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*  Capsaicin Cough Threshold in Chronic Cough Due to Postnasal Drip - Full Text View - ClinicalTrials.gov
The objective of the protocol is to determine the pathogenesis of cough in diseases of the aerodigestive tract. There were over 24 million ambulatory chronic cough visits nationally in 1991 and over 8,000 visits in 2004 at MCR. Current guidelines for chronic cough are based on case series and on empirical expert opinions. Studies have implicated mucosal inflammation, heightened sensitivity of capsaicin cough receptors on peripheral nerves and elaboration of inflammatory mediators including tussigenic neuropeptides. There are gaps in our knowledge of what triggers cough in many disease states. For example, postnasal drip syndrome has been estimated to account for 70% of chronic cough, yet it is known that not all patients with postnasal drip have chronic cough. Our hypothesis is that there must be critical factor/s that cause cough in one patient with postnasal drip but not ...
  https://clinicaltrials.gov/ct2/show/NCT00588627?term=cough&rank=17
*  Influence of smoking status on cough reflex sensitivity in subjects with COPD.
Cough reflex sensitivity has not been studied extensively in patients with chronic obstructive pulmonary disease (COPD). The aim of the study was to evaluate cough reflex sensitivity to capsaicin in current and former smokers with COPD and examine it
  http://www.biomedsearch.com/nih/Influence-smoking-status-cough-reflex/18949517.html
*  Cough Variant Asthma: Cough Variant Asthma is a Chronic Disease
Cough-variant asthma (CVA) is a form of asthma. It is a chronic disease of the respiratory system. In contrast to classical asthma, the only symptom is a chronic, dry cough without the typical sign of asthma like shortness of breath or wheezing. In some cases CVA turns into classical asthma within some years. The causes of most forms of asthma are not fully understood yet. Practically all studies show that asthma is caused by a combination of environmental and genetic factors. Environmental factors can be a high pollution of the air, tobacco smoke, chemicals or cleaning agents. As an example, CVA can be caused by Beta-blockers that are used for the treatment of high blood pressure or heart failures. Also certain eye-drops contain beta-blockers which can cause CVA. ...
  http://cough-variantasthma.blogspot.com/2014/03/cough-variant-asthma-is-chronic-disease.html
*  Interferon-alpha Treatment of Chronic Cough in Chronic Obstructive Pulmonary Disease and Idiopathic Pulmonary Fibrosis - Full...
Both chronic obstructive pulmonary disease (COPD) and idiopathic pulmonary fibrosis (IPF) frequently lead to a chronic cough that negatively impacts the quality of life (QOL) for patients and those around them. This is a randomized, double-blind, placebo-controlled trial to determine whether interferon-alpha, delivered in low doses via orally dissolving lozenges given 3 times per day for 4 weeks, can reduce the frequency and severity of chronic cough in patients with COPD or IPF. Cough frequency will be assessed via 24-hour digital audio recordings made prior to entry, and at weeks 2 and 4 of treatment. Cough severity will be assessed via a 100-mm visual analog scale questionnaire completed by the subject prior to entry and then weekly during treatment. Subjects will also complete questionnaires regarding cough frequency, duration and intensity, QOL, dyspnea, and antitussive medication usage weekly during treatment. All ...
  https://clinicaltrials.gov/ct2/show/NCT00690885
*  P241 Anti-Reflux Surgery Conveys a Long Term Improvement in Respiratory Symptoms in Asthma and Chronic Cough | Thorax
Results Twenty-eight patients (71% female, mean age = 50.1 years) completed an AQLQ (13 asthmatics) or cough score questionnaire (15 chronic cough patients) at a mean of 66 months following surgery (range = 6-100 months). The Hull reflux cough questionnaire (HRCQ) was also completed. All had significant reflux at baseline confirmed with oesophageal manometry and pH studies (mean DeMeester score of 47.26 [normal , 14.72], mean lower oesophageal sphincter pressure of 4.6mmHg [normal = 12-25] and a mean reflux time of 11.7% [normal , 4%]). The mean baseline FEV1 in the asthma group was 2.22 L (76% predicted) with a mean FEV1/FVC of 74%. In the cough group, mean FEV1 at baseline was 2.45 L (90% predicted) with a mean FEV1/FVC of 84%.. In the asthma group there was significant improvement in mean AQLQ (7 = best, 0 = worst) from baseline of 3.29 (SD=1.1) to 4.38 (SD=1.2) at 3 months and 4.44 (SD=1.4) long term (Figure 1). In the ...
  http://thorax.bmj.com/content/69/Suppl_2/A182.3
*  Plus it
Recent studies have demonstrated that blockade of P2X3 ATP receptors can profoundly inhibit chronic cough. We have considered whether inhaled ATP produces a tussive response and whether chronic cough patients are hypersensitive to inhaled ATP compared to healthy volunteers.. A standardised inhalational cough challenge was performed with ATP and AMP. We randomised 20 healthy volunteers and 20 chronic cough patients as to the order of challenges. The concentration of challenge solution causing at least five coughs (C5) was compared for ATP and AMP.. The study population consisted of six male and 14 female volunteers in each group. Two out of 19 healthy volunteers coughed with AMP (one volunteer could not take part in this challenge) and none reached C5. Eight out of 20 chronic cough patients coughed with AMP and two reached C5. Of the 20 healthy volunteers, 18 ...
  http://erj.ersjournals.com/content/49/2/1601452
*  Chronic Cough Archives - Center for Cough
Are you over-thinking your Chronic Cough? Certainly you're feeling tired, depressed, and blah… who wouldn't? Your nagging Chronic Cough is interrupting your and/or your partner's sleep. Your hacking Chronic Cough is embarrassing you and annoying to those around you so you are staying home and feeling socially isolated. Your Chronic Cough seems to be relentless. You've seen lots of doctors and tried lots of Cough remedies but you're still coughing and feeling blah about ever feeling better. But could there be some underlying psychological conditions contributing to how you're feeling? Dr. Mandel Sher and Center for Cough team address the multiple factors that could be contributing to unexplained Chronic Cough. This COMPREHENSIVE TREATMENT APPROACH is helping patients to achieve REMARKABLE COUGH RELIEF RESULTS.. Does unexplained Chronic ...
  http://centerforcough.com/category/chronic-cough/
*  Cough Variant Asthma: ABOUT US
In This Blog , I Wanna Discuss about cough variant asthma which im suffering with since Past 5 Years . Hope this blog will be insightful for you if you have same condition.. ...
  http://cough-variantasthma.blogspot.com/p/about-us.html
*  diagnostic tools Archives - Center for Cough
We all cough. Cough is an important function. But like many things, too much of a good thing is no good. The first and most important step toward effective cough treatment is understanding what's causing cough. And there's a meaningful difference between identifying the underlying cause of your cough and the triggers or irritants or stimuli that tickle your body's cough mechanism and produce cough. Real and lasting success relies on addressing what's causing cough rather than the symptom.. Dr. Mandel Sher and Center for Cough team accurately diagnose the cause and triggers of your unique cough. Accurate diagnosis is the foundation of an individualized and effective cough treatment plan.. Cough evaluation includes a thorough medical history and physical exam exploring your cough symptoms and ...
  http://centerforcough.com/tag/diagnostic-tools/
*  chronic cough Archives - Center for Cough
SAN MATEO, Calif.-(BUSINESS WIRE)-Afferent Pharmaceuticals, a leader in the development of small molecule compounds targeting P2X3 for the treatment of poorly managed and common neurogenic disorders, such as chronic cough, today announced positive top-line results from its Phase 2b dose escalation clinical trial of AF-219 in chronic cough patients. AF-219 is a selective, non-narcotic and orally administered P2X3 antagonist that targets the mechanism by which certain nerve fibers become hyper-sensitized and can lead to chronic and debilitating symptoms. The results of this clinical trial will be presented at a scientific meeting in the future.. "Our promising Phase 2b results demonstrate AF-219's potential to be a first-in-class therapy, with the potential to replace the current, often ad hoc treatments that have little impact on cough frequency or result in possibly serious side effects or carry abuse potential," said Kathleen Sereda Glaub, Afferent's chief ...
  http://centerforcough.com/tag/chronic-cough/
*  whooping cough - Symptoms, Treatments and Resources for whooping cough
whooping cough - MedHelp's whooping cough Center for Information, Symptoms, Resources, Treatments and Tools for whooping cough. Find whooping cough information, treatments for whooping cough and whooping cough symptoms.
  http://www.medhelp.org/tags/show/54014/whooping-cough
*  Pomalidomide for Cough in Patients With Idiopathic Pulmonary Fibrosis - Full Text View - ClinicalTrials.gov
The purpose of this study is to determine the safety and efficacy of pomalidomide over a 12 week duration in the treatment of chronic cough in patients with IPF as measured by a Cough Symptom Diary, Visual Analogue Scale for Cough Severity, Leicester Cough Questionnaire, St. George Respiratory Questionnaire, Cough-Specific Quality-of-Life Questionnaire, and adverse event reporting. There will be an option open to participants, who respond to treatment by meeting pre-determined criteria, to remain in the study for an additional 9 months or for a total of 54 weeks ...
  https://clinicaltrials.gov/ct2/show/NCT01135199
*  Efficacy and Safety Study of Procaterol Hydrochloride to Treat Patients With Cough Variant Asthma (CVA) - Full Text View -...
This is a 8-week, double-blind, randomized, placebo-controlled study, the patients with CVA will be randomized to experimental or placebo control group.. During the screening period, eligible patients will be evaluated by cough symptom score and LCQ life quality score. After 4 and 8 weeks treatment, patients will be evaluated by cough symptom score and LCQ life quality score respectively. Adverse events will also be captured at every visit. ...
  https://clinicaltrials.gov/ct2/show/NCT01170429
*  Dog dry cough - Doggy Small Talk
Dogs Cough. By Admin. Why dogs cough? Coughing in dogs in a common problem. All dogs that cough do not have a serious illness. A dog that coughs can have a sore throat. A canine cough is one of your dogs best defense mechanisms. Any irritation of the breathing tubes will trigger a cough reflex in dogs. A violent rush of air cleans material from the breathing tubes and the lungs. Pollution and pollens in the air can irritate the respiratory system.. If the dog cough is accompanied by fever, weight loss, difficulty breathing, lethargy, blue gums and tongue, with a history of heart disease, heart murmur, or a malignant tumor, you should call your vet immediately.. If your dog is coughing, it could have canine influenza which is commonly called dog flu.. Tracheobronchitis or dog kennel cough causes a dog dry ...
  http://doggysmalltalk.com/tag/dog-dry-cough/
*  Physiology of Cough in Asthma: Comparison of Sensory-Mechanical Responses to Mannitol and Methacholine Challenge Tests -...
Cough is a common, disruptive and at times disabling symptom which often prompts patients to seek medical attention. Determining the cause(s) of chronic cough can be challenging, and costly. Asthma and other airway disorders are among the most common causes of chronic cough; and cough can be the sole symptom of asthma. Little is known about why some patients with asthma primarily cough and do not develop the other symptoms of asthma such as shortness of breath or wheeze. Improved understanding of the reasons for these different manifestations may lead to new and more effective treatment strategies. We have notices differences in pressure measurements inside the chest in patients who mostly cough during induced bronchoconstriction, which might be part of the explanation for varying symptoms. This study will compare lung mechanical responses during methacholine and mannitol-induced induced ...
  https://clinicaltrials.gov/ct2/show/record/NCT01064245
*  Angiotensin-Converting Enzyme Inhibitors Archives - Center for Cough
Angiotensin-Converting Enzyme (ACE) Inhibitors found in some prescription medications can be associated with Chronic Cough. It is important to never stop a medication without first discussing the consequences with the ordering physician. But a Cough Doctor can precisely diagnose the cause(s) of your Chronic Cough and the role of ACE Inhibitor medication in your situation.. A persistent, dry, tickling cough is a relatively common result of ACE inhibitors, such as lisinopril, which are used to treat hypertension, heart and kidney diseases. Cough may occur within hours of the first dose of medication, or its onset can be delayed for weeks to months after the initiation of therapy. Treatment with ACE inhibitors may sensitize the cough reflex, thereby potentiating other causes of chronic cough.. The mechanism of ACE inhibitor induced cough is not fully understood but probably is ...
  http://centerforcough.com/tag/angiotensin-converting-enzyme-inhibitors/
*  ACE Inhibitor Archives - Center for Cough
Angiotensin-Converting Enzyme (ACE) Inhibitors found in some prescription medications can be associated with Chronic Cough. It is important to never stop a medication without first discussing the consequences with the ordering physician. But a Cough Doctor can precisely diagnose the cause(s) of your Chronic Cough and the role of ACE Inhibitor medication in your situation.. A persistent, dry, tickling cough is a relatively common result of ACE inhibitors, such as lisinopril, which are used to treat hypertension, heart and kidney diseases. Cough may occur within hours of the first dose of medication, or its onset can be delayed for weeks to months after the initiation of therapy. Treatment with ACE inhibitors may sensitize the cough reflex, thereby potentiating other causes of chronic cough.. The mechanism of ACE inhibitor induced cough is not fully understood but probably is ...
  http://centerforcough.com/tag/ace-inhibitor/
*  Prospective Validation of Cough, Dyspnea, and Quality of Life Questionnaires in Patients With Idiopathic Pulmonary Fibrosis ...
This study in patients with IPF will determine the validity, responsiveness, and reliability of two cough measures (the Leicester Cough Questionnaire (LCQ), as well as Visual Analogue Scales (VASs) for cough severity and distress; one dyspnea measure (the Baseline and Transition Dyspnea Index (BDI/TDI); and two health-related quality of life (HRQL) measures (the obstructive lung disease-specific Saint George's Respiratory Questionnaire (SGRQ) and the IPF-specific 'A Tool to Assess QOL in IPF' (ATAQ-IPF). Both the SGRQ and ATAQ include cough questions. Study participants will complete all questionnaires at baseline, 6, 12, and 18 months at the time of their usual clinic visits. Physiologic data will be collected at the same time of these visits including pulmonary function testing, exercise oxygen saturation, and changes in medications and health status. Changes in cough, dyspnea and QOL scores will be correlated with ...
  https://clinicaltrials.gov/ct2/show/NCT01874223?recr=Open&cond=%22Pulmonary+Fibrosis%22&rank=4
*  Dog kennel cough - Doggy Small Talk
Dogs Cough. By Admin. Why dogs cough? Coughing in dogs in a common problem. All dogs that cough do not have a serious illness. A dog that coughs can have a sore throat. A canine cough is one of your dogs best defense mechanisms. Any irritation of the breathing tubes will trigger a cough reflex in dogs. A violent rush of air cleans material from the breathing tubes and the lungs. Pollution and pollens in the air can irritate the respiratory system.. If the dog cough is accompanied by fever, weight loss, difficulty breathing, lethargy, blue gums and tongue, with a history of heart disease, heart murmur, or a malignant tumor, you should call your vet immediately.. If your dog is coughing, it could have canine influenza which is commonly called dog flu.. Tracheobronchitis or dog kennel cough causes a dog dry ...
  http://doggysmalltalk.com/tag/dog-kennel-cough/
*  Plus it
The aim of the present study was to determine whether the ability to suppress cough voluntarily is an index of cough severity in upper respiratory tract infection. Cough was measured by means of a microphone linked to a pen recorder and subjects were instructed to voluntarily suppress cough in order to determine cough suppression time. Subjective scores of symptom severity, mood and psychological parameters were made prior to cough measurements. The baseline frequency of cough showed a distribution towards the higher frequencies, with a median of 2.1 (lower quartile 1.2, upper quartile 3.2) coughs.min-1. The results for cough suppression fell into two distinct groups, one group reaching a breaking point within 12.6 min; and another group which did not cough during the 20 min cough suppression period. In the group of subjects ...
  http://erj.ersjournals.com/content/6/10/1449
*  Whooping Cough Symptoms + 12 Natural Treatments - Health | Food is Medicine
1. Ginger. Ayurvedic medicine praises ginger's ability to boost the immune system by warming the body so it can break down the accumulation of toxins in the organs. Ginger also has antibacterial properties. It cleans the lymphatic system, preventing the accumulation of toxins that make us susceptible to infections, especially in the respiratory system. (16). 2. Raw Honey. There are many health benefits of raw honey, including its ability to treat coughs just as effectively as over-the-counter commercial cough syrups. Increasing evidence shows that a single dose of honey can reduce mucus secretion and coughs. (17) To help relieve whooping cough symptoms, anyone over the age of one should take 1 to 2 teaspoons of raw honey at bedtime.. 3. Turmeric. It can be argued that turmeric is the most powerful herb on the planet at fighting and potentially reversing disease. Turmeric can be used to reduce inflammation and ease pain. ...
  http://curiositiesandnews.org/whooping-cough-symptoms-12-natural-treatments/
*  Effect of changes in inspiratory flow rate on cough responses to inhaled capsaicin | Clinical Science
1. Twelve non-smoking subjects inhaled capsaicin at three different inspiratory flow rates: 50, 100 and 150 litres/min. Capsaicin was delivered by a breath-actuated dosimeter; inhalations consisted of 0.21-13.6 nmol of capsaicin in doubling amounts given in random order.. 2. The mean number of coughs per challenge decreased with increasing inspiratory flow rate. The difference in cough numbers were significant: 7.7 (95% confidence interval 2.5-12.8) for 50 versus 100 litres/min and 10.9 (95% confidence interval 5.0-16.9) for 100 versus 150 litres/min.. 3. On a separate day, a cough threshold was measured by giving increasing doses of citric acid that were inhaled at 50 litres/min. There was a positive correlation between the sensitivity to capsaicin and the cough threshold to citric acid (r = 0.69, P = 0.01), and also between the cough latencies (r = 0.67, P = 0.02).. 4. The negative relationship between the ...
  http://www.clinsci.org/content/81/s25/539
*  Kennel Cough Vaccination - tailsofsuccessny
Many kennels, groomers, doggy daycares, and training facilities these days require dogs to be vaccinated for kennel cough before they are allowed to attend. But, just what is kennel cough, and how safe is the vaccine? Kennel cough is a viral infection that passes between dogs, especially in stressful environments. It typically takes about 8-10 days after exposure for symptoms to develop, including sneezing, runny eyes or nose, and of course, a dry horrible-sounding cough. While kennel cough certainly sounds scary because of its characteristic dry, hacking cough, it is a mild illness that can be easily treated with gentle, natural remedies. There are many resources to consult on treating kennel cough at home. These treatments typically include boosting the dog's immune system and gently soothing its cough. Kennel cough is a self-limiting ...
  http://tailsofsuccessny.com/kennel-cough-vaccination/4585789165
*  The value of cough peak flow measurements in the assessment of extubation or decannulation readiness
In the Pascal Beuret et al. study,9 which included ICU patients who had successfully passed the spontaneous breathing trial, the optimal cough PEF value to predict extubation failure was ,35 L/min.. In patients unable to cooperate voluntarily cough PEF cannot be evaluated. Involuntary cough may be assessed either by instilling normal saline2 or by advancing a suctioning catheter through the patient's tracheostomy tube to induce a cough.10 Although not compared directly two different studies using voluntary11 and involuntary cough PEF2 have come out with approximately the same cut-off point (60 versus 58.5 L/min respectively). In the Salam et al. study11 Cough PEFs were measured in all but five patients who were unable to understand instructions or could not attempt a cough. For the remaining 83 patients who attempted to cough, the Cough PEFs ranged from 10 ...
  http://www.elsevier.pt/en/revistas/revista-portuguesa-pneumologia-420/artigo/the-value-cough-peak-flow-measurements-in-assessment-X0873215915933092
*  Cough Responses to Tussive Agents in Health and Disease - Full Text View - ClinicalTrials.gov
Coughing is a distressing symptom which has a major impact on quality of life. It has been estimated that cough costs the UK economy £1 billion each year. Currently there are no effective anti-tussive agents to treat subjects with cough. Although drugs such as morphine may have some anti-tussive effect, side effects unacceptable.. Currently our understanding of the mechanisms which lead to coughing in different diseases is poor. Many mechanistic studies rely on testing the sensitivity of the cough reflex by inhalation of capsaicin (chilli-pepper extract) or citric acid. These challenges do not differentiate well between health and disease or between different disease states. Other agents such as prostaglandins and bradykinin are known to stimulate a coughing but responses to these agents have rarely been used as a measure of cough reflex sensitivity and not been compared to standard ...
  https://clinicaltrials.gov/ct2/show/NCT01297790?term=cough&rank=3