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*  poly(linoleic acid hydroperoxide)-coated iron oxide nanoparticles
Page contains details about poly(linoleic acid hydroperoxide)-coated iron oxide nanoparticles . It has composition images, properties, Characterization methods, synthesis, applications and reference articles : nano.nature.com
  http://nano.nature.com/nano/GR-M9298236
*  Publications of Faculty of Medicine: Significance Of Serum Lipid Peroxides, Total And Lipid-Bound Sialic Acid As Markers For...
Paper: Significance Of Serum Lipid Peroxides, Total And Lipid-Bound Sialic Acid As Markers For Liver Diseases , Author: Thanaa Hamed, Mahasen Abdel Sattar, Fauna Abd El- Salam*, Sherif Abou El Dahab**, and Amal Idris , Year: 2000 , Faculty of Medicine, Benha University
  http://bu.edu.eg/medicine_publications/1625
*  Phospholipid hydroperoxide glutathione peroxidase elisa and antibody
Shop Phospholipid hydroperoxide glutathione peroxidase ELISA Kit, Recombinant Protein and Phospholipid hydroperoxide glutathione peroxidase Antibody at MyBioSource. Custom ELISA Kit, Recombinant Protein and Antibody are available.
  https://www.mybiosource.com/protein_family.php?root=phospholipid-hydroperoxide-glutathione-peroxidase
*  Purification, stabilization and characterization of tomato fatty acid hydroperoxide lyase
Fatty acid hydroperoxide lyase (HPO-lyase) was purified 300-fold from tomatoes. The enzymatic activity appeared to be very unstable, but addition of Triton X100 and beta-mercaptoethanol to the buffer yielded an active enzyme that could be stored for several months at −80°C. The enzyme was inhibited by desferoxamine mesylate (desferal), 2-methyl-1,2-di-3-pyridyl-1-propanone ... read more (metyrapone), nordihydroguaiaretic acid (NDGA), n-propyl gallate and butylated hydroxyanisole, suggesting the involvement of free radicals in the reaction mechanism and the existence of a prosthetic group in the active center. However, no heme group could be demonstrated with the methods commonly used to identify heme groups in proteins. Only 13-hydroperoxides from linoleic acid (13-HPOD) and alpha-linolenic acid (alpha-13-HPOT) were cleaved by the tomato enzyme, with a clear preference for the latter substrate. The pH-optimum was 6.5, and for concentrations lower than 300 mu M a typical ...
  https://dspace.library.uu.nl/handle/1874/5554
*  Glutathione and the mitochondrial reduction of hydroperoxides. - Semantic Scholar
Various organic hydroperoxides are reduced when added to rat liver mitochondrial suspensions. Succinate increases the rate and duration of the reductions except for linoleic acid hydroperoxide which appears to inhibit its own reduction. 3-Hydroxybutyrate replaces succinate but other reductants used are less effective. The rate of reduction of tert-butyl hydroperoxide by succinate is not inhibited by cyanide but is partly inhibited if antimycin or rotenone are also added; ATP reverses the antimycin inhibition. Other inhibitors include the uncoupler, carbonyl cyanide p-trifluoromethoxyhydrazone, ADP + Pi, the thiol reagents N-ethylmaleimide and p-hydroxymercuribenzoate and inhibitors of the mitochondrial transport of carboxylic acids. In some cases, the GSH concentration of the mitochondria during the reductions correlates with the reduction rate (e.g. with succinate and after N-ethylmaleimide) but in others it is dissociated. The results suggest that hydroperoxide reduction requires the ...
  https://www.semanticscholar.org/paper/Glutathione-and-the-mitochondrial-reduction-of-hyd-Jocelyn-Dickson/c7556da856d0f187179fb3c5dfc92fab1c7fbb8b
*  EXAFS of soybean lipoxygenase-1: influence of lipid hydroperoxide activation and lyophilization on the structure of the soybean...
EXAFS of soybean lipoxygenase-1: influence of lipid hydroperoxide activation and lyophilization on the structure of the soybean lipoxygenase non-heme iron active ...
  https://dspace.library.uu.nl/handle/1874/5337
*  Exploring the antiperoxidative potential of morin on cyclophosphamide and flutamide-induced lipid peroxidation and changes in...
Considering drug-induced lipid peroxidation as a possible mediator of drug-induced toxicity and exploiting the free radical scavenging action of antioxidants, the present study was designed to evaluate the antiperoxidative potential of morin on cyclophosphamide/flutamide-induced lipid peroxidation and also to evaluate the effect of morin on cyclophosphamide/flutamide-induced changes in cholesterol content in rabbit blood sample. This evaluation was done by measuring the malondialdehyde (MDA), reduced glutathione (GSH), 4-hydroxy-2-nonenal (4-HNE) and nitric oxide (NO) content of blood samples as markers of lipid peroxidation. In the cholesterol profile total cholesterol and high density lipoprotein cholesterol content of rabbit blood was determined. The study reveals the lipid peroxidation induction capacity of cyclophosphamide/flutamide and the antiperoxidative potential of ...
  https://www.semanticscholar.org/paper/Exploring-the-antiperoxidative-potential-of-morin-Ray-Chowdhury/6585cb3edc768e50153be6c4b50eae5e5297a1f7
*  Hydroperoxide dehydratase - Wikipedia
In enzymology, a hydroperoxide dehydratase (EC 4.2.1.92) is an enzyme that catalyzes the chemical reaction (9Z,11E,14Z)-(13S)-hydroperoxyoctadeca-9,11,14-trienoate ⇌ {\displaystyle \rightleftharpoons } (9Z)-(13S)-12,13-epoxyoctadeca-9,11-dienoate + H2O Hence, this enzyme has one substrate, (9Z,11E,14Z)-(13S)-hydroperoxyoctadeca-9,11,14-trienoate, and two products, (9Z)-(13S)-12,13-epoxyoctadeca-9,11-dienoate and H2O. This enzyme belongs to the family of lyases, specifically the hydro-lyases, which cleave carbon-oxygen bonds. The systematic name of this enzyme class is (9Z,11E,14Z)-(13S)-hydroperoxyoctadeca-9,11,14-trienoate 12,13-hydro-lyase [(9Z)-(13S)-12,13-epoxyoctadeca-9,11-dienoate-forming]. Other names in common use include hydroperoxide isomerase, linoleate hydroperoxide isomerase, linoleic acid hydroperoxide isomerase, HPI, (9Z,11E,14Z)-(13S)-hydroperoxyoctadeca-9,11,14-trienoate, and 12,13-hydro-lyase. As of late 2007, only one structure has been solved for this class of enzymes, ...
  https://en.wikipedia.org/wiki/Hydroperoxide_dehydratase
*  Role of lipid peroxides in the pathogenesis of arteriosclerosis. Detoxication of lipid peroxides by the glutathione-peroxidase...
Abstract: In aorta of intact rabbits the high activity of glutathione-peroxidase, which detoxicates lipoperoxides, was observed. In aorta of animals with pronounced experimental atheromatosis the enzyme activity did not distinctly differ from the control values. The animals with high initial content of glutathione-peroxidase in aorta were shown to be less subjected to the impairment in alimentary atherosclerosis ...
  http://pbmc.ibmc.msk.ru/index.php/en/article/PBMC-1976-22-3-392-en
*  Chapter 11. Free Radical Reactions - PDF
hapter 11 Free Radical Reactions A free radical is a species containing one or more unpaired electrons Free radicals are electron-deficient species, but they are usually uncharged, so their chemistry is
  http://docplayer.net/20979101-Chapter-11-free-radical-reactions.html
*  In vitro anti-oxidant and DNA protective effects of the novel 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitor...
1. Free radical-induced lipid peroxidation and changes in protein and nucleic acid structures can result in various human ailments, including ageing, neurodegenerative disorders and cancer. High body fat or dietary fat further enhances the free radical-mediated pathogenesis of various diseases. 2. In the present study, the in vitro anti-oxidant and DNA protective effects of the novel cardiovascular drug rosuvastatin were evaluated. Anti-oxidant activity was evaluated on the basis of inhibition of lipid peroxidation, scavenging of superoxide radical and the reduction of ferric ions (Fe(3+)). Inhibition of lipid peroxidation was determined using Fenton's reaction-induced lipid peroxidation in rat liver and brain homogenates and liver mitochondria. Superoxide radical-scavenging activity was evaluated by scavenging of the ...
  https://www.semanticscholar.org/paper/In-vitro-anti-oxidant-and-DNA-protective-effects-o-Ajith-Riji/19cac427b5e6edc69e7b7d76535429880e100faf
*  Mechanisms of Pro- and Antioxidation1 - Redorbit
EXPANDED ABSTRACT KEY WORDS: * antioxidants * prooxidants * dietary fat Prooxidants often are considered synonymous with reactive species, toxic substances that can cause oxidative damage to major constituents of biological systems. In contradistinction, antioxidants are defined as any substance that, when present at low concentrations compared with that of the oxidizable substrate, significantly prevents the prooxidant-initiated oxidation of that substrate. In this context, and based on the potential of free radical reactions contributing to the degradation of biological systems, it was suggested that it might be possible to reduce the extent of damage caused by free radicals through 3 dietary changes: i) reducing energy intake (i.e., lowering the level of free radical reactions arising in the course of normal metabolism), ii) minimizing dietary components that increase the level of free radical reactions (e.g., polyunsaturated fats), and ...
  http://www.redorbit.com/news/health/106409/mechanisms_of_pro_and_antioxidation1/
*  What Are the Different Hydrogen Peroxide Concentrations?
There are many different hydrogen peroxide concentrations, including concentrations of 90%, which are used for rocket fuel and...
  http://www.wisegeek.com/what-are-the-different-hydrogen-peroxide-concentrations.htm
*  Apitherapy News: September 2014
This study aimed to test the protective role of natural bee honey against melamine toxicity in the kidney of male albino rats. The dietary supplementation of melamine at a dose of 20,000 ppm for 28 days induced renal dysfunction, as reflected by a significant increase in kidney function parameters (urea, creatinine, and uric acid) and an increase in potassium levels. In addition, a decrease in catalase and glutathione-S-transferase and an increase in lipid peroxide in the kidney tissue homogenate were also observed. Histological changes in the melamine-treated group revealed hyperplasia and damage in kidney cells and the accumulation of melamine crystals in kidney tissues. Honey treatment for 28 days in rats concurrently administered melamine at a dose of 2.5 g/kg body weight for 28 days improved the kidney function, increased antioxidant enzymes, and decreased lipid peroxide levels. The morphology of the kidney cells of the melamine-fed rats was also improved as a result of ...
  http://apitherapy.blogspot.co.nz/2014/09/
*  Apitherapy News: September 2014
This study aimed to test the protective role of natural bee honey against melamine toxicity in the kidney of male albino rats. The dietary supplementation of melamine at a dose of 20,000 ppm for 28 days induced renal dysfunction, as reflected by a significant increase in kidney function parameters (urea, creatinine, and uric acid) and an increase in potassium levels. In addition, a decrease in catalase and glutathione-S-transferase and an increase in lipid peroxide in the kidney tissue homogenate were also observed. Histological changes in the melamine-treated group revealed hyperplasia and damage in kidney cells and the accumulation of melamine crystals in kidney tissues. Honey treatment for 28 days in rats concurrently administered melamine at a dose of 2.5 g/kg body weight for 28 days improved the kidney function, increased antioxidant enzymes, and decreased lipid peroxide levels. The morphology of the kidney cells of the melamine-fed rats was also improved as a result of ...
  http://apitherapy.blogspot.com/2014/09/
*  Subretinal Lipid Hydroperoxide Induced-Oxidative Stress and Retinal Degeneration Results in a Rat Model of Age-Related Macular...
Methods : HpODE was administered via subretinal injection in Sprague Dawley rats on day 0 and the time course of oxidative stress and retinal degeneration was studied qualitatively using immunohistochemistry (flatmount and crossections), and quantitatively via qPCR and western blot on day 2, 5 12 and 20. Results : Subretinal lipid provoked oxidative stress and damage in retinal tissue and retinal pigment epithelium (RPE) with accumulated autofluoresent material in subretina. RPE degeneration and atrophy was detected early at day 5 followed by neural tissue degeneration at day 12 with robust TUNEL positive cells. Oxidative stress marker, 8-OHdG, was demonstrated in RPE cells at day 2 and oxidative damage (4-HNE, MDA, NT and 8-OHdG) increased in retinal tissue from day 5 to 12. Retinal inflammation was confirmed by subretinal microglial/macrophage accumulation and Müller glial activation in the lipid injected area was present at day 5. Western blot and RT-qPCR confirmed an ...
  http://iovs.arvojournals.org/article.aspx?articleid=2639954
*  Science - Biomol-Med - Antioxidative barrier
Transition metal ions also catalyze the breakdown of lipid peroxides:. LOOH + Fe2+ → LO• + OH-Fe3+. LOOH + Fe3+ → LOO• + H+Fe2+. The stage of propagation is inhibited by the competitive termination occurring between reactive radical forms:. LOO• + L1 OO• → LOOL1 + O2. LOO• + L1OO• → LOOL1. L• + L1• → L - L1. The effect of the process is the formation of lipids with branched aliphatic chains or protein-lipid complexes. The breakdown of lipid peroxides leads to the formation of many compounds, such as saturated hydrocarbons (ethane, penthane, hexane) and unsaturated hydrocarbons, aldehydes (saturated and unsaturated, hydroxyaldehydes), and dialdehydes (e.g. malone dialdehyde - MDA). Some of these compounds can be causes of pathologies or can be metabolized to other potential endogenous toxins.. Special attention should be paid to γ-diketones, which may cause the networking of lipids and ...
  http://biomol.pl/biomol/en_GB/articles/science/antioxidative-barrier.html
*  The effect of middle molecules isolated from the serum of burn patients on the state of lipid peroxidation in animal tissues
Abstract: Intensity of ascorbate-, NADPH-dependent and spontaneous lipid peroxidation were studied in mice brain and liver tissues after intravenous administration of middle molecular mass peptides, isolated from blood serum of animals with thermic burns. Positive effect of these peptides on lipid peroxidation was detected in tissues of animals with altered rate of lipid peroxidation (strong burns of 10-12% of body surface served as a biological model). The data obtained suggest that individual components of blood serum middle molecular fraction appear to exhibit the regulating effects on lipid peroxidation in animal tissues ...
  http://pbmc.ibmc.msk.ru/index.php/en/article/PBMC-1990-36-3-24-en
*  Plus it
1472 Introduction Docosahexaenoic acid (DHA, 22:6, n-3) is known to have anticancer activity. While the cellular mechanisms of DHA's anticancer action remain incompletely defined, the involvement of lipid peroxidation has been well recognized. We have recently reported that DHA reduces expression of superoxide dismutase 1 (a primary antioxidant enzyme), leading to enhanced lipid peroxide levels and cytotoxicity in human cancer cells. To understand the mechanisms whereby DHA down-regulates SOD-1 gene expression, this study examined the effects of DHA on SOD-1 gene transcription. Method A2780, a well-characterized ovarian cancer cell model system, was used for this study. Human SOD-1 gene promoter was cloned into PGL-3 luciferase reporter constructs and deletion of DNA binding elements was performed using a Quick-Change Site-Directed Mutagenesis kit (Stratagene). These reporter constructs were transfected into A2780 cells and luciferase ...
  http://cancerres.aacrjournals.org/content/68/9_Supplement/1472
*  Omega Research
Lipid metabolism, inflammation, oxidative stress and endothelial function play important roles in the pathogenesis of cardiovascular disease (CVD), which may be affected by an imbalance in the n-6/n-3 polyunsaturated fatty acid (PUFA) ratio. This study aimed to investigate the effects of the n-6/n-3 PUFA ratio on these cardiovascular risk factors in rats fed a high-fat diet using plant oils as the main n-3 PUFA source. The 1:1 and 5:1 ratio groups had significantly decreased serum levels of total cholesterol, low-density lipoprotein cholesterol, and proinflammatory cytokines compared with the 20:1 group (p < 0.05). Additionally, the 20:1 group had significantly increased serum levels of E-Selectin, von Willebrand factor (vWF), and numerous markers of oxidative stress compared with the other groups (p < 0.05). The 1:1 group had a significantly decreased lipid peroxide level compared with the other groups (p < 0.05). Serum levels of malondialdehyde, reactive oxygen species and ...
  http://omega-research.com/researchview.php?ID=3626&catid=8
*  Lipid Peroxides | Running Raw
Today, I want to discuss a new study that recently appeared in the Journal of Functional Foods. This study looked at the consumption of apples and it's effect on heart disease factors such as the oxidation of LDL cholesterol in the bloodstream. Continue reading →. ...
  http://runningraw.com/blog/?tag=lipid-peroxides
*  Lipid hydroperoxides mediate protein fragmentation | Biochemical Society Transactions
Thank you for your interest in spreading the word about Biochemical Society Transactions.. NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address.. ...
  http://www.biochemsoctrans.org/content/15/6/1063
*  JoVE Author Search: Decea N
Oxygen, Superoxide, Administration, Adult, Antioxidant Effect, Catalase, Cells, Diabetes Mellitus, Grape, Grape Seed Extract, Injection, Lipid Peroxides, Liver, Oral Administration, Peroxides, Plasma, Proteins, Rat, Rats, Reactive Oxygen Species
  http://labindex.jove.com/author/Decea-N
*  KAKEN - Researchers | SYUKUYA Akinori (80226290)
Affiliation:The Jikei University School of Medicine Pediatrics,医学部,助手, Research Field:Pediatrics, Keywords:腎微少循環,Denervation,腎臓神経,ピューロマイシンアシノタクレオシド,除神経,腎組織カテコ-ルアミン,蛋白尿,Nephrotic syndrome,Lipid peroxide,ピュ-ロマイシン腎症, # of Research Projects:1, # of Research Products:0
  https://nrid.nii.ac.jp/nrid/1000080226290/
*  Peroxidized lipids dilate blood vessels | Science
Thank you for your interest in spreading the word about Science.. NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address.. ...
  http://science.sciencemag.org/content/347/6218/141.9