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*  Frontiers | Fc Engineering for Developing Therapeutic Bispecific Antibodies and Novel Scaffolds | Immunology
Promisingly, Fc antigen binding fragment [Fcab] and monomeric antibody or half antibody may be particularly advantageous to ... Promisingly, Fc antigen binding fragment [Fcab] and monomeric antibody or half antibody may be particularly advantageous to ... to antibody fragments. Impressively, antibody fragments such as bispecific T-cell engager [BiTE], bispecific killer cell ... to antibody fragments. Impressively, antibody fragments such as bispecific T-cell engager [BiTE], bispecific killer cell ...
  https://www.frontiersin.org/articles/10.3389/fimmu.2017.00038/full
*  IJMS | Free Full-Text | Bispecific Antibodies as a Development Platform for New Concepts and Treatment Strategies | HTML
Bispecific antibodies that can simultaneously bind to cell surface antigens and payloads are a very ideal delivery system for ... The single-chain-based bispecific antibodies usually bridge tumor cells with immune cells and form an immunological synapse ... Bispecific antibodies in the IgG format include asymmetric bispecific antibodies and homodimerized bispecific antibodies, all ... Bispecific antibodies can also be used to treat hemophilia A by mimicking the function of factor VIII. Bispecific antibodies ...
  http://www.mdpi.com/1422-0067/18/1/48/htm
*  Discovery Biology News
In a report by Tereshko et al., camelid single domain antibodies, specifically the variable heavy chain (VHH) domains can be ... This monoclonal cocktail consists of three antibodies, each recognizing different, non-overlapping EBOV glycoprotein epitopes1. ... One of the challenges, particularly with membrane bound proteins and transmembrane receptors, is the ability to obtain a well ... which encodes a protein required for polymerase II function and shown previously to bind to triptolide. From the screen, the ...
  https://www.genscript.com/DiscoveryBiology_news.html
*  William Weis | Stanford Medicine Profiles
Here we report stabilization of two distinct β2AR conformations using single domain camelid antibodies (nanobodies)-a ... Axin is shown to act as a scaffold for substrate phosphorylation by these kinases. Phosphorylated APC and axin bind to the same ... Crystal structures of carbohydrate-recognition domains of DC-SIGN and of DC-SIGNR bound to oligosaccharide, in combination with ... The conformation of the Abeta peptide recognized by all three antibodies was highly related and is also remarkably similar to ...
  https://med.stanford.edu/profiles/william-weis
*  A Human Single-Domain Antibody Elicits Potent Antitumor Activity by Targeting an Epitope in Mesothelin Close to the Cancer Cell...
It moderately bound CCA cell line (Mz-ChA-1) and weakly bound human NSCLC cell lines (EKVX and L55). It did not bind to ... whereas SD1 is a fully human VH single-domain antibody isolated from a naïve human antibody phage library. SD1 recognizes the C ... Construction of a large phage-displayed human antibody domain library with a scaffold based on a newly identified highly ... we also constructed VH single-domain molecules based on SS1 as well as HN1. We expressed and compared the VH domains of SD1, ...
  http://mct.aacrjournals.org/content/12/4/416?rss=1
*  TWO-DIMENSIONAL PHOTONIC BANDGAP STRUCTURES FOR ULTRAHIGH-SENSITIVITY BIOSENSING - Patent application
... single-chain antibodies (i.e., covalently linked variable heavy (VH) and light (VL) domains), single-domain antibodies (i.e., ... For example, a first probe that recognizes a first target can be bound to a surface of the substrate exposed to one central ... human fibronectin type III domain (10Fn3) (Koide et al., "The Fibronectin Type III Domain as a Scaffold for Novel Binding ... Patent applications in class By measuring the ability to specifically bind a target molecule (e.g., antibody-antigen binding, ...
  http://www.patentsencyclopedia.com/app/20100279886
*  Rational design of antibodies targeting specific epitopes within intrinsically disordered proteins | PNAS
A Single Domain Antibody Scaffold for the Grafting of the Complementary Peptides.. To assess the viability of the design method ... We illustrate the method by designing six single-domain antibodies to bind different epitopes within three disease-related ... and IAPP bound to DesAb-F was estimated measuring the absorbance at 492 nm after verifying that the primary antibodies ... 2008) Comprehensive analysis of the factors contributing to the stability and solubility of autonomous human VH domains. J Biol ...
  http://www.pnas.org/content/112/32/9902
*  DiVA - Search result
Four affinity domains of different origin and structure; the IgG-binding domains Z and C2, the albumin-binding domain ABD, and ... Affinity reagents recognizing constant parts of antibody molecules are invaluable tools in immunotechnology applications, ... Single domain affinity proteins for the detection of the genome organizer protein SATB1Manuscript (preprint) (Other academic). ... Here we show that the coding sequence for a disulfide bond-independent three-helix bundle scaffold Z, derived from domain B of ...
  http://kth.diva-portal.org/smash/resultList.jsf?af=%5B%5D&aq=%5B%5B%7B%22personId%22%3A%22authority-person%3A31099+OR+0000-0003-4214-6991%22%7D%5D%5D&aqe=%5B%5D&aq2=%5B%5B%5D%5D&language=en&query=
*  RECOMBINANT RENEWABLE POLYCLONAL ANTIBODIES - Patent application
Protein L can be used to identify and select correctly folded VL domains. [0070] Single-scaffold library: A synthetic antibody ... scFv-Fc fusions recognizing bound Ag85 at a site different to the yeast displayed scFv will be able to bind the Ag85 and confer ... will bind to the Fc domain of the polyclonal antibodies, and which have been shown to improve antibody orientation (Matson et ... In some embodiments, the synthetic antibody library is based on a single antibody scaffold, or a limited number of antibody ...
  http://www.patentsencyclopedia.com/app/20130085072
*  Antibodies Directed To Alpha V Beta 6 And Uses Thereof - Patent application
... single domain antibodies, generation of peptide therapeutics, αVβ6 binding domains in novel scaffolds, gene therapies, ... the antibodies that were tested were raised against the cell-bound form of the antigen and may not bind with as high an ... The scaffold may be a human or non-human protein. An advantage of a non-antibody protein scaffold is that it may provide an ... One subfamily consists of all of the integrins that recognize and bind the RGD tripeptide. These receptors include the αIIb/β3 ...
  http://www.patentsencyclopedia.com/app/20130202621
*  CONSTRUCTS AND LIBRARIES COMPRISING ANTIBODY SURROGATE LIGHT CHAIN SEQUENCES - Patent application
... single domain, or single chain antibody (scFv), or a full length antibody, for example, an IgG (e.g., an IgG1, IgG2, IgG3, or ... while the antibody heavy chain or heavy chain fragment may bind to effector cells. This way, a single entity with targeting and ... domains. Any reference to an antibody light chain herein includes both κ and λ light chains. [0085]"Antibody fragments" ... 0081]The term "framework region" refers to the art recognized portions of an antibody variable region that exist between the ...
  http://www.patentsencyclopedia.com/app/20100004139
*  Neurodegenerative Diseases | Leaders in Pharmaceutical Business Intelligence (LPBI) Group
Choosing the right antibody platform can speed the discovery of a new therapeutics against these new targets. Single domain ... Although it had well-characterized protein domains such as coiled-coil domains and leucine-zipper domains, its function was ... This finding suggests that the ASD1 peptoid recognizes antibody(-ies) of an IgG1 subtype that is (are) significantly lower in ... The IgG bound to the SLE-peptoid was found to react with several autoantigens, suggesting that the peptoids are capable of ...
  https://pharmaceuticalintelligence.com/category/neurodegenerative-diseases/
*  Ceramide-activated protein phosphatase - Wikipedia
... and a conserved 65 kDa scaffold subunit, A, tightly bound to one another (Janssens & Goris, 2001). The scaffold subunit ... The catalytic subunit of ceramide-activated PP1 is a single-domain protein consisting of a central β-sandwich, of two mixed β- ... The catalytic subunit recognizes and associates with the scaffold subunit through this ridge (Groves et al., 1999). Two other ... I1PP2A and I2PP2A inhibit all possible forms of CAPP by associating with the catalytic subunit using their C-terminal domains ( ...
  https://en.wikipedia.org/wiki/Ceramide-activated_protein_phosphatase
*  Fibronectin Type III Domain Based Scaffold Compositions, Methods And Uses - Patent application
... single domain antibodies, and fragments thereof. Functional fragments include antigen-binding fragments that bind to a ... 0124]Recognized devices comprising single vial systems include pen-injector devices for delivery of a solution, such as BD Pens ... 2A-N. Melting profiles of the purified FN3 domains (except for the 7th domain) from human fibronectin as determined by DSC in ... The protein and/or antibody is immobilized or insolubilized before or after the competition and the sample bound to the target ...
  http://www.patentsencyclopedia.com/app/20100255056
*  Methods and Compositions for Generating Bioactive Assemblies of Increased Complexity and Uses - Patent application
... and includes antibody fragments such as Fab', Fab, F(ab')2, single domain antibodies (DABs), Fv, scFv (single chain Fv), and ... so long as the fragments bind to the antigen that is recognized by the intact antibody. For example, Fv fragments comprise an ... The recombinant host cells synthesize a single polypeptide chain with a linker peptide bridging the two V domains. Methods for ... which are bound to hP1 by complexation. A further embodiment is to generate type-d adaptor modules based on hP1 for linking to ...
  http://www.patentsencyclopedia.com/app/20090202433
*  Antibodies Against Angiopoietins 1 and 2, and Their Use - Patent application
... and can be incorporated into single domain antibodies, such as single chain antibodies, maxibodies, minibodies, intrabodies, ... VH and CH1 domains), scFv (VL and VH is joined by a linker), a domain antibody, bispecific antibodies, a minibody, a scab (an ... antibodies or antibodies in a different format comprising a portion that binds to an antigen, and optionally, a scaffold or ... Screening of Antibodies that Bind to Angiopoietins 1 and 2 [0082] Two different phage display libraries were used in the ...
  http://www.patentsencyclopedia.com/app/20140112933
*  COMPOSITIONS AND METHODS OF USE FOR THERAPEUTIC ANTIBODIES - Patent application
... domains of Protein A. Protein A is a surface protein from the bacterium Staphylococcus aureus. This scaffold domain consists of ... consisting of the VH and CH1 domains; a Fv fragment consisting of the VL and VH domains of a single arm of an antibody; a dAb ... Antibodies that Bind to the Same Epitope as Anti-IL12Rβ1 Antibodies of the Invention [0087] In another embodiment, the ... Thereafter, the chip is treated to remove all of the bound antibody without damaging the chip-bound IL12Rβ1, e.g. by way of ...
  http://www.patentsencyclopedia.com/app/20120034231
*  ACTRIIB BINDING AGENTS AND USES THEREOF - Patent application
... can be incorporated into single-domain antibodies, single-chain antibodies, maxibodies, minibodies, intrabodies, diabodies, ... fragments bind to the antigen that is recognized by the intact antibody. [0039] An antibody fragment may also be any synthetic ... domain as found in a Fab fragment, or to provide further domains, such as antibody CH2 and CH3 domains. [0044] As described ... The chip is again treated to remove all of the bound antibody without damaging the chip-bound ActRIIB-mFc. [0102] The solution ...
  http://www.patentsencyclopedia.com/app/20130189269
*  Anti-TNF Alpha Fibronectin Type III Domain Based Scaffold Compositions, Methods and Uses - Patent application
... single domain antibodies, and fragments thereof. Functional fragments include antigen-binding fragments that bind to a ... Detection of bound Tencon was accomplished using an anti-HIS-HRP antibody (Qiagen). Results of the ELISA are shown in FIG. 7. ... 0125] Recognized devices comprising single vial systems include pen-injector devices for delivery of a solution, such as BD ... In a preferred embodiment, the protein scaffold is comprised of a consensus sequence of multiple FN3 domains from human ...
  http://www.patentsencyclopedia.com/app/20130274145
*  SMART: Secondary literature for CA domain
Polyclonal antibodies raised against the cytoplasmic domain of a cloned sea urchin cadherin recognize three major polypeptides ... The cadherins typically consist of five tandemly repeated extracellular domains, a single membrane-spanning segment and a ... domain must bind alpha- and beta-catenins, which link it to the actin cytoskeleton. However, the IC domain of pemphigus ... On the free cell surface, cadherin molecules interact with the cytoskeleton/membrane skeleton by being bound or corralled, and ...
  http://smart.embl.de/smart/show_secondary.cgi?domain=CA
*  CD37-Binding Molecules and Immunoconjugates Thereof - Patent application
... single-domain antibody, DVD-Ig, Fcab, mAb2, (scFv)2, or scFv-Fc. [0028] In some embodiments, the antibody or antigen-binding ... the antibodies can specifically recognize and bind a CD37 as well as, for example, 1) an effector molecule on a leukocyte such ... being recognized and specifically bound by a particular antibody. When the antigen is a polypeptide, epitopes can be formed ... In some embodiments, the constant domains of the light and heavy chains of, for example, a mouse monoclonal antibody can be ...
  http://www.patentsencyclopedia.com/app/20120276119
*  Protocols and Video Articles Authored by Peter Nagy (Translated to Norwegian)
... single- and multi-domain cyclophilins, TPR-domain co-chaperones and cellular ion pumps. These restriction factors frequently ... Detection of PKCγ antibodies should be considered in PCD and adenocarcinoma without typical onconeural antibodies. ... we show that the WW domain inhibits the ability of p33 to bind to the viral RNA and to other p33 and p92 replication proteins ... in 8 human tissues we found that in all 3 domains the ASM is restricted to single differentially methylated regions (DMRs), ...
  https://www.jove.com/author/Peter_Nagy?language=Norwegian
*  System, devices, and methods for real-time monitoring of cerebrospinal fluid for markers of progressive conditions - Patent...
Further examples of antibodies or fragments include bispecific antibodies, trispecific antibodies, single domain antibodies (e. ... Some lectins will bind only to structures with mannose or glucose residues, while others can recognize only galactose residues ... those including VH and CH1 domains), Fv fragments (e.g., those including VL and VH domains of a single arm of an antibody), ... bound, or associated with at least one biomarker or biological sample component. [0098] In an embodiment, the one or more ...
  http://www.patentsencyclopedia.com/app/20120238837
*  RSV IMMUNOGENS, ANTIBODIES AND COMPOSITIONS THEREOF - Patent application
... a single domain of Protein A from S. aureus is shown (labeled Original), as well as the sequence of the 1lp1b--003 scaffold ( ... antibody-binding domains of the F protein when they are bound to their respective monoclonal antibodies: motavizumab, which ... the neutralizing antibody can be any antibody that binds an antibody-binding domain recognized by 101F antibody (also referred ... This technique can also be used to modify other antibodies that bind to the motavizumab-binding site or the 101F antibody- ...
  http://www.patentsencyclopedia.com/app/20120315270
*  Antievolution.org - Antievolution.org Discussion Board -Topic::The Origin of 'Information' via natural causes
... supporting their proposed evolution from a single domain channel, while the exons encoding the cytoplasmic loops are less ... Analysis by phage ELISA using anti-M13 antibody and anti-T7 antibody revealed that about 37-fold increase in the infectivity of ... Occurrences of homologous domains in otherwise different proteins suggest the recurrent use orf modular units in evolution. The ... However, this specific situation is the only type of motif generation that can still be recognized after millions of years of ...
  http://www.antievolution.org/cgi-bin/ikonboard/ikonboard.cgi?s=5071d649b5e9c721