Autoantibodies and genetic variation in rheumatoid arthritis : aspects on susceptibility and disease course - OpenThesis
RIIIA genotype is likely to affect RA susceptibility and further work should apply a gender perspective. Inflammasome genetics ... Autoantibodies and genetic variation in rheumatoid arthritis : aspects on susceptibility and disease course. by Kastbom, Alf ... Rheumatoid arthritis (RA) is an autoimmune disease characterized by chronic inflammation and subsequent destruction of synovial ... Rheumatoid arthritis; autoantibodies; single-nucleotide polymorphisms; disease course ...http://www.openthesis.org/documents/Autoantibodies-genetic-variation-in-rheumatoid-423655.html
Research Career Development Fellowships: people we've funded | Wellcome
Linking genotype to phenotype for the rheumatoid arthritis susceptibility locus 6q23: beyond genome-wide association studies ... Statistical methods for understanding the genetics of human disease phenotypes. Chris is a statistical geneticist who has ... More recently he has focused on understanding the host genetics of severe malaria susceptibility as part of the MalariaGEN ... genetics techniques and behavioural experiments. Her aim is to offer new insight into brain function in both health and disease ...https://wellcome.ac.uk/what-we-do/directories/research-career-development-fellowships-people-funded
A new classification of HLA-DRB1 alleles differentiates predisposing and protective alleles for autoantibody production in...
An approach to understanding the molecular genetics of susceptibility to rheumatoid arthritis . Arthritis Rheum 1987 , 30 : ... Impact of shared epitope genotype and ethnicity on erosive disease: a meta-analysis of 3,240 rheumatoid arthritis patients . ... Seldin MF , Amos CI , Ward R , Gregersen PK : The genetics revolution and the assault on rheumatoid arthritis . Arthritis Rheum ... Rheumatoid factor-positive Rheumatoid factor-negative Rheumatoid factor-positive Rheumatoid factor-negative Rheumatoid factor- ...http://paperity.org/p/58834099/a-new-classification-of-hla-drb1-alleles-differentiates-predisposing-and-protective
KIR2DS1 - Wikipedia
"Associations of killer cell immunoglobulin-like receptor genes with complications of rheumatoid arthritis". Genes and Immunity ... Zhang HQ, Zhao JJ, Zhao YR, Guan QB, Gao L, Song HD (August 2009). "[Genotype analysis of killer cell immunoglobulin-like ... Journal of Applied Genetics. 50 (4): 391-8. PMID 19875891. Majorczyk E, Pawlik A, Łuszczek W, Nowak I, Wiśniewski A, Jasek M, ... "Killer cell immunoglobulin-like receptor gene-cluster 3DS1-2DL5-2DS1-2DS5 predisposes susceptibility to Vogt-Koyanagi-Harada ...https://en.wikipedia.org/wiki/KIR2DS1
Genetic Variations in the NLRP3 Inflammasome : Susceptibility Factor for Chronic Inflammation
Disease course, Genetics, Inflammasome, Rheumatoid arthritis National Category Medical and Health Sciences Identifiers. urn:nbn ... Methods: Genotype frequencies were assessed in 174 Swedish patientswith early RA and 360 population-based controls without ... 2. Genetic variation in proteins of the cryopyrin inflammasome influences susceptibility and severity of rheumatoid arthritis ( ... Genetic variation in proteins of the cryopyrin inflammasome influences susceptibility and severity of rheumatoid arthritis (the ...http://liu.diva-portal.org/smash/record.jsf?pid=diva2:435304
Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls | Nature
An approach to understanding the molecular genetics of susceptibility to rheumatoid arthritis. . Arthritis Rheum. 30, 1205-1213 ... 1 in coronary artery disease, 9 in Crohn's disease, 3 in rheumatoid arthritis, 7 in type 1 diabetes and 3 in type 2 diabetes. ... Inference of population structure using multilocus genotype data: linked loci and correlated allele frequencies. . Genetics 164 ... Rheumatoid Arthritis *Anne Barton*, The Biologics in RA Genetics and Genomics (BRAGGS)*, Ian N. Bruce*, Hannah Donovan*, Steve ...http://www.nature.com/articles/nature05911?error=cookies_not_supported&code=447da94f-a4c5-4349-a407-ddb4cda51bcc
Genetic basis of tissue specificity of vasculitis in MRL/lpr mice - Yamada - 2003 - Arthritis & Rheumatology - Wiley Online...
In previous studies of the genetics of vasculitis in MRL/lpr mice (6, 7), we identified 2 distinct recessive susceptibility ... Next article in issue: CD25+ cell depletion hastens the onset of severe disease in collagen-induced arthritis Next article in ... rheumatoid arthritis, and Sjögren's syndrome (2). Vasculitic lesions in these diseases show variation in tissue distribution, ... Genotype analysis.. The genotypes of F2 intercross mice (MRL/MRL, MRL/C3H, and C3H/C3H) were determined by polymerase chain ...http://onlinelibrary.wiley.com/doi/10.1002/art.10952/full
rs2104286 - SNPedia
Rheumatoid arthritis Title Novel rheumatoid arthritis susceptibility locus at 22q12 identified in an extended UK genome-wide ... Multiple sclerosis susceptibility-associated SNPs do not influence disease severity measures in a cohort of Australian MS ... Genotype data for SNP rs2104286 for controls was combined with the data for that SNP obtained from a genome-wide association ... The complex genetics of multiple sclerosis: pitfalls and prospects. [PMID 18565446. ] Refining genetic associations in multiple ...https://www.snpedia.com/index.php/Rs2104286
SOD1 Gene +35A/C (exon3/intron3) Polymorphism in Type 2 Diabetes Mellitus among South Indian Population
Open Access journal that publishes original research articles as well as review articles in all areas of genetics and genomics ... Absence of mutant genotype (CC) shows that the Cu/Zn SOD gene polymorphism may not be associated with the susceptibility to ... and rheumatoid arthritis . It has been demonstrated that oxidative stress in diabetes can be accelerated not only due to ... Diabetes mellitus is a polygenic metabolic disease characterized by hyperglycemia resulting from defects in both insulin ...https://www.hindawi.com/journals/gri/2016/3787268/
CNstream: A method for the identification and genotyping of copy number polymorphisms using Illumina microarrays | BMC...
KLF12 as a risk locus for rheumatoid arthritis susceptibility. Arthritis & Rheumatism 2008, 588(8):2275-2286.View ArticleGoogle ... Population Analysis of Large Copy Number Variants and Hotspots of Human Genetic Disease. The American Journal of Human Genetics ... A similar trend was found in the Illumina genotype data and a reference Hapmap dataset (Figure 8). Comparing the results of ... Gaussian Mixture ModelRheumatoid Arthritis SusceptibilityCopy Number StateCircular Binary SegmentationCopy Number Polymorphism ...https://bmcbioinformatics.biomedcentral.com/articles/10.1186/1471-2105-11-264
Association between the rs7700944 polymorphism in the TIM-4 gene and rheumatoid arthritis in Zahedan, southeast Iran. -...
In males, the GA+AA genotype increased the risk of RA in comparison with the GG genotype (OR = 5.15, 95% CI = 1.30-20.48, P = ... OBJECTIVE The present study aimed at investigating the impact of that polymorphism on susceptibility to RA in a sample of the ... an association between rheumatoid arthritis (RA) and the rs7700944 G,A variant in the T-cell immunoglobulin and mucin domains 4 ... impact on disease susceptibility and hepatocellular carcinoma traits.. *Zhongqiao Li, Z Liu, +8 authors Fubin Li ...https://www.semanticscholar.org/paper/Association-between-the-rs7700944-polymorphism-in-Zakeri-Hashemi/3cf54a1398191ddce6254d90a51da08b8d19898f
Genome-Wide Joint Meta-Analysis of SNP and SNP-by-Smoking Interaction Identifies Novel Loci for Pulmonary Function
Author Summary Measures of pulmonary function provide important clinical tools for evaluating lung disease and its progression ... 2012) Five amino acids in three HLA proteins explain most of the association between MHC and seropositive rheumatoid arthritis ... Center of Excellence in Complex Disease Genetics and SALVE), University Hospital Oulu, Biocenter, University of Oulu, Finland ( ... Imputed genotype dosage values (estimated reference allele count with a fractional value ranging from 0 to 2.0) were generated ...https://journals.plos.org/plosgenetics/article?id=10.1371/journal.pgen.1003098
The Host Genetic Diversity in Malaria Infection
"HMOX1 promoter polymorphism modulates the relationship between disease activity and joint damage in rheumatoid arthritis," ... D. Kwiatkowski, "Genetic susceptibility to malaria getting complex," Current Opinion in Genetics and Development, vol. 10, no. ... H. J. Chin, H. J. Cho, T. W. Lee et al., "The heme oxygenase-1 genotype is a risk factor to renal impairment of IgA nephropathy ... D. J. Weatherall, "Host genetics and infectious disease," Parasitology, vol. 112, supplement, pp. S23-S29, 1996. View at Google ...https://www.hindawi.com/journals/jtm/2012/940616/ref/
A polymorphic variant in the MHC2TA gene is not associated with systemic lupus erythematosus
Alleles, Case-Control Studies, Female, Genetic Predisposition to Disease, Genotype, Histocompatibility Antigens Class II, ... rheumatoid arthritis, and myocardial infarction in the Swedish population. We used a case-control approach to investigate the ... Myocardial Infarction/genetics, Nuclear Proteins/*genetics, Polymorphism, Single Nucleotide, Sweden, Trans-Activators/*genetics ... This particular polymorphism rs3087456 of the MHC2TA gene does not appear to influence genetic susceptibility to SLE in the ...http://uu.diva-portal.org/smash/record.jsf?pid=diva2:41422
Analysis of Single Nucleotide Polymorphisms within ADAM12 and Risk of Knee Osteoarthritis in a Chinese Han Population
2 scale). Other etiologies of knee joint disease such as posttraumatic or postseptic arthritis, inflammatory arthritis, and ... For a recessive model of the C allele, the CC homozygote genotype was also associated with increased susceptibility to OA (CC ... previous rheumatoid arthritis, and a variety of bone turnover and blood clotting disorders. Nowadays, the individual ... Limited power to detect genetic associations is a significant problem in studying genetics of any complex disease. This study ...https://www.hindawi.com/journals/bmri/2015/518643/
Analysis of Complex Disease Association Studies: A Practical Guide by Eleftheria Zeggini | NOOK Book (eBook) | Barnes & Noble®
... of the Analysis of Complex Disease Association Studies: A Practical Guide by Eleftheria Zeggini at Barnes & Noble. FREE ... genetics and linkage disequilibrium Chapter 3 Genetic association study design Chapter 4 Selection of SNPs Chapter 5 Genotype ... rheumatoid arthritis ... in explaining individual differences in disease susceptibility ... Genetics of Cardiovascular Disease This volume of the esteemed Progress in Molecular Biology and Translational Science series ...https://www.barnesandnoble.com/w/analysis-of-complex-disease-association-studies-eleftheria-zeggini/1111447705
Dienekes' Anthropology Blog: 02/2007
American Journal of Human Genetics (in press). Measuring European Population Stratification using Microarray Genotype Data. ... The results will enable studies of type 2 diabetes, rheumatoid arthritis and other diseases where epidemiological studies ... We are seeing the impact of this mismatch in the explosion of diabetes, heart disease and obesity. But it also has consequences ... suggest differences in the distribution of ancestry associated susceptibility.. Link. No comments: ...http://dienekes.blogspot.com/2007_02_01_archive.html?m=1
An X chromosome-wide association analysis identifies variants in GPR174 as a risk factor for Graves' disease | Journal of...
Analysis of skewed X-chromosome inactivation in females with rheumatoid arthritis and autoimmune thyroid diseases. Arthritis ... disease; the two methods gave consistent results, both showing that GPR174 was associated with disease susceptibility. ... Therefore, the genotype distributions of rs3827440 explain little of the difference in Graves' disease prevalence between males ... International Consortium for the Genetics of Autoimmune Thyroid Disease. J Clin Endocrinol Metab 1998;83:3290-5. ...http://jmg.bmj.com/content/50/7/479
HLA heterozygosity contributes to susceptibility to rheumatoid arthritis. - Nuffield Department of Orthopaedics, Rheumatology...
... suggesting that this genotype may be particularly associated with more severe disease. We also found four cases with the rare ... not selected for severe disease, the excess of Dw4/Dw14 was much less striking (RR 1.4; not significant), ... Dw4/Dw15 genotype (expected less than or equal to 0.5; P less than or equal to .02). Since the Dw4, Dw14, Dw15, and DR1 ... We have investigated the role of HLA-DR genotypes in 184 patients with severe rheumatoid arthritis (RA) and in 46 patients with ...https://www.ndorms.ox.ac.uk/publications/108767
Why, Oh Y? | The Scientist Magazine®
Autoimmune diseases such as rheumatoid arthritis and lupus, for example, are more common among women, while autism spectrum ... pairs that exist in different copies on the X and the Y chromosomes that may explain sex differences in disease susceptibility. ... But in a 2013 Nature Genetics paper, Page and colleagues found that even in the absence of meiosis, mouse ovarian germ cells ... And if the iso-Y is lost, what would remain is an XO genotype-typically associated with Turner syndrome, a developmental ...https://www.the-scientist.com/?articles.view/articleNo/41689/title/Why--Oh-Y-/
... such as celiac disease, rheumatoid arthritis, and autoimmune thyroid disease (AITD). It is also known that some of these ... Biologics in RA Genetics and Genomics Study Syndicate (BRAGGS) Steering Committee, ; Breast Cancer Susceptibility Collaboration ... as disease association can cause genotype frequencies to deviate in affected offspring families. ... Genetic susceptibility to autoimmune thyroid disease: past, present, and future. Thyroid 2010;20:715-725pmid:20604685. ...http://care.diabetesjournals.org/content/38/Supplement_2/S8
Genome-wide complex trait analysis - Wikipedia
... celiac disease: 0.33(0.042) Macular degeneration: 0.242(0.029), 0.36(0.016) Arthritis: 0.11(0.031), 0.57(0.06), 0.098(0.014), ... rheumatoid arthritis, systemic lupus erythematosus, systemic sclerosis, ankylosing spondylitis): 0.2(0.048) T-cell mediated ... "The Evolutionary Genetics of Personality", Penke et al 2007; "The Evolutionary Genetics of Personality Revisited", Penke & ... Simulate GWAS data based upon the observed genotype data; Convert Illumina raw genotype data into PLINK format; Conditional & ...https://en.wikipedia.org/wiki/Genome-wide_complex_trait_analysis
P676. Primary response to infliximab in Crohn's disease is associated with the TNFRSF1A rs1800693 gene polymorphism
In IBD, rheumatoid arthritis (RA) and psoriasis infliximab (IFX) shows good efficacy, however in multiple sclerosis (MS) ... The TNFRSF1A gene has been implicated in susceptibility to MS but not to Crohn's disease (CD), RA or psoriasis. Recent data ... Genotype. Allele. Genotype. G. AA. AG. GG. G. AA. AG. GG. Responders. 38%. 211 (38%). 269 (48%). 78 (14%). 43%. 55 (32%). 88 ( ... HomePublicationsCongress AbstractsAbstracts 2013Poster presentations: Genetics (2013)P676. Primary response to infliximab in ...https://www.ecco-ibd.eu/publications/congress-abstract-s/abstracts-2013/item/p676-primary-response-to-infliximab-in-crohn-s-disease-is-associated-with-the-tnfrsf1a-rs1800693-gene-polymorphism.html
Tenascin X - Wikipedia
"Genetic association of the major histocompatibility complex with rheumatoid arthritis implicates two non-DRB1 loci". Arthritis ... 2009). "Association of MHC SNP genotype with susceptibility to type 1 diabetes: a modified survival approach". Diabetes Obes ... Yu CY (1998). "Molecular genetics of the human MHC complement gene cluster". Exp. Clin. Immunogenet. 15 (4): 213-30. doi: ... 2009). "Transcriptomic and genetic studies identify IL-33 as a candidate gene for Alzheimer's disease". Mol. Psychiatry. 14 (11 ...https://en.wikipedia.org/wiki/Tenascin_X
Overview of MMP Biology and Gene Associations in Human Diseases | IntechOpen
40 - Ye S. Influence of matrix metalloproteinase genotype on cardiovascular disease susceptibility and outcome. Cardiovascular ... and rheumatoid arthritis . MMP-28 overexpression up-regulated MT-MMP1 and MMP-9 in A549 lung adenocarcinoma cells . ... Genetics of MMPs in brain disease. In the central nervous system, MMPs have an important role and may influence proteolysis of ... but not with susceptibility to coronary heart disease [100, 102]. The 6A/6A genotype was associated with greater progression of ...https://www.intechopen.com/books/the-role-of-matrix-metalloproteinase-in-human-body-pathologies/overview-of-mmp-biology-and-gene-associations-in-human-diseases/