*  Excitatory synaptic responses mediated by GABAA receptors in the hippocampus | Science
Gamma-aminobutyric acid (GABA) is a major inhibitory neurotransmitter in the cortex. Activation of postsynaptic GABAA receptors ... Excitatory synaptic responses mediated by GABAA receptors in the hippocampus Message Subject. (Your Name) has forwarded a page ... Excitatory synaptic responses mediated by GABAA receptors may thus provide a mechanism for the recruitment of GABAergic ... Synaptic responses mediated by GABAA receptors also strongly excited hippocampal neurons. This excitatory response was recorded ...
  http://science.sciencemag.org/content/253/5026/1420
*  Effects of Ethanol on GABAA Receptors in GABAergic and Glutamatergic Presynaptic Nerve Terminals | Journal of Pharmacology and...
Such highly sensitive GABAA receptor subunits may also comprise the presynaptic GABAA receptors seen in the present study. δ ... Presynaptic GABAB receptors have been shown to modulate acute EtOH actions on GABAA receptor-mediated transmission in ... Effects of EtOH on Presynaptic GABAA Receptors on Single Glutamatergic Terminals.. GABAA receptors also exist on glutamatergic ... whereas the extrasynaptic GABAA receptor responses were evident only at 30 mM EtOH. It has been reported that GABAA receptors ...
  http://jpet.aspetjournals.org/content/341/3/809
*  GABRB2 - Gamma-aminobutyric acid receptor subunit beta-2 precursor - Homo sapiens (Human) - GABRB2 gene & protein
Functions also as histamine receptor and mediates cellular responses to histamine. Functions as receptor for diazepines and ... Component of the heteropentameric receptor for GABA, the major inhibitory neurotransmitter in the vertebrate brain. ... R-HSA-112314. Neurotransmitter receptors and postsynaptic signal transmission. R-HSA-977441. GABA A receptor activation. ... R-HSA-112314. Neurotransmitter receptors and postsynaptic signal transmission. R-HSA-977441. GABA A receptor activation. ...
  http://www.uniprot.org/uniprot/P47870
*  Chronic stress impairs GABAergic control of amygdala through suppressing the tonic GABAA receptor currents | Molecular Brain |...
GABA receptor A (GABAAR) mediates the primary component of inhibition in brain and its activation produces two forms of ... To test this, we employed a GABAAR-containing outside-out patch as a sensor of ambient GABA and compared the efficacy of GABA ... CIS weakens tonic GABAAR currents through activation of glucocorticoid receptors. In brain, CORT functions through binding to ... The ambient GABA is similar in LA from control and CIS mice. A, Representative traces showing GABAAR currents in an outside-out ...
  https://molecularbrain.biomedcentral.com/articles/10.1186/1756-6606-7-32
*  Frontiers | Metabotropic regulation of extrasynaptic GABAA receptors | Frontiers in Neural Circuits
Specifically, we address the ability of protein kinase A and C to phosphorylate the extrasynaptic receptors responsible for the ... Specifically, we address the ability of protein kinase A and C to phosphorylate the extrasynaptic receptors responsible for the ... A large body of work now shows the importance of GABAA receptor-mediated tonic inhibition in regulating CNS function. However, ... A large body of work now shows the importance of GABAA receptor-mediated tonic inhibition in regulating CNS function. However, ...
  https://www.frontiersin.org/articles/10.3389/fncir.2013.00171/full
*  Plus it
6, top row, arrowhead). Such punctate GABAA receptor immunoreactivity is likely representing GABAA receptor clusters that ... but both measurements lagged behind the detection of functional GABAA receptors. Remarkably, the GABAA receptors of newly ... functional GABAA receptors are expressed early in dissociated embryonic neurons and these GABAA receptors can be rapidly ... All synaptic events were abolished by GABAA receptor antagonist BIC (20 μm), but not AMPA receptor antagonist CNQX (10 μm). D, ...
  http://www.jneurosci.org/content/27/40/10860
*  The Effects of Acute and Chronic Ethanol Exposure on Presynaptic and Postsynaptic GABAA Receptor Function in Cultured Cortical...
First, ethanol acts directly on postsynaptic GABAA receptors (GABAARs) to increase their response to GABA (Roberto et al., ... First, GABAB receptors were not blocked during our experiments, and these receptors, when activated by ambient or synaptically- ... This regimen produces changes in GABA-mediated Cl− uptake, GABAAR subunit mRNA levels, GABAAR protein levels, and receptor ... Keywords: GABA, GABAA Receptor, In Vitro, Cerebral Cortex, Hippocampus, Primary Culture ...
  http://pubmedcentralcanada.ca/pmcc/articles/PMC2796564/
*  Pagoclone | CI-1043 | RP-62955 | IP-456 | CAS#133737-32-3 | GABA receptor agonist | MedKoo
It is a partial agonist at α1-, α2- and α5-containing GABAA receptors and a full agonist at receptors containing an α3 subunit. ... It binds with roughly equivalent high affinity (0.7-9.1 nM) to the benzodiazepine binding site of human GABAA receptors ... is a GABA receptor agonist potentially for the treatment of stuttering, panic disorder and generalised anxiety. ... Description: Pagoclone, also known as CI-1043; IP-456; RP-62955; RP-59037, is a GABA receptor agonist potentially for the ...
  http://www.medkoo.com/products/10931
*  Effects of Ethanol on Tonic GABA Currents in Cerebellar Granule Cells and Mammalian Cells Recombinantly Expressing GABAA...
We found that the β2-containing GABAA receptors were expressed better than the β3-containing receptors. The rat GABAA receptor ... and δ combinations of GABA receptor subunits expressed in CHO cells and on the GABAA receptors of cerebellar granule cells when ... Furosemide Block of GABA-Induced Currents in Granule Cells. To confirm the existence of α6-containing GABAA receptors in the ... Akk G, Bracamontes J, and Steinbach JH (2004) Activation of GABAA receptors containing the α4 subunit by GABA and pentobarbital ...
  http://jpet.aspetjournals.org/content/319/1/431
*  Plus it
GABAA Receptor Functional Assay. Our behavioral data suggested that GABAA receptor function may have been altered by null ... GABAA receptor functional assays (36Cl- influx) supported our behavioral results; the actions of the GABAA agonists, THIP and ... These data suggest that fyn-kinase may alter the function of GABAA receptors, perhaps via actions on β2 and/or β3 receptor ... If fyn-kinase phosphorylates the β2 and/or β3 receptor subunits, then one would predict an associated change in GABAA receptor ...
  http://jpet.aspetjournals.org/content/309/3/1154
*  Etomidate | GABAA receptor beta2 and beta3 subunit modulator | Hello Bio
... high quality GABAA receptor beta2 and beta3 subunit modulator from Hello Bio, a trusted supplier for life science researchers ... Potent GABAA receptor positive allosteric modulator. Selective for β2 and β3 subunits (EC50 values are 0.6, 0.7 and 7.4 µM for ... α6β3γ2 and α6β1γ2 GABAA receptor subtypes respectively). Shows short acting hypnotic actions. Blood-brain barrier permeable. ... Distinct actions of etomidate and propofol at beta3-containing gamma-aminobutyric acid type A receptors.. Drexler B et al (2009 ...
  https://www.hellobio.com/etomidate.html
*  Plus it
... activation of extrasynaptic GABAA receptors containing the δ subunit. This week, two papers examined the action of tonic GABAA ... inhibition results both from fast-decaying glycine receptor-mediated IPSCs and slow-decaying GABAA receptor-mediated IPSCs. ... Tonic GABAA Receptor Currents in the Thalamus Delia Belelli, Dianne R. Peden, Thomas W. Rosahl, Keith A. Wafford, and Jeremy J ... also examined tonic GABAA current in VB cells using the hypnotic drug etomidate, which acts on β2 subunit-containing receptors ...
  http://www.jneurosci.org/content/25/50/0.1
*  Frontiers | Methods for recording and measuring tonic GABAA receptor-mediated inhibition | Frontiers in Neural Circuits
Tonic inhibitory conductances mediated by GABAA receptors have now been identified and characterised in many different brain ... Tonic inhibitory conductances mediated by GABAA receptors have now been identified and characterised in many different brain ... 2013). GABA-independent GABAA receptor openings maintain tonic currents. J. Neurosci. 33, 3905-3914. doi: 10.1523/JNEUROSCI. ... Adding GABA may also cause problems since increased GABA levels may recruit additional populations of receptors to contribute ...
  https://www.frontiersin.org/articles/10.3389/fncir.2013.00193/full
*  Gamma-aminobutyric acid receptor subunit alpha-1 - Wikipedia
GABA is the major inhibitory neurotransmitter in the mammalian brain where it acts at GABA-A receptors, which are ligand-gated ... At least 16 distinct subunits of GABA-A receptors have been identified. The GABRA1 receptor is the specific target of the z- ... 1999). "Dopamine receptor D2 and D4 genes, GABA(A) alpha-1 subunit genes and response to lithium prophylaxis in mood disorders ... Sarto I, Wabnegger L, Dögl E, Sieghart W (2002). "Homologous sites of GABA(A) receptor alpha(1), beta(3) and gamma(2) subunits ...
  https://en.wikipedia.org/wiki/Gamma-aminobutyric_acid_receptor_subunit_alpha-1
*  Principles of Receptor Binding Assays: The Gaba Receptor | SpringerLink
In order to fully exploit the potential of receptor binding assays and to avoid the misinterpretation of data, it is essential ... Enna S.J. (1984) Principles of Receptor Binding Assays: The Gaba Receptor. In: Reid E., Cook G.M.W., Morré D.J. (eds) ... Binding Assay Recognition Site Tissue Preparation Gaba Receptor Incubation Condition These keywords were added by machine and ... 1983) GABA Receptors, Humana Press, Clifton, N.J., in press.Google Scholar ...
  https://link.springer.com/chapter/10.1007/978-1-4684-4631-9_3
*  GABA receptor - Wikipedia
Although the term "GABAС receptor" is frequently used, GABAС may be viewed as a variant within the GABAA receptor family. ... The GABA receptors are a class of receptors that respond to the neurotransmitter gamma-aminobutyric acid (GABA), the chief ... GABA receptors influence neural function by coordinating with glutamatergic processes. A subclass of ionotropic GABA receptors ... Over-excitation of this receptor induces receptor remodeling and the eventual invagination of the GABA receptor. As a result, ...
  https://en.wikipedia.org/wiki/GABA_receptor
*  GABA Receptor Epsilon RNAi: Novus Biologicals
Browse our GABA Receptor Epsilon RNAi catalog backed by our Guarantee+. ... GABA Receptor Epsilon RNAi available through Novus Biologicals. ... GABA Receptor Epsilon RNAi. We offer GABA Receptor Epsilon RNAi ... Alternate Names for GABA Receptor Epsilon RNAi. GABA Receptor Epsilon RNAi, GABRE RNAi, GABA(A) receptor subunit epsilon RNAi, ... Our GABA Receptor Epsilon RNAi can be used in a variety of model species: Human. Use the list below to choose the GABA Receptor ...
  https://www.novusbio.com/rnai/gaba-receptor-epsilon
*  GABA receptor antagonist - Wikipedia
GABA receptor antagonists are drugs that inhibit the action of GABA. In general these drugs produce stimulant and convulsant ... Also thujone, ginkgo biloba, kudzu and muira puama[citation needed] may have properties of GABAA receptor antagonism. GABA ... Examples include bicuculline, securinine and metrazol, and the benzodiazepine GABAA receptor antagonist flumazenil. ...
  https://en.wikipedia.org/wiki/GABA_receptor_antagonist
*  Ionotropic GABA receptor - Wikipedia
Ionotropic GABA receptors (iGABARs) are ligand-gated ion channel GABA receptors and include: GABAA receptor GABAA-ρ receptor ... The GABAB receptor, a G protein-coupled receptor, is the only metabotropic GABA receptor.. ...
  https://en.wikipedia.org/wiki/Ionotropic_GABA_receptor
*  GABA receptor agonist - Wikipedia
GABA-α and GABAreceptors produce sedative and hypnotic effects and have anti-convulsion properties. GABAreceptors too ... A GABA receptor agonist is a drug that is an agonist for one or more of the GABA receptors, producing typically sedative ... There are three receptors of the gamma-aminobutyric acid. The two receptors GABA-α and GABA-ρ are ion channels that signal ... Alcohol is believed to mimic GABA's effect in the brain, binding to GABA receptors and inhibiting neuronal signaling. GABA ...
  https://en.wikipedia.org/wiki/GABA_receptor_agonist
*  GABA Receptors - Neuronal Signaling
GABA(A) receptor agonist Muscimol hydrobromide is a potent but toxic structural analog of g-aminobutyric acid (GABA), with a ... GABA receptor agonist Piperazine is an organic compound that consists of a six-membered ring containing two nitrogen atoms at ... GABAA receptor ligand U-93631 is a GABAA receptor ligand of novel chemical structure with IC50 of 100 nM,and has been shown to ... GABA uptake inhibitor SKF 89976A hydrochloride is a potent inhibitor of GABA uptake with IC50 of 0.13, 550, 944 and 7210 μM for ...
  http://www.adooq.com/gaba-receptors.html
*  Diabetes Modulates GABA Receptor Activity on Rat Retinal Neurons | IOVS | ARVO Journals
... the GABAC receptor-mediated responses on diabetic cells exhibit slower kinetics with GABA inactivation time constants of 1.77 ... Diabetes Modulates GABA Receptor Activity on Rat Retinal Neurons You will receive an email whenever this article is corrected, ... Noise analysis was used to estimate the single channel conductances for the GABAC receptor, and the averaged values were 0.94 ... Conclusions:: Diabetes modulates the GABAC receptor properties on retinal bipolar cells, most likely through alterations in the ...
  https://iovs.arvojournals.org/article.aspx?articleid=2387259
*  Coexistence of GABA receptors and GABA-modulin in primary cultures of rat cerebellar granule cells | Journal of Neuroscience
Coexistence of GABA receptors and GABA-modulin in primary cultures of rat cerebellar granule cells. FM Vaccarino, H Alho, MR ... Coexistence of GABA receptors and GABA-modulin in primary cultures of rat cerebellar granule cells ... Coexistence of GABA receptors and GABA-modulin in primary cultures of rat cerebellar granule cells ... Coexistence of GABA receptors and GABA-modulin in primary cultures of rat cerebellar granule cells ...
  http://www.jneurosci.org/content/7/1/65