*  JOMR | Review of MicroRNA Proposed Target Genes in Oral Cancer. Part II
... tumour suppressor genes and most recently microRNA genes not as a single event or single change but rather as a multistep ... The role of microRNA genes in carcinogenesis is recently explored and appears to be an early event in the pathogenesis of this ... The purpose of this article was to review the literature concerning MicroRNA proposed target genes in oral cancer. ... as well as other disease processes and occurs via gene regulation by their own products, the microRNAs. ...
  http://ejomr.org/JOMR/archives/2011/2/e2/v2n2e2ht.htm
*  Plus it
Ras activates Raf, which subsequently activates MAP/ERK (extracellular signal-regulated kinase) kinase (MEK). MEK ... thus inhibiting the ability of TSC2 to act as a GTPase activating protein. This allows Rheb, a small G-protein, to remain in a ... similar to that seen in Ras family members (46). Because Gα inactivation is mediated by this intrinsic GTPase, such mutations ... hypothesis is based upon the hypothesis that tumorigenesis is dependent upon dysregulation of a gene or gene product. Protein ...
  http://clincancerres.aacrjournals.org/content/17/8/2087
*  G-protein signaling - RhoA regulation pathway Pathway Map - PrimePCR | Life Science | Bio-Rad
Select your gene target of interest using an interactive pathway map, and select your plate. ... GTPase-activating proteins (GAPs) that enhance the intrinsic GTP-hydrolysis activity, leading to GTPase inactivation; and ... There are several known GAPs which negatively regulate RhoA: Myosin IXb [22], Rho GTPase activating protein 26 (GRAF) [23], Rho ... Protein kinase N (PKN) and PKN-related protein rhophilin as targets of small GTPase Rho. Science (New York, N.Y.) 1996 Feb 2; ...
  http://www.bio-rad.com/en-us/prime-pcr-assays/pathway/g-protein-signaling-rhoa-regulation-pathway
*  Gene Expression Literature Summary - MGI
YY1 activates Msx2 gene independent of bone morphogenetic protein signaling. Nucleic Acids Res. 2002 Mar 1;30(5):1213-23 ... Genes Dev. 2002 May 1;16(9):1089-101 2. J:162170 Roybal PG, Wu NL, Sun J, Ting MC, Schafer CA, Maxson RE, Inactivation of Msx1 ... J:139170 Imayoshi I, Shimogori T, Ohtsuka T, Kageyama R, Hes genes and neurogenin regulate non-neural versus neural fate ... J:90386 Wang CK, Omi M, Ferrari D, Cheng HC, Lizarraga G, Chin HJ, Upholt WB, Dealy CN, Kosher RA, Function of BMPs in the ...
  http://www.informatics.jax.org/gxdlit/marker/MGI:97169
*  The Ras guanine nucleotide exchange factor RasGRF1 promotes matrix metalloproteinase-3 production in rheumatoid arthritis...
RasGRF1 expression was manipulated in RA FLS by cDNA transfection and gene silencing, and effects on MMP-1, TIMP-1, MMP-3, IL-6 ... Double staining was performed to detect proteins in specific cell populations, and cells producing MMP-1 and MMP-3. ... Production of MMP-1 and MMP-3 in RA but not non-RA synovial tissue positively correlated with expression of RasGRF1 and co- ... and abrogation of Ras family signaling is therapeutic in animal models of RA. Recently, expression and post-translational ...
  https://arthritis-research.biomedcentral.com/articles/10.1186/ar2785
*  Gene Report for G00001444 - Genes2Cognition Neuroscience Research Programme
GTPase-activating proteins and Ras with effectors including MAPK pathway components. Several proteins were encoded by activity- ... Heptad repeats regulate protein phosphatase 2a recruitment to I-kappaB kinase gamma/NF-kappaB essential modulator and are ... The Vpr protein of primate lentiviruses arrests cell cycling at the G(2)/M phase through an inactivation of cyclin B-p34(cdc2) ... Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite ...
  http://www.genes2cognition.org/db/Gene/G00001444
*  Localization of nectin-free afadin at the leading edge and its involvement in directional cell movement induced by platelet...
Yamada, T., Sakisaka, T., Hisata, S., Baba, T. and Takai, Y. (2005). RA-RhoGAP, Rap-activated Rho GTPase-activating protein ... Afadin prevents the inactivation of Rap1, which is activated by PDGF at the leading edge, and promotes the binding of activated ... two Ras-binding (RA) domains, a dilute (DIL) domain, a PDZ (post synaptic density protein, Drosophila disc large tumor ... Regulation of cell motility by mitogen-activated protein kinase. J. Cell Biol. 137, 481-492. ...
  http://jcs.biologists.org/content/122/23/4319
*  PtdIns(3,4,5)P3-Dependent Activation of the mTORC2 Kinase Complex | Cancer Discovery
The human stress-activated protein kinase-interacting 1 gene encodes JNK-binding proteins. Cell Signal 2005;17:761-7. ... Roth RA. . Akt, a pleckstrin homology domain containing kinase, is activated primarily by phosphorylation. J Biol Chem 1996;271 ... Distinct from mTORC1 that depends on proteins including RAG GTPase and RHEB GTPase for lysosomal recruitment and activation (12 ... Human Sin1 contains Ras-binding and pleckstrin homology domains and suppresses Ras signalling. Cell Signal 2007;19:1279-89. ...
  http://cancerdiscovery.aacrjournals.org/content/5/11/1194
*  Alan Hall - Wikipedia
... a member of the Ras gene family. In 1986, Hall helped uncover properties of the human p21 protein, which is encoded by N-ras. ... He then determined that CNK1 acts together with these four targets to activate the JNK MAP kinase pathway, but not other Rho- ... In addition, the inactivation of Rho protein by ADP-ribosylation in Rac1 microinjection reduced the formation of actin stress ... Results showed no correlation between the wild-type or mutant N-ras p21's GTPase activity and transforming potential. These ...
  https://en.wikipedia.org/wiki/Alan_Hall
*  NEDD9 - Wikipedia
... preventing association of E-cadherin with cell membrane and activating SRC-kinase. Activated SRC provides internalization and ... cloned the gene encoding a protein hyperphosphorylated following ligation of β1-integrins in T cells and hypothesized to play a ... Merrill RA, Ahrens JM, Kaiser ME, Federhart KS, Poon VY, Clagett-Dame M (2004). "All-trans retinoic acid-responsive genes ... NEDD9 Crk complexes activate Rho and Ras family GTPases via the recruitment of their nucleotide exchange factors (GEFs), such ...
  https://en.wikipedia.org/wiki/NEDD9
*  CDKN1B - Wikipedia
... or Ras-mitogen activated protein kinase(MAPK). These act to accelerate the proteolysis of the p27 protein and allow the cancer ... Transcription of the CDKN1B gene is activated by Forkhead box class O family (FoxO) proteins which also acts downstream to ... A structured cis-regulatory element has been found in the 5' UTR of the P27 mRNA where it is thought to regulate translation ... Liu X, Sun Y, Ehrlich M, Lu T, Kloog Y, Weinberg RA, Lodish HF, Henis YI (November 2000). "Disruption of TGF-beta growth ...
  https://en.wikipedia.org/wiki/CDKN1B
*  PAK1 - Wikipedia
Shin YJ, Kim YB, Kim JH (September 2013). "Protein kinase CK2 phosphorylates and activates p21-activated kinase 1". Molecular ... Serine/threonine-protein kinase PAK 1 is an enzyme that in humans is encoded by the PAK1 gene. PAK1 is one of six members of ... Wang RA, Vadlamudi RK, Bagheri-Yarmand R, Beuvink I, Hynes NE, Kumar R (May 2003). "Essential functions of p21-activated kinase ... Zhang B, Chernoff J, Zheng Y (April 1998). "Interaction of Rac1 with GTPase-activating proteins and putative effectors. A ...
  https://en.wikipedia.org/wiki/PAK1
*  Ras subfamily - Wikipedia
GTPase Activating Protein inactivates Ras by activating its GTPase activity. Thus, GAPs accelerate Ras inactivation. GEFs ... "A mutant type 2 herpes simplex virus deleted for the protein kinase domain of the ICP10 gene is a potent oncolytic virus". ... Ras is the prototypical member of the Ras superfamily of proteins, which are all related in 3D structure and regulate diverse ... Hall A, Marshall CJ, Spurr NK, Weiss RA (1983). "Identification of transforming gene in two human sarcoma cell lines as a new ...
  https://en.wikipedia.org/wiki/Ras_subfamily
*  MTORC1 - Wikipedia
... which activates the Ras G protein. Ras activates Raf (MAPKKK), which activates Mek (MAPKK), which activates Erk (MAPK). Erk can ... TSC2 is a GTPase activating protein (GAP). Its GAP activity interacts with a G protein called Rheb by hydrolyzing the GTP of ... Nagalingam A, Arbiser JL, Bonner MY, Saxena NK, Sharma D (2012). "Honokiol activates AMP-activated protein kinase in breast ... Sancak Y, Peterson TR, Shaul YD, Lindquist RA, Thoreen CC, Bar-Peled L, Sabatini DM (Jun 2008). "The Rag GTPases bind raptor ...
  https://en.wikipedia.org/wiki/MTORC1
*  RAC1 - Wikipedia
"The Ras GTPase-activating-protein-related human protein IQGAP2 harbors a potential actin binding domain and interacts with ... It is encoded by the RAC1 gene. This gene can produce a variety of alternatively spliced versions of the Rac1 protein, which ... activate myotonic dystrophy protein kinase". FEBS Letters. 475 (3): 273-7. doi:10.1016/S0014-5793(00)01692-6. PMID 10869570. ... Hanahan D, Weinberg RA (Mar 2011). "Hallmarks of cancer: the next generation". Cell. 144 (5): 646-74. doi:10.1016/j.cell. ...
  https://en.wikipedia.org/wiki/RAC1
*  TSC2 - Wikipedia
... phorbol esters and activated Ras inactivate the tuberous sclerosis tumor suppressor complex via p90 ribosomal S6 kinase". Proc ... is a protein that in humans is encoded by the TSC2 gene. Mutations in this gene lead to tuberous sclerosis. Its gene product is ... Inoki K, Li Y, Xu T, Guan KL (2003). "Rheb GTPase is a direct target of TSC2 GAP activity and regulates mTOR signaling". Genes ... Ma L, Chen Z, Erdjument-Bromage H, Tempst P, Pandolfi PP (2005). "Phosphorylation and functional inactivation of TSC2 by Erk ...
  https://en.wikipedia.org/wiki/TSC2