Upregulated Parkin expression protects mitochondrial homeostasis in DJ-1 konckdown cells and cells overexpressing the DJ-1...
Yu W, Sun Y, Guo S, Lu B (2011) The PINK1/Parkin pathway regulates mitochondrial dynamics and function in mammalian hippocampal ... Parkinson's disease-associated DJ-1 mutations impair mitochondrial dynamics and cause mitochondrial dysfunction. J Neurochem ... Poole AC, Thomas RE, Andrews LA, McBride HM, Whitworth AJ, Pallanck LJ (2008) The PINK1/Parkin pathway regulates mitochondrial ... implication of dysregulated mitochondrial dynamics in Parkinson disease. J Biol Chem 286:11649-11658PubMedCrossRefGoogle ...https://rd.springer.com/article/10.1007/s11010-013-1884-3
Glass Bottom Dishes & Glass Bottom Plates
The PINK1/Parkin pathway regulates mitochondrial dynamics and function in mammalian hippocampal ... Detection and Quantitation of Circulating Tumor Cell Dynamics by Bioluminescence Imaging in an ... A Novel Alpha Kinase EhAK1 Phosphorylates Actin and Regulates Phagocytosis in Entamoeba histolytica ...http://www.uniscience.co.kr/cellvis_references.html
Computational Analysis of AMPK-Mediated Neuroprotection Suggests Acute Excitotoxic Bioenergetics and Glucose Dynamics Are...
The model also predicted necrotic bioenergetic collapse and altered calcium dynamics following more severe excitotoxic insults ... can closely resemble the rapid dynamics and cell-to-cell heterogeneity of ATP levels and AMPK activity, as confirmed by single- ... and well resembled the delayed recovery and cell-to-cell heterogeneity of experimentally measured glucose dynamics. ... Mitochondrial calcium as a key regulator of mitochondrial ATP production in mammalian cells. Biochimica et biophysica acta. ...https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0148326
Regulation of mitochondrial permeability transition pore by PINK1 | Molecular Neurodegeneration | Full Text
Our findings show that loss of PINK1 causes selective increases in mPTP opening and mitochondrial calcium, and that the ... We previously reported that loss of PINK1 impairs mitochondrial respiratory activity in mouse brains. In this study, we ... Consistent with our earlier findings in mouse brains, mitochondrial morphology is similar between PINK1−/− and wild-type cells ... Interestingly, the opening of the mitochondrial permeability transition pore (mPTP) is increased in PINK1−/− cells, and this ...https://molecularneurodegeneration.biomedcentral.com/articles/10.1186/1750-1326-7-22
Most recent papers with the keyword ICG-001 | Read by QxMD
DRP1 is an essential modulator of mitochondrial fission and dynamics within mammalian cells. Its fission activity is regulated ... WNT signaling cascades cross-talk with the FGF, Notch, Hedgehog and TGFβ/BMP signaling cascades and regulate expression of ... Impact of miR-26b on cardiomyocyte differentiation in P19 cells through regulating canonical/non-canonical Wnt signalling. ... https://www.readbyqxmd.com/read/28810055/impact-of-mir-26b-on-cardiomyocyte-differentiation-in-p19-cells-through-regulating- ...https://www.readbyqxmd.com/keyword/63485
Keystone Symposia | Scientific Conferences on Biomedical and Life Science Topics
ER-Mitochondria Tethering by PDZD8 Regulates Ca2+ Dynamics in Mammalian Neurons. Yvette C. Wong, Northwestern University, USA ... Dynamics of Autophagy and Mitophagy in Neurons. Koji Okamoto, Osaka University, Japan Regulation of Mitochondrial Clearance via ... Mitochondria-Lysosome Contacts Regulate Mitochondrial Fission via Rab7 GTP Hydrolysis. Thomas Ryan Hurd, New York University ... The Role of MTP18 in Mitochondrial Dynamics and Metabolism. Ken Nakamura, Gladstone Institutes and University of California, ...https://www.keystonesymposia.org/index.cfm?e=web.Meeting.Program&meetingid=1528
Frontiers | Emerging roles of mitochondria in the evolution, biogenesis, and function of peroxisomes | Physiology
Taken together it is clear that the mitochondria and peroxisomes are functionally coupled, regulating cellular metabolism and ... The functional similarities to mitochondria within mammalian systems expanded these ideas, as both organelles scavenge peroxide ... Taken together it is clear that the mitochondria and peroxisomes are functionally coupled, regulating cellular metabolism and ... The functional similarities to mitochondria within mammalian systems expanded these ideas, as both organelles scavenge peroxide ...https://www.frontiersin.org/articles/10.3389/fphys.2013.00268/full
Membrane topology and mitochondrial targeting of mitofusins, ubiquitous mammalian homologs of the transmembrane GTPase Fzo |...
... little is known about the factors governing mitochondrial membrane dynamics. In the budding yeast, mitochondrial fission is ... Sesaki, H. and Jensen, R. E. ( 1999). Division versus Fusion: Dnm1p and Fzo1p Antagonistically Regulate Mitochondrial Shape. J ... Mammalian mitofusins are ubiquitously expressed. (A,B) RT-PCR of mitofusins (Mfn1, Mfn2) and of mitochondrial transcription ... Membrane topology and mitochondrial targeting of mitofusins, ubiquitous mammalian homologs of the transmembrane GTPase Fzo ...http://jcs.biologists.org/content/115/8/1663?ijkey=bf0832c21f16ed20e81caa46cdad2240e7cf130e&keytype2=tf_ipsecsha
Frontiers | Hypoxia and Selective Autophagy in Cancer Development and Therapy | Cell and Developmental Biology
2016b). FUNDC1 regulates mitochondrial dynamics at the ER-mitochondrial contact site under hypoxic conditions. EMBO J. 35, 1368 ... 2012). Mitochondrial outer-membrane protein FUNDC1 mediates hypoxia-induced mitophagy in mammalian cells. Nat. Cell Biol. 14, ... 2016). Mitophagy receptor FUNDC1 regulates mitochondrial dynamics and mitophagy. Autophagy 12, 689-702. doi: 10.1080/ ... 2017a). Mitochondrial E3 ligase MARCH5 regulates FUNDC1 to fine-tune hypoxic mitophagy. EMBO Rep. 18, 495-509. doi: 10.15252/ ...https://www.frontiersin.org/articles/10.3389/fcell.2018.00104/full
Ups1p, a conserved intermembrane space protein, regulates mitochondrial shape and alternative topogenesis of Mgm1p | JCB
Dynamics of mitochondrial morphology in healthy cells and during apoptosis. Cell Death Differ. 10:870-880. ... Cloning of the YAP19 gene encoding a putative yeast homolog of AP19, the mammalian small chain of the clathrin-assembly ... Ups1p regulates the steady-state level of s-Mgm1p and mitochondrial shape in a carbon source-dependent manner. To identify ... Mitochondrial morphology is essential for the functions of the organelle. Mitochondria fuse and divide in highly regulated ...http://jcb.rupress.org/content/173/5/651
What drives cell morphogenesis: A look inside the vertebrate photoreceptor - Kennedy - 2009 - Developmental Dynamics - Wiley...
SARA-regulated vesicular targeting underlies formation of the light-sensing organelle in mammalian rods. Cell 130: 535-547.. * ... Critical dependence of neurons on mitochondrial dynamics. Curr Opin Cell Biol 18: 453-459.. *CrossRef, ... CRB3 binds directly to Par6 and regulates the morphogenesis of the tight junctions in mammalian epithelial cells. Mol Biol Cell ... Mouse disabled 1 regulates the nuclear position of neurons in a Drosophila eye model. Mol Cell Biol 26: 1510-1517.. *CrossRef, ...http://onlinelibrary.wiley.com/doi/10.1002/dvdy.22010/references
Frontiers | Targeting mitochondrial dysfunction in lung diseases: emphasis on mitophagy | Physiology
... summarizes recent studies highlighting the molecular pathways that facilitate mitochondria to alter its morphological dynamics ... summarizes recent studies highlighting the molecular pathways that facilitate mitochondria to alter its morphological dynamics ... Understanding mitochondrial dynamics is essential to knowing underlying biology as they regulate mitochondrial morphology, ... Liesa, M., Palacin, M., and Zorzano, A. (2009). Mitochondrial dynamics in mammalian health and disease. Physiol. Rev. 89, 799- ...https://www.frontiersin.org/articles/10.3389/fphys.2013.00384/full
The Golgi ribbon in mammalian cells negatively regulates autophagy by modulating mTOR activity | Journal of Cell Science
JCS Meeting - Cell dynamics: organelle-cytoskeleton interface. The second in our series of cell dynamics meetings now turns to ... Mitochondrial and glycolytic remodeling during nascent neural differentiation of human pluripotent stem cells.. Jarmon G. Lees ... The Golgi ribbon in mammalian cells negatively regulates autophagy by modulating mTOR activity ... The Golgi ribbon in mammalian cells negatively regulates autophagy by modulating mTOR activity ...http://jcs.biologists.org/content/131/3/jcs211987
Mitochondrial Heterogeneity: Evaluating Mitochondrial Subpopulation Dynamics in Stem Cells
"Murine mesenchymal stem cell commitment to differentiation is regulated by mitochondrial dynamics," Stem Cells, vol. 34, no. 3 ... "Dynamin-related protein Drp1 is required for mitochondrial division in mammalian cells," Molecular Biology of the Cell, vol. 12 ... Mitochondrial Heterogeneity: Evaluating Mitochondrial Subpopulation Dynamics in Stem Cells. D. C. Woods ... J. D. Wikstrom, G. Twig, and O. S. Shirihai, "What can mitochondrial heterogeneity tell us about mitochondrial dynamics and ...https://www.hindawi.com/journals/sci/2017/7068567/ref/
The E3 Ubiquitin Ligases, HUWE1 and NEDD4-1, Are Involved in the Post-translational Regulation of the ABCG1 and ABCG4 Lipid...
... a mitochondrial E3 that regulates the organelle's dynamics and signaling. PLoS ONE 3, e1487. [PMC free article] [PubMed] ... Scheffner M., Kumar S. (2014) Mammalian HECT ubiquitin-protein ligases: Biological and pathophysiological aspects. Biochim. ... Tarr P. T., Edwards P. A. (2008) ABCG1 and ABCG4 are coexpressed in neurons and astrocytes of the CNS and regulate cholesterol ... Furthermore, it implies that these two E3s have a fundamental role in regulating ABCG1-mediated cellular cholesterol export ...http://pubmedcentralcanada.ca/pmcc/articles/PMC4591838/
Research of Ishihara Lab - 久留米大学 分子生命科学研究所 高分子
Mitochondrial fusion regulated by two mitofusin (Mfn) isoforms in mammalian cells To analyze mitochondrial fusion in living ... New role of mitochondrial dynamics: Regulation of mtDNA nucleoid morphology Mammalian cells typically contain thousands of ... Thus, mitochondrial dynamics by fission and fusion play a critical role in controlling mitochondrial nucleoid structures, ... Mitochondrial dynamics: Molecular mechanism and physiological roles of fusion and fission in mammals ...http://mitochondria.jp/englishpage/eresearch
DNM1L Variant Alters Baseline Mitochondrial Function and Response to Stress in a Patient with Severe Neurological Dysfunction,...
"DNM1L Variant Alters Baseline Mitochondrial Function and Response to Stress in a Patient with Severe Neurological Dysfunction, ... Drp1 levels constitutively regulate mitochondrial dynamics and cell survival in cortical neurons ... Mitochondrial biogenesis and mitochondrial DNA maintenance of mammalian cells under oxidative stress ... Preventing mitochondrial fission impairs mitochondrial function and leads to loss of mitochondrial DNA ...https://www.deepdyve.com/lp/springer_journal/dnm1l-variant-alters-baseline-mitochondrial-function-and-response-to-gJJxfe79NM
Insulin Stimulates Mitochondrial Fusion and Function in Cardiomyocytes via the Akt-mTOR-NFκB-Opa-1 Signaling Pathway | Diabetes
Insulin Increases Mitochondrial Protein Opa-1 Levels and Mitochondrial Function. In mammalian cells, Mfn and Opa-1 are the main ... Studies have indicated that insulin can also regulate mitochondrial function. Relevant to this idea, mitochondrial function is ... mitochondrial dynamics in cultured cardiomyocytes by stimulation of mitochondrial fusion without changing mitochondrial ... Flow Cytometry Analysis of Mitochondrial Membrane Potential and Mitochondrial Mass. Mitochondrial membrane potential (Ψmt) and ...http://diabetes.diabetesjournals.org/content/63/1/75
Mitofusins Mfn1 and Mfn2 coordinately regulate mitochondrial fusion and are essential for embryonic development | JCB
An essential role for mitochondrial fusion in mouse development. Although mitochondrial dynamics involving fusion and fission ... The mammalian mitofusins, Mfn1 and Mfn2, function in three distinct molecular complexes to promote mitochondrial fusion and ... Altered mitochondrial dynamics in Mfn-deficient cells. Because mitochondria are such dynamic organelles, we used time-lapse ... Videos 1-3 show mitochondrial dynamics in wild-type and mutant MEFs. Videos 1 and 3 are 20-min recordings; video 2 is a 10-min ...http://jcb.rupress.org/content/160/2/189?ijkey=1ef7f0ea9f9917fc4329f005d32954b35b801af6&keytype2=tf_ipsecsha
Protocols and Video Articles Authored by Audrey Salles (Translated to Spanish)
Among the multiple mechanisms that appear to regulate mitochondrial fission, the ER and actin have recently been shown to play ... Here, we report that the cytoskeletal component septin 2 is involved in Drp1-dependent mitochondrial fission in mammalian cells ... strongly suggesting that the role of septins in mitochondrial dynamics is evolutionarily conserved. ... A Role for Septin 2 in Drp1-mediated Mitochondrial Fission EMBO Reports. May, 2016 , Pubmed ID: 27215606 Mitochondria are ...https://www.jove.com/author/Audrey_Salles?language=Spanish
Anti-Mitofusin 2抗体(ab50838)参考文献| Abcam中国官方网站
Xiao L et al. Death-associated Protein 3 Regulates Mitochondrial-encoded Protein Synthesis and Mitochondrial Dynamics. J Biol ... Kühl I et al. POLRMT regulates the switch between replication primer formation and gene expression of mammalian mtDNA. Sci Adv ... Jacobi D et al. Hepatic Bmal1 Regulates Rhythmic Mitochondrial Dynamics and Promotes Metabolic Fitness. Cell Metab 22:709-20 ( ... Manczak M et al. Impaired mitochondrial dynamics and abnormal interaction of amyloid beta with mitochondrial protein Drp1 in ...http://www.abcam.cn/mitofusin-2-antibody-ab50838-references.html
DNA replication - Wikipedia
E. coli regulates this process through the use of termination sequences that, when bound by the Tus protein, enable only one ... Huberman, Joel A.; Riggs, Arthur D. (March 1968). "On the mechanism of DNA replication in mammalian chromosomes". Journal of ... Replication of chloroplast and mitochondrial genomes occurs independently of the cell cycle, through the process of D-loop ... foci in budding yeast cells and revealed that replication origins move constantly in G1 and S phase and the dynamics decreased ...https://en.wikipedia.org/wiki/DNA_replication
Identification of an upstream regulatory pathway controlling actin-mediated apoptosis in yeast | Journal of Cell Science
Actin dynamics are linked to mitochondrial membrane polarity in end3-1 cells. (A) The temperature-sensitive end3-1 allele ... In support of this model is the fact that both yeast and mammalian complexes are regulated by the homologous E3 ubiquitin ... Overexpression of RSP5 can improve mitochondrial function, increase viability and restore actin dynamics in Δend3 cells. (A) ... We have discovered that certain proteins that regulate the dynamics of the actin cytoskeleton during remodelling at the cell ...http://jcs.biologists.org/content/118/10/2119
Pyoverdine - Wikipedia
... destabilizes mitochondrial dynamics, and induces a hypoxic response. Exposure triggers a response that is consistent with ... In addition to this role, pyoverdine has a number of other functions, including regulating virulence, limiting the growth of ... fluorescens exhibited profound cytotoxicity to mammalian macrophages and that this effect was at least partially dependent upon ... Pyoverdine biosynthesis seems to be largely regulated through the activity of the alternate sigma factor PvdS which, in turn, ...https://en.wikipedia.org/wiki/Pyoverdine
IJMS | Free Full-Text | Comparative Analysis of Mafriwal (Bos taurus × Bos indicus) and Kedah Kelantan (Bos indicus) Sperm...
M up regulated. 3.8. 69. P19483. ATP synthase subunit alpha, mitochondrial. Bos taurus. 169.9. 36 (23). M up regulated. 3.4. ... Toshimori, K. Dynamics of the Acrosome. In Dynamics of the Mammalian Sperm Head; Springer: Berlin, Germany, 2009; Volume 204, ... M up regulated. 2.0. 72. P53353. Sperm acrosomal protein FSA-ACR.1 (Fragment). Vulpes vulpes. 82.6. 11 (5). M up regulated. 3.2 ... KK up regulated. 15.9. 91. Q9Z1B2. Glutathione S-transferase Mu 5. Rattus norvegicus. 139.6. 61 (17). KK up regulated. 2.0. 39 ...http://www.mdpi.com/1422-0067/14/8/15860/htm