*  Pituitary adenylate cyclase-activating polypeptide 38-mediated rin activation requires src and contributes to the regulation of...
Article Pituitary adenylate cyclase-activating polypeptide 38-mediated rin activation requires src and contributes to the regulation of hsp27 signaling during neuronal differentiation. Pituitary adenylate cyclase-activating polypeptide 38 (PACAP38) i...
  https://www.environmental-expert.com/articles/pituitary-adenylate-cyclase-activating-polypeptide-38-mediated-rin-activation-requires-src-and-contr-36524
*  Neuroprotective Effects of Pituitary Adenylate Cyclase-Activating Polypeptide | Open Access Journals
Pituitary adenylate cyclase-activating polypeptide (PACAP) is a member of the secretin/glucagon/vasoactive intestinal peptide (VIP) super family. PACAP was first isolated..
  https://www.omicsonline.org/open-access/neuroprotective-effects-of-pituitary-adenylate-cyclaseactivating-polypeptide-2277-1891.1000156.php?aid=27860
*  Neurotrophic and neuroprotective effects of pituitary adenylate cyclase-activating polypeptide (PACAP) on mesencephalic...
Neurotrophic and neuroprotective effects of pituitary adenylate cyclase-activating polypeptide (PACAP) on mesencephalic dopaminergic neurons ...
  http://uu.diva-portal.org/smash/record.jsf?pid=diva2:84589
*  adenocarcinoma of pituitary gland 2005:2010[pubdate] *count=100 - BioMedLib™ search engine
Chemical-registry-number] 0 / ADCYAP1R1 protein, human; 0 / JV 1-53; 0 / RNA, Messenger; 0 / Receptors, Cell Surface; 0 / Receptors, Pituitary Adenylate Cyclase-Activating Polypeptide; 0 / Receptors, Pituitary Adenylate Cyclase-Activating Polypeptide, Type I; 0 / Receptors, Vasoactive Intestinal Peptide; 0 / Receptors, Vasoactive Intestinal Peptide, Type II; 0 / Receptors, Vasoactive Intestinal Polypeptide, Type I; 0 / VIPR1 protein, human; 0 / VIPR2 protein, human; 37221-79-7 / Vasoactive Intestinal Peptide; 9034-39-3 / Growth Hormone-Releasing ...
  http://www.bmlsearch.com/?kwr=adenocarcinoma+of+pituitary+gland+2005:2010%5Bpubdate%5D&cxts=100&stmp=b0
*  Pituitary Adenylate Cyclase-Activating Polypeptide | CTD
A multi-function neuropeptide that acts throughout the body by elevating intracellular cyclic AMP level via its interaction with PACAP RECEPTORS. Although first isolated from hypothalamic extracts and named for its action on the pituitary, it is widely distributed in the central and peripheral nervous systems. PACAP is important in the control of endocrine and homeostatic processes, such as secretion of pituitary and gut hormones and food intake ...
  http://ctdbase.org/detail.go?type=chem&acc=D051219
*  Pituitary adenylate cyclase-activating polypeptide (PACAP) has neuroprotective function in dopamine-based neurodegeneration...
It has been observed that pituitary-adenylate cyclase activating polypeptide (PACAP) rescued DAergic neurons from neurodegeneration and improved motor alterations induced by 6-hydroxy-dopamine (6-OHDA) in rat parkinsonian models. Recently we investigated the molecular background of the neuroprotective effect of PACAP in DA-based neurodegeneration using rotenone-induced snail and 6-OHDA-induced rat models of Parkinson's disease. The behavioural activity, monoamine (DA and serotonin), metabolic enzyme (S-COMT, MB-COMT and MAO-B) and PARK7/DJ-1 protein contents were measured before and after PACAP-treatment in both models.. Locomotion and feeding activity were decreased in rotenone-treated snails which corresponded well to findings obtained in 6-OHDA- induced rat experiments. PACAP was able to prevent the behavioural malfunctions caused by the toxins. The monoamine levels decreased in both models and the decreased DA level ...
  http://dmm.biologists.org/content/early/2016/12/14/dmm.027185
*  Modulation of Pituitary Adenylate Cyclase-Activating Polypeptide (PACAP) Expression in Explant-Cultured Guinea Pig Cardiac...
If you are a society or association member and require assistance with obtaining online access instructions please contact our Journal Customer Services team ...
  http://onlinelibrary.wiley.com/doi/10.1196/annals.1317.030/pdf
*  "Pacap and vip modulation of neuroexcitability in rat intracardiac neur" by Wayne I. DeHaven
Autonomic control of cardiac function depends on the coordinated activity generated by neurons within the intracardiac ganglia, and intrinsic feedback loops within the ganglia provide precise control of cardiac function. Both pituitary adenylate cyclase-activating polypeptide (PACAP) and vasoactive intestinal polypeptide (VIP) are important regulators of cell-to-cell signaling within the intracardiac ganglia, and PACAP and VIP action on these ganglia, mediated through associated receptors, play an important role in the regulation of coronary blood flow, cardiac contraction, relaxation, and heart rate. Results reported here using PACAP and VIP provide direct evidence of some of the complex signaling which occurs in neurons of the rat intracardiac ganglia.
  http://scholarcommons.usf.edu/etd/2852/
*  Plus it
One of the first studies to show convincing proof of agonist-specific states was transfection studies using the type-1 pituitary adenylyl cyclase-activating polypeptide (PACAP) receptor. The agonists (PACAP-27 and -38) stimulated adenylate cyclase (AC) with equal potencies, but only PACAP-38 could invoke the inositol phosphate response through phospholipase C (PLC) (Spengler et al., 1993). In subsequent work, the authors document the existence of a new splice variant of the PACAP receptor that was characterized by a 21-amino acid deletion in the N-terminal extracellular domain. They demonstrated that this domain modulates the receptor selectivity with respect to PACAP-27 and -38 binding and controls the relative potencies of the two agonists in phospholipase C stimulation (Pantaloni et al., 1996).. One of the first examples of agonist-specific states from mutational analysis was a Cys to Phe ...
  http://pharmrev.aspetjournals.org/content/57/2/147
*  Microglial VPAC1R mediates a novel mechanism of neuroimmune-modulation of hippocampal precursor cells via IL-4 release - Nunan ...
Harmar AJ, Arimura A, Gozes I, Journot L, Laburthe M, Pisegna JR, Rawlings SR, Robberecht P, Said SI, Sreedaran SP, Wank SA, Waschek JA. 1998. International Union of Pharmacology. XVIII. Nomenclature of receptors for vasoactive intestinal peptide and pituitary adenylate cyclase-activating polypeptide. Pharmacol Rev 50:265-270 ...
  http://onlinelibrary.wiley.com/doi/10.1002/glia.22682/references
*  Max Planck Society - eDoc Server
Expression of novel neurotrophin-1/B-cell stimulating factor-3 (NNT-1/BSF-3) in murine pituitary folliculostellate TtT/GF cells: Pituitary adenylate cyclase-activating polypeptide and vasoactive intestinal peptide-induced stimulation of NNT-1/BSF-3 is mediated by protein kinase A, protein kinase C, and extracellular-signal-regulated kinase1/2 pathways ...
  http://edoc.mpg.de/display.epl?mode=people&fname=C.%20J.&svir=0&name=Auernhammer
*  The Evolution of a Migraine Attack - A Review of Recent Evidence - Charles - 2012 - Headache: The Journal of Head and Face Pain...
A migraine attack is an extraordinarily complex brain event that takes place over hours to days. This review focuses on recent human studies that shed light on the evolution of a migraine attack. It begins with a constellation of premonitory symptoms that are associated with activation of the hypothalamus and may involve the neurotransmitter dopamine. Even in the premonitory phase, patients experience sensitivity to sensory stimuli, indicating that central sensitization is a primary phenomenon. The migraine attack progresses to a phase that in some patients includes aura, which involves changes in cortical function, blood flow, and neurovascular coupling. The aura phase overlaps with the headache phase, which is associated with further changes in blood flow and function of the brainstem, thalamus, hypothalamus, and cortex. Serotonin receptors, nitric oxide, calcitonin gene-related peptide, pituitary adenylate ...
  http://onlinelibrary.wiley.com/doi/10.1111/head.12026/abstract?globalMessage=0
*  KAKEN - Researchers | SHIMOZONO Masami (80271138)
Affiliation:宮崎大学,医学部,助教, Research Field:Otorhinolaryngology,Otorhinolaryngology, Keywords:パッチクランプ,Endolymph,RT-PCR,Basigin,Endocochlear potential,Cochlea,Pituitary adenylate cyclase-activating polypeptide,In situ hybridization,血管条,分子生物学, # of Research Projects:4, # of Research Products:6
  https://nrid.nii.ac.jp/nrid/1000080271138/
*  HKU Scholars Hub: Catfish-like Pituitary Adenylate Cyclase Activating Polypeptide in the Goldfish : - Molecular Cloning, Tissue...
Conference Paper: Catfish-like Pituitary Adenylate Cyclase Activating Polypeptide in the Goldfish : - Molecular Cloning, Tissue Distribution, and Functional ...
  http://hub.hku.hk/handle/10722/110621
*  Pituitary Adenylate Cyclase Acti : Severn Biotech, Limited
Severn Biotech, Limited : Pituitary Adenylate Cyclase Acti - Electrophoresis Products PBS & Saline Solutions Hybridisation Reagents Biological Buffers & SDS Sodium Azide Solutions General Bio-chemical Products Fingerprinting Chemical Product Forensic Dyes & Chemicals HPLC Laboratory Solvents DNA / RNA Extraction Specialist Pure Water Products Protein Linker Conjugates Peptide Synthesis Reagents Alcohol Sprays Hand Sanitiser Products Customised Services Comet Assay Products Protein Antibody Reagents Scientific Plastics Catalogue Peptides Affinity Purification Materials Cytology Screening Antibodies Specials severn, biotech
  http://www.severnbiotech.com/index.php?main_page=index&cPath=109_169
*  Plus it
Vasoactive intestinal peptide (VIP) appears to be responsible for atropine-resistant, neurally mediated pancreatic ductal bicarbonate secretion and plays a role in both stimulation and inhibition of neoplastic growth in other organs. cDNAs encoding high affinity VIP-1 and VIP-2 receptors have been cloned, and these receptors may be differentiated based on the ability of VIP-1, but not VIP-2, receptors to couple to adenylyl cyclase in response to stimulation with micromolar concentrations of secretin. Recent data from our laboratory suggest expression of a low affinity secretin receptor in seven cell lines derived from human ductal pancreatic adenocarcinomas. In combination with the recent use of 123I-labeled VIP to successfully image pancreatic adenocarcinomas in humans and the high affinity binding of both VIP and pituitary adenylate cyclase-activating peptides to sections ...
  http://cancerres.aacrjournals.org/content/57/8/1475
*  Items where Author is "Márk, László" - Repository of the Academy's Library
Márk, László and Dani, Győző (2016) Diabeteses dyslipidaemia és atherosclerosis. Orvosi Hetilap, 157 (19). pp. 746-752. ISSN 0030-6002 Márk, László and Hanyecz, Vince (2015) Hogyan változtak a koleszterinszintek az elmúlt 20 év alatt egy Békés megyei községben? Orvosi Hetilap, 156 (40). pp. 1614-1617. ISSN 0030-6002 Li, Hang and Smith, Brian K. and Márk, László and Nemes, Péter and Nazarian, javad (2014) Ambient molecular imaging by laser ablation electrospray ionization mass spectrometry with ion mobility separation. INTERNATIONAL JOURNAL OF MASS SPECTROMETRY. ISSN 1387-3806 Maász, Gábor and Pirger, Zsolt and Reglődi, Dóra and Petrovics, Dóra and Schmidt, János and Kiss, Péter and Rivnyák, Ádám and Hashimoto, Hitoshi and Avar, Péter and Jámbor, Éva and Tamás, Andrea and Gaszner, Balázs and Márk, László (2014) Comparative Protein Composition of the Brains of PACAP-Deficient Mice Using Mass Spectrometry-Based Proteomic Analysis. Journal of Molecular ...
  http://real.mtak.hu/view/creators/M=E1rk=3AL=E1szl=F3=3A=3A.html
*  CiNii 論文 - Perspectives on Pituitary Adenylate Cyclase Activating Polypeptide (PACAP) in the...
PACAP is a pleiotropic neuropeptide that belongs to the secreting/glucagon/VIP family. PACAP functions as a hypothalamic hormone, neurotransmitter, neuromodulator, vasodilator, and neurotrophic factor. Its structure has been remarkably conserved during evolution. The PACAP receptor is G protein-coupled with seven transmembrane domains and also belongs to the VIP receptor family. PACAP, but not VIP, binds to PAC,SUB,1,/SUB,-R, whereas PACAP and VIP bind to VPAC,SUB,1,/SUB,-R and VPAC,SUB,2,/SUB,-R with a similar affinity. Despite the sizable homology of the structures of PACAP and VIP and their receptors, the distribution of these peptides and receptors is quite different. At least eight subtypes of PACAP specific, or PAC,SUB,1,/SUB,-R, result from alternate splicing. Each subtype is coupled with specific signaling pathways, and its expression is tissue or cell specific. Although PACAP fulfills most requirements for a physiological ...
  http://ci.nii.ac.jp/naid/10008305053
*  Waschek, James | UCLA NSIDP
Dr. Waschek is a Professor of Psychiatry and Biobehavioral Science at the David Geffen School of Medicine at the University of California at Los Angeles (UCLA), and is an expert in the molecular and cellular biology and physiological actions of neuropeptides. Dr. Waschek received a Ph.D. in Pharmaceutical Chemistry in 1984 from the University of California at San Francisco, after which he took a postdoctoral position at the National Institutes of Health (NIH). In 1988 he came to UCLA, where his research has centered on three broad, but related topics: 1) CNS development, degeneration, injury, and repair, 2) neuroinflammatory conditions such as multiple sclerosis, and maternal inflammation-induced perinatal white matter disease, and 3) brain tumor pathogenesis. A past and continuing objective has been to better understand the biological roles of neuropeptides in these processes, especially the two related peptides PACAP and VIP (pituitary adenylyl cyclase ...
  http://neuroscience.ucla.edu/profile/waschek-james
*  "Interactions between BNST PACAP stress system and Estrous Cycling in N" by Beniah Brumbaugh
The objective of this investigation is to examine possible interactions between the BNST PACAP stress system and hormone levels during the estrous cycle of naturally cycling female rats. This is significant as behavioral consequences, analogous to anxiety disorders in humans, including increased startle, anxious behavior during open arm tests, and decreased feeding are associated with increased transcripts of PACAP and PAC1 within the BNST of animals undergoing a chronic variant stress paradigm (reviewed by Hammack & May, 2014). As females are at a greater risk to suffer from symptoms of PTSD than men (Veteran Affairs, 2017), studying females is of great importance to stress researchers. To study the interaction between estrous cycle and the BNST PACAP system, this research examines PACAP mRNA transcript levels as well as its associated PAC1 receptor mRNA transcript levels in non-overectomized female rats. PACAP and PAC1 transcript levels were determined at each of the four stages of the estrous cycle
  http://scholarworks.uvm.edu/hcoltheses/134/
*  "Homology Modeling and Molecular Docking of Antagonists to Class B G-Pr" by Suzanne Louise Stanton
Recent studies have identified the Class B g-protein coupled receptor (GPCR) pituitary adenylate cyclase activating polypeptide type 1 (PAC1R) as a key component in physiological stress management. Over-activity of neurological stress response systems due to prolonged or extreme exposure to traumatic events has led researchers to investigate PAC1R inhibition as a possible treatment for anxiety disorders such as post-traumatic stress disorder (PTSD). In 2008, Beebe and coworkers identified two such small molecule hydrazide antagonists and a general pharmacaphore for PAC1R inhibition. However, a relative dearth of information about Class B GPCRs in general, and PAC1R in specific, has significantly hindered progress toward the development of small molecule antagonists of PAC1R. The recent crystallization of the homologically similar glucagon receptor (GCGR) by Siu and coworkers in 2013, also a Class B receptor, ...
  https://scholarworks.uvm.edu/graddis/624/
*  Plus it
A number of studies have exploited KH7, CEs, or ddAdo to discern whether sAC or tmACs represent the physiologically relevant source of cAMP. In some systems, it proved essential to have inhibitors able to distinguish between sAC and tmACs because both sAC-generated and tmAC-generated cAMP elicited similar cellular effects, but they responded to distinct extracellular signals. Axonal outgrowth in response to the neuronal guidance cue netrin-1 was demonstrated to be sAC-dependent because it was blocked by KH7 and CEs and insensitive to ddAdo (Wu et al., 2006). Conversely, in the same cultures, axonal outgrowth in response to the hormone (PACAP) was confirmed to act via tmACs. PACAP signals via a Gs-coupled GPCR; therefore, it had been presumed to signal via tmACs. Consistently, its activity was inhibited by ddAdo and insensitive to KH7. Similarly, in PC12 cells, the PACAP-induced, cAMP-dependent activation of Rap1 was blocked exclusively by ddAdo, whereas nerve growth factor-stimulated Rap ...
  http://jpet.aspetjournals.org/content/347/3/589
*  PACAP (1-38), Human, Ovine, Rat - CCP1370-10mg | acris-antibodies.com
PACAP (1-38), Human, Ovine, Rat, 10 mg. Kojro et al. observed that the PAC1 agonists PACAP-27 and PACAP-38 strongly increased the activity of ��-secretase.
  https://www.acris-antibodies.com/synthetic-peptides/pacap-1-38-human-ovine-rat-ccp1370-10mg.htm
*  Utmattet, smerter og mageubehag (irritabel tarm) - Balderklinikken
De siste årene har det skjedd store endringer når det gjelder synet på hvordan mikrober påvirker oss. Imidlertid er den kliniske tilnærmingen til behandling av forstyrrelser i vår mikrobielle flora ikke i vesentlig grad endret de siste tiårene. En del av grunnen til dette er at det rett og slett tar tid å utvikle nye behandlingsmetoder, og at det ikke finnes gode og enkle metoder som kan være med på å avsløre ubalansene. En annen grunn kan være at utdaterte oppfatninger preger den kliniske forskningen.. Én slik utdatert oppfatning kan være at man antar at det alltid er slik at én mikrobeart forårsaker én bestemt sykdom (i motsetning til at flere mikrobearter kan være ansvarlige for den samme sykdommen). Det synes mer og mer klart at når det gjelder kroniske sykdommer er det ofte et samarbeid mellom ulike mikrobearter som kan føre til utviklingen av ulike sykdommer. Blant annet vet vi at flere mikrober bruker ulike mekanismer for å redusere evnen menneskets immunsystem har ...
  http://balderklinikken.no/utmattet-smerter-og-mageubehag-irritabel-tarm/