*  Autoantibodies and genetic variation in rheumatoid arthritis : aspects on susceptibility and disease course - OpenThesis
RIIIA genotype is likely to affect RA susceptibility and further work should apply a gender perspective. Inflammasome genetics ... Autoantibodies and genetic variation in rheumatoid arthritis : aspects on susceptibility and disease course. by Kastbom, Alf ... Rheumatoid arthritis (RA) is an autoimmune disease characterized by chronic inflammation and subsequent destruction of synovial ... Rheumatoid arthritis; autoantibodies; single-nucleotide polymorphisms; disease course ...
  http://www.openthesis.org/documents/Autoantibodies-genetic-variation-in-rheumatoid-423655.html
*  KIR2DS1 - Wikipedia
"Associations of killer cell immunoglobulin-like receptor genes with complications of rheumatoid arthritis". Genes and Immunity ... Zhang HQ, Zhao JJ, Zhao YR, Guan QB, Gao L, Song HD (August 2009). "[Genotype analysis of killer cell immunoglobulin-like ... Journal of Applied Genetics. 50 (4): 391-8. PMID 19875891. Majorczyk E, Pawlik A, Łuszczek W, Nowak I, Wiśniewski A, Jasek M, ... "Killer cell immunoglobulin-like receptor gene-cluster 3DS1-2DL5-2DS1-2DS5 predisposes susceptibility to Vogt-Koyanagi-Harada ...
  https://en.wikipedia.org/wiki/KIR2DS1
*  Genetic Variations in the NLRP3 Inflammasome : Susceptibility Factor for Chronic Inflammation
Disease course, Genetics, Inflammasome, Rheumatoid arthritis National Category Medical and Health Sciences Identifiers. urn:nbn ... Methods: Genotype frequencies were assessed in 174 Swedish patientswith early RA and 360 population-based controls without ... 2. Genetic variation in proteins of the cryopyrin inflammasome influences susceptibility and severity of rheumatoid arthritis ( ... Genetic variation in proteins of the cryopyrin inflammasome influences susceptibility and severity of rheumatoid arthritis (the ...
  http://liu.diva-portal.org/smash/record.jsf?pid=diva2:435304
*  Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls | Nature
An approach to understanding the molecular genetics of susceptibility to rheumatoid arthritis. . Arthritis Rheum. 30, 1205-1213 ... 1 in coronary artery disease, 9 in Crohn's disease, 3 in rheumatoid arthritis, 7 in type 1 diabetes and 3 in type 2 diabetes. ... Inference of population structure using multilocus genotype data: linked loci and correlated allele frequencies. . Genetics 164 ... Rheumatoid Arthritis *Anne Barton*, The Biologics in RA Genetics and Genomics (BRAGGS)*, Ian N. Bruce*, Hannah Donovan*, Steve ...
  http://www.nature.com/articles/nature05911?error=cookies_not_supported&code=447da94f-a4c5-4349-a407-ddb4cda51bcc
*  Genetic basis of tissue specificity of vasculitis in MRL/lpr mice - Yamada - 2003 - Arthritis & Rheumatology - Wiley Online...
In previous studies of the genetics of vasculitis in MRL/lpr mice (6, 7), we identified 2 distinct recessive susceptibility ... Next article in issue: CD25+ cell depletion hastens the onset of severe disease in collagen-induced arthritis Next article in ... rheumatoid arthritis, and Sjögren's syndrome (2). Vasculitic lesions in these diseases show variation in tissue distribution, ... Genotype analysis.. The genotypes of F2 intercross mice (MRL/MRL, MRL/C3H, and C3H/C3H) were determined by polymerase chain ...
  http://onlinelibrary.wiley.com/doi/10.1002/art.10952/full
*  rs2104286 - SNPedia
Rheumatoid arthritis Title Novel rheumatoid arthritis susceptibility locus at 22q12 identified in an extended UK genome-wide ... Multiple sclerosis susceptibility-associated SNPs do not influence disease severity measures in a cohort of Australian MS ... Genotype data for SNP rs2104286 for controls was combined with the data for that SNP obtained from a genome-wide association ... The complex genetics of multiple sclerosis: pitfalls and prospects. [PMID 18565446. ] Refining genetic associations in multiple ...
  https://www.snpedia.com/index.php/Rs2104286
*  CNstream: A method for the identification and genotyping of copy number polymorphisms using Illumina microarrays | BMC...
KLF12 as a risk locus for rheumatoid arthritis susceptibility. Arthritis & Rheumatism 2008, 588(8):2275-2286.View ArticleGoogle ... Population Analysis of Large Copy Number Variants and Hotspots of Human Genetic Disease. The American Journal of Human Genetics ... A similar trend was found in the Illumina genotype data and a reference Hapmap dataset (Figure 8). Comparing the results of ... Gaussian Mixture ModelRheumatoid Arthritis SusceptibilityCopy Number StateCircular Binary SegmentationCopy Number Polymorphism ...
  https://bmcbioinformatics.biomedcentral.com/articles/10.1186/1471-2105-11-264
*  A polymorphic variant in the MHC2TA gene is not associated with systemic lupus erythematosus
Alleles, Case-Control Studies, Female, Genetic Predisposition to Disease, Genotype, Histocompatibility Antigens Class II, ... rheumatoid arthritis, and myocardial infarction in the Swedish population. We used a case-control approach to investigate the ... Myocardial Infarction/genetics, Nuclear Proteins/*genetics, Polymorphism, Single Nucleotide, Sweden, Trans-Activators/*genetics ... This particular polymorphism rs3087456 of the MHC2TA gene does not appear to influence genetic susceptibility to SLE in the ...
  http://uu.diva-portal.org/smash/record.jsf?pid=diva2:41422
*  Dienekes' Anthropology Blog: 02/2007
American Journal of Human Genetics (in press). Measuring European Population Stratification using Microarray Genotype Data. ... The results will enable studies of type 2 diabetes, rheumatoid arthritis and other diseases where epidemiological studies ... We are seeing the impact of this mismatch in the explosion of diabetes, heart disease and obesity. But it also has consequences ... suggest differences in the distribution of ancestry associated susceptibility.. Link. No comments: ...
  http://dienekes.blogspot.com/2007_02_01_archive.html?m=1
*  An X chromosome-wide association analysis identifies variants in GPR174 as a risk factor for Graves' disease | Journal of...
Analysis of skewed X-chromosome inactivation in females with rheumatoid arthritis and autoimmune thyroid diseases. Arthritis ... disease; the two methods gave consistent results, both showing that GPR174 was associated with disease susceptibility. ... Therefore, the genotype distributions of rs3827440 explain little of the difference in Graves' disease prevalence between males ... International Consortium for the Genetics of Autoimmune Thyroid Disease. J Clin Endocrinol Metab 1998;83:3290-5. ...
  http://jmg.bmj.com/content/50/7/479
*  Why, Oh Y? | The Scientist Magazine®
Autoimmune diseases such as rheumatoid arthritis and lupus, for example, are more common among women, while autism spectrum ... pairs that exist in different copies on the X and the Y chromosomes that may explain sex differences in disease susceptibility. ... But in a 2013 Nature Genetics paper, Page and colleagues found that even in the absence of meiosis, mouse ovarian germ cells ... And if the iso-Y is lost, what would remain is an XO genotype-typically associated with Turner syndrome, a developmental ...
  https://www.the-scientist.com/?articles.view/articleNo/41689/title/Why--Oh-Y-/
*  Plus it
... such as celiac disease, rheumatoid arthritis, and autoimmune thyroid disease (AITD). It is also known that some of these ... Biologics in RA Genetics and Genomics Study Syndicate (BRAGGS) Steering Committee, ; Breast Cancer Susceptibility Collaboration ... as disease association can cause genotype frequencies to deviate in affected offspring families. ... Genetic susceptibility to autoimmune thyroid disease: past, present, and future. Thyroid 2010;20:715-725pmid:20604685. ...
  http://care.diabetesjournals.org/content/38/Supplement_2/S8
*  P676. Primary response to infliximab in Crohn's disease is associated with the TNFRSF1A rs1800693 gene polymorphism
In IBD, rheumatoid arthritis (RA) and psoriasis infliximab (IFX) shows good efficacy, however in multiple sclerosis (MS) ... The TNFRSF1A gene has been implicated in susceptibility to MS but not to Crohn's disease (CD), RA or psoriasis. Recent data ... Genotype. Allele. Genotype. G. AA. AG. GG. G. AA. AG. GG. Responders. 38%. 211 (38%). 269 (48%). 78 (14%). 43%. 55 (32%). 88 ( ... HomePublicationsCongress AbstractsAbstracts 2013Poster presentations: Genetics (2013)P676. Primary response to infliximab in ...
  https://www.ecco-ibd.eu/publications/congress-abstract-s/abstracts-2013/item/p676-primary-response-to-infliximab-in-crohn-s-disease-is-associated-with-the-tnfrsf1a-rs1800693-gene-polymorphism.html
*  Genome-wide complex trait analysis - Wikipedia
... celiac disease: 0.33(0.042) Macular degeneration: 0.242(0.029), 0.36(0.016) Arthritis: 0.11(0.031), 0.57(0.06), 0.098(0.014), ... rheumatoid arthritis, systemic lupus erythematosus, systemic sclerosis, ankylosing spondylitis): 0.2(0.048) T-cell mediated ... "The Evolutionary Genetics of Personality", Penke et al 2007; "The Evolutionary Genetics of Personality Revisited", Penke & ... Simulate GWAS data based upon the observed genotype data; Convert Illumina raw genotype data into PLINK format; Conditional & ...
  https://en.wikipedia.org/wiki/Genome-wide_complex_trait_analysis
*  Overview of MMP Biology and Gene Associations in Human Diseases | IntechOpen
40 - Ye S. Influence of matrix metalloproteinase genotype on cardiovascular disease susceptibility and outcome. Cardiovascular ... and rheumatoid arthritis [34]. MMP-28 overexpression up-regulated MT-MMP1 and MMP-9 in A549 lung adenocarcinoma cells [35]. ... Genetics of MMPs in brain disease. In the central nervous system, MMPs have an important role and may influence proteolysis of ... but not with susceptibility to coronary heart disease [100, 102]. The 6A/6A genotype was associated with greater progression of ...
  https://www.intechopen.com/books/the-role-of-matrix-metalloproteinase-in-human-body-pathologies/overview-of-mmp-biology-and-gene-associations-in-human-diseases/
*  Tenascin X - Wikipedia
"Genetic association of the major histocompatibility complex with rheumatoid arthritis implicates two non-DRB1 loci". Arthritis ... 2009). "Association of MHC SNP genotype with susceptibility to type 1 diabetes: a modified survival approach". Diabetes Obes ... Yu CY (1998). "Molecular genetics of the human MHC complement gene cluster". Exp. Clin. Immunogenet. 15 (4): 213-30. doi: ... 2009). "Transcriptomic and genetic studies identify IL-33 as a candidate gene for Alzheimer's disease". Mol. Psychiatry. 14 (11 ...
  https://en.wikipedia.org/wiki/Tenascin_X
*  Azathioprine - Wikipedia
It is used in rheumatoid arthritis, Crohn's disease, ulcerative colitis, and in kidney transplants to prevent rejection. It is ... September 2014). "A common missense variant in NUDT15 confers susceptibility to thiopurine-induced leukopenia". Nature Genetics ... "Clinical Pharmacogenetics Implementation Consortium guidelines for thiopurine methyltransferase genotype and thiopurine dosing ... including rheumatoid arthritis, pemphigus, systemic lupus erythematosus, Behçet's disease, and other forms of vasculitis, ...
  https://en.wikipedia.org/wiki/Azathioprine
*  PTPN22 Trp620 Explains the Association of Chromosome 1p13 With Type 1 Diabetes and Shows a Statistical Interaction With HLA...
We cannot comment on the validity of additional variants in rheumatoid arthritis and Graves' disease (22,24,28), except that ... The heterogeneity of rs2476601/Trp620 disease risk by HLA class II genotype is consistent with previous studies, and the joint ... could have a role in disease susceptibility, as it is not known how many more SNPs are in the region because the entire linkage ... and the Department of Medical Genetics, Cambridge Institute for Medical Research, University of Cambridge. Most affected ...
  http://diabetes.diabetesjournals.org/content/57/6/1730.long?patientinform-links=yes&legid=diabetes
*  The F158V polymorphism in FcγRIIIA shows disparate associations with rheumatoid arthritis in two genetically distinct...
... is the true disease susceptibility locus. Incomplete linkage disequilibrium between the 158FV polymorphism and the actual RA ... Distribution of the genotype frequencies of the FcγRIIIA 158F/V polymorphism among the patients with RA and controls in the ... Dr A Milicic, Wellcome Trust Centre for Human Genetics, Headington, Oxford, UK;. anitam{at}well.ox.ac.uk ... Involvement of Fcγreceptor IIIA genotypes in susceptibility to rheumatoid arthritis. Arthritis Rheum2000;43:735-9. ...
  http://ard.bmj.com/content/61/11/1021
*  Dag Erik Undlien - Institute of Clinical Medicine
... including rheumatoid arthritis (RA). Recently, an intronic SNP rs8048002 has been suggested as a better susceptibility marker ... association of the 1858T-allele with Addison's disease. European Journal of Human Genetics. ISSN 1018-4813. 16(8), s 977- 982 ... Results: The rs3087456 GG genotype was significantly associated with RA in a recessive model, both in our material (OR 1.50 [95 ... to confer susceptibility to autoimmune thyroid disease and type 1 diabetes also confer susceptibility to Addison's disease. ...
  http://www.med.uio.no/klinmed/english/people/aca/dagerik/index.html
*  rs1570360 - SNPedia
PMID 21388351] Vascular endothelial growth factor A and cardiovascular disease in rheumatoid arthritis patients. ... Further evidence for the contribution of the vascular endothelial growth factor gene in coronary artery disease susceptibility ... Human genetics of diabetic retinopathy: current perspectives. [PMID 21080079] Gene polymorphism of vascular endothelial growth ... PMID 20132989] Phenotype and Genotype Characteristics of Age-related Macular Degeneration in a Japanese Population ...
  https://www.snpedia.com/index.php/Rs1570360
*  Polymorphism | Postgraduate Medical Journal
... levels and rheumatoid arthritis, and between MIF gene polymorphisms and disease susceptibility: a meta-analysis Sang-Cheol Bae ... The ID genotype of MDM2 40 bp insertion/deletion polymorphism was associated with lower risk of SLE Saeedeh Salimi, Mahnaz ... between circulating IL-17 levels and rheumatoid arthritis and between IL-17 gene polymorphisms and disease susceptibility: a ... Association between the autophagy-related gene ULK1 and ankylosing spondylitis susceptibility in the Chinese Han population: a ...
  http://pmj.bmj.com/taxonomy/term/4794
*  horse Archives | Omega Fields
We get a break when examining specifically for arthritis: it is a disease that's centered in the joints, which narrows down ... Of the autoimmune diseases linked to vitamin D deficiency, these include type I diabetes mellitus, Crohn's disease, rheumatoid ... Even within ponies, there does appear to be a decided link to genetics. In a study examining the pedigrees of an inbred herd of ... Their comparatively thrifty genotype may make their utilization of carbohydrates and insulin sensitivity differ from breeds ...
  https://www.omegafields.com/blog/tag/horse/
*  CARD15 Gene Variants and Risk of Reoperation in Crohn's Disease Patients
... juvenile idiopathic arthritis, rheumatoid arthritis or psoriatic arthritis. ... Genetics versus environment in inflammatory bowel disease: Results of a British twin study. Thompson, Nick P.; Driscoll, ... in A Dutch Study Sample Identifies More Ulcerative Colitis Susceptibility Loci and Shows Their Additive Role in Disease Risk. ... This finding does not justify more aggressive prophylactic therapy on the basis of CARD15 genotype. ...
  http://connection.ebscohost.com/c/articles/44461528/card15-gene-variants-risk-reoperation-crohns-disease-patients
*  Books - Lane Medical Library - Stanford University School of Medicine
Disease-Modifying Antirheumatic Drug Use in Older Rheumatoid Arthritis Patients / Sogol S. Amjadi, Veena K. Ranganath and ... Core concepts in human genetics : understanding the complex phenotype of sport performance and susceptibility to sport injury ... Our approach of combining both expression and genotype data can be applied to any phenotype of interest to increase the power ... With chapters dedicated to cardiovascular disease, oncology, inflammatory disease, metabolic disease, neuropsychiatric disease ...
  http://lane.stanford.edu/biomed-resources/eb.html?a=g&page=2&proxy-links=false