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*  Use of a newly developed technique to isolate rat pinealocytes and study the effects of adenosine agonists on melatonin...
... melatonin synthesis, A(2b) receptors, pineal gland, adenosine, N-ACETYLTRANSFERASE, GLAND, RECEPTORS, BRAIN ... Use of a newly developed technique to isolate rat pinealocytes and study the effects of adenosine agonists on melatonin ... Use of a newly developed technique to isolate rat pinealocytes and study the effects of adenosine agonists on melatonin ...
  http://epubs.surrey.ac.uk/821899/
*  Distribution of 2-[125i]iodomelatonin Binding Sites in the Brain of the Pied Flycatcher (ficedula Hypoleuca) and the Zebra...
Sexual differences and effect of photoperiod on melatonin receptor in avian brain.. *N Aste. , B Cozzi. , B Stankov. , G ... Central melatonin receptors: Implications for a mode of action. *P. J. Morgan. , L. M. Williams ... Melatonin receptors: current status, facts, and hypotheses.. *B Stankov. , R J Reiter ... Neurophysiological responses to melatonin in the SCN of short-day sensitive and refractory hamsters.. *R Mason. , B Rusak ...
  https://www.semanticscholar.org/paper/Distribution-of-2-125i-iodomelatonin-Binding-Sites-GUTTATA-Schneider/cfda2904fa4576a5b606a73caeabcde1a5c3c505
*  IJMS | Free Full-Text | A Molecular and Chemical Perspective in Defining Melatonin Receptor Subtype Selectivity
The two melatonin receptor subtypes display identical ligand binding characteristics and mediate a myriad of signaling pathways ... However, all of the melatoninergics in the market act on both subtypes of melatonin receptors without significant selectivity. ... Given the broad therapeutic implications of melatonin receptors in chronobiology, immunomodulation, endocrine regulation, ... Both MT1 and MT2 receptors are widely expressed in the central nervous system as well as many peripheral tissues, but each ...
  http://mdpi.com/1422-0067/14/9/18385/xml
*  Recombinant Human Melatonin Receptor 1A protein (ab114688)
Buy our Recombinant Human Melatonin Receptor 1A protein. Ab114688 is a protein fragment produced in Wheat germ and has been ... High affinity receptor for melatonin. Likely to mediates the reproductive and circadian actions of melatonin. The activity of ... this receptor is mediated by pertussis toxin sensitive G proteins that inhibit adenylate cyclase activity. ...
  http://www.abcam.com/recombinant-human-melatonin-receptor-1a-protein-ab114688.html
*  IJMS | Free Full-Text | New Radioligands for Describing the Molecular Pharmacology of MT1 and MT2 Melatonin Receptors
Recently, we attempted to expand the panel of radioligands available for studying the melatonin receptors by using the newly ... low expression of the receptors in tissues led the scientific community to find a substitute for the natural hormone melatonin ... SD6 is a full agonist, equilibrated between the receptor isoforms, whereas S70254 and DIV880 are only partial MT2 agonists, ... These compounds were characterized for their affinities to the hMT1 and hMT2 recombinant receptors and their functionality in ...
  http://mdpi.com/1422-0067/14/5/8948
*  Aralkylamine N-acetyltransferase - Wikipedia
It is the penultimate enzyme in the melatonin synthesis controlling the night/day rhythm in melatonin production in the ... "Receptor- and ligand-based study on novel 2,2'-bithienyl derivatives as non-peptidic AANAT inhibitors". J Chem Inf Model. 50 (3 ... It is most highly abundant in the pineal gland which is the site of melatonin synthesis. Brain and pituitary AANAT may be ... Melatonin is essential for seasonal reproduction, modulates the function of the circadian clock in the suprachiasmatic nucleus ...
  https://en.wikipedia.org/wiki/Aralkylamine_N-acetyltransferase
*  Melatonin receptor agonists | EPICOS
Global Melatonin Supplements Market - Analysis, Technologies & Forecasts to 2021 - Key Vendors are Natrol, NOW Foods, Optimum ... Neurim Pharmaceuticals' New Paediatric Prolonged-Release Melatonin ('PedPRM') to be Marketed by Flynn Pharma in UK and Ireland ... Neurim Pharmaceuticals' New Paediatric Prolonged-Release Melatonin ('PedPRM') to Be Marketed by BIOCODEX Oy in Finland ... Positive Phase III Results for Neurim Pharmaceuticals' Pediatric Prolonged-Release Melatonin for Insomnia in Children with ...
  https://www.epicos.com/tags/melatonin-receptor-agonists
*  Anti-Melatonin Receptor 1B antibody (ab115336) | Abcam
Rabbit polyclonal Melatonin Receptor 1B antibody validated for IHC and tested in Human. Immunogen corresponding to synthetic ... Anti-Melatonin Receptor 1B antibody. See all Melatonin Receptor 1B primary antibodies. ... High affinity receptor for melatonin. Likely to mediates the reproductive and circadian actions of melatonin. The activity of ... ab115336 at 10ug/ml staining Melatonin Receptor 1B in Formalin-fixed, Paraffin-embedded Human eye (retina) tissue by ...
  https://www.abcam.com/melatonin-receptor-1b-antibody-ab115336.html
*  Anti-Melatonin Receptor 1B antibody (ab92339) | Abcam
Goat polyclonal Melatonin Receptor 1B antibody validated for IHC and tested in Human. Immunogen corresponding to synthetic ... Anti-Melatonin Receptor 1B antibody. See all Melatonin Receptor 1B primary antibodies. ... High affinity receptor for melatonin. Likely to mediates the reproductive and circadian actions of melatonin. The activity of ... by a Cysteine residue linker, corresponding to C terminal amino acids 334-347 of Human Melatonin Receptor 1B (NP_005950.1.). ...
  http://www.abcam.com/melatonin-receptor-1b-antibody-ab92339.html
*  IJMS | Free Full-Text | Homology Models of Melatonin Receptors: Challenges and Recent Advances
These receptor models differ in the binding modes hypothesized for melatonin and melatonergic ligands, with distinct patterns ... The receptor models will be described, and they will be discussed in light of the available information from mutagenesis ... So far, a number of different MT1 and MT2 receptor homology models, built either from the prototypic structure of rhodopsin or ... The ability of these ligand-receptor complexes to rationalize structure-activity relationships of known series of melatonergic ...
  http://www.mdpi.com/1422-0067/14/4/8093
*  Genetic Dysfunction in Melatonin Receptor Gene May Be Responsible for Diabetes | EmaxHealth
The MT2 protein is a receptor for melatonin, encoded by a gene known as melatonin receptor 1B or MTNR1B. Mutations in this gene ... Four of these were rare, but rendered the melatonin receptor completely incapable of responding to melatonin, suggesting a ... Genetic Dysfunction in Melatonin Receptor Gene May Be Responsible for Diabetes. By Denise Reynolds RD G+ Jan 31 2012 - 8:58am ... Rare MTNR1B variants impairing melatonin receptor 1B function contribute to type 2 diabetes' Nature Genetics, published online ...
  https://www.emaxhealth.com/1506/genetic-dysfunction-melatonin-receptor-gene-may-be-responsible-diabetes
*  Melatonin Receptor 1B antibody | acris-antibodies.com
Melatonin (N-acetyl-5-methoxytryptamine) is a product of tryptophan metabolism. It is synthesized in the pineal gland and is ... Melatonin exerts its effects through two G-protein coupled receptors (GPCRs); melatonin receptor type 1 and melatonin receptor ... Alternative names for Melatonin Receptor 1B antibody. MTNR1B, Melatonin receptor type 1B ... Anti-Melatonin Receptor Type 2 antibody, (1:200). 3,4. Anti-Melatonin Receptor Type 2 antibody, preincubated with the control ...
  https://www.acris-antibodies.com/target/melatonin-receptor-1b-antibody.htm
*  Participation of Melatonin receptors on dendrite format | Open-i
To evaluate the involvement of MEL receptors, hippocampal organotypic cultures ... Participation of Melatonin receptors on dendrite formation elicited by Melatonin. ... Participation of Melatonin receptors on dendrite formation elicited by Melatonin. To evaluate the involvement of MEL receptors ... Participation of Melatonin receptors on dendrite formation elicited by Melatonin. To evaluate the involvement of MEL receptors ...
  https://openi.nlm.nih.gov/detailedresult.php?img=PMC4307341_ijms-16-01907-g006a&req=4
*  Melatonin receptor - Wikipedia
A melatonin receptor is a G protein-coupled receptor (GPCR) which binds melatonin. Three types of melatonin receptors have been ... "Molecular characterization of a second melatonin receptor expressed in human retina and brain: the Mel1b melatonin receptor". ... Afobazole Luzindole Prazosin Discovery and development of melatonin receptor agonists Reppert SM (1997). "Melatonin receptors: ... "Melatonin Receptors". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. ...
  https://en.wikipedia.org/wiki/Melatonin_receptor
*  Melatonin receptor agonist - Wikipedia
... melatonin receptor 1 (MT1) and melatonin receptor 2 (MT2). Melatonin and melatonin receptor agonists, on market or in clinical ... Melatonin receptor agonists are analogues of melatonin that bind to and activate the melatonin receptor. Agonists of the ... Melatonin receptor agonists were developed with the melatonin structure as a model. The melatonin receptors are G protein- ... Activation of the receptor can lead to ion flux inside the cell. When melatonin receptor agonists activate their receptors it ...
  https://en.wikipedia.org/wiki/Melatonin_receptor_agonist
*  Melatonin receptor 1A - Wikipedia
Melatonin - full agonist Afobazole - agonist Agomelatine - agonist Melatonin receptor Discovery and development of melatonin ... This receptor is a G protein-coupled, 7-transmembrane receptor that is responsible for melatonin effects on mammalian circadian ... "Entrez Gene: MTNR1A melatonin receptor 1A". Brzezinski A (Jan 1997). "Melatonin in humans". The New England Journal of Medicine ... melatonin receptor overexpression enhances the growth suppressive effect of melatonin in human breast cancer cells". Molecular ...
  https://en.wikipedia.org/wiki/Melatonin_receptor_1A
*  Melatonin receptor 1C - Wikipedia
Melatonin receptor 1C, also known as MTNR1C, is a protein that is encoded by the Mtnr1c gene. This receptor has been identified ... 2003). "MT(1) melatonin receptor overexpression enhances the growth suppressive effect of melatonin in human breast cancer ... Sugden D, Davidson K, Hough KA, Teh MT (2004). "Melatonin, melatonin receptors and melanophores: a moving story". Pigment Cell ... 2000). "Melatonin receptor mRNA expression in human granulosa cells". Mol. Cell. Endocrinol. 156 (1-2): 107-10. doi:10.1016/ ...
  https://en.wikipedia.org/wiki/Melatonin_receptor_1C
*  Melatonin receptor 1B - Wikipedia
... agonist Melatonin receptor Discovery and development of melatonin receptor agonists GRCh38: Ensembl release 89: ENSG00000134640 ... "Molecular characterization of a second melatonin receptor expressed in human retina and brain: the Mel1b melatonin receptor". ... "Molecular characterization of a second melatonin receptor expressed in human retina and brain: the Mel1b melatonin receptor". ... "Melatonin Receptors: MT2". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical ...
  https://en.wikipedia.org/wiki/Melatonin_receptor_1B
*  Removal of Melatonin Receptor Type 1 Induces Insulin Resistance in the Mouse - Contreras-Alcantara - 2010 - Obesity - Wiley...
... mice lacking MT2 receptors (MT2−/−)-the melatonin receptor recently implicated in the pathogenesis of T2D (3,6,7)-did not show ... melatonin receptor type 1 (MT1) and MT2) (1). Previous studies have suggested a role for the pineal gland and melatonin in the ... a study using melatonin receptor knock-out mice has indicated an active role of these receptors in the regulation of blood ... Melatonin modulates visual function and cell viability in the mouse retina via the MT1 melatonin receptor. Proc Natl Acad Sci ...
  http://onlinelibrary.wiley.com/doi/10.1038/oby.2010.24/full?globalMessage=0
*  International Union of Basic and Clinical Pharmacology. LXXV. Nomenclature, Classification, and Pharmacology of G Protein...
... with high levels at night providing timing cues to target tissues endowed with melatonin receptors. Melatonin receptors receive ... The melatonin message is translated through activation of two G protein-coupled receptors, MT1 and MT2, that are potential ... Nomenclature, Classification, and Pharmacology of G Protein-Coupled Melatonin Receptors. Margarita L. Dubocovich, Philippe ... Nomenclature, Classification, and Pharmacology of G Protein-Coupled Melatonin Receptors. Margarita L. Dubocovich, Philippe ...
  http://pharmrev.aspetjournals.org/content/early/2010/07/06/pr.110.002832
*  TABLE 6 | International Union of Basic and Clinical Pharmacology. LXXV. Nomenclature, Classification, and Pharmacology of G...
Nomenclature, Classification, and Pharmacology of G Protein-Coupled Melatonin Receptors. Margarita L. Dubocovich, Philippe ... Regulation of oxytocin receptor gene expression and contractility in uterus. MT2. PLC, PKC activation. Human myometrium. 4P- ... Correlation between antagonist KB in retina and Ki values on MT2 recombinant receptors. Dubocovich et al., 1997. ...
  http://pharmrev.aspetjournals.org/content/62/3/343/T6
*  Melatonin receptor signalling is involved in insulin secretion in the INS-1 832/13 beta cell line
... Nagorny, Cecilia LU and ... 1}, pages = {401--401}, publisher = {Springer Verlag}, series = {Diabetologia}, title = {Melatonin receptor signalling is ...
  https://lup.lub.lu.se/search/publication/1476584