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*  NewYork-Presbyterian Queens - Reactive Arthritis (Reiter's Syndrome)
Reactive arthritis, also known as Reiter's syndrome, is a type of arthritis that occurs as a reaction to an infection somewhere in the body. Most infections that cause the disease originate in the genitourinary tract (the bladder, urethra, penis, or vagina) and are spread through sexual intercourse, a form of the disease called genitourinary Reiter's syndrome, or urogenital Reiter's syndrome. Other infections that can cause reactive arthritis include gastrointestinal infections due to eating contaminated food or handling contaminated substances, a form of the disease called gastrointestinal Reiter's syndrome, or enteric Reiter's syndrome.. ...
  http://www.nyhq.org/diw/Content.asp?PageID=DIW007517&More=DIW&language=Spanish
*  British Library EThOS: The seronegative spondarthritides : a clinical and genetic study with particular reference to the...
In a clinical, radiological and histocompatibility typing study of 3 60 patients the association between individual types of seronegative spondarthritis and HLA-B27 is confirmed. HLA-B27 was associated with recurrent acute anterior uveitis in 119 patients with ankylosing spondylitis, but not with severity of the spinal disease. HLA-B27 negative patients had a later mean age of onset and more dactylitis of the toes. In 77 patients with Reiter's syndrome the presence of HLA-B27 was associated with the occurrence of keratoderma blenorrhagica, acute anterior uveitis and radiological sacroiliitis but not with conjunctivitis. No particular pattern of peripheral psoriatic arthritis was associated with HLA-B27 in the 79 patients studied. The ...
  http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.454289
*  HLA-B59 - Wikipedia
HLA-B59 (B59) is an HLA-B serotype. The serotype identifies the more common HLA-B*## gene products. B59 is a hybrid between B*55 and B*51. B59 is more common in Japan, Korea, N. China and Mongolia. (For terminology help see: HLA-serotype tutorial) Marsh SG, Albert ED, Bodmer WF, et al. (2005). "Nomenclature for factors of the HLA system, 2004". Tissue Antigens. 65 (4): 301-69. doi:10.1111/j.1399-0039.2005.00379.x. PMID 15787720. Hildebrand WH, Domena JD, Parham P (1993). "Primary structure shows HLA-B59 to be a hybrid of HLA-B55 and HLA-B51, ...
  https://en.wikipedia.org/wiki/HLA-B59
*  THU0363 Position 97 (P97) of HLA-B, A Residue Implicated in Ankylosing Spondylitis Pathogenesis, Plays A Key Role in Cell...
Results Mutation of P97 to AS risk residue Threonine, but not to the protective residues (Serine and Valine) or the non-associated residues (Arginine and Tryptophan), increased surface free heavy chain (FHC) expression in C1R and HeLa cells. The HLA-B*27-N97D mutation significantly reduced both of HLA-B*27 FHC and classical complex expression on the surface of C1R and HeLa cells. Only β2m, not TAP, Tapasin or ERAP1, was essential for the reduction of cell surface HLA-B*27 FHC expression in HLA-B*27-N97D mutant. The expression of HLA-B*7 and HLA-B*51 was also affected by P97 residue mutations. ...
  http://ard.bmj.com/content/75/Suppl_2/318.2
*  UVEITIS AND HLA-B27 : Prospective Study of 175 Cases | IOVS | ARVO Journals
Abstract: : Purpose: To assess the systemic manifestations associated with HLA-B27 uveitis. To analyze the characteristics of ocular inflammation. Methods: Monocentric, prospective study of 175 patients seen between January 1996 and March 2001 with acute anterior uveitis and HLA-B27 allele. Patients were systematically referred for a rheumatologic evaluation and diagnosis were based on criteria from the European Spondylarthropathy Study Group. Results: There were 99 males and 76 females. The mean age was 40.4 ± 13.3 years at the time of the study and 34.5 ± 13.9 years at the time of the first episode of uveitis. The average time between the first episode of uveitis and the last visit during the study period was 7.5 ± 7.2 years (median : 5.1). The mean number of episodes of uveitis since the onset of the disease was 4.9 ± 7.9 ...
  http://iovs.arvojournals.org/article.aspx?articleid=2421496
*  Efficacious early antiviral activity of HIV Gag- and Pol-specific HLA-B 2705-restricted CD8+ T cells. - Department of...
The association between HLA-B 2705 and the immune control of human immunodeficiency virus type 1 (HIV-1) has previously been linked to the targeting of the HLA-B 2705-restricted Gag epitope KRWIILGLNK (KK10) by CD8(+) T cells. In order to better define the mechanisms of the HLA-B 2705 immune control of HIV, we first characterized the CD8(+) T-cell responses of nine highly active antiretroviral therapy (HAART)-naïve B 2705-positive subjects. Unexpectedly, we observed a strong response to an HLA-B 2705-restricted Pol epitope, KRKGGIGGY (KY9), in 8/9 subjects. The magnitude of the KY9 response was only marginally lower than that of the KK10-specific response (median, 695 versus 867 spot-forming ...
  https://www.paediatrics.ox.ac.uk/publications/121085
*  Multilayered Defense in HLA-B51-Associated HIV Viral Control | The Journal of Immunology
Polymorphism in the HLA region of a chromosome is the major source of host genetic variability in HIV-1 outcome, but there is limited understanding of the mechanisms underlying the beneficial effect of protective class I alleles such as HLA-B57, -B27, and -B51. Taking advantage of a unique cohort infected with clade B' HIV-1 through contaminated blood, in which many variables such as the length of infection, the infecting viral strain, and host genetic background are controlled, we performed a comprehensive study to understand HLA-B51-associated HIV-1 control. We focused on the T cell responses against three dominant HLA-B51-restricted epitopes: Gag327-345(NI9) NANPDCKTI, Pol743-751(LI9) LPPVVAKEI, and Pol283-289(TI8) TAFTIPSI. Mutations in ...
  http://www.jimmunol.org/content/early/2011/06/13/jimmunol.1100316
*  HLA-B57 - Wikipedia
HLA-B57 (B57) is an HLA-B serotype. B57 is a split antigen from the B17 broad antigen, the sister serotype B58. The serotype identifies the more common HLA-B*58 gene products. (For terminology help see: HLA-serotype tutorial) Like B58, B57 is involved in drug-induced inflammatory skin disorders. HLA-B*5701 is associated with drug-induced inflammatory disease of the skin. Individuals with B57 are more sensitive to the drug abacavir. Abacavir is an antiretroviral drug used in treatment of HIV, however in sensitive individuals fever, skin rash, fatigue, gastrointestinal symptoms such as nausea, vomiting, diarrhea or abdominal pain and ...
  https://en.wikipedia.org/wiki/HLA-B57
*  Prospective Epidemiological Study Of The Prevalence Of HLA-B*5701 In HIV-1 Infected Patients - Full Text View - ClinicalTrials...
This study is a cross-sectional observational study to evaluate the prevalence of HLA-B*5701 in the European area and in major European ethnotypes.. Any HIV-1 infected patient will be eligible for this study including treatment naïve and experienced patients, as well as patients previously tested for HLA-B*5701. Patients will be approached during a standard clinic visit, and will be consented prior to any study specific procedure. They will be asked to provide a tissue sample (cheek cells and blood sample) which will be used to assess HLA-B*5701 status by local and central laboratories.. In selected sites patients may be asked to provide an additional blood sample. This sample will be used ...
  https://clinicaltrials.gov/show/NCT00481390?order=129
*  Presence of IBD Specific Antibodies (ASCA, ALCA, ACCA, AMCA) in the Sera of Patients With Spondyloarthropathy - Full Text View ...
A relationship between IBD and spondyloarthropathy is well recognized. ASCA ( anti saccharomyces cerevisiae antibodies)are considered to be a serological marker for Crohn's disease and have been studied in patients with spondyloarthropathy with conflicting results. More recently, new serological markers for IBD have been described. These markers are antibodies to certain defined glycans , and their use may permit an improved diagnosis of IBD.. The aim of our study is to investigate wether these new serological markers are present in the sera of patients with spondyloarthropathy. ...
  https://clinicaltrials.gov/ct2/show/NCT00517101?recr=Open&cond=%22Arthritis%2C+Psoriatic%22&rank=20
*  Presence of IBD Specific Antibodies (ASCA, ALCA, ACCA, AMCA) in the Sera of Patients With Spondyloarthropathy - Tabular View -...
A relationship between IBD and spondyloarthropathy is well recognized. ASCA ( anti saccharomyces cerevisiae antibodies)are considered to be a serological marker for Crohn's disease and have been studied in patients with spondyloarthropathy with conflicting results. More recently, new serological markers for IBD have been described. These markers are antibodies to certain defined glycans , and their use may permit an improved diagnosis of IBD.. The aim of our study is to investigate wether these new serological markers are present in the sera of patients with spondyloarthropathy. ...
  https://clinicaltrials.gov/ct2/show/record/NCT00517101
*  Genetic modulation of antigen presentation by HLA-B27 molecules. | JEM
In studies of antigenic peptide presentation, we have found a healthy volunteer whose lymphoblastoid cells were unable to present three different virus-derived epitopes to cytotoxic T lymphocytes (CTL) despite expressing the correct restricting HLA-B27 molecules on the cell surface. B cell lines were established from other members of the donor's family, including individuals suffering from ankylosing spondylitis and related diseases, and were tested for their ability to function as target cells in the same assay. None of the eight B cell lines that expressed HLA-B27 presented a known peptide epitope to CTL. However, cells from a family member that expressed HLA-B8 could present an epitope peptide restricted by that molecule. The ...
  http://jem.rupress.org/content/175/2/361
*  The critical role of interleukin-23 in spondyloarthropathy. - The Kennedy Institute of Rheumatology
The spondyloarthropathies represent highly enigmatic conditions and although their clinical features, anatomical distribution of disease and genetic predisposing factors have been known for some time, a unified concept of the basic pathobiology underlying these illnesses has remained undefined. Recently progress has been made because numerous independent studies have converged upon IL-23 as a central cytokine in spondyloarthropathy and the mechanism and sites of action of this cytokine have now become much clearer. These findings enable the rational design of therapeutic strategies which it is hoped will profoundly modify the progression of these diseases. We will review the anatomical sites affected and the evidence for the importance of IL-23 in these conditions, before drawing these lines of investigation together to propose a model for the unified ...
  https://www.kennedy.ox.ac.uk/publications/432682
*  HIV subtype influences HLA-B*07:02-associated HIV disease outcome. - Department of Paediatrics
Genetic polymorphisms within the MHC encoding region have the strongest impact on HIV disease progression of any in the human genome and provide important clues to the mechanisms of HIV immune control. Few analyses have been undertaken of HLA alleles associated with rapid disease progression. HLA-B*07:02 is an HLA class I molecule that is prevalent in most populations worldwide and that has previously been consistently linked to accelerated disease progression in B-clade infection. This study investigates the observation that HLA-B*07:02 is not associated with a high viral setpoint in C-clade infection. We examine the hypothesis that this clade-specific difference in association with disease outcome may be related to distinct targeting of CD8(+) T cell epitopes. We observed that ...
  https://www.paediatrics.ox.ac.uk/publications/434113
*  Prospective Epidemiological Study Of The Prevalence Of HLA-B*5701 - Full Text View - ClinicalTrials.gov
This is a study to determine the prevalence of a genetic marker, HLA-B5701, in the UK population. HLA-B*5701 has been strongly associated with the risk of an allergic reaction to a HIV medicine, Abacavir. The allergic reaction is known as a hypersensitivity reaction.. The study is a prospective study inviting HIV-1 positive patients over the age of 18 years to participate. Each participant will complete one study visit. They will be asked for details of their background including their age, sex, ethnicity, country of origin and parental country of origin.. They will be asked to give two samples to test for the presence of the genetic marker HLA-B*5701. The two samples are:. ...
  https://clinicaltrials.gov/show/NCT00453440?order=122
*  Imputing the presence of the HLA-B27 antigen using your 23andMe genome
sub type, and it has the same probabilities.. So, even if there is such a big uncertainty in the results, it does give a very crude indication, even for the small reference data set. And, it did match up with the result of the blood test, which was fun, but could just as well have been pure luck.. Bottom line: It's pretty awesome that ordinary people can do stuff like this. I can easily imagine a professional service built around imputation: Patient gets genotyped, it's stored on a secure server. The doctor can then, based on a permission scheme, run imputation for things like HLA-B27 as one of many tools when diagnosing. A blood test will always be more accurate than imputation, but is time consuming and costs money. If a doctor could quickly see that the ...
  https://csl.name/post/hla-b27/
*  HLA-B8 molecule functions as a restriction element for | Open-i
HLA-B8 molecule functions as a restriction element for M3-W1-B9 CD8+ T cells. (A) T cell recognition of peptide-pulsed HLA-B8-expressing cell lines. (B) Ident
  https://openi.nlm.nih.gov/detailedresult.php?img=PMC2211826_20031219f4&req=4
*  A Study of Patient Management in HIV-1 Infected Patients Found to Have the Genetic Marker HLA-B*5701 - Full Text View -...
This is a retrospective observational study which follows on from CNA106030 (a study evaluating whether prospective genetic screening for HLA-B*5701 can reduce the incidence of hypersensitivity reactions to abacavir). This study aims to collect data on approximately 35 subjects who withdrew from CNA106030 when found to be HLA-B*5701 positive. HIV disease management and adverse event data in these subjects, where the risk/benefit ratio of treatment with abacavir may alter subsequent prescribing, will be ...
  https://clinicaltrials.gov/show/NCT00435838?order=389
*  A Study of Patient Management in HIV-1 Infected Patients Found to Have the Genetic Marker HLA-B*5701 - Full Text View -...
This is a retrospective observational study which follows on from CNA106030 (a study evaluating whether prospective genetic screening for HLA-B*5701 can reduce the incidence of hypersensitivity reactions to abacavir). This study aims to collect data on approximately 35 subjects who withdrew from CNA106030 when found to be HLA-B*5701 positive. HIV disease management and adverse event data in these subjects, where the risk/benefit ratio of treatment with abacavir may alter subsequent prescribing, will be ...
  https://clinicaltrials.gov/show/NCT00435838?order=394
*  A Study of Patient Management in HIV-1 Infected Patients Found to Have the Genetic Marker HLA-B*5701 - Full Text View -...
This is a retrospective observational study which follows on from CNA106030 (a study evaluating whether prospective genetic screening for HLA-B*5701 can reduce the incidence of hypersensitivity reactions to abacavir). This study aims to collect data on approximately 35 subjects who withdrew from CNA106030 when found to be HLA-B*5701 positive. HIV disease management and adverse event data in these subjects, where the risk/benefit ratio of treatment with abacavir may alter subsequent prescribing, will be ...
  https://clinicaltrials.gov/show/NCT00435838?order=397
*  Specific lysis of HLA-B8-matched EBV-transformed LCLs | Open-i
Specific lysis of HLA-B8-matched EBV-transformed LCLs by M3-W1-B9 CD8+ T cells. (A) Recognition of HLA-B8-matched LCLs by M3-W1-B9 CD8+ T cells. LCLs were c
  https://openi.nlm.nih.gov/detailedresult.php?img=PMC2211826_20031219f5&req=4
*  A Naturally Selected Dimorphism within the HLA-B44 Supertype Alters Class I Structure, Peptide Repertoire, and T Cell...
The impact of point mutations and other micropolymorphisms on the structure and function of class I molecules has been studied extensively by in vitro mutagenesis (53, 54) and through exploitation of the experimentally derived Kb mutant system (3, 44, 47, 48). These systems have been enormously important for unraveling key details of structure-function relationships in MHC molecules. However, it is equally important to study the structural and functional consequences of naturally selected microvariation in HLA allotypes found in outbred human populations. To this end, we have determined the structural and functional properties of two closely related, naturally occurring human class I alleles, HLA-B*4402 and B*4403. These were studied because of their evolutionary success as common alleles in diverse human ...
  http://jem.rupress.org/content/198/5/679
*  KAKEN - Research Projects | Analysis of HLA-B27, investigating of the susceptibility of AS and AAU (KAKENHI-PROJECT-07671903)
Principal Investigator:JOKO Satoru,沼賀 二郎, Project Period (FY):1995 - 1996, Research Category:Grant-in-Aid for Scientific Research (C), Section:一般, Research Field:Ophthalmology
  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-07671903/
*  What Type of Antigen Is HLA B27? | Reference.com
HLA-B27 is a human leukocyte antigen that helps the body differentiate its own cells from foreign substances. A test indicating that HLA-B27 is present means that the patient might have a risk of...
  https://www.reference.com/health/type-antigen-hla-b27-dd6fa97390c2edda
*  disease News Results and Analysis |OOYUZ
The HLA-B*52:01 and -C*12:02-restricted CTLs strongly suppress HIV-1 replication resulting in slower disease progression. In contrast, the HLA-B*52:01-C*12:02 haplotypes are suscep ...
  https://www.ooyuz.com/newsanalysis?term=disease