*  Patent US6475738 - Methods for detecting mutations using primer extension for detecting disease - Google Patents
Profiles of Mononucleotide Repeat Microsatellites in Control Individuals and in Colorectal Tumors With and Without Replication ... Five highly informative microsatellite repeat polymorphic DNA markers. US5378602. Nov 27, 1991. Jan 3, 1995. The Government Of ... Highly informative microsatellite repeat polymorphic DNA markers twenty-[seven]six. US5380645. Mar 16, 1989. Jan 10, 1995. The ... Three highly informative microsatellite repeat polymorphic DNA markers. US5468613. Mar 9, 1990. Nov 21, 1995. Hoffmann-La Roche ...
  http://www.google.com/patents/US6475738?dq=4393663
*  POLD1 | Cancer Genetics Web
Virus Replication. *Microsatellite Repeats. *Signal Transduction. *Mutation. Tag cloud generated 11 March, 2017 using data from ... DNA replication - DNA replication proofreading - DNA replication, removal of RNA primer - DNA strand elongation involved in DNA ... Polδ function is essential for replication, with a primary role as the replicase for the lagging strand. Polδ also has an ... DNA polymerase delta possesses both polymerase and 3' to 5' exonuclease activity and plays a critical role in DNA replication ...
  http://www.cancerindex.org/geneweb/POLD1.htm
*  Patent US7704689 - Method for generating hypermutable plants - Google Patents
... microsatellite) repeats that occur throughout the genome of an organism after cellular replication. This process is very ... At least two microsatellite markers in test cells or a test plant are compared to the at least two microsatellite markers in ... Cancer of the microsatellite mutator phenotype. Biol Chem. 377:675-684.. *9. Strand, M., Prolla, T. A., Liskay, R. M., and ... Microsatellite instability in plants expressing dominant negative MMR hPMS134 gene.. FIG. 13. . MMR defective plants produce ...
  http://www.google.co.uk/patents/US7704689
*  MSH6 - DM429-05 | acris-antibodies.com
... repeats is the result of slippage owing to strand misalignment during DNA replication and is referred to as microsatellite ... An alteration of microsatellite repeats is the result of slippage owing to strand misalignment during DNA replication and is ... Avoid repeated freezing and thawing.. Shelf life: one year from despatch.. Format. Purification:. Affinity Chromatography.. ... referred to as microsatellite instability (MSI). These defects in DNA repair pathways have been related human carcinogenesis. ...
  https://www.acris-antibodies.com/antibodies/primary-antibodies/msh6-dm429-05.htm
*  IJMS | Free Full-Text | The Clinical Utilization of Circulating Cell Free DNA (CCFDNA) in Blood of Cancer Patients | HTML
Microsatellites are repeated sequences of DNA in which a short motif (usually 1-6 base pairs in length) is repeated 5-100 times ... Frequently, these disorders involve nearly all DNA transactions including replication, repair, recombination, and transcription ... Microsatellite instability affecting the T17 repeats in intron 8 of HSP110, as well as five mononucleotide repeats in patients ... Expansions of microsatellite DNA repeats contribute to the inheritance of nearly 30 developmental and neurological disorders. ...
  http://mdpi.com/1422-0067/14/9/18925/htm
*  Interactive
Hypothesis: Local dNTP depletion as the cause of microsatellite repeat instability during replication Michael Leffak BioEssays ... Here we will be posting papers and other replication news. Please feel free to add your comments to any of the postings here. ... A Resource for Eukaryotic DNA Replication. Welcome to the Interactive Section of the site. ...
  http://www.dnareplication.net/interactive/interactive.php?id=111639369210824519
*  Chaotic linear systems in mathematical biology
... transpositions or faults during replications. The shortest non-coding repeats of DNA are called microsatellites; they are ... to shortening or elongation of microsatellites with one or more repeated units. The stability of the number of repeats in a ... Model 2. Microsatellite repeats. More than 95% of the human genome does not code any proteins. The non-coding DNA plays an ... Formation of multiple repeats of such short units occurs most probably as a result of DNA replication errors in which slippage ...
  http://www.scielo.org.za/scielo.php?script=sci_arttext&pid=S0038-23532008000300006&lng=pt&nrm=iso
*  Slipped strand mispairing - Wikipedia
... tandem repeats, microsatellites) are prone to strand slippage during DNA replication. The combination of SSM events with point ... In long repeats, expansions may involve two or more units. For example, insertion of a single repeat unit in GAGAGA expands the ... For example, a transversion could change the simple two- base repeat [GA]10 to [GA]4GATA[GA]2. This could then be expanded to[ ... Mutations followed by expansion would result in the formation of new types of adjacent short tandem repeat units. ...
  https://en.wikipedia.org/wiki/Slipped_strand_mispairing
*  Difference between revisions of "Yeast rebuild" - OpenWetWare
... mismatch repair of frameshift mutations in microsatellite repeats varies depending on genomic position of microsatellite repeat ... Chromosome replication. * Survey paper: MacAlpine and Bell, '05. * Autonomous replication sequences (ARS), are about 200 bp ... There doesn't seem to be any correlation between repair efficiency and position with respect to replication origin, replication ... Not clear how applicable their findings are to non-repeating sequence, like protein-coding regions. ...
  https://openwetware.org/wiki/?title=Yeast_rebuild&diff=18358&oldid=18357
*  Mutation Rates, Spectra, and Genome-Wide Distribution of Spontaneous Mutations in Mismatch Repair Deficient Yeast | G3: Genes |...
Microsatellite instability is a consequence of unrepaired slippage events during DNA replication of these repeat regions ( ... We find that microsatellite instability increases with repeat length and that microsatellites adjacent to other repeats are ... Microsatellites proximal to other repeats are more mutable. (A) The cumulative frequency plots for microsatellites sorted ... To assess mutation rates at microsatellites, an accurate count of the repeat number was required. Microsatellites in the draft ...
  http://www.g3journal.org/content/3/9/1453.full
*  St. Clair Research
Slippage Replication: A mutation process whereby a simple sequence tandem (microsatellite) repeat grows by addition or ... repeat is the microsatellite. By running back and forth across the repeat one can amplify a few copies of the microsatellite ... Microsatellite variation appears to result from slippage in replication, which is most likely to add or delete a single repeat ... such as micro- satellite repeats or short tandem repeats. But it has been the discovery that some SNPs are linked to particular ...
  http://www.stclairresearch.com/content/glossary.html
*  TGF-β Signaling Alterations and Colon Cancer | SpringerLink
Deficiencies in these enzymes lead to numerous errors in DNA replication, especially in tandem repeat sequences, and cause ... In addition, BMPR2 expression was significantly more frequently impaired in microsatellite unstable tumors than microsatellite ... This association was significantly stronger in cases with microsatellite stable tumors compared with microsatellite unstable ... TGFBR1*6A, a TGFBR1 polymorphism that consists of a deletion of three alanines within a nine-alanine repeat at the 3′ end of ...
  https://link.springer.com/chapter/10.1007%2F978-1-4419-6033-7_5
*  A survey of tandem repeat instabilities and associated gene expression changes in 35 colorectal cancers | BMC Genomics | Full...
Tandem repeatsColorectal cancerMSIMicrosatellite instabilityExpressionRepeat instabilityMicrosatelliteCancer pathwaysCancer ... The difference was more pronounced when we focused on mononucleotide repeats, in agreement with the finding that replication ... 3). We repeated this analysis also for repeats whose repeat unit consisted only of a single base (monucleotide repeats) to find ... Tandem repeat identification. We used the program Tandem Repeat Finder 4.07b [61] to identify tandem repeats in the consensus ...
  https://bmcgenomics.biomedcentral.com/articles/10.1186/s12864-015-1902-9
*  Ploidy Dictates Repair Pathway Choice under DNA Replication Stress | Genetics
Sia, E. A., R. J. Kokoska, M. Dominska, P. Greenwell and T. D. Petes, 1997 Microsatellite instability in yeast: dependence on ... Each test was performed with 10 colonies and repeated twice for each strain (Xu et al. 2004). ... DNA replication stress, induced by oncogene activation, genotoxic stress, or defects in the DNA replication machinery, is ... Barbour, L., and W. Xiao, 2003 Regulation of alternative replication bypass pathways at stalled replication forks and its ...
  http://www.genetics.org/content/187/4/1031
*  Winfried Edelmann, Ph.D. | Albert Einstein College of Medicine
... in these patients display increased genomic mutation rates as indicated by increased instability at microsatellite repeat ... These steps are carried out by exonculeases, polymerases and a number of replication associated proteins. In addition to ... sequences (termed microsatellite instability, MSI). MMR in eukaryotes is complex and involves several homologs of the bacterial ... genomic integrity in all organisms requires multiple DNA repair pathways that are involved in the processes of DNA replication ...
  http://www.einstein.yu.edu/faculty/862/winfried-edelmann/
*  Local population structure of white pine weevil (Pissodes strobi [Peck]) in interior and Sitka spruce stands in British...
Microsatellites vary in repeat sequence length through proofreading errors and slippage during DNA replication (Schlötterer ... Microsatellites, also called simple sequence repeats (SSRs), variable number of tandem repeats (VNTRs) or short tandem repeats ... The entire length of the microsatellite can vary from 5-40 repeats in length or greater. ... Microsatellites were found from the first build using MicroSAtellite identification tool (MISA) (Thiel et al. 2003). A total of ...
  https://open.library.ubc.ca/cIRcle/collections/ubctheses/24/items/1.0071762
*  Printing...
Owing to their repeated structures, microsatellites are particularly prone to replication errors that are normally repaired by ... Microsatellites are short DNA motifs of 1 to 6 bases that are repeated and distributed throughout the genome both in coding and ... 11 CRCs can be classified as microsatellite instability-high (MSI-H), and microsatellite instability-low (MSI-L), depending on ... microsatellite unstable, strong immune activation and BRAF mutations); CMS2 (canonical: 37%, epithelial, marked Wnt and MYC ...
  http://www.gotoper.com/print_pub.php?url=/publications/ajho/2017/2017july/advances-in-immunotherapy-in-the-treatment-of-colorectal-cancer
*  AIDS-related Kaposi's sarcoma is a clonal neoplasm. - PubMed - NCBI
... and the third case had a clonal expansion of cells with an altered microsatellite repeat sequence. These data suggest that ... A fundamental characteristic of neoplasms is clonality, in that they arise from clonal replication of a single cell whereas ...
  https://www.ncbi.nlm.nih.gov/pubmed/9815980
*  PeakSeeker: a program for interpreting genotypes of mononucleotide repeats | BMC Research Notes | Full Text
... of repeat sequences contained by a microsatellite and are the consequence of mutations which occur during DNA replication, when ... Microsatellites are short (1- to 5-bp), tandemly repeated DNA motifs that are useful as genetic markers because they display a ... Mononucleotide repeat microsatellites are abundant, highly polymorphic DNA sequences, having the potential to serve as valuable ... Consequently, microsatellites with larger repeating subunits (dinucleotide and trinucleotide motifs) are used, which produce ...
  https://bmcresnotes.biomedcentral.com/articles/10.1186/1756-0500-2-17
*  Optimization of sequence alignment for simple sequence repeat regions | BMC Research Notes | Full Text
Repeated UnitPhylogenic TreeReplication SlippageSequence CaseTemporary Array. Background. Microsatellites, or simple sequence ... Microsatellites, or simple sequence repeats (SSRs), are tandemly repeated DNA sequences, including tandem copies of specific ... Kruglyak S, Durrett R, Schug D, Aquadro C: Equilibrium distributions of microsatellite repeat length resulting from a balance ... The user should determine his tandem repeats by putting a space character between each repeated unit and the next one in the ...
  https://bmcresnotes.biomedcentral.com/articles/10.1186/1756-0500-4-239
*  PPT - More Molecular Genetic Technologies (Chapters 8, 9, 10) Polymerase Chain Reaction (PCR) Standard PCR method Real-time qu...
Microsatellites (short tandem repeats or STRs):. Heterozygote Male 5'-TAATAATAATAATAATAATAA----3'. Female 5'- ... One proposed explanation for their fast rate of evolution is slippage during DNA replication. ... Amplify microsatellites using PCR from mother, baby, father.. Electrophores microsatellite PCR products on a DNA sequencer (w/ ... Synthesize oligonucleotide microsatellite primers and label one primer with fluorescent dye (2 primers per microsatellite). ...
  https://www.slideserve.com/Ava/polymerase-chain-reaction-pcrstandard-pcr-methodreal-time-quantitative-pcrdna-sequencing-manual-dideoxy-automated-fluore
*  IJMS | Free Full-Text | DNA Damage Due to Oxidative Stress in Chronic Obstructive Pulmonary Disease (COPD) | HTML
The microsatellite repeats are identical in the different cells of each individual, and unique. Their characteristics are that ... as it is designed to correct single-base mismatches and small insertion/deletion loops that may occur during DNA replication [ ... The oxidative DNA damage in the lung generally affects the base composition of the repeated sequences (microsatellite DNA) ... Ever since the Microsatellite DNA Instability (MI) was established in benign lung diseases, such as COPD and asthma [58,61,62 ...
  http://www.mdpi.com/1422-0067/13/12/16853/htm
*  Lynch Syndrome via the MLH3 Gene - PreventionGenetics
... microsatellites) (reviewed by Grady & Carethers in Gastroenterology 135:1079-1099, 2008). This phenomenon of microsatellite ... Runs of mononucleotide repeats (eg (A)n or (T)n) with n ,8 in the reference sequence are generally not analyzed because of ... MMR genes are responsible for repairing small sequence errors, or mismatches, during DNA replication. Mutations in a single ... deletions and duplications present at low levels of mosaicism or those present in genes that have pseudogene copies or repeats ...
  https://www.preventiongenetics.com/testInfo.php?sel=test&val=Lynch+Syndrome+via+the+MLH3+Gene
*  Microsatellite instability - Wikipedia
Microsatellites are also known as simple sequence repeats (SSRs). Microsatellite instability structure consists of repeated ... DNA replication occurs in the "S" phase of the cell cycle; the faulty event creating an MSI region occurs during the second ... Microsatellites are repeated sequences of DNA. These sequences can be made of repeating units of one to six base pairs in ... each individual has microsatellites of a set length. The most common microsatellite in humans is a dinucleotide repeat of the ...
  https://en.wikipedia.org/wiki/Microsatellite_instability
*  Dissecting the role of low-complexity regions in the evolution of vertebrate proteins.
Given their high abundance, and their capacity to expand in relatively short periods of time through replication slippage, they ... Many amino acid tandem repeats are likely to originate by replication slippage of triplet repeats in the coding sequence. ... Replication slippage is a mutational process that expands or contracts microsatellite sequences [9]. However, it has also been ... ATRs single amino acid tandem repeats, of size 5 or longer. SPRs short period repeats, of size 3 or longer repeat units. ...
  http://www.biomedsearch.com/nih/Dissecting-role-low-complexity-regions/22920595.html