*  World's first physiologically relevant, in vitro Ischemia-Reperfusion Model
... in vitro Ischemia-Reperfusion Model in conjunction with BMG LABTECH and Ncardia. ... Ischemia-reperfusion (IR) injury, occurs in the body when blood supply returns to tissues after a period of oxygen and nutrient ... While significant advances have been made in understanding IR injury, progress has been impaired by i. the absence of a method ... "We are really excited about this innovative new tool for the ischemia reperfusion field, made possible by our recently reported ...
  http://www.ddw-online.com/product-news/p320715-world-s-first-physiologically-relevant--in-vitro-ischemia-reperfusion-model.html
*  ARA290, a non-erythropoietic EPO derivative, attenuates renal ischemia/reperfusion injury. - Surgical Intervention Trials Unit
Furthermore, ARA290 tended to reduce MCP-1 and IL-6 expression 15 minutes post-reperfusion. Seven days post-reperfusion ARA290 ... but potentially has cytoprotective capacities in prevention of renal ischemia/reperfusion injury. METHODS: Eight female Dutch ... ARA290 or saline was administered by an intravenous injection at 0, 2, 4 and 6 hours post-reperfusion. The animals were ... CONCLUSIONS: The improvement in renal function following renal ischemia/reperfusion and reduced structural damage observed in ...
  https://www.situ.ox.ac.uk/publications/384202
*  Depletion of gut commensal bacteria attenuates intestinal ischemia/reperfusion injury | Gastrointestinal and Liver Physiology
Depletion of gut commensal bacteria attenuates intestinal ischemia/reperfusion injury. Kazuhisa Yoshiya, Peter H. Lapchak, To- ... Intestinal reperfusion injury is mediated by IgM and complement. J Appl Physiol 86: 938-942, 1999. ... tissue injury following ischemia/reperfusion (I/R) may occur in multiple clinical situations such as shock, trauma, sepsis, and ... Accelerated ischemia/reperfusion-induced injury in autoimmunity-prone mice. J Immunol 173: 4230-4235, 2004. ...
  http://ajpgi.physiology.org/content/301/6/G1020.long
*  Beneficial effects of adenosine triphosphate-sensitive K+ channel opener on liver ischemia/reperfusion injury. | Sigma-Aldrich
Beneficial effects of adenosine triphosphate-sensitive K+ channel opener on liver ischemia/reperfusion injury.. [Mateus Antunes ... To investigate the effect of diazoxide administration on liver ischemia/reperfusion injury. Wistar male rats underwent partial ... Diazoxide maintains liver mitochondrial function, increases liver tolerance to ischemia/reperfusion injury, and reduces the ... 15 min before liver reperfusion. 4 h and 24 h after reperfusion, blood was collected for determination of aspartate ...
  https://www.sigmaaldrich.com/catalog/papers/25386080
*  Increased peripheral and local soluble FGL2 in the recovery of renal ischemia reperfusion injury in a porcine kidney auto...
Ischemia reperfusion (IR) injury, an inevitable issue in transplantation, contributes to delayed graft function, acute and ... Soluble FGL2Ischemia reperfusion injuryKidney auto-transplantationPorcineFcγRIIB. Introduction. Kidney transplantation serves ... Increased peripheral and local soluble FGL2 in the recovery of renal ischemia reperfusion injury in a porcine kidney auto- ... Based on the dynamic changes of sFGL2 throughout 2 weeks of renal ischemia reperfusion injury, its secreting cells, Tregs, were ...
  https://translational-medicine.biomedcentral.com/articles/10.1186/1479-5876-12-53
*  Omega 3 has a beneficial effect on ischemia/reperfusion injury, but cannot reverse the effect of stressful forced exercise. -...
Omega 3 has a beneficial effect on ischemia/reperfusion injury, but cannot reverse the effect of stressful forced exercise.. ... After a 30min global ischemic event and 2h reperfusion, hearts of sedentary-omega3 animals recovered about 37% of left ...
  https://www.ncbi.nlm.nih.gov/pubmed/18455377
*  Ulinastatin Preconditioning Attenuates Inflammatory Reaction of Hepatic Ischemia Reperfusion Injury in Rats via High Mobility...
The nuclear factor HMGB1 mediates hepatic injury after murine liver ischemia-reperfusion. J Exp Med. 2005;201:1135-43 doi: ... Bahde R, Spiegel H. Hepatic ischaemia-reperfusion injury from bench to bedside. Br J Surg. 2010;97:1461-75 doi:10.1002/bjs.7176 ... Cutting edge: high-mobility group box 1 preconditioning protects against liver ischemia-reperfusion injury. J Immunol. 2006;176 ... Kudo Y, Egashira T, Yamanaka Y. Protective effect of ulinastatin against liver injury caused by ischemia-reperfusion in rats. ...
  http://www.medsci.org/v11p0337.htm
*  Effects of acute angiotensin II on ischemia reperfusion injury following myocardial infarction.
... the acute effects of angiotensin II in ischemia-reperfusion injury (IR) remains unclear. In the present study, we tested ... 30 minutes of reperfusion) during vehicle or angiotensin II infusions (10(-7) M). MI hearts were dilated and had reduced ...
  http://www.biomedsearch.com/nih/Effects-acute-angiotensin-II-ischemia/25487980.html
*  "Ischemia Induces P-Selectin-Mediated Selective Progenitor Cell Engraft" by Jason A. Burdick, Jeremy A. Elser et al.
Blocking P-selectin in ischemic hearts ablated selectivity for c-kit+/CD45+ BMCs at 30 min reperfusion (selectivity ratio of 3 ... a time-dependent selective retention of c-kit+ cells was apparent starting at 30 min of reperfusion, at which time c-kit+/CD45+ ... Myocardial ischemia-reperfusion stress induces selective engraftment of c-kit+ bone marrow progenitor cells via P-selectin ... stop-flow ischemia was followed by variable-duration reperfusion (0-60 min) before addition of labeled syngenic BMCs to the ...
  https://repository.upenn.edu/be_papers/220/
*  KAKEN - Research Projects | STUDY ON THE ROLE OF Na +-H + EXCHANGE ON ISCHEMIA-REPERFUSION INjURY (KAKENHI-PROJECT-07670816)
Reperfusion injury / Na^+-H^+ exchange / SSwine in vivo model / 再潅流障害 / Na^+-H^+変換系 / アミロライド / 収縮帯壊死 / 単相活動電位 / 再灌流不整脈. ... Publications] Motoyuki Fukuta: 'Role of Na^+-H^+ exchange on reperfusion related myocardial injury and arrkythmia in an open ... Publications] Motokuki Fukuta: 'Role of Na^+-H^+ Exchange Inhibitor on Ischemia-reperfusion Injury' J.Aichi.Med.Univ.Assoc. 24 ... Publications] MOTOYUKI FUKUTA YASUSHI WAKIDA: 'Role of Na^+-H^+ Exchange on Reperfusion Related
  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-07670816/
*  Patent US7635680 - Attenuation of reperfusion injury - Google Patents
... enhancing the survivability of platelets during storage or transfusion and to attenuate ischemia-reperfusion injury (IPI), are ... The modified annexin decreases the binding of leukocytes and platelets during post-ischemic reperfusion, thereby restoring ... myocytes are viable before reperfusion then progress to irreversible injury during reperfusion. Apoptosis can contribute to ... up to at least about 3 hours prior to reperfusion, up to at least about 1 hour prior to reperfusion, during reperfusion, and/or ...
  http://www.google.com/patents/US7635680?dq=6,411,947
*  Ischemia/Reperfusion Injury in Liver Surgery and Transplantation
... Guest Editors: Peter Schemmer, John J. Lemasters, and Pierre- ... Ischemia/Reperfusion Injury in Liver Surgery and Transplantation, Peter Schemmer, John J. Lemasters, and Pierre-Alain Clavien ... Ischemia/Reperfusion Injury in Liver Surgery and Transplantation: Pathophysiology, Kilian Weigand, Sylvia Brost, Niels ... Desferrioxamine Attenuates Pancreatic Injury after Major Hepatectomy under Vascular Control of the Liver: Experimental Study in ...
  https://www.hindawi.com/journals/hpb/si/239537/
*  Smad1 Protects Cardiomyocytes From Ischemia-Reperfusion Injury | Circulation
Reperfusion injury induces apoptosis in rabbit cardiomyocytes. J Clin Invest. 1994; 94: 1621-1628. ... Smad1 Protects Cardiomyocytes From Ischemia-Reperfusion Injury. Mitsuru Masaki, Masahiro Izumi, Yuichi Oshima, Yoshikazu ... Nakamura T, Mizuno S, Matsumoto K, Sawa Y, Matsuda H. Myocardial protection from ischemia/reperfusion injury by endogenous and ... Smad1 Protects Cardiomyocytes From Ischemia-Reperfusion Injury. Mitsuru Masaki, Masahiro Izumi, Yuichi Oshima, Yoshikazu ...
  http://circ.ahajournals.org/content/111/21/2752
*  Fibrin-Derived Peptide FX06 Reduces Cardiac Reperfusion Injury
After 4 months, the resulting scar mass was reduced by 37%, suggesting that a reduction of reperfusion injury indeed may lead ... Cardiology »F.I.R.E. »FX06 »Fibrin-Derived »PCI »Reperfusion »STEMI »Thrombolysis »blood flow »blood vessel »myocardial ... Further reports about: , Cardiology , F.I.R.E. , FX06 , Fibrin-Derived , PCI , Reperfusion , STEMI , Thrombolysis , blood flow ... "reperfusion injury". FX06 is a novel compound intended to prevent that damage. ...
  http://www.innovations-report.com/hrml/reports/studies/fibrin-derived-peptide-fx06-reduces-cardiac-117326.html
*  Salvianolate for treatment of cerebral ischemia-reperfusion injuries | EurekAlert! Science News
... and improves energy metabolism against cerebral ischemia-reperfusion injuries. Dr. Wei Lu and his team from the Second Xiangya ... Hospital, Central South University, China found that administration of salvianolate during reperfusion after ischemia appears ... Salvianolate increases heat shock protein expression in a cerebral ischemia-reperfusion injury model. Neural Regen Res. 2013;8( ... Salvianolate for treatment of cerebral ischemia-reperfusion injuries. Neural Regeneration Research. Journal. Neural ...
  https://www.eurekalert.org/pub_releases/2013-10/nrr-sft102513.php
*  Visualizing and targeting oxidative stress in hepatic ischemia-reperfusion injury
Ischemia-reperfusion (IR) injury is the inevitable result of liver resection performed using vascular inflow occlusion (VIO), ... Visualizing and targeting oxidative stress in hepatic ischemia-reperfusion injury. Supervisors. T.M. van Gulik. ... In addition, the protective effect of hypothermia on IR injury was investigated using a new method for in situ hypothermic ... Hepatocellular oxidative stress forms a pivotal aspect of IR injury, predominantly during the early (0-30 min) phase of ...
  http://dare.uva.nl/search?identifier=f53b5a16-0615-450e-9ee7-33e0f5bff6f0
*  A New Light on the Mechanisms of Early Stage Liver Reperfusion Injury
Reperfusion of a previously ischemic tissue is associated with additional injury leading to structural and functional ... The injury induced during reperfusion is evolved a biphasic pattern consisting of an early stage started upon reoxygenation and ... Reperfusion of a previously ischemic tissue is associated with additional injury leading to structural and functional ... in the early stage of hepatic reperfusion injury and the presence of apoptotic bodies were augmented as the time of reperfusion ...
  http://www.medindia.net/news/A-New-Light-on-the-Mechanisms-of-Early-Stage-Liver-Reperfusion-Injury-51079-1.htm
*  Attenuation of Ischemia/Reperfusion Injury in Rats by a Caspase Inhibitor | Circulation
Attenuation of Ischemia/Reperfusion Injury in Rats by a Caspase Inhibitor. Hiroyuki Yaoita, Kazuei Ogawa, Kazuhira Maehara, ... Attenuation of Ischemia/Reperfusion Injury in Rats by a Caspase Inhibitor. Hiroyuki Yaoita, Kazuei Ogawa, Kazuhira Maehara and ... Attenuation of Ischemia/Reperfusion Injury in Rats by a Caspase Inhibitor. Hiroyuki Yaoita, Kazuei Ogawa, Kazuhira Maehara and ... Positive Control for the Rat Model of Reperfusion Injury. The ischemic area at risk was 53.0±2.5% (NS versus group 1 and group ...
  http://circ.ahajournals.org/content/97/3/276
*  Reperfusion injury - Wikipedia
Reperfusion injury or reperfusion insult, sometimes called ischemia-reperfusion injury (IRI) or reoxygenation injury, is the ... Reperfusion can cause hyperkalemia. Reperfusion injury is a primary concern in liver transplantation surgery. A study of aortic ... or what is termed reperfusion injuries. In fact an individual suffering from an ischemic insult continues suffering injuries ... Reperfusion injury plays a part in the brain's ischemic cascade, which is involved in stroke and brain trauma. Similar failure ...
  https://en.wikipedia.org/wiki/Reperfusion_injury
*  Patente US20060100639 - System and method for the treatment of reperfusion injury - Google Patentes
... the reperfusion of acute MI which includes modulation of coronary blood flow or oxygen delivery following the reperfusion of ... A method and apparatus for the prevention and treatment of reperfusion injury following ... One hallmark of reperfusion injury is that it may be attenuated by interventions initiated before or during the reperfusion. ... This invention relates to a method for reducing reperfusion injury after therapeutic reperfusion of an infarct of a heart or ...
  http://www.google.es/patents/US20060100639?dq=flatulence
*  AQP4 Knockout Aggravates Ischemia/Reperfusion Injury in Mice. | Internet Stroke Center
Home » Blog » News » AQP4 Knockout Aggravates Ischemia/Reperfusion Injury in Mice. Post navigation. ← Previous Next → AQP4 ... Knockout Aggravates Ischemia/Reperfusion Injury in Mice.. Posted on April 30, 2012. by RSS ...
  http://www.strokecenter.org/aqp4-knockout-aggravates-ischemiareperfusion-injury-in-mice/
*  Does remifentanil attenuate renal ischemia-reperfusion injury better t | DDDT
In I/R injury groups, the left renal artery and vein were occluded together by a clamp for 30Â minutes and reperfusion lasted ... Ischemiaâ reperfusion (I/R) injury is a common cause of patient morbidity and mortality in the perioperative period. Patients ... saline-infused rats without I/R injury), the saline group (group S, n=6, saline-infused rats with I/R injury), the remifentanil ... Objectives: We aimed to investigate the protective effects of an intravenous anesthetic remifentanil in renal I/R injury in the ...
  https://www.dovepress.com/does-remifentanil-attenuate-renal-ischemiandashreperfusion-injury-bett-peer-reviewed-article-DDDT
*  Cellular and Molecular Dissection of Reperfusion Injury | Circulation Research
Reperfusion injury in the heart can occur either as a result of transient arterial occlusion (eg, due to vasospasm or thrombus ... Cellular and Molecular Dissection of Reperfusion Injury. ROS Within and Without. Gregg L. Semenza ... Transgenic mice that overexpress copper-zinc superoxide dismutase manifest dramatically reduced myocardial reperfusion injury ... Reperfusion results in the production of chemotactic cytokines by vascular endothelial cells that result in the binding of ...
  http://circres.ahajournals.org/content/86/2/117
*  Retroinfusion of Embryonic Endothelial Progenitor Cells Attenuates Ischemia-Reperfusion Injury in Pigs | Circulation
New directions for protecting the heart against ischaemia-reperfusion injury: targeting the Reperfusion Injury Salvage Kinase ( ... Conclusion- Our findings show that eEPCs reduce ischemia-reperfusion injury in a preclinical pig model. The rapid effect (as ... Attenuation of myocardial ischemia-reperfusion (I/R) injury is experimentally accomplished (ie, by preservation of endothelial ... Retroinfusion of Embryonic Endothelial Progenitor Cells Attenuates Ischemia-Reperfusion Injury in Pigs. Role of ...
  http://circ.ahajournals.org/content/112/9_suppl/I-117
*  Ischemia-reperfusion injury: enthusiasm in laboratory research but dilemma in clinical trials? | Circulation
Ischemia-reperfusion injury: enthusiasm in laboratory research but dilemma in clinical trials?. H A Lehr, M D Menger, D N ... Ischemia-reperfusion injury: enthusiasm in laboratory research but dilemma in clinical trials? ... Ischemia-reperfusion injury: enthusiasm in laboratory research but dilemma in clinical trials? ... Ischemia-reperfusion injury: enthusiasm in laboratory research but dilemma in clinical trials? ...
  http://circ.ahajournals.org/content/90/3/1580.1