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*  Defining Genetic Factors That Modulate Intergenerational CAG Repeat Instability in Drosophila melanogaster | Genetics
1 repeat expansions, consistent with the "replication slippage" model (Kovtun and McMurray 2008). When the CAG repeat was then ... Brouwer, J. R., R. Willemsen and B. A. Oostra, 2009 Microsatellite repeat instability and neurological disease. Bioessays 31: ... Most repeat size changes involved a small number of repeats, with +1 repeat expansions observed most frequently. Repeat changes ... 1 repeat expansions of noncoding CAG repeats at the expense of repeat contractions. Although a repeat change of +1 may seem ...
  http://www.genetics.org/content/187/1/61
*  http://ufdc.ufl.edu/UFE0041491/00001
Genomic DNA replication errors promote microsatellite repeat expansions and contractions. (CTG)n DNA expansions (red) form ... n microsatellite repeat expansion in the 3 untranslated region (UTR) of the DMPK gene. In the normal population, CTG repeats ... 27 1 2 Genomic DNA replication errors promote microsatellite repeat expansions and contractions ... Noncoding microsatellite repeat expansions in myotonic dystrophy. (A) The DMPK gene with a (CTG)n expansion in the 3 UTR. DMPK ...
  http://ufdc.ufl.edu/UFE0041491/00001
*  Patent US6475738 - Methods for detecting mutations using primer extension for detecting disease - Google Patents
Profiles of Mononucleotide Repeat Microsatellites in Control Individuals and in Colorectal Tumors With and Without Replication ... Five highly informative microsatellite repeat polymorphic DNA markers. US5378602. Nov 27, 1991. Jan 3, 1995. The Government Of ... Highly informative microsatellite repeat polymorphic DNA markers twenty-[seven]six. US5380645. Mar 16, 1989. Jan 10, 1995. The ... Three highly informative microsatellite repeat polymorphic DNA markers. US5468613. Mar 9, 1990. Nov 21, 1995. Hoffmann-La Roche ...
  http://www.google.com/patents/US6475738?dq=4393663
*  POLD1 | Cancer Genetics Web
Virus Replication. *Microsatellite Repeats. *Signal Transduction. *Mutation. Tag cloud generated 11 March, 2017 using data from ... DNA replication - DNA replication proofreading - DNA replication, removal of RNA primer - DNA strand elongation involved in DNA ... Polδ function is essential for replication, with a primary role as the replicase for the lagging strand. Polδ also has an ... DNA polymerase delta possesses both polymerase and 3' to 5' exonuclease activity and plays a critical role in DNA replication ...
  http://www.cancerindex.org/geneweb/POLD1.htm
*  Patent US7704689 - Method for generating hypermutable plants - Google Patents
... microsatellite) repeats that occur throughout the genome of an organism after cellular replication. This process is very ... At least two microsatellite markers in test cells or a test plant are compared to the at least two microsatellite markers in ... Cancer of the microsatellite mutator phenotype. Biol Chem. 377:675-684.. *9. Strand, M., Prolla, T. A., Liskay, R. M., and ... Microsatellite instability in plants expressing dominant negative MMR hPMS134 gene.. FIG. 13. . MMR defective plants produce ...
  http://www.google.co.uk/patents/US7704689
*  MSH6 - DM429-05 | acris-antibodies.com
... repeats is the result of slippage owing to strand misalignment during DNA replication and is referred to as microsatellite ... An alteration of microsatellite repeats is the result of slippage owing to strand misalignment during DNA replication and is ... Avoid repeated freezing and thawing.. Shelf life: one year from despatch.. Format. Purification:. Affinity Chromatography.. ... referred to as microsatellite instability (MSI). These defects in DNA repair pathways have been related human carcinogenesis. ...
  https://www.acris-antibodies.com/antibodies/primary-antibodies/msh6-dm429-05.htm
*  IJMS | Free Full-Text | The Clinical Utilization of Circulating Cell Free DNA (CCFDNA) in Blood of Cancer Patients | HTML
Microsatellites are repeated sequences of DNA in which a short motif (usually 1-6 base pairs in length) is repeated 5-100 times ... Frequently, these disorders involve nearly all DNA transactions including replication, repair, recombination, and transcription ... Microsatellite instability affecting the T17 repeats in intron 8 of HSP110, as well as five mononucleotide repeats in patients ... Expansions of microsatellite DNA repeats contribute to the inheritance of nearly 30 developmental and neurological disorders. ...
  http://mdpi.com/1422-0067/14/9/18925/htm
*  Microsatellite Instability in Double Primary Cancers of the Colorectum and Stomach - Semantic Scholar
We hypothesized that microsatellite instability (MSI) is one of the underlying genetic factors in the development of double ... Incidence of DNA replication errors in patients with multiple primary cancers.. Steve R Brown, Paul J. Finan, Nigel R. Hall, D ... phenotype in human tumors without the requirement for matching normal DNA by analysis of mononucleotide repeat microsatellites. ... Microsatellite Instability in the Adenoma-Carcinoma Sequence of the Stomach. Hee Sung Kim, Dong-Kyun Woo, Soo In Bae, Yong Il ...
  https://www.semanticscholar.org/paper/Microsatellite-Instability-in-Double-Primary-of-the-Kim-Cho/3c98d42d85843ceb73bbae9d3eea142788be7d8a
*  Interactive
Hypothesis: Local dNTP depletion as the cause of microsatellite repeat instability during replication Michael Leffak BioEssays ... Here we will be posting papers and other replication news. Please feel free to add your comments to any of the postings here. ... A Resource for Eukaryotic DNA Replication. Welcome to the Interactive Section of the site. ...
  http://www.dnareplication.net/interactive/interactive.php?id=111639369210824519
*  Slipped strand mispairing - Wikipedia
... tandem repeats, microsatellites) are prone to strand slippage during DNA replication. The combination of SSM events with point ... In long repeats, expansions may involve two or more units. For example, insertion of a single repeat unit in GAGAGA expands the ... For example, a transversion could change the simple two- base repeat [GA]10 to [GA]4GATA[GA]2. This could then be expanded to[ ... Mutations followed by expansion would result in the formation of new types of adjacent short tandem repeat units. ...
  https://en.wikipedia.org/wiki/Slipped_strand_mispairing
*  Chaotic linear systems in mathematical biology
... transpositions or faults during replications. The shortest non-coding repeats of DNA are called microsatellites; they are ... to shortening or elongation of microsatellites with one or more repeated units. The stability of the number of repeats in a ... Model 2. Microsatellite repeats. More than 95% of the human genome does not code any proteins. The non-coding DNA plays an ... Formation of multiple repeats of such short units occurs most probably as a result of DNA replication errors in which slippage ...
  http://www.scielo.org.za/scielo.php?script=sci_arttext&pid=S0038-23532008000300006&lng=pt&nrm=iso
*  Wisconsin State Laboratory of Hygiene | Wisconsin's Public Health and Environmental Laboratory Since 1903
... or one can assess microsatellite instability (MSI). Microsatellites are tandem repeats found throughout the human genome. Their ... repetitive nature makes the DNA polymerase prone to slippage during DNA replication, but these errors are usually corrected by ... By monitoring the sizes (number of repeats) of several different microsatellites within a tumor, one can assess the function of ... Loci: BAT 25, BAT26, NR21, NR24 and NR27; Pentanucleotide repeats: PentaC and PentaD.. The MSI assay consists of five ...
  http://www.slh.wisc.edu/wslhApps/RefMan/wslhSearch.php?searchTerm=msi&TEST_REFERENCE_ID=7762&submitIt=testDetail
*  Clonal diversity and estimation of relative clone age: application to agrobiodiversity of yam (Dioscorea rotundata) | BMC Plant...
We used 12 microsatellite markers to identify intra-clonal diversity in yam varieties. We then used this diversity to assess ... microsatellite repeats increase or decrease randomly due to errors during the DNA replication process. The longer a variety ... Mutations are then added to each microsatellite locus according to the mutation rate μ. The number of microsatellite ... We used 12 microsatellite markers to identify intra-clonal diversity in yam varieties. We then used this diversity to assess ...
  https://0-bmcplantbiol-biomedcentral-com.brum.beds.ac.uk/articles/10.1186/1471-2229-13-178
*  Difference between revisions of "Yeast rebuild" - OpenWetWare
... mismatch repair of frameshift mutations in microsatellite repeats varies depending on genomic position of microsatellite repeat ... Chromosome replication. * Survey paper: MacAlpine and Bell, '05. * Autonomous replication sequences (ARS), are about 200 bp ... There doesn't seem to be any correlation between repair efficiency and position with respect to replication origin, replication ... Not clear how applicable their findings are to non-repeating sequence, like protein-coding regions. ...
  https://openwetware.org/wiki/?title=Yeast_rebuild&diff=18358&oldid=18357
*  Oooc oc - Gene Therapy - Barnard Health Care
... microsatellites); Transposable genetic elements; Triplet repeat diseases DNA replication, 4:12-19 ... replication fork (unwinding),. 4:14, 4:14 single-strand binding protein (SSB), 4:13, 4:14, 4:18 DNA, selfish. See Transposable ... 4:16, 4:17, 4:18 by plasmids, 3:151-152 recombinant DNA, 4:5-6 regulation of, 4:17-18 replication fork (unwinding), ... RPA), 4:14 of telomeres, 4:17 topoisomerase, 4:14-15, 4:18 DNA replication, prokaryotes distinguished from eukaryotes, 4:17 ...
  https://www.barnardhealth.us/gene-therapy/oooc-oc-fkv.html
*  С ?? ҩ ??.??Ϣ?? .11369501??11370000
11369909:Simultaneous detection of microsatellite repeats and SNPs in the macro. *11369910:Characterization of zebrafish Rad52 ... 11369556:Dynamic regulation of replication independent deposition of histone H3. *11369557:WASp is required for the correct ... 11369948:Both CAG repeats and inverted DNA repeats stimulate spontaneous unequa. *11369950:Multiplex PCR/liquid chromatography ... 11369501:REPPER repeats and their periodicities in fibrous proteins. *11369502:MEDock: a web server for efficient prediction of ...
  http://www.100md.com/index/other/byinfono/022/740.htm
*  Mutation Rates, Spectra, and Genome-Wide Distribution of Spontaneous Mutations in Mismatch Repair Deficient Yeast | G3: Genes |...
Microsatellite instability is a consequence of unrepaired slippage events during DNA replication of these repeat regions ( ... We find that microsatellite instability increases with repeat length and that microsatellites adjacent to other repeats are ... Microsatellites proximal to other repeats are more mutable. (A) The cumulative frequency plots for microsatellites sorted ... To assess mutation rates at microsatellites, an accurate count of the repeat number was required. Microsatellites in the draft ...
  http://www.g3journal.org/content/3/9/1453.full
*  St. Clair Research
Slippage Replication: A mutation process whereby a simple sequence tandem (microsatellite) repeat grows by addition or ... repeat is the microsatellite. By running back and forth across the repeat one can amplify a few copies of the microsatellite ... Microsatellite variation appears to result from slippage in replication, which is most likely to add or delete a single repeat ... such as micro- satellite repeats or short tandem repeats. But it has been the discovery that some SNPs are linked to particular ...
  http://www.stclairresearch.com/content/glossary.html
*  PARTHENOGENIC ACTIVATION OF HUMAN OOCYTES FOR THE PRODUCTION OF HUMAN EMBRYONIC STEM CELLS - Patent application
... monomer in microsatellite repeat) due to slipped-strand mispairing during DNA replication and DNA repair. [0297] These results ... 0279] Other known alleles (# of repeats): none [0280] Promega K562 DNA® Allele sizes (# of repeats): 8/9 [0281] PCR Protocol: ... 0252] Other known alleles (# of repeats): 7 [0253] Promega K562 DNA® Allele sizes (# of repeats): 8/8 [0254] PCR Protocol: ... 0270] Other known alleles (# of repeats): 6 [0271] Promega K562 DNA® Allele sizes (# of repeats): 9/10 [0272] PCR Protocol: ...
  http://www.patentsencyclopedia.com/app/20160143956
*  A survey of tandem repeat instabilities and associated gene expression changes in 35 colorectal cancers | BMC Genomics | Full...
Tandem repeatsColorectal cancerMSIMicrosatellite instabilityExpressionRepeat instabilityMicrosatelliteCancer pathwaysCancer ... The difference was more pronounced when we focused on mononucleotide repeats, in agreement with the finding that replication ... 3). We repeated this analysis also for repeats whose repeat unit consisted only of a single base (monucleotide repeats) to find ... Tandem repeat identification. We used the program Tandem Repeat Finder 4.07b [61] to identify tandem repeats in the consensus ...
  https://bmcgenomics.biomedcentral.com/articles/10.1186/s12864-015-1902-9
*  TGF-β Signaling Alterations and Colon Cancer | SpringerLink
Deficiencies in these enzymes lead to numerous errors in DNA replication, especially in tandem repeat sequences, and cause ... In addition, BMPR2 expression was significantly more frequently impaired in microsatellite unstable tumors than microsatellite ... This association was significantly stronger in cases with microsatellite stable tumors compared with microsatellite unstable ... TGFBR1*6A, a TGFBR1 polymorphism that consists of a deletion of three alanines within a nine-alanine repeat at the 3′ end of ...
  https://link.springer.com/chapter/10.1007%2F978-1-4419-6033-7_5
*  Treatment with the PARP inhibitor, niraparib, sensitizes colorectal cancer cell lines to irinotecan regardless of MSI/MSS...
... in MSI versus microsatellite stable (MSS) CRC cell lines in vitro and in vivo. We compiled a large panel of MSI and MSS CRC ... Microsatellite instability (MSI) accounts for 10-15% of colorectal cancer (CRC) and is hypothesized to lead to HR defects due ... profiles of mononucleotide repeat microsatellites in control individuals and in colorectal tumors with and without replication ... Microsatellite repeat analysis. DNA was extracted using standard methods from cells that were plated one day prior. Cell lines ...
  https://cancerci.biomedcentral.com/articles/10.1186/s12935-015-0162-8
*  Ploidy Dictates Repair Pathway Choice under DNA Replication Stress | Genetics
Sia, E. A., R. J. Kokoska, M. Dominska, P. Greenwell and T. D. Petes, 1997 Microsatellite instability in yeast: dependence on ... Each test was performed with 10 colonies and repeated twice for each strain (Xu et al. 2004). ... DNA replication stress, induced by oncogene activation, genotoxic stress, or defects in the DNA replication machinery, is ... Barbour, L., and W. Xiao, 2003 Regulation of alternative replication bypass pathways at stalled replication forks and its ...
  http://www.genetics.org/content/187/4/1031
*  Local population structure of white pine weevil (Pissodes strobi [Peck]) in interior and Sitka spruce stands in British...
Microsatellites vary in repeat sequence length through proofreading errors and slippage during DNA replication (Schlötterer ... Microsatellites, also called simple sequence repeats (SSRs), variable number of tandem repeats (VNTRs) or short tandem repeats ... The entire length of the microsatellite can vary from 5-40 repeats in length or greater. ... Microsatellites were found from the first build using MicroSAtellite identification tool (MISA) (Thiel et al. 2003). A total of ...
  https://open.library.ubc.ca/cIRcle/collections/ubctheses/24/items/1.0071762
*  Printing...
Owing to their repeated structures, microsatellites are particularly prone to replication errors that are normally repaired by ... Microsatellites are short DNA motifs of 1 to 6 bases that are repeated and distributed throughout the genome both in coding and ... 11 CRCs can be classified as microsatellite instability-high (MSI-H), and microsatellite instability-low (MSI-L), depending on ... microsatellite unstable, strong immune activation and BRAF mutations); CMS2 (canonical: 37%, epithelial, marked Wnt and MYC ...
  http://www.gotoper.com/print_pub.php?url=/publications/ajho/2017/2017july/advances-in-immunotherapy-in-the-treatment-of-colorectal-cancer