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*  Neutrophil-mediated Activation of Epithelial Protease-Activated Receptors-1 and -2 Regulates Barrier Function and...
Indeed, our model of filter-inhibited PMN transmigration limits the physical interactions between PMNs or PMN membrane-bound ... which increase in expression after limited degranulation from primary granules upon stimulation (8, 27). A major difference ... Activation of human oral epithelial cells by neutrophil proteinase 3 through protease-activated receptor-2. J. Immunol. 169: ... Neutrophil-mediated Activation of Epithelial Protease-Activated Receptors-1 and -2 Regulates Barrier Function and ...
  http://www.jimmunol.org/content/181/8/5702
*  anti-ADAM10 antibody | Rabbit anti-Human A Disintegrin And Metalloprotease 10 (ADAM10) Polyclonal Antibody-NP 001101.1
... monocyte activation; negative regulation of cell adhesion; neutrophil degranulation; Notch receptor processing; Notch signaling ... Golgi membrane; Golgi-associated vesicle; integral component of membrane; membrane; nucleus; plasma membrane; postsynaptic ... ADAM10: Cleaves the membrane-bound precursor of TNF-alpha at '76-Ala-,-Val-77' to its mature soluble form. Responsible for the ... Involved in the cleavage of the adhesion molecule L1 at the cell surface and in released membrane vesicles, suggesting a ...
  https://www.mybiosource.com/prods/Antibody/Polyclonal/A-Disintegrin-And-Metalloprotease-10-ADAM10/ADAM10/datasheet.php?products_id=2002720&cacheID=82ecee54136182f7141bc43a693b1972&att=6
*  anti-ADAM10 antibody | Rabbit anti-Human A Disintegrin And Metalloprotease 10 (ADAM10) Polyclonal Antibody-NP 001101.1
... monocyte activation; negative regulation of cell adhesion; neutrophil degranulation; Notch receptor processing; Notch signaling ... Golgi membrane; Golgi-associated vesicle; integral component of membrane; membrane; nucleus; plasma membrane; postsynaptic ... ADAM10: Cleaves the membrane-bound precursor of TNF-alpha at '76-Ala-,-Val-77' to its mature soluble form. Responsible for the ... Retinoid X Receptor, b-Isotype (RXRB) Antibody. • Goserelin Native Protein. • Pro-Brain Natriuretic Peptide (NT-PROBNP) ELISA ...
  https://www.mybiosource.com/prods/Antibody/Polyclonal/A-Disintegrin-And-Metalloprotease-10-ADAM10/ADAM10/datasheet.php?products_id=2002720&cacheID=0c21f0d05ea242ee8c00563902ac5f1c
*  Neutrophil and T-Cell Homeostasis in the Closed Eye | IOVS | ARVO Journals
... but following primary granule degranulation and release of neutrophil elastase, neutrophils may lose some membrane receptor ... CD66b is involved later in neutrophil activation and is a hallmark of degranulation of specific granules.55 This implies that ... Neutrophil phenotype changed with increasing sleep, with a downregulation of membrane receptors CD16, CD11b, CD14, and CD15, ... Its downregulation by the 7-hour time point may simply be explained by membrane receptor recycling into the neutrophil. However ...
  https://iovs.arvojournals.org/article.aspx?articleid=2665993
*  Anti-Syk antibody [SYK-01] (ab3993) | Abcam
Regulates neutrophil degranulation and phagocytosis through activation of the MAPK signaling cascade. Also mediates the ... May be coupled to the collagen receptor by the ITAM domain-containing FCER1G. Also activated by the membrane lectin CLEC1B that ... Assembles into signaling complexes with activated receptors at the plasma membrane via interaction between its SH2 domains and ... Also involved in mast cells activation. Also functions downstream of receptors mediating cell adhesion. Relays for instance, ...
  http://www.abcam.com/syk-antibody-syk-01-ab3993.html
*  Biofyzikální ústav AV ČR
... degranulation, and receptor mobilization at the plasma membrane. Soluble GM at the tested concentrations did not stimulate ... time and concentration dependent degranulation characterized by increased surface expression of receptors stored in neutrophil ... Activation of phagocyte anti-microbial mechanisms is a crucial part of the innate host defense against invading pathogens. ... Therefore, in this study we analyzed the effect of soluble GM on some neutrophil functions such as reactive oxygen species ...
  http://www.ibp.cz/cs/oddeleni/patofyziologie-volnych-radikalu/publication-3337/
*  CD14 - Monocyte differentiation antigen CD14 precursor - Homo sapiens (Human) - CD14 gene & protein
... leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (PubMed:8612135). Acts as a coreceptor for ... R-HSA-6798695 Neutrophil degranulation. R-HSA-9014325 TICAM1,TRAF6-dependent induction of TAK1 complex. R-HSA-936964 Activation ... "Membrane sorting of toll-like receptor (TLR)-2/6 and TLR2/1 heterodimers at the cell surface determines heterotypic ... R-HSA-6798695 Neutrophil degranulation. R-HSA-9014325 TICAM1,TRAF6-dependent induction of TAK1 complex. R-HSA-936964 Activation ...
  https://www.uniprot.org/uniprot/P08571
*  PDB-5fn5: Cryo-EM structure of gamma secretase in class 3 of the apo- state... - Yorodumi
Nicastrin / Neutrophil degranulation / Noncanonical activation of NOTCH3 / NOTCH3 Activation and Transmission of Signal to the ... membrane protein ectodomain proteolysis / astrocyte activation / post-embryonic development / kinetochore / regulation of ... Notch receptor processing / neural retina development / amyloid-beta formation / T cell activation involved in immune response ... nuclear outer membrane / somitogenesis / smooth endoplasmic reticulum calcium ion homeostasis / azurophil granule membrane / ...
  https://pdbj.org/emnavi/quick.php?id=pdb-5fn5
*  Reactome | NRAS [plasma membrane]
Neutrophil degranulation (Homo sapiens) * Exocytosis of tertiary granule membrane proteins (Homo sapiens) * Tertiary granule ... Fc epsilon receptor (FCERI) signaling (Homo sapiens) * FCERI mediated MAPK activation (Homo sapiens) * SOS mediated nucleotide ... Activation of RAS by p-KIT bound SOS1 (Homo sapiens) * p21 RAS:GDP [plasma membrane] (Homo sapiens) * RAS [plasma membrane] ( ... RAS:GTP [plasma membrane] (Homo sapiens) * RAS [plasma membrane] (Homo sapiens) * NRAS [plasma membrane] (Homo sapiens) ...
  https://reactome.org/content/detail/R-HSA-62725
*  Frontiers | Resolving Viral-Induced Secondary Bacterial Infection in COPD: A Concise Review | Immunology
SAA is a functional agonist for formyl peptide receptor 2 (FPR2/ALX), where it promotes chemotaxis and survival of neutrophils ... SAA is a functional agonist for formyl peptide receptor 2 (FPR2/ALX), where it promotes chemotaxis and survival of neutrophils ... Neutrophil elastase induces mucin production by ligand-dependent epidermal growth factor receptor activation. Am J Physiol Lung ... We have previously shown that the degranulation of neutrophil-derived proteinases, such as neutrophil elastase and MMP9 ...
  https://www.frontiersin.org/articles/10.3389/fimmu.2018.02345/full
*  The role of neutrophils in immune dysfunction during severe inflammation | Critical Care | Full Text
Neutrophil extravasation, homing and activation are mediated by activation of several surface receptors, including β2 integrins ... These receptors are important as they mediate chemotaxis, degranulation and proper recognition of opsonised microbial targets ... the NADPH oxidase complex is assembled from both cytosolic and membrane-bound components [31]. The active oxidase complex ... Fcγ-receptors, and formyl peptide receptors. Uncontrolled activation of neutrophils is mediated through these same receptors by ...
  https://ccforum.biomedcentral.com/articles/10.1186/s13054-016-1250-4
*  Reactome | RHOA [plasma membrane]
Neutrophil degranulation (Homo sapiens) * Exocytosis of ficolin-rich granule membrane proteins (Homo sapiens) * Ficolin-rich ... Activation of Rho by LARG and PDZ-RhoGEF (Homo sapiens) * RHOA/B/C:GTP [plasma membrane] (Homo sapiens) * RHOA/B/C [plasma ... Death Receptor Signalling (Homo sapiens) * p75 NTR receptor-mediated signalling (Homo sapiens) * p75NTR regulates axonogenesis ... RHOA,B,C:GTP:RTKN [plasma membrane] (Homo sapiens) * RHOA/B/C:GTP [plasma membrane] (Homo sapiens) * RHOA/B/C [plasma membrane ...
  https://reactome.org/content/detail/R-HSA-194510
*  TLR2 (human)
... plasma membrane; secretory granule membrane Molecular Function: lipopolysaccharide binding; lipopolysaccharide receptor ... neutrophil degranulation; nitric oxide metabolic process; positive regulation of chemokine production; positive regulation of ... microglial cell activation; MyD88-dependent toll-like receptor signaling pathway; myelin formation in the central nervous ... Names/Synonyms: CD282; TIL4; TLR2; Toll-like receptor 2; toll/interleukin 1 receptor-like 4; Toll/interleukin-1 receptor-like ...
  https://www.phosphosite.org/proteinAction.action?id=20211
*  Frontiers | NET Confusion | Immunology
... and to prevent unintended neutrophil activation and/or lysis during the resolution of inflammatory responses or during steady- ... and to prevent unintended neutrophil activation and/or lysis during the resolution of inflammatory responses or during steady- ... The notion that neutrophil extracellular traps (NETs) form by cytolysis as a standard host defense mechanism seems inconsistent ... The notion that neutrophil extracellular traps (NETs) form by cytolysis as a standard host defense mechanism seems inconsistent ...
  https://www.frontiersin.org/articles/10.3389/fimmu.2016.00259/full
*  Tyrosine-protein kinase SYK
Regulates neutrophil degranulation and phagocytosis through activation of the MAPK signaling cascade. Also mediates the ... May be coupled to the collagen receptor by the ITAM domain-containing FCER1G. Also activated by the membrane lectin CLEC1B that ... Assembles into signaling complexes with activated receptors at the plasma membrane via interaction between its SH2 domains and ... Also involved in mast cells activation. Also functions downstream of receptors mediating cell adhesion. Relays for instance, ...
  https://pharos.nih.gov/idg/targets/SYK
*  Fibrinogen Promotes Neutrophil Activation and Delays Apoptosis | The Journal of Immunology
... and neutrophil degranulation. We also observed the loss of surface type III receptors for the Fc region of IgG (FcγRIII) (CD16 ... Membrane surface antigen expression on neutrophils: a reappraisal of the use of surface markers for neutrophil activation. ... Since neutrophil degranulation is an important inflammatory event secondary to PMN activation, we quantified degranulation upon ... Moreover, neutrophil recruitment is intimately linked to neutrophil activation and cell survival (10). In this context, it has ...
  http://www.jimmunol.org/content/166/3/2002
*  Phospho anti-Hck (Y410) antibody (ab61055) | Abcam
May serve as part of a signaling pathway coupling the Fc receptor to the activation of the respiratory burst. May also ... contribute to neutrophil migration and may regulate the degranulation process of neutrophils. ... At least half of this isoform is found in the cytoplasm, some of this fraction is myristoylated and Membrane. Membrane , ...
  http://www.abcam.com/hck-phospho-y410-antibody-ab61055.html
*  Anti-INPP5D / SHIP1 / SHIP Antibody (N-Terminus, clone SHIP-01)
Colocalizes with FC-gamma-RIIB receptor (FCGR2B) or FCGR3/CD16 at membrane ruffles. Tyrosine phosphorylation may also ... Key regulator of neutrophil migration, by governing the formation of the leading edge and polarization required for chemotaxis ... Acts as a negative regulator of myeloid cell proliferation/survival and chemotaxis, mast cell degranulation, immune cells ... Regulates proliferation of osteoclast precursors, macrophage programming, phagocytosis and activation and is required for ...
  http://www.abgent.com/products/ALS17381-Anti-INPP5D--SHIP1--SHIP-Antibody-N-Terminus-clone-SHIP-01
*  EMR2 - Wikipedia
Upon neutrophil activation, EMR2 rapidly moves to membrane ruffles and the leading edge of the cell. Additionally, ligation of ... in excessive degranulation by mast cells resulting in vibratory urticaria EGF module-containing mucin-like hormone receptor ... "Activation of myeloid cell-specific adhesion class G protein-coupled receptor EMR2 via ligation-induced translocation and ... "Autocatalytic cleavage of the EMR2 receptor occurs at a conserved G protein-coupled receptor proteolytic site motif". The ...
  https://en.wikipedia.org/wiki/EMR2
*  Application Index: Complement Proteins | China-Mainland | Sigma-Aldrich
... complement system is a complex cascade involving proteolytic cleavage of serum glycoproteins often activated by cell receptors ... Other deleterious effects of complement activation include, degranulation of neutrophils, basophils and mast cells, unwanted ... Excessive deposits of membrane attack complexes in tissues may occur following ischaemic injury. ... release of the neutrophil products elastase and oxygen radicals, and extracorporeal blood circulation. Complement inhibitors ...
  http://www.sigmaaldrich.com/china-mainland/zh/life-science/metabolomics/enzyme-explorer/cell-signaling-enzymes/complement-proteins.html
*  A1.06 Phagocyte involvement in systemic onset juvenile idiopathic arthritis | Annals of the Rheumatic Diseases
Methods We determined neutrophil activation ex vivo (phenotype and cell membrane markers) and after stimulation (ROS-production ... reflected by increased cell membrane activation markers, ROS production and degranulation. The exact role of each cell type and ... reflected by higher ex vivo cell membraneexpression of FC-gamma receptors (CD32 and CD64), markers of secretory vesicles (CD35 ... and specific granules (CD66b). ROS production and degranulation were also enhanced in onset sJIA. Neutrophil ...
  http://ard.bmj.com/content/75/Suppl_1/A3.1
*  Novel Neutrophil Autoantigens in Systemic Lupus Erythematosus - Kaihong Su
Neutrophil activation has also been linked to tissue injury in acute infections and autoimmune conditions. Using our collection ... 2) We will determine if SLE derived anti-neutrophil antibodies activate neutrophils through the classical Fc3 receptor pathway ... In particular, S4Ab2 antibody recognizes membrane bound protein disulfide isomerase (PDI) and also induces strong Ca++ influx ... found that a high frequency of SLE-derived recombinant antibodies bind to and activate neutrophils as examined by degranulation ...
  http://grantome.com/grant/NIH/R01-AR059351-04
*  S100A9 Gene - GeneCards | S10A9 Protein | S10A9 Antibody
Upon neutrophil activation or endothelial adhesion of monocytes, is secreted via a microtubule-mediated, alternative pathway.. ... Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence ... molecule and stimulates innate immune cells via binding to pattern recognition receptors such as Toll-like receptor 4 (TLR4) ... and ERK1/2 and can induce degranulation of neutrophils by a MAPK-dependent mechanism. Predominantly found as calprotectin ( ...
  http://www.genecards.org/cgi-bin/carddisp.pl?gene=S100A9
*  PSAP Gene - GeneCards | SAP Protein | SAP Antibody
Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence ... Prosaposin: Behaves as a myelinotrophic and neurotrophic factor, these effects are mediated by its G-protein-coupled receptors ... platelet degranulation. TAS. --. GO:0006629. lipid metabolic process. IEA. --. GO:0006665. sphingolipid metabolic process. IEA ... Vectors and viruses for KO, Activation, Repression, and more. *PSAP-CRISPR-CAS9-Knockout ...
  http://www.genecards.org/cgi-bin/carddisp.pl?gene=PSAP&keywords=GH10G071887&prefilter=genomic_location
*  To Infuse or Not to Infuse? | Natural Solutions Radio
... binds to a receptor site on the cell membrane, and stimulates the activation of adenylate cyclase. This enzyme is incorporated ... inhibition of platelet activation and degranulation, inhibition of mast cell degranulation and histamine release, increased ... PAF plays a central role in many inflammatory and allergic processes, including neutrophil activation, increasing vascular ... Forskolin appears to bypass the need for direct hormonal activation of adenylate cyclase via transmembrane activation. As a ...
  http://naturalsolutionsradio.com/blog/natural-solutions-radio/infuse-or-not-infuse