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*  CHRONOTHERAPY
The advantages of the field of chronotherapy are endless. If we can properly time our use of drugs to follow the circadian ... is significantly more effective at sleep-time than at wake-time in hypertensive models. It is thus intuitive to say that the ... When administered at night, this drug causes a dip in blood pressure that is seen in our normal circadian rhythms and can help ... But the idea that the entirety of our physiology is subject to regulation by three main biological rhythms still isn't common ...
  http://circadianmedicine.my-free.website/chronotherapy/
*  Diurnal Variation in Blood Pressure and Arterial Stiffness in Chronic Kidney DiseaseNovelty and Significance | Hypertension
... chronotherapy) is a well-recognized treatment strategy. In a study where untreated hypertensive subjects were randomized to ... A circadian rhythm of plasma ET-1, in both healthy volunteers36 and patients with CKD,37 has been previously described, but it ... At each time point, the arteriograph records aortic PWV, aortic systolic BP (SBP) and diastolic BP (DBP), brachial SBP and DBP ... Recently, we showed that chronic selective ETA receptor antagonism-using the orally active drug sitaxentan-reduces BP, ...
  http://hyper.ahajournals.org/content/64/2/296
*  Cronoterapia în hipertensiunea arterială - un ajutor în atingerea ţintelor terapeutice | www.stetoscop.ro
Circadian rhythmic and environmental determinants of 24-hour blood pressure regulation in normal and hypertensive conditions. ... Smolensky M.H., Peppas (eds.) - Chronobiology, drug-delivery and chronotherapeutics - Adv. Drug Deliv. Rev. 2007, 59, 823-1069 ... SMOLENSKY M.H., HERMIDA R.C. et al., Administration-time-dependent effect of blood pressure-lowering medications:basis for the ... HERMIDA R.C., Ambulatory blood pressure monitoring in the prediction of cardiovascular events and effects of chronotherapy: ...
  http://www.stetoscop.ro/cronoterapia-hipertensiunea-arteriala-un-ajutor-atingerea-tintelor-terapeutice?mini=2018-03
*  Sleep-Time Blood Pressure | JACC: Journal of the American College of Cardiology
2007) Circadian variation in blood pressure: the basis for chronotherapy of hypertension. Adv Drug Deliv Rev 59:904-922. ... In most individuals (normotensive or hypertensive), BP has a predictable circadian pattern characterized by a rapid increase at ... from the present study group demonstrating that bedtime administration of ramipril results in superior nocturnal BP regulation ... 2010) Administration time-dependent effects of blood pressure lowering medications: basis for the chronotherapy of hypertension ...
  http://www.onlinejacc.org/content/58/11/1174
*  cardiovascular physiologic phenomena
Sleep-related changes in cardiovascular neural regulation in spontaneously hypertensive rats. Terry B J Kuo. Institute of ... A real-time emotionality assessment (RTEA) system based on psycho-physiological evaluation. Soon Cheol Chung. Department of ... Chronotherapy. Treating patients in a timely fashion. Christine A Kessler. Department of Endocrinology and Metabolic Medicine, ... GPCRs: Evolving Concepts and Drug Discovery. Paul Insel; Fiscal Year: 2004. ..Attendees will thus have the chance to learn and ...
  https://www.labome.org/topics/physical/natural/biological/circulatory/cardiovascular/cardiovascular-physiologic-phenomena-19998.html
*  The Circadian Protein Period 1 Contributes to Blood Pressure Control and Coordinately Regulates Renal Sodium Transport Genes |...
Circadian variation of blood pressure: the basis for the chronotherapy of hypertension. Adv Drug Deliv Rev. 2007;59:904-922. ... Significant differences in mRNA levels between 2 time points are suggestive of clock-controlled regulation.10,24 Like Per1 and ... Increasing evidence suggests a role for the circadian clock in the control of blood pressure (BP). A subset of hypertensive ... Regulation of αenac expression by the circadian clock protein period 1 in mpkccd(c14) cells. Biochim Biophys Acta. 2010;1799: ...
  http://hyper.ahajournals.org/content/59/6/1151
*  diltiazem
Drug Metab Dispos 37:1587-97. 2009. Prediction of the extent and time course of drug-drug interactions (DDIs) between the ... REGULATION OF MEMBRANE MEDIATED MUSCLE DEGENERATION. Syamal Bhattacharya; Fiscal Year: 1992. ..the mechanism(s) of EICA at the ... The introduction of chronotherapy (that is improving a drugs therapeutic efficacy by paralleling the drugs plasma levels to ... Pharmacokinetic-pharmacodynamic modeling of diltiazem in spontaneously hypertensive rats: a microdialysis study. Facundo M ...
  https://www.labome.org/topics/chemicals/heterocyclic/2/benzazepines/diltiazem-11350.html
*  Circadian Levels of Serum Melatonin and Cortisol in relation to Changes in Mood, Sleep, and Neurocognitive Performance,...
F. Portaluppi and B. Lemmer, "Chronobiology and chronotherapy of ischemic heart disease," Advanced Drug Delivery Reviews, vol. ... 1) Simple Reaction Time. The subjects were instructed to click the left mouse button each time a triangle was flashed on the ... Four (20%) were hypertensive, requiring antihypertensive drugs in addition to lifestyle and diet modification. Two of these ... Another study also evaluated the usage of light intensity regulation at the stations to influence sleep behavior and mood ...
  https://www.hindawi.com/journals/neuroscience/2013/254090/
*  Neurotransmitters of the suprachiasmatic nuclei
The role of AVP in circadian time keeping has been well established. Its role in the control of circadian rhythm of food and ... Regulation of circadian rhythms by excitatory amino acids. Excitatory amino acids: Their role in neuroendocrine function. New ... Green, CB (2005). Time for chronotherapy? Clock genes dictate sensitivity to cyclophosphamide. Proc Nat Acad Sci USA 102: 3529- ... NO synthesis is required for phase changes of electrical activity [64]. Intracerebroventricular application of L-NAME (a drug ...
  https://www.jcircadianrhythms.com/articles/10.1186/1740-3391-4-2/print/
*  circadian rhythm sleep disorders
In circadian rhythm sleep disorders (CRSD), the patient's preferred sleeping time is malsynchronized with the sleep phase ... Altered sleep regulation in leptin-deficient mice. Aaron D Laposky. Northwestern University, Center for Sleep and Circadian ... chronotherapy*severity of illness index*electroencephalography*hypnotics and sedatives*rem sleep*cross sectional studies*body ... Drug Effects on Behavior: Workplace Implications. Carl Hart; Fiscal Year: 2008. ..Together, the data from the proposed studies ...
  https://www.labome.org/topics/diseases/nervous/chronobiology/circadian-rhythm-sleep-disorders-7010.html