*  Excitatory synaptic responses mediated by GABAA receptors in the hippocampus | Science
Gamma-aminobutyric acid (GABA) is a major inhibitory neurotransmitter in the cortex. Activation of postsynaptic GABAA receptors ... Excitatory synaptic responses mediated by GABAA receptors in the hippocampus Message Subject. (Your Name) has forwarded a page ... Excitatory synaptic responses mediated by GABAA receptors may thus provide a mechanism for the recruitment of GABAergic ... Synaptic responses mediated by GABAA receptors also strongly excited hippocampal neurons. This excitatory response was recorded ...
  http://science.sciencemag.org/content/253/5026/1420
*  Peripheral benzodiazepine receptor ligands as antiinflammatory agents - MCGEER; PATRICK L.
Compounds which bind with high affinity to peripheral benzodiazepine receptors are useful as antiinflammatory agents. Such ... not interact with GABA receptors and do not possess the same pharmacological properties as the central benzodiazepine receptor ... In this application, "peripheral benzodiazepine receptors" means the class of peripheral benzodiazepine receptors as ... produce an interaction with GABAA receptors, enhancing the activity of GABA (gamma-aminobutyric acid). These ligands possess ...
  http://www.freepatentsonline.com/5776946.html
*  Extrasynaptic GABAA Receptors by Adam C. Errington, Giuseppe Di Giovanni, Vincenzo Crunelli - Jian Kang Di E-books
GABA is the vital inhibitory neurotransmitter within the CNS and acts through GABAA and GABAB receptors. lately, a singular ... Extrasynaptic GABAA receptors are composed of receptor subunits that exhibit biophysical houses excellent to the iteration of ... while synaptic GABAA receptors underlie classical "phasic" GABAA receptor-mediated inhibition (inhibitory postsynaptic currents ... receptor-mediated inhibition effects from the activation of extrasynaptic receptors via low concentrations of ambient GABA. ...
  http://asian.kuron.jp/kindle/extrasynaptic-gabaa-receptors-the-receptors
*  OriGene - GABRG1 (NM 173536) cDNA Clone
A receptor, gamma 1 (GABRG1) available for purchase from OriGene - Your Gene Company. ... Gabrg1 (Myc-DDK-tagged ORF) - Rat gamma-aminobutyric acid (GABA) A receptor, gamma 1 (Gabrg1), (10 ug). $580. 3 weeks. ... Gabrg1 (Myc-DDK-tagged) - Mouse gamma-aminobutyric acid (GABA) A receptor, subunit gamma 1 (Gabrg1). $580. Next day. ... GABRG1 (untagged)-Human gamma-aminobutyric acid (GABA) A receptor, gamma 1 (GABRG1), NM_173536.3, 10ug. $190. In Stock. ...
  http://www.origene.com/cdna/trueclone/accession/NM_173536/SC101135.aspx
*  Frontiers | Metabotropic regulation of extrasynaptic GABAA receptors | Frontiers in Neural Circuits
Specifically, we address the ability of protein kinase A and C to phosphorylate the extrasynaptic receptors responsible for the ... Specifically, we address the ability of protein kinase A and C to phosphorylate the extrasynaptic receptors responsible for the ... A large body of work now shows the importance of GABAA receptor-mediated tonic inhibition in regulating CNS function. However, ... A large body of work now shows the importance of GABAA receptor-mediated tonic inhibition in regulating CNS function. However, ...
  https://www.frontiersin.org/articles/10.3389/fncir.2013.00171/full
*  Frontiers | Functional role of ambient GABA in refining neuronal circuits early in postnatal development | Frontiers in Neural...
GABA exerts its action via synaptic and extrasynaptic GABAA receptors mediating phasic and tonic inhibition, respectively. Here ... GABA exerts its action via synaptic and extrasynaptic GABAA receptors mediating phasic and tonic inhibition, respectively. Here ... Tonic GABA exerts also a chemotropic action on cell migration. Later on, when synapses are formed, GABA spilled out from ... Tonic GABA exerts also a chemotropic action on cell migration. Later on, when synapses are formed, GABA spilled out from ...
  https://www.frontiersin.org/articles/10.3389/fncir.2013.00136/full
*  Plus it
6, top row, arrowhead). Such punctate GABAA receptor immunoreactivity is likely representing GABAA receptor clusters that ... but both measurements lagged behind the detection of functional GABAA receptors. Remarkably, the GABAA receptors of newly ... functional GABAA receptors are expressed early in dissociated embryonic neurons and these GABAA receptors can be rapidly ... All synaptic events were abolished by GABAA receptor antagonist BIC (20 μm), but not AMPA receptor antagonist CNQX (10 μm). D, ...
  http://www.jneurosci.org/content/27/40/10860
*  The Effects of Acute and Chronic Ethanol Exposure on Presynaptic and Postsynaptic GABAA Receptor Function in Cultured Cortical...
First, ethanol acts directly on postsynaptic GABAA receptors (GABAARs) to increase their response to GABA (Roberto et al., ... First, GABAB receptors were not blocked during our experiments, and these receptors, when activated by ambient or synaptically- ... This regimen produces changes in GABA-mediated Cl− uptake, GABAAR subunit mRNA levels, GABAAR protein levels, and receptor ... Keywords: GABA, GABAA Receptor, In Vitro, Cerebral Cortex, Hippocampus, Primary Culture ...
  http://pubmedcentralcanada.ca/pmcc/articles/PMC2796564/
*  Martin Wallner, Ph.D. | UCLA Brain Research Institute
... propofol and the neurosteroid THDOC increase the GABA efficacy of recombinant alpha4beta3delta and alpha4beta3 GABA A receptors ... Wallner Martin, Hanchar H Jacob, Olsen Richard W Low dose acute alcohol effects on GABA A receptor subtypes Pharmacol. Ther, ... Alcohol-induced motor impairment caused by increased extrasynaptic GABA(A) receptor activity Nat. Neurosci, 2005; 8(3): 339-45 ... Wallner M, Hanchar H J, Olsen R W Low-dose alcohol actions on alpha4beta3delta GABAA receptors are reversed by the behavioral ...
  http://www.bri.ucla.edu/node/820
*  Plus it
GABAA Receptor Functional Assay. Our behavioral data suggested that GABAA receptor function may have been altered by null ... GABAA receptor functional assays (36Cl- influx) supported our behavioral results; the actions of the GABAA agonists, THIP and ... These data suggest that fyn-kinase may alter the function of GABAA receptors, perhaps via actions on β2 and/or β3 receptor ... If fyn-kinase phosphorylates the β2 and/or β3 receptor subunits, then one would predict an associated change in GABAA receptor ...
  http://jpet.aspetjournals.org/content/309/3/1154
*  Plus it
... activation of extrasynaptic GABAA receptors containing the δ subunit. This week, two papers examined the action of tonic GABAA ... inhibition results both from fast-decaying glycine receptor-mediated IPSCs and slow-decaying GABAA receptor-mediated IPSCs. ... Tonic GABAA Receptor Currents in the Thalamus Delia Belelli, Dianne R. Peden, Thomas W. Rosahl, Keith A. Wafford, and Jeremy J ... also examined tonic GABAA current in VB cells using the hypnotic drug etomidate, which acts on β2 subunit-containing receptors ...
  http://www.jneurosci.org/content/25/50/0.1
*  Frontiers | Methods for recording and measuring tonic GABAA receptor-mediated inhibition | Frontiers in Neural Circuits
Tonic inhibitory conductances mediated by GABAA receptors have now been identified and characterised in many different brain ... Tonic inhibitory conductances mediated by GABAA receptors have now been identified and characterised in many different brain ... 2013). GABA-independent GABAA receptor openings maintain tonic currents. J. Neurosci. 33, 3905-3914. doi: 10.1523/JNEUROSCI. ... Adding GABA may also cause problems since increased GABA levels may recruit additional populations of receptors to contribute ...
  https://www.frontiersin.org/articles/10.3389/fncir.2013.00193/full
*  GABA Receptor Epsilon RNAi: Novus Biologicals
Browse our GABA Receptor Epsilon RNAi catalog backed by our Guarantee+. ... GABA Receptor Epsilon RNAi available through Novus Biologicals. ... GABA Receptor Epsilon RNAi. We offer GABA Receptor Epsilon RNAi ... Alternate Names for GABA Receptor Epsilon RNAi. GABA Receptor Epsilon RNAi, GABRE RNAi, GABA(A) receptor subunit epsilon RNAi, ... Our GABA Receptor Epsilon RNAi can be used in a variety of model species: Human. Use the list below to choose the GABA Receptor ...
  https://www.novusbio.com/rnai/gaba-receptor-epsilon
*  Coexistence of GABA receptors and GABA-modulin in primary cultures of rat cerebellar granule cells | Journal of Neuroscience
Coexistence of GABA receptors and GABA-modulin in primary cultures of rat cerebellar granule cells. FM Vaccarino, H Alho, MR ... Coexistence of GABA receptors and GABA-modulin in primary cultures of rat cerebellar granule cells ... Coexistence of GABA receptors and GABA-modulin in primary cultures of rat cerebellar granule cells ... Coexistence of GABA receptors and GABA-modulin in primary cultures of rat cerebellar granule cells ...
  http://www.jneurosci.org/content/7/1/65
*  Insect GABA Receptors: Splicing, Editing, and Targeting by Antiparasitics and Insecticides | Molecular Pharmacology
... to yield receptors with properties of both GABAA and GABAC subtypes. Furthermore, GABAA and GABAB receptors, which differ ... ABBREVIATIONS: GABAR, GABA receptor; RDL, resistant to dieldrin; GRD, GABA receptor of Drosophila; TM, transmembrane; CACA, cis ... The GABAA γ2S subunit also forms a complex with both GABABR1 and GABABR2 subunits to allow agonist-induced receptor ... melanogaster GABA receptors, RDL shares a number of distinctive features with native GABA receptors of other insect species. ...
  http://molpharm.aspetjournals.org/content/68/4/942
*  Presynaptic GABA Receptors Mediate Temporal Contrast Enhancement in Drosophila Olfactory Sensory Neurons and Modulate Odor...
After a 1:25 pulse (D) knockdown of GABAB receptors and simultaneous knockdown of GABAA (8-10G) and GABAB receptors affect ... or GABAB receptors individually in OR22a-expressing OSNs. Simultaneous knockdown of GABAA (8-10G) and GABAB receptors reduces ... 1 Eb odor pulses is unaffected by the knockdown of GABA receptors. However, simultaneous knockdown of GABAA and GABAB receptors ... knockdown in OR22a-expressing OSNs of GABAA receptors individually or simultaneous knockdown of GABAA and GABAB receptors, ...
  https://www.ncbi.nlm.nih.gov/pubmed?term=27588305
*  GABA receptor - Wikipedia
Although the term "GABAС receptor" is frequently used, GABAС may be viewed as a variant within the GABAA receptor family. ... The GABA receptors are a class of receptors that respond to the neurotransmitter gamma-aminobutyric acid (GABA), the chief ... GABA receptors influence neural function by coordinating with glutamatergic processes. A subclass of ionotropic GABA receptors ... Over-excitation of this receptor induces receptor remodeling and the eventual invagination of the GABA receptor. As a result, ...
  https://en.wikipedia.org/wiki/GABA_receptor
*  Multiple GABA receptor subtypes mediate inhibition of calcium influx at rat retinal bipolar cell terminals | Journal of...
... a conventional GABAA receptor and a bicuculline/baclofen-insensitive GABA receptor. Activation of either GABA receptor ... However, these two GABA receptor subtypes have distinct properties. GABAA receptors suppress the Ca2+ response only at ... insensitive GABA receptor at bipolar cell terminals is most similar to the GABAC receptor reported by Feigenspan et al. (1993 ... Multiple GABA receptor subtypes mediate inhibition of calcium influx at rat retinal bipolar cell terminals. ZH Pan and SA ...
  http://www.jneurosci.org/content/15/4/2668
*  Genetic Association of Recovery from Eating Disorders: The Role of GABA Receptor SNPs
... Bloss, Cinnamon S.; Berrettini, Wade; ... Keywords: Gaba ; anorexia nervosa ; recovery from eating disorders ; genetic association ; single nucleotide polymorphisms ; ... Enrichment analyses revealed that GABA (gamma-aminobutyric acid) SNPs were over-represented among SNPs associated at po0.05 in ...
  https://infoscience.epfl.ch/record/170948
*  GABA receptor antagonist - Wikipedia
GABA receptor antagonists are drugs that inhibit the action of GABA. In general these drugs produce stimulant and convulsant ... Also thujone, ginkgo biloba, kudzu and muira puama[citation needed] may have properties of GABAA receptor antagonism. GABA ... Examples include bicuculline, securinine and metrazol, and the benzodiazepine GABAA receptor antagonist flumazenil. ...
  https://en.wikipedia.org/wiki/GABA_receptor_antagonist
*  Ionotropic GABA receptor - Wikipedia
Ionotropic GABA receptors (iGABARs) are ligand-gated ion channel GABA receptors and include: GABAA receptor GABAA-ρ receptor ... The GABAB receptor, a G protein-coupled receptor, is the only metabotropic GABA receptor.. ...
  https://en.wikipedia.org/wiki/Ionotropic_GABA_receptor
*  GABA receptor agonist - Wikipedia
GABA-α and GABAreceptors produce sedative and hypnotic effects and have anti-convulsion properties. GABAreceptors too ... A GABA receptor agonist is a drug that is an agonist for one or more of the GABA receptors, producing typically sedative ... There are three receptors of the gamma-aminobutyric acid. The two receptors GABA-α and GABA-ρ are ion channels that signal ... Alcohol is believed to mimic GABA's effect in the brain, binding to GABA receptors and inhibiting neuronal signaling. GABA ...
  https://en.wikipedia.org/wiki/GABA_receptor_agonist
*  JOINT MANIPULATION REDUCES HYPERALGESIA BY ACTIVATION OF MONOAMINE RECEPTORS BUT NOT OPIOID OR GABA RECEPTORS IN THE SPINAL CORD
This page contains the abstract Joint Manipulation Reduces Hyperalgesia By Activation of Monoamine Receptors But Not Opioid or ... GABA Receptors in the Spinal Cord http://www.chiro.org/LINKS/ABSTRACTS/Joint_Manipulation_Reduces_Hyperalgesia.shtml ... By Activation of Monoamine Receptors But Not Opioid or GABA Receptors in the Spinal Cord This section is compiled by Frank M. ... blocks opioid receptors; yohimbine blocks, alpha2-adrenergic receptors; and methysergide, blocks 5-HT(1/2) receptors. In ...
  http://www.chiro.org/LINKS/ABSTRACTS/Joint_Manipulation_Reduces_Hyperalgesia.shtml
*  Anti-GABA A receptor pi antibody (ab26055) | Abcam
Rabbit polyclonal GABA A receptor pi antibody validated for WB, ELISA, IHC, ICC/IF and tested in Human, Mouse and Rat. ... Anti-GABA A receptor pi antibody. See all GABA A receptor pi primary antibodies. ... The binding of this pI subunit with other GABA(A) receptor subunits alters the sensitivity of recombinant receptors to ... Anti-GABA A receptor pi antibody (ab26055) at 0.5 µg/ml (in 5% skim milk / PBS buffer) + Jurkat cell lysate 10ug.. Secondary. ...
  http://www.abcam.com/gaba-a-receptor-pi-antibody-ab26055.html