Burkitt Lymphoma and Burkitt-like Lymphoma: Practice Essentials, Background, Etiology and Pathophysiology
... that is characterized by the translocation and deregulation of the c-myc gene on chromosome 8. Malignant small noncleaved ... Overproduction of the c-myc product may change the lymphocytes into cancer cells, but other gene mutations may be responsible ... myc gene and is considered responsible for tumor proliferation. Translocation t(8;14) is the most common, present in 80% of ... C-myc oncogene activation. The classic t(8;14)(q24;q32) reciprocal translocation (85% of cases) results in the transposition of ...https://emedicine.medscape.com/article/1447602-overview
Burkitt lymphoma facts, information, pictures | Encyclopedia.com articles about Burkitt lymphoma
Called the C-myc oncogene, it is responsible for the uncontrolled production of B-lymphocytes. It results from a translocation ... The C-myc onco-gene appears to stimulate the HMG-I/Y gene, which then triggers the changes in normal B-cells that cause them to ... While this type of lymphoma is still relatively rare in the United States, it is responsible for 50% of cancer deaths in ... In addition, patients with Burkitt's lymphoma may want to consider genetic counseling because of the role of the C-myc oncogene ...http://www.encyclopedia.com/medicine/diseases-and-conditions/pathology/burkitt-lymphoma
Differential requirement of Ldha in Myc-induced tumorigenesis based on cooperating oncogenic lesion and tumor immunogenicity
The assumption that the important target genes responsible for the biological effects of Myc overexpression were those encoding ... 1. Myc-induced Lymphomagenesis: In vivo assessment of downstream pathways. Open this publication in new window or tab ,,Myc- ... Myc-inducerad lymfomutveckling : Utvärdering av målgener in vivo Abstract [en]. Myc oncogenes encode transcription factors that ... the targeting of Myc target genes encoding metabolic enzymes has the potential of providing a new treatment strategy of Myc- ...http://umu.diva-portal.org/smash/record.jsf?pid=diva2:300919
KAKEN - Researchers | KAWANO Michio (40161343)
Presentation] MYC responsible for down-regulation of CD33 expression in myeloma cells2008. *. Author(s). Shamsasenjan K, ... Journal Article] IL-6-induced activation of MYC is responsible for the down-regulation of CD33 expression in CD33+ myeloma ...https://nrid.nii.ac.jp/nrid/1000040161343/
"Hypoxic Regulation of MYC and Epidermal Barrier Development" by Waihay J. Wong
First, HIF is partly responsible for MYC inhibition in hypoxic human colon carcinoma cells. Hypoxic MYC down-regulation ... Reduced MYC protein correlated with hypoxic inhibition of RNA polymerase III-dependent MYC target genes, suggesting that MYC ... MYC overexpression in hypoxic cells induced cell death in a NOXA- and PUMA-dependent manner. Therefore, MYC degradation can be ... First, HIF is partly responsible for MYC inhibition in hypoxic human colon carcinoma cells. Hypoxic MYC down-regulation ...https://repository.upenn.edu/edissertations/721/
Donald E. Ayer, PhD - Faculty Details - U of U School of Medicine - | University of Utah
In normal cells, Myc is responsible for turning on the genes that are required for cell division. In cancer cells, Myc is " ... His research focuses on how cells regulate a transcription factor known as Myc, which is mutated in a wide variety of cancers. ... Peterson CW, Ayer DE (2011). An extended Myc network contributes to glucose homeostasis in cancer and diabetes. [Review]. Front ... Ayer's research group investigates how Myc functions in normal and cancer cells, and they work to increase the understanding of ...https://medicine.utah.edu/faculty/mddetail.php?facultyID=u0029835
Sweatt, Tansey discuss influence of epigenetics on research | Vanderbilt News | Vanderbilt University
"It's estimated that MYC is responsible for about one third of all cancer deaths each year in the United States." ... There is a good side to MYC. It plays an important role in embryonic development. "The goal here is to get MYC down below that ... "If cancer is the emperor of all maladies, then I would argue that MYC is the emperor of all oncogenes," he said. " ... MYC's tumorigenic potential depends on its interaction with a chromosome-binding protein called WDR5. Working with Tansey's ...https://news.vanderbilt.edu/2017/11/02/sweatt-tansey-discuss-influence-of-epigenetics-on-research/
Modeling Aggressive Medulloblastoma Using Human Induced Pluripotent Stem Cells | Kennedy Krieger Institute
... herein referred to as MYC-driven MB. Modeling MYC-driven MB is critical for developing and testing potential therapies for this ... Group 3 MB is characterized by amplification and overexpression of oncogenic transcription factor MYC, ... Aim 2. To identify the genome-wide MYC-regulated transcriptional network responsible for MYC-driven tumorigenesis, and to ... herein referred to as MYC-driven MB. Modeling MYC-driven MB is critical for developing and testing potential therapies for this ...https://www.kennedykrieger.org/research-training/current-research-projects/clinical-research/modeling-aggressive-medulloblastoma-human-induced-pluripotent
Wnt signaling and its downstream target N-myc regulate basal progenitors in the developing neocortex | Development
It is of note that N-myc is not the only downstream target responsible for the functions of Wnt signaling in the neocortex (see ... In the N-myclox/lox;Nes-Cre mouse (N-Myc-cKO mouse), the levels of N-myc mRNA in the neocortex were reduced to ~30% at E12.5 ... N-myc is a member of the Myc family of transcription factors (Eilers and Eisenman, 2008), and conditional deletion of the N-myc ... In other systems, members of the Cyclin D and the Myc families, such as Cyclin D1, c-Myc and N-myc, have been implicated in ...http://dev.biologists.org/content/137/7/1035
FOXM1/SKP2 and c-Myc signaling were partially responsible for the increased hepatocyte proliferation and liver tumorigenesis ( ... c-Myc itself is an important regulator of proliferation, differentiation, and apoptosis. Interestingly, c-Myc was found to be a ... FOXM1c transactivates the human c-myc promoter directly via the two TATA boxes P1 and P2. FEBS J 2006;273:4645-67. ... Induction of Mxi1-SR alpha by FOXO3a contributes to repression of Myc-dependent gene expression. Mol Cell Biol 2007;27:4917-30 ...http://mct.aacrjournals.org/content/12/3/245
Biology-Online • View topic - is it possible to knockdown a gene in a living adult now
... based RNA therapeutic agent aimed at silencing C-MYC, one of the genes responsible for causing arteries to reclose after ... c-myc) responsible for causing arteries to reclose after stenting (restenosis).. ,snip, ...http://www.biology-online.org/biology-forum/post-105503.html
c-Myc and Cancer Metabolism | Clinical Cancer Research
Induced overexpression of the c-Myc gene is responsible for many of the changes that induce malignant changes (see Fig. 1). ... c-Myc mRNA is very short-lived and in the absence of positive regulatory signals, c-Myc transcription decreases and c-Myc ... The miRNAs are intertwined in the c-Myc regulatory network, both as targets of c-myc and as regulators of c-Myc expression. The ... The other members of the myc gene family (l-Myc and n-Myc) also encode essential transcription regulators whose expression is ...http://clincancerres.aacrjournals.org/content/18/20/5546.full
Dormant stem cells for emergencies ( Many specialized cells such as in th...)
Trumpp explains: "In tumors, too, c-Myc and N-Myc are presumably responsible for the self-renewal of cancer stem cells and, ... If both c-Myc and N-Myc are switched off at the same time in mice, the animals quickly start suffering from a general lack of ... Elisa Laurenti from Trumpp's team shows that the two cancer genes c-Myc and N-Myc play a vital role in the functioning of stem ... The two genes are not only responsible for survival of nearly all blood cells, but they also jointly control the two prime ...http://www.bio-medicine.org/medicine-news-1/Dormant-stem-cells-for-emergencies-31312-1/
c-Myc Function - Proteins > Nuclear Proteins > Transcription Factors > c-Myc - Reviews - Review Articles on Protein Expression,...
c-Myc Function - Proteins > Nuclear Proteins > Transcription Factors > c-Myc - Reviews - Review Articles on Protein Expression ... These growth stimulating properties are most likely responsible for Myc's ability to initiate and promote tumor formation. ... The myc family of nuclear oncogenes contains three well-characterized members, c-myc, N-myc, and L-myc. These genes encode ... The c-myc gene and the expression of the c-Myc protein are frequently altered in human cancers. The c-myc gene encodes the ...http://biologicalworld.com/articles/modules/smartsection/item.php?itemid=117
ZAK negatively regulates RhoGDIβ-induced Rac1-mediated hypertrophic growth and cell migration | Journal of Biomedical Science |...
LCY was responsible for the SiRNA knockdown. KYL was responsible for the cell migration assay. ICC, JIY, MYC and WWL were ... CYH was responsible for the pull-down assay. ... PHL was responsible for cell staining. JJY wrote the manuscript ...https://jbiomedsci.biomedcentral.com/articles/10.1186/1423-0127-16-56
Enzyme That Mutates Antibodies Also Targets Cancer-Causing Gene
Previous work had shown that AID was responsible for breaking antibody genes but not c-myc. In fact, scientists thought a host ... AID »Antibodies »DNA »Enzym »c-Myc »cancer-causing »gene mutator »genetic malfunction »immune system »lymphoma »lymphomas » ... Further reports about: , AID , Antibodies , DNA , Enzym , c-Myc , cancer-causing , gene mutator , genetic malfunction , immune ... He then inserted a DNA tag into the mouse genome that allowed him to induce a break at the c-myc gene, which occurs only very ...http://www.innovations-report.com/html/reports/life-sciences/enzyme-mutates-antibodies-targets-cancer-causing-124312.html
AU-rich element - Wikipedia
c-myc gene, also responsible for producing transcription factors found in several cancers, has also been reported to lack the ...https://en.wikipedia.org/wiki/AU-rich_element
Molecules | Free Full-Text | Studies on the Interaction Mechanism of Pyrene Derivatives with Human Tumor-Related DNA | HTML
The binding constants of 1-OHP are 1.16 × 106 L×mol−1 and 4.04 × 105 L×mol−1 for p53 DNA and C-myc DNA, respectively, while ... Besides, the binding of pyrene derivatives to p53 DNA is stronger than that for C-myc DNA. CD and PAGE results indicate that ... that of 1-PBO are only 2.04 × 103 L×mol−1 and 1.39 × 103 L×mol−1 for p53 DNA and C-myc DNA, respectively. ... p53 DNA and C-myc DNA) are investigated by spectroscopic and non-native polyacrylamide gel electrophoresis (PAGE) methods. ...http://www.mdpi.com/1420-3049/17/12/14159/htm
Resveratrol Exerts Antiproliferative Activity and Induces Apoptosis in Waldenström's Macroglobulinemia | Clinical Cancer...
... including myc and survivin, responsible for cell cycle progression, cell survival, cell proliferation, and disease progression ... Myc-induced T cell leukemia in transgenic zebrafish. Science 2003;299:887-90. ... 5B); resveratrol also down-regulated the protein expression of myc and survivin (Fig. 5C). ... myc and survivin, both downstream target genes in the β-catenin/TCF pathway (Fig. 5A ; refs. 32, 33). Moreover, we confirmed ...http://clincancerres.aacrjournals.org/content/14/6/1849.long
Cancers | Free Full-Text | Induction of Chromosomal Instability via Telomere Dysfunction and Epigenetic Alterations in Myeloid...
Genomic instability may play an essential role in leukemogenesis by promoting the accumulation of genetic lesions responsible ... indicated that the ALT mechanism was mainly responsible for telomere maintenance in c-Myc-induced leukemias. Microarray ... 86], we demonstrated a c-Myc-induced increase of DNA double-strand breaks (DSBs). However, DSBs were markedly reduced in c-Myc/ ... As expected, clonal chromosomal aberrations induced by c-Myc overexpression were found in c-Myc/wt leukemias of about one-third ...http://mdpi.com/2072-6694/5/3/857/htm
Aberrant immunoglobulin class switch recombination and switch translocations in activated B cell-like diffuse large B cell...
Accordingly, aberrant switch recombination was responsible for translocations in ABC DLBCLs involving BCL6, MYC, and a novel ... FISH analyses of DLBCL samples were performed using "break-apart" probes spanning the MYC and BCL6 loci, revealing MYC ... Diverse karyotypic abnormalities of the c-myc locus associated with c-myc dysregulation and tumor progression in multiple ... MYC translocation in ABC DLBCL case 1000; lane 2, Sγ-MYC translocation in GCB DLBCL cell line NUDUL-1; lane 3, Sμ-BCL6 ...http://jem.rupress.org/content/204/3/633
Linda Boxer, MD, PhD | Stanford Medicine Profiles
We are looking at the c-myc promoter and regions of the immunoglobulin locus that are responsible for the deregulation of the ... Translocations involving c-myc and c-myc function ONCOGENE Boxer, L. M., DANG, C. V. 2001; 20 (40): 5595-5610 Abstract. c-MYC ... Herein, aspects of c-myc gene activation and the function of the c-Myc protein are reviewed. The c-myc gene produces an ... ACTIVATION OF C-MYC EXPRESSION BY C-ABL IS INDEPENDENT OF BOTH THE DNA-BINDING FUNCTION OF C-ABL AND THE C-MYC EP SITE JOURNAL ...https://med.stanford.edu/profiles/linda-boxer?tab=teaching
Suppressing nonsense-a surprising function for 5‐azacytidine | EMBO Molecular Medicine
MYC overexpression is responsible for inhibiting NMD in tumors (Wang et al, 2011a). ... This provided strong evidence that 5AzaC acts through C‐MYC to inhibit NMD. Given that C‐MYC is often overexpressed in tumors, ... Wang D, Wengrod J, Gardner LB (2011a) Overexpression of the c‐myc oncogene inhibits nonsense‐mediated RNA decay in B ... One of the most strongly upregulated proteins was the oncoprotein, C‐MYC. To test its causal role, the authors asked whether ...http://embomolmed.embopress.org/content/6/12/1518
Drosophila insulin and target of rapamycin (TOR) pathways regulate GSK3 beta activity to control Myc stability and determine...
... a kinase responsible for Myc protein degradation. We found Myc protein regulated in vivo both by insulin and TOR pathways in ... Schwinkendorf D, Gallant P: The conserved Myc box 2 and Myc box 3 regions are important, but not essential, for Myc function in ... a kinase that is responsible for Myc protein degradation. Induction of Myc by insulin is inhibited by the presence of the TOR ... D) Clones expressing UAS- UAS-Rheb AV4 showed increased Myc protein that was decreased in UAS-TOR TED clones (E). Notably, Myc ...https://0-bmcbiol-biomedcentral-com.brum.beds.ac.uk/articles/10.1186/1741-7007-9-65
Combinatorial depletion analysis to assemble the network architecture of the SAGA and ADA chromatin remodeling complexes |...
... which are responsible for different functions of the SAGA complex, are capable of assembling independently from the remaining ... Myc. Oncogene 26: 5626-5634. ... which are responsible for the different functions of the SAGA ... This implies that Ahc2 is responsible for tethering Ahc1 into the ADA complex. Since the hallmark of these complexes is their ...http://msb.embopress.org/content/7/1/503