The PINK1/Parkin pathway regulates mitochondrial dynamics and function in mammalian hippocampal and dopaminergic neurons. Hum ... Polarized endosome dynamics engage cytoplasmic Par-3 that recruits dynein during asymmetric cell division. Sci Adv. 2021 06; 7( ... Fezf2 regulates multilineage neuronal differentiation through activating basic helix-loop-helix and homeodomain genes in the ... A subunit of the mediator complex regulates vertebrate neuronal development. Proc Natl Acad Sci U S A. 2006 Nov 14; 103(46): ...
The dynamics of histone-DNA interactions govern chromosome organization and regulates the processes of transcription, ... However, inhibition of ADP/ATP exchange led to aberrant cristae morphology and impaired cristae dynamics in a mitochondrial ... combined with in-depth quantification were employed to analyse cristae morphology and dynamics after treatment of mammalian ... AgNPs and SiNPs can also disturb mitochondrial dynamics manifested as increasing Mfn2 expression and decreasing Drp1 expression ...
E. coli regulates this process through the use of termination sequences that, when bound by the Tus protein, enable only one ... Replication of chloroplast and mitochondrial genomes occurs independently of the cell cycle, through the process of D-loop ... D. A. Jackson et al.(1998) revealed that neighboring origins fire simultaneously in mammalian cells. Spatial juxtaposition of ... foci in budding yeast cells and revealed that replication origins move constantly in G1 and S phase and the dynamics decreased ...
Dynamics of the DYNLL1-MRE11 complex regulate DNA end resection and recruitment of Shieldin to DSBs Here, the authors show that ... Molecular pathway of mitochondrial preprotein import through the TOM-TIM23 supercomplex Here the authors report structural and ... Nucleosome density shapes kilobase-scale regulation by a mammalian chromatin remodeler Here authors present SAMOSA-ChAAT, a ... The authors use this approach to study how NuRD assembles on chromatin and how it regulates enhancer dynamics. ...
Currently, mitochondrial transplantation is an available approach for restoring mitochondrial function in mitochondrial ... Mitochondrial transplantation also consistently decreased Drp-1, which resulted in an enhancement of the tubular mitochondrial ... Herein, effects of mitochondrial transplantation via different approaches in breast cancer were investigated. Whole ... This study reveals the antitumour potential of mitochondrial transplantation in breast cancer via distinct regulation of ...
Among them, the sirtuin, AMP-activated protein kinase, mammalian target of rapamycin, p53, and insulin/insulin-like growth ... Among them, the sirtuin, AMP-activated protein kinase, mammalian target of rapamycin, p53, and insulin/insulin-like growth ... It can also be used to regulate mitochondrial endoplasmic reticulum coupling and has potential therapeutic effects on various ... inhibiting the mammalian target of rapamycin (mTOR) signaling pathway, and maintaining mitochondrial function (Benameur et al ...
Mitochondrial DHODH regulates hypoxia-inducible factor 1 expression in OTSCC.. Wei Gao, Lingyin Hu, Minjuan Zhang, Shuai Liu, ... Additionally, we show that modifying MiNT expression in breast cancer cells affects the dynamics of mitochondrial structure and ... Mechanistically, SREBF1c restrains the excessive activation of mammalian target of rapamycin (mTOR) signaling and mitochondrial ... We also find that STAMP2 regulates mitochondrial respiration. These findings suggest that STAMP2 has significant metabolic ...
... in nascent polycistronic mitochondrial RNA4-6. We further show that ALKBH7 regulates the processing and structural dynamics of ... Members of the mammalian AlkB family are known to mediate nucleic acid demethylation1,2. ALKBH7, a mammalian AlkB homologue, ... ALKBH7-mediated demethylation regulates mitochondrial polycistronic RNA processing. Zhang, Li-Sheng; Xiong, Qing-Ping; Peña ... Thus, we identify ALKBH7 as an RNA demethylase that controls nascent mitochondrial RNA processing and mitochondrial activity. ...
NRL-Regulated Transcriptome Dynamics of Developing Rod Photoreceptors. Cell Rep. 2016;17(9):2460-2473. PMID:27880916. ... How does mitochondrial function affect progression of retinal and macular disease?. *Are mitochondrial defects an early marker ... Protein kinase CK2 modulates the activity of Maf-family bZIP transcription factor NRL in rod photoreceptors of mammalian retina ... Mitochondrial Respiration in Outer Retina Contributes to Light-Evoked Increase in Hydration In Vivo. Invest. Ophthalmol. Vis. ...
8- Examining mitochondrial dynamics in healthy cells and in human disease processes. ... Student projects are available in my lab to study the basic mechanisms of regulating mitochondria dynamics, and to examine how ... construction of mammalian expression vectors), cell culture (tissue culture techniques for various cell types, aseptic ... In addition we study the role of mitochondrial dynamics in disease processes, particularly in neurodegenerative disorders ...
... research team studies the mechanisms by which genes are regulated and coordinated to provide critical functions in mammalian ... "Mitochondrial proteostasis in aged skeletal muscle". Laura de Smalen (group Christoph Handschin). "Dynamic mechanism of the ... "Explorations of brain dynamics in reptilian sleep and cuttlefish camouflage". Gilles Laurent, Director, Max Planck Institute ... "How microRNAs regulate stem cell proliferation and fate decisions in the adult stem cell niche". Fabrizio Favaloro (group ...
... analysis demonstrated a panel of 13 significant miRNAs and their 33 CNIT-specific gene targets involved with mitochondrial ... Oxidative phosphorylation and mitochondrial dysfunction were the top molecular pathways associated with overexpressed genes in ... Sato, T.; Ishii, J.; Ota, Y.; Sasaki, E.; Shibagaki, Y.; Hattori, S. Mammalian target of rapamycin (mTOR) complex 2 regulates ... Zhan, M.; Brooks, C.; Liu, F.; Sun, L.; Dong, Z. Mitochondrial dynamics: Regulatory mechanisms and emerging role in renal ...
... is an essential component of the mammalian circadian clock machinery, which governs robust circadian behavioral and other ... 2002) Control of intracellular dynamics of mammalian period proteins by casein kinase I epsilon (CKIepsilon) and CKIdelta in ... investigating mitochondrial abundance near functionally and structurally characterized spines. Surprisingly, we found no ... 2009) Casein kinase 1 delta regulates the pace of the mammalian circadian clock Molecular and Cellular Biology 29:3853-3866. ...
2005). Control of mammalian circadian rhythm by CKIepsilon-regulated proteasome-mediated PER2 degradation. Mol. Cell. Biol. 25 ... 2009). Amyloid-beta dynamics are regulated by orexin and the sleep-wake cycle. Science 326, 1005-1007. doi: 10.1126/science. ... Fatokun, A. A., Dawson, V. L., and Dawson, T. M. (2014). Parthanatos: mitochondrial-linked mechanisms and therapeutic ... CDT2 E3 ligase regulates the molecular clock activity by promoting ubiquitination-dependent degradation of the mammalian CRY1. ...
... or pink1 function in mammalian cells, indicating that Pink1 and Parkin may regulate mitochondrial dynamics in a context- ... Because mitochondrial dynamics is important for mitochondrial function and Pink1-KO flies have defects in mitochondrial fission ... Keywords - regulates mitochondrial fusion, regulates core components of the mitochondrial morphogenesis machinery, serves as a ... Pink1 regulates mitochondrial dynamics through interaction with the fission/fusion machinery. Mitochondria form dynamic tubular ...
Bok regulates mitochondrial fusion and morphology.﻽. Schulman JJ, Szczesniak LM, Bunker EN, Nelson HA, Roe MW, Wagner LE, Yule ... Ca2+ release dynamics in parotid and pancreatic exocrine acinar cells evoked by spatially limited flash photolysis.﻽. Won JH, ... Redox regulation of type-I inositol trisphosphate receptors in intact mammalian cells.﻽. Joseph SK, Young M, Alzayady K, Yule ... IP receptor isoforms differently regulate ER-mitochondrial contacts and local calcium transfer.﻽. Bartok A, Weaver D, Golenár T ...
... but mitochondrial dynamics were later analyzed in mammalian cellular models as well [31-33]. The discovery of the first gene ... The Parkin-PINK 1 axis plays a regulating role in mitochondrial quality control, participating in MFN2 ubiquitination and ... Alterations in mitochondrial dynamics due to mutations in proteins involved in the fusion-fission machinery represent an ... Mitochondrial fusion and fission are fundamental processes underlying cellular dynamics [1]. They are closely related, and ...
... with current estimates of the core mammalian mitochondrial proteome ranging from 1,000 to 1,500 proteins. The creation of these ... refine the mitochondrial proteome and are assisting in characterizing mitochondrial protein functions, paving the way for ... functionally annotated mitochondrial proteome in a translational setting for aiding both diagnosis of mitochondrial disease and ... The mitochondrial proteome is highly complex, comprising ~1,000-1,500 proteins in mammals. Recent technological advances are ...
Opa1(enu/+) mice show a slow progressive loss of RGCs, activation of astroglia and microglia, and pronounced mitochondrial ... Optic atrophy gene 1 (OPA1) is an inner membrane protein important for mitochondrial fusion. Autosomal dominant optic atrophy ( ... Our results conclusively demonstrate that not only glutamate excitotoxicity and/or oxidative stress alters mitochondrial ... fission/fusion, but that an imbalance in mitochondrial fission/fusion in turn leads to NMDA receptor upregulation and oxidative ...
Beyond the organelle dynamics, the constant interaction with the ubiquitin-proteasome-system (UPS) has become an emerging ... Moreover, nonreversible mitochondrial damage targets the organelle to a specific autophagic removal, namely, mitophagy. ... discuss the functional cross talk of proteostasis and mitostasis in cellular homeodynamics and the impairment of mitochondrial ... An interconnected highly integrated system of mitochondrial and cytosolic chaperones and proteases along with the fission/ ...
Aging might start from subtle changes in the TFs profile that regulate expression of genes encoding DNA-repair/mitochondrial/ ... The Cys2His2, or the zinc fingers C2H2 (ZNF) type, is the typical motif in the mammalian TFs. SP1, KLF4, KLF5, EGR3, and ... Bainor AJ, David G. The dynamics of histone modifications during aging. In: Fraga M, Fernández AF, editors. Epigenomics in ... Lin R, Chen X, Li W, Han Y, Liu P, Pi R. Exposure to metal ions regulates mRNA levels of APP and BACE1 in PC12 cells: Blockage ...
2017) ER-mitochondria tethering by PDZD8 regulates Ca2+ dynamics in mammalian neurons. Science 358(6363):623-630. * Co-first ... Lewis, T.L.*, Kwon SK.*, Lee A., Shaw and Polleux F. (2018) MFF-dependent mitochondrial fission regulates presynaptic release ... SRGAP2 and Its Human-Specific Paralog Co-Regulate the Development of Excitatory and Inhibitory Synapses. Neuron. 91(2):356-69 ... Dr Polleux has focused on the identification of the molecular mechanisms underlying neuronal development in the mammalian brain ...
CERKL, a retinal dystrophy gene, regulates mitochondrial function and dynamics in the mammalian retina. ... Mitochondrial unfolded protein response gene CLPP changes mitochondrial dynamics and affects mitochondrial function. ... N-acetyl-L-cysteine alleviates FUNDC1-mediated mitophagy by regulating mitochondrial dynamics in type 1 diabetic nephropathy ... PINCH-1 regulates mitochondrial dynamics to promote proline synthesis and tumor growth. ...
Neuron-specific regulation of apoptotic genes by NF-kappa B and mechanisms regulating CNS-specific mitochondrial bioenergetics. ... Actin Cytoskeletal Dynamics in the leukocyte inflammatory phenotype.. *Ying Huang, MD, PhD. Professor. Oncogenic signaling in ... Mammalian retinal stem cells formation; molecular mechanism of retinal cell fate decisions; vascular development in the CNS; ... Neuron-specific regulation of apoptotic genes by NF-kappa B and mechanisms regulating CNS-specific mitochondrial bioenergetics. ...
... and maintains mitochondrial Ca2+ homeostasis by chaperoning the IP3 receptor type 3 in the membrane, thus regulating its ... The σR1 is ubiquitously expressed in various mammalian tissues, and its sequence is highly conserved across mammalian species [ ... Molecular dynamics, Sunnyvale, CA). ... The sigma receptor as a ligand-regulated auxiliary potassium ... and becomes available to regulate inositol trisphosphate (IP3) receptor-mediated Ca2+ release to maintain mitochondrial Ca2+ ...
The mitochondrial peptidase, neurolysin, regulates respiratory chain supercomplexformation and is necessary for AML viability. ... Single-Cell RNA Sequencing: A New Window into Cell Scale Dynamics. Dasgupta S, Bader GD, Goyal S. Biophys J. 2018 Aug 7;115(3): ... BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain. Pourhaghighi R, Ash PEA, Phanse S, Goebels F ... The Mitochondrial Transacylase, Tafazzin, Regulates for AML Stemness by Modulating Intracellular Levels of Phospholipids. ...
An Enzyme-Linked Immunosorbent Assay for the Detection of Mitochondrial DNA-Protein Cross-Links from Mammalian Cells by Wenyan ... We will discuss how altering the dynamics of NCPs initiates a domino effect that results in the regulation of BER enzymes. Full ... In contrast to NEIL1, OGG1 functions as a key transcription factor in regulating inflammation and other complex gene cascades. ... Transcription factor A, mitochondrial (TFAM) is a key player in mitochondrial DNA (mtDNA) transcription and replication [...] ...
... up-regulated 2 main gene networks of protection from apoptosis and increased cell motility.9 Indeed, tumor cells treated with ... and mammalian target of rapamycin (mTOR). In normal cells, the phosphatase and tensin homolog (PTEN) restrains the pathways ... Indeed, a link between hypoxia and mitochondrial dynamics, fission via Drp1 mostly, continues to be noted. * Post author By ... Indeed, a link between hypoxia and mitochondrial dynamics, fission via Drp1 mostly, continues to be noted.38 In addition, ...
The cell wall regulates dynamics and size of plasma-membrane nanodomains in Arabidopsis. J. F. McKenna, D. J. Rolfe, S. E. D. ... Myosin VI regulates the spatial organisation of mammalian transcription initiation.. Yukti Hari-Gupta, Natalia Fili, Ália dos ... SARS-CoV-2 and EBV; the cost of a second mitochondrial "whammy"?​. Nunn, A.V., Guy, G.W., Botchway, S.W. et al.. Immun. Ageing ... Inhibits CXCR4 Dynamics and CXCL12-Mediated Directed Cell Migration in Human T Cells.​. Gardeta SR, Garc´ıa-Cuesta EM, ...
Phactr4 regulates neural tube and optic fissure closure by controlling PP1-, Rb-, and E2F1-regulated cell-cycle progression ... Efficient bicistronic expression of cre in mammalian cells Journal Article * Essential and separable roles for Syndecan-3 and ... Dynamics of intrapulmonary bacterial growth in a murine model of repeated microaspiration Journal Article ... Alterations in mitochondrial function in a mouse model of hypertrophic cardiomyopathy Journal Article ...