*  Tissue and gene specificity of mouse renin expression. | Hypertension
In contrast, kidney renin levels appear to be unaffected by the gene duplication. Sequence analysis of a 319 bp renin cDNA ... Tissue and gene specificity of mouse renin expression.. L J Field, R A McGowan, D P Dickinson, K W Gross ... Some strains of mice appear to carry a duplication of the renin structural gene (Ren-2) near the Ren-1 locus. Strains with the ... Moreover, a single base substitution of A for G at residue #996 in the kidney renin mRNA creates a potential glycosylation ...
  http://hyper.ahajournals.org/content/6/4/597
*  α-Adrenoceptors and Age-Dependent Decrease of Plasma Renin Activity in Essential Hypertension | Clinical Science
3. The maximum increment of plasma renin activity was inversely related to age and the dose-response curve of plasma renin ... α-Adrenoceptors and Age-Dependent Decrease of Plasma Renin Activity in Essential Hypertension. A. Salvetti, R. Pedrinelli, F. ... 2. Phentolamine caused a dose-related increase of plasma renin activity, which was independent of mean blood pressure and heart ... α-Adrenoceptors and Age-Dependent Decrease of Plasma Renin Activity in Essential Hypertension ...
  http://www.clinsci.org/content/61/s7/311s
*  Abstract 191: Transcriptional Regulation of Renin by Nuclear Receptors Co-regulated With Renin | Hypertension
Abstract 191: Transcriptional Regulation of Renin by Nuclear Receptors Co-regulated With Renin. Ko-Ting Lu, Eric T Weatherford ... We tested the hypothesis that a nuclear receptor that is co-regulated with renin may participate in renin gene regulation. To ... Abstract 191: Transcriptional Regulation of Renin by Nuclear Receptors Co-regulated With Renin ... Abstract 191: Transcriptional Regulation of Renin by Nuclear Receptors Co-regulated With Renin ...
  http://hyper.ahajournals.org/content/62/Suppl_1/A191
*  Evidence for an extrarenal source of inactive renin in rats. | Hypertension
Inactive renin was separated from active renin by a Cibacron blue column, and the 0 time inactive renin eluted in the same ... In summary, inactive renin is present in the anephric rat and does not appear to be converted to active renin in the peripheral ... Active renin rapidly decreased after bilateral nephrectomy, with a half-life of approximately 15 minutes. Inactive renin, on ... The pH optimum of inactive renin in rat renin substrate was between 5.5 and 7.5, which differs from the optimal value of pepsin ...
  http://hyper.ahajournals.org/content/6/5/627
*  Integrating drug pharmacokinetics for phenotyping individual renin response to angiotensin II blockade in humans.
Renin release into plasma has been used to investigate the drug dose-dependence of renin-angiotensin system inhibition because ... it is proportional to the interruption of the permanent negative feedback loop of angiotensin II on renin secretion. We inv ... Renin / blood*, secretion. Renin-Angiotensin System / drug effects*. Reproducibility of Results. Tetrazoles / administration & ... Renin release into plasma has been used to investigate the drug dose-dependence of renin-angiotensin system inhibition because ...
  http://www.biomedsearch.com/nih/Integrating-drug-pharmacokinetics-phenotyping-individual/15023936.html
*  Identification of Renin and Renin-like Enzymes in Rat Brain by a Renin-Specific Antibody | Clinical Science
Identification of Renin and Renin-like Enzymes in Rat Brain by a Renin-Specific Antibody. V. J. Dzau, Amy Brenner, Neremiah ... Identification of Renin and Renin-like Enzymes in Rat Brain by a Renin-Specific Antibody ... Identification of Renin and Renin-like Enzymes in Rat Brain by a Renin-Specific Antibody ... Identification of Renin and Renin-like Enzymes in Rat Brain by a Renin-Specific Antibody ...
  http://www.clinsci.org/content/59/s6/45s
*  A radiochemical renin assay | Biochemical Journal
1. A synthetic 3-([14C]valine)-labelled tetradecapeptide renin substrate was used to measure renin concentration. Renin ... A radiochemical renin assay. F. A. Mendelsohn, C. I. Johnston. Biochemical Journal Jan 01, 1971, 121 (2) 241-244; DOI: 10.1042/ ... 2. The rate of conversion of the substrate into angiotensin I was shown to be linearly related to renin concentration and time ... It is suggested that the use of a pure substrate offers advantages that include the standardization of current units of renin ...
  http://www.biochemj.org/content/121/2/241
*  A Genetic Variant in the Distal Enhancer Region of the Human Renin Gene Affects Renin Expression - pdf descargar
A Genetic Variant in the Distal Enhancer Region of the Human Renin Gene Affects Renin Expression. . Biblioteca virtual para ... A Genetic Variant in the Distal Enhancer Region of the Human Renin Gene Affects Renin Expression - Descarga este documento en ... A Genetic Variant in the Distal Enhancer Region of the Human Renin Gene Affects Renin Expression. ... The results suggest that variants in the enhancer region of the human renin gene have an effect on the expression levels of ...
  http://libros.duhnnae.com/2017/jun9/149846632086-A-Genetic-Variant-in-the-Distal-Enhancer-Region-of-the-Human-Renin-Gene-Affects-Renin-Expression.php
*  Anti-Hypertensive Adrenergic-Blocking Agents: Effects on Sodium Balance, the Renin-Angiotensin System and Haemodynamics |...
... between plasma volume and plasma renin activity, and between plasma renin activity and plasma aldosterone. ... 5. This study suggests that the decrease in plasma renin activity was related to the lowering of the heart rate rather than to ... Anti-Hypertensive Adrenergic-Blocking Agents: Effects on Sodium Balance, the Renin-Angiotensin System and Haemodynamics. M. E. ... 1. The changes in plasma volume, haemodynamic variables, plasma renin activity and plasma aldosterone were studied in forty-one ...
  http://www.clinsci.org/content/48/s2/93s
*  Role of prostaglandins in the control of renin secretion in the dog. | Circulation Research
... and of renin secretion rate to 2,582.6 +/- 786.4 U/min (P less than 0.005). The decrease in renin secretion rate during the ... Role of prostaglandins in the control of renin secretion in the dog.. J Yun, G Kelly, F C Bartter, H Smith ... Renin secretion rate decreased from 1,194.1 +/- 353.9 U/min during control periods to reach 384.0 +/- 125.8 U/min (P less than ... The data suggest that PGE1 and PGE2 play a role in the control of renin secretion. ...
  http://circres.ahajournals.org/content/40/5/459
*  Gentaur Molecular :Molecular Innovations \ RENIN PRORENIN Rat Renin Prorenin Double Depleted Plasma \ RPLA-SC-PREN
RENIN_PRORENIN Rat Renin_Prorenin Double Depleted Plasma \ RPLA-SC-PREN for more molecular products just contact us ... Index / Molecular Innovations / RENIN_PRORENIN Rat Renin_Prorenin Double Depleted Plasma / Product Detail : RPLA-SC-PREN RENIN_ ... We have also other products like : RENIN_PRORENIN Rat Renin_Prorenin Double Depleted Plasma. Related products : RENIN_PRORENIN ... RPLA-SC-PREN RENIN_PRORENIN Rat Renin_Prorenin Double Depleted Plasma Ask technical file . ...
  http://www.antibody-antibodies.com/product_det.php?id=2627201&supplier=search&name=%20RENIN_PRORENIN%20Rat%20Renin_Prorenin%20Double%20Depleted%20Plasma
*  Control of Renin Synthesis and Secretion.
Renin is synthesized as an enzymatically inactive proenzyme which is constitutively secreted from several tissues. Only renin- ... The aspartyl protease renin is the rate limiting activity of the renin-angiotensin-aldosterone system (RAAS). ... The aspartyl protease renin is the rate limiting activity of the renin-angiotensin-aldosterone system (RAAS). Renin is ... Only renin-expressing cells in the kidney are capable of generating active renin from prorenin, which is stored in prominent ...
  http://www.biomedsearch.com/nih/Control-Renin-Synthesis-Secretion/22237158.html
*  Angiotensin subtype-2 receptors inhibit renin biosynthesis and angiotensin II formation. - Semantic Scholar
We monitored changes in renal Ang II, renin mRNA and protein expression, and plasma renin concentration (PRC) in response to ... Renin mRNA increased 63% during LS, and either valsartan or PD increased it further by 600% and 250% from NS and 538% and 187% ... Similarly, renal renin content and PRC increased in response to LS and increased further in response to combined LS and ... Immunostaining for renal renin protein demonstrated an increase in its expression in juxtaglomular and tubular cells during LS ...
  https://www.semanticscholar.org/paper/Angiotensin-subtype-2-receptors-inhibit-renin-bios-Siragy-Xue/0cc273503bf8d60dfb2419a18439a53c839ed97c
*  Exchangeable Sodium in Experimental Hypertension in Rats | Clinical Science
4. The fact that both plasma renin levels and exchangeable sodium levels increase according to this method, suggests that ... which developed severe hypertension had a marked increase in exchangeable sodium with a concomitant rise in plasma renin; the ... removal of the other kidney produced severe hypertension with no significant changes in exchangeable sodium or plasma renin ...
  http://www.clinsci.org/content/51/s3/133s
*  Effects of Renal Arterial Infusion of Sodium and Potassium on Renin Secretion in the Dog | Circulation Research
Effects of Renal Arterial Infusion of Sodium and Potassium on Renin Secretion in the Dog. ROBERT E. SHADE, JAMES O. DAVIS, J. ... An increase in renal venous plasma sodium concentration from 141 to 154-158 mEq/liter caused no change in renin secretion for ... The nonfiltering kidney model was used to determine whether sodium or potassium inhibits renin secretion in the absence of a ... In contrast, dogs with thoracic caval constriction but with a filtering kidney showed a striking decrease in renin secretion ...
  http://circres.ahajournals.org/content/31/5/719
*  Evidence for Hemodynamic Autoregulation of Renin Release | Circulation Research
... renin release remained high. Therefore, renin release appears to be related to autoregulated dilatation of the renal arterioles ... Renin release, determined by both bioassay and radioimmunoassay, averaged 2.7 ± 0.9 (SE) µg/min at control pressure and ... Evidence for Hemodynamic Autoregulation of Renin Release. IVAR EIDE, EINAR LOslash;YNING, FREDRIK KIIL ... However, renin release then remained constant during further lowering of arterial perfusion pressure despite reductions in ...
  http://circres.ahajournals.org/content/32/2/237
*  Cardiac Hypertrophy and Microvascular Deficit in Kinin B2 Receptor Knockout Mice | Hypertension
Mice with the 2-renin gene, such as the 129/J strain, show extremely elevated plasma renin activity, higher basal BP levels ... 10-fold higher plasma renin activity, and 100-fold higher plasma renin concentration.10 Thus, the severe cardiomyopathy ... It should be noted that wild-type 129/J and C57BL/6 mice differ from each other in that the former strain has a 2-renin gene, ... Wild-type mice are polymorphic for the number of renin genes, with some inbred strains harboring 1 gene (Ren-1[c]) and other ...
  http://hyper.ahajournals.org/content/41/5/1151
*  Characterization of recombinant human prorenin and renin. | Hypertension
Characterization of recombinant human prorenin and renin.. C T Carilli, J L Vigne, L C Wallace, L M Smith, M A Wong, J A ... Characterization of recombinant human prorenin and renin.. C T Carilli, J L Vigne, L C Wallace, L M Smith, M A Wong, J A ... Characterization of recombinant human prorenin and renin.. C T Carilli, J L Vigne, L C Wallace, L M Smith, M A Wong, J A ... The purified inactive prorenin was not a substrate for active renin and was not capable of self-activation. Prorenin could be ...
  http://hyper.ahajournals.org/content/11/6_Pt_2/713
*  High-Renin Essential Hypertension: Adrenergic Cardiovascular Correlates | Clinical Science
High-Renin Essential Hypertension: Adrenergic Cardiovascular Correlates. M. Esler, S. Julius, O. Randall, V. Dequattro, A. ... High-Renin Essential Hypertension: Adrenergic Cardiovascular Correlates. M. Esler, S. Julius, O. Randall, V. Dequattro, A. ... High-Renin Essential Hypertension: Adrenergic Cardiovascular Correlates Message Subject (Your Name) has forwarded a page to you ... The high plasma renin activity is seen as an expression of sympathetic nervous system overactivity. ...
  http://www.clinsci.org/content/51/s3/181s
*  Aldosterone and Renin
Renin is an enzyme that controls aldosterone production. Aldosterone and renin tests help diagnose primary (Conn syndrome) and ... Renin is an enzyme that controls aldosterone production. These tests measure the levels of aldosterone and renin in the blood ... blood levels of aldosterone and renin are measured and a calculation is done by dividing the aldosterone result by the renin ... The kidneys release renin when there is a drop in blood pressure or a decrease in sodium chloride concentration in the tubules ...
  https://labtestsonline.org/tests/aldosterone-and-renin
*  Renin-1 (P06281) | InterPro | EMBL-EBI
InterPro provides functional analysis of proteins by classifying them into families and predicting domains and important sites. We combine protein signatures from a number of member databases into a single searchable resource, capitalising on their individual strengths to produce a powerful integrated database and diagnostic tool.
  http://www.ebi.ac.uk/interpro/protein/P06281
*  Renin in Experimental Hypertension | The BMJ
Renin in Experimental Hypertension. Br Med J 1942; 2 doi: https://doi.org/10.1136/bmj.2.4258.179 (Published 15 August 1942) ...
  http://www.bmj.com/content/2/4258/179
*  Evolution of renin. | Hypertension
In this way, they discovered renin. This paper covers the methods by which its mode of action was uncovered, as well as its ...
  http://hyper.ahajournals.org/content/18/5_Suppl/III100
*  Renin FRET Substrate I
... also called Renin Substrate I in some literature) contains a renin cleavage site that occurs in the N-terminal peptide of human ... The kinetics of renin-catalyzed hydrolysis of this substrate is shown to be consistent with a simple substrate inhibition model ... The substrate can detect renin as low as 30 ng/mL after an incubation of only 3-5 min.; Minimum Purity: 95%; DABCYL-g-Abu- ... Cleavage of the substrate occurs specifically at the Leu-Val bond and corresponds to the renin cleavage site of angiotensinogen ...
  https://www.anaspec.com/products/product.asp?id=48589&productid=17790