Grafts From Adoptively Transferred Immune Rejection ... Here, we used a dual-purpose therapy/imaging small interfering (si)RNA magnetic nanoparticle (MN) probe that targets β2 ...
  http://diabetes.diabetesjournals.org/content/61/12/3247
*  Oral History | CSHL | Research | Ron Plasterk on Small Interfering RNAs
Actually I think that at the core of it more important that double-stranded RNA are the small interfering RNAs - the SiRNAs - ... Small Interfering RNAs (Ron Plasterk) Then use your browser's back button to return ... these small RNAs that were made by the dicer-protein so you have long double stranded RNA which is diced by these dicer-RNAs ... RNA Induced Silencing Complex - and that can find the messenger RNA and base pair to it. And if it base pairs to it ...
  http://library.cshl.edu/oralhistory/interview/cshl/research/small-interfering-rnas/
*  Chemical Modification Patterns Compatible with High Potency Dicer-Substrate Small Interfering RNAs
Dicer-substrate small interfering RNAs (DsiRNAs) are synthetic RNA duplexes that are processed by Dicer into 21-mer species and ... O-methyl RNA, phosphorothioates and small interfering RNA. Nucleic Acids Res. 2003;31:3185-3193. [PMC free article] [PubMed] ... called small interfering RNAs (siRNAs), are the actual molecular triggers of RNAi and direct target specificity of the RNA- ... and structural variation of small interfering RNAs and short hairpin RNAs and the effect on mammalian gene silencing. Antisense ...
  http://pubmedcentralcanada.ca/pmcc/articles/PMC2582043/
*  Evaluation of locked nucleic acid-modified small interfering RNA in vitro and in vivo | Molecular Cancer Therapeutics
RNA interference has become widely used as an experimental tool to study gene function. In addition, small interfering RNA ( ... ATP requirements and small interfering RNA structure in the RNA interference pathway. Cell 2001;107:309-21. ... Sequence, chemical, and structural variation of small interfering RNAs and short hairpin RNAs and the effect on mammalian gene ... Evaluation of locked nucleic acid-modified small interfering RNA in vitro and in vivo. Olaf R. Mook, Frank Baas, Marit B. de ...
  http://mct.aacrjournals.org/content/6/3/833.long
*  Kallikrein gene 'knock-down' by small interfering RNA transfection induces a profibrotic phenotype in rat mesangial cells.
RNA, Messenger / antagonists & inhibitors, genetics. RNA, Small Interfering / pharmacology*. Rats. Rats, Wistar. Receptor, ... 0/Culture Media, Conditioned; 0/Fibronectins; 0/LDL-Receptor Related Protein 1; 0/RNA, Messenger; 0/RNA, Small Interfering; 0/ ... its expression using specific small interfering RNAs (siRNA). METHODS: Rat mesangial cells were treated with 12, 60, 120 nmol/l ...
  http://www.biomedsearch.com/nih/Kallikrein-gene-knock-down-by/18090545.html
*  Safety and Efficacy Study of Small Interfering RNA Molecule (Cand5) to Treat Diabetic Macular Edema - Full Text View -...
Cand5 is a small interfering RNA molecule that selectively silences the mRNA encoding for VEGF. The target population are ... Safety and Efficacy Study of Small Interfering RNA Molecule (Cand5) to Treat Diabetic Macular Edema. This study has been ... The molecule is a duplex formed by the hybridization of two partially complementary single strand RNAs in which the 3' end are ... Cand5 is a synthetic double stranded RNA (dsRNA) oligonucleotide. ...
  https://clinicaltrials.gov/ct2/show/NCT00306904
*  PREventing Progression of Adipose Tissue Redistribution - Tabular View - ClinicalTrials.gov
Plasma HIV-1 RNA levels , 50 copies/mL for at least 6 months at screening. Isolated measurements of plasma HIV-1 RNA levels ... In this study we therefore aim to demonstrate a small but statistically significant mean increase in peripheral body fat in the ... Patients with malabsorption syndrome or other gastrointestinal dysfunction which may interfere with drug absorption or prevent ... proportion of patients with plasma HIV-1 RNA concentrations , 50 copies/mL after 48 weeks and proportion of patients that ...
  https://clinicaltrials.gov/ct2/show/record/NCT00389194