*  Degos' disease (malignant atrophic papulosis) - Derm101
Degos' disease (malignant atrophic papulosis) Synonyms Degos' syndrome Malignant atrophic papulosis Papulosis atrophicans maligna Koehlmeier-Degos syndrome Thromboangiitis cutaneointestinalis disseminata Fatal cutaneointestinal syndrome Lethal intestinocutaneous syndrome Papuleuse maligne atrophiante Lethal cutaneous and gastrointestinal arteriolar thrombosis Thromboangiitis cutaneointestinalis disseminata Presentation stereotypical Age and sex Men affected more, and more severely than women; infants and the elderly rarely […] ...
  http://www.derm101.com/inflammatory/lupus-erythematosus-3/degos-disease-malignant-atrophic-papulosis/
*  Degos disease - meddic
The disease is named for Robert Degos, who recognised it as a clinical entity in 1942, after it was first described by Kohlmeier in 1941.[5][6] Degos himself subsequently suggested the name "papulose atrophiante maligne," translated as malignant atrophic papulosis.. In November 2007, a research symposium on Degos disease was held at Massachusetts General Hospital in Boston, bringing together 19 patients and a group of clinicians and researchers to study the clinical presentation and underlying causes of the disease, in conjunction with a study group on Degos held at the annual meeting of the American College of Rheumatology that year in Boston. No successful treatments were identified until late 2009. A male patient in the fifth decade was diagnosed with the systemic form of the disease and was severely ill. The diagnosing pathologist, Cynthia Magro MD, identified the presence of C5b-9 complexes in the involved vessels of the skin biopsy.[7] She suggested ...
  http://meddic.jp/Degos_disease
*  Degos Disease | Health Encyclopedia | Dartmouth-Hitchcock
Degos disease is an extremely rare disorder in which small and medium sized arteries become blocked (occlusive arteriopathy), restricting the flow of blood to affected areas. Degos disease usually causes characteristic skin lesions that may last for a period of time ranging from weeks to years. In some individuals...
  http://www.cheshire-med.com/health_wellness/health_encyclopedia/nord352
*  Nervous System Involvement in Degos Disease | American Journal of Neuroradiology
Degos disease generally affects young adults and is characterized, at the beginning, by typical skin lesions with papulous aspect, erythematous rim, and white porcelainlike atrophic center, localized over the trunk and the lower limbs. These lesions are asymptomatic or mildly itchy (5, 6). After a variable period of weeks, months, or (in some cases) years, the pathologic process involves also other organs and, in particular, the gastrointestinal tract (50% of cases) and the CNS (20-60% of cases) (4). Eyes, urinary tract, heart, and lungs can also be involved, but with a lower incidence (7, 8). The multisystem involvement is often fatal and generally leads to death in 2-3 years, most frequently as a consequence of intestinal perforation (6). Beyond this classic presentation, many cases with favorable evolution and good prognosis have also been reported in recent years, which showed a prevalent or exclusive involvement of the skin (9). In particular, in a large series from the Mayo Clinic more ...
  http://www.ajnr.org/content/26/3/646.full
*  Chronic cutaneous Lupus erythematosus: study of 290 patients
The distribution according to sex showed that 255 (77.6%) patients were female and 65 (22.4%) were male, therefore showing a sex bias of 3.4:1.. As for skin color, 164 patients were white, 92 black, 33 mixed race and one yellow. There were no significant differences in the cross comparison of the variables of color and sex.. The occurrence of familial cases of LE was reported by 13 (4.4%) of the 290 patients. The authors actually examined only three of these familial cases, with proven LE and attended at the dermatology clinic. Four patients reported that more than one family member had the disease, while the remaining nine only reported one familial case. Altogether these 13 patients referred to 17 familial cases of which, six with probable CCLE, three with SLE and eight with LE.. As for the questionnaire on local clinical symptoms (itch and aggravation following solar exposure), 179 (58.7%) patients answered that they had one or more symptoms: 45.7% reported pruritus, and 37.2% referred to ...
  http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0365-05962003000600005&lng=en&nrm=iso&tlng=en
*  Papulosis | definition of papulosis by Medical dictionary
Looking for online definition of papulosis in the Medical Dictionary? papulosis explanation free. What is papulosis? Meaning of papulosis medical term. What does papulosis mean?
  https://medical-dictionary.thefreedictionary.com/papulosis
*  DMOZ - Health: Conditions and Diseases: Cardiovascular Disorders: Vascular Disorders: Degos
Degos Disease is a rare systemic disorder that affects small and medium sized arteries, causing them to become blocked (occlusive arteriopathy).
  http://dmoztools.net/Health/Conditions_and_Diseases/Cardiovascular_Disorders/Vascular_Disorders/Degos/
*  Facial blaschkitis: case and review - Zurich Open Repository and Archive
We report on a 15-year-old female with a 3-month history of a pruritic, erythematous cutaneous eruption on the right cheek and perioral area. The lesion had a linear distribution following the lines of Blaschko. Histopathological findings and direct immunofluorescence were compatible with chronic cutaneous lupus erythematosus (LE). Treatment with topical steroids and systemic antimalarial agents over 2 months showed hardly any improvement contrary to similar cases reported in the literature in the past. Histological findings move this case close to LE. However, the unusual clinical presentation as well as the resistance to antimalarial drugs do not fully allow to confirm this suspicion. Therefore, we recommend to call this new entity LE-like facial Blaschkitis of the adult. ...
  http://www.zora.uzh.ch/id/eprint/48842/
*  Response of discoid and subacute cutaneous lupus erythematosus to recombinant interferon alpha 2a. - Semantic Scholar
Ten patients suffering from discoid lupus erythematosus (DLE) or subacute cutaneous lupus erythematosus (SCLE) were treated with interferon alpha 2a. A marked improvement or clearing of cutaneous lupus erythematosus lesions was observed in eight of them. However, the response to interferon was of short duration and within a few weeks after interferon withdrawal all patients who were improved or cleared relapsed. This study suggests that interferon alpha 2a represents a new interesting approach in the treatment of DLE and SCLE. Ongoing trials will define the optimal treatment schedule for the maintenance of interferon-induced improvement of cutaneous lupus erythematosus.
  https://www.semanticscholar.org/paper/Response-of-discoid-and-subacute-cutaneous-lupus-e-Nicolas-Thivolet/ce1c423efbe10bebe22495d153ad05eaa78599d4
*  Pathology of Lymphomatoid Papulosis - Dr Sampurna Roy MD
Lymphomatoid papulosis (LyP) is a recurrent hemorrhagic papular skin eruption with a clinically benign course and histopathologic features of lymphoma. Dermatopathology patterns that remind us of something else. The lesions usually present as papules and nodules that spontaneously involute. Initially the lesions are smooth but later these lesions become crusted, ulcerated and necrotic.. Lymphomatoid papulosis can only be diagnosed accurately through a careful history in which the characteristic waxing and waning of the skin lesions is identified and through proper communication between clinicians and pathologists.. Age: Usually occurs in the third and fourth decade of life. This lesion may also occur in children.. Site: Trunk ; Proximal parts of the limb ; face ; scalp ; palms and sole.. Microscopic features: Subtypes- LyP Type A ; LyP Type B ; LyP Type C ; LyP Type D LyP Type A : Wedge-shaped, superficial and deep mixed infiltrate of small lymphocytes, abnormal lymphocytes ...
  http://www.histopathology-india.net/LymPa.htm
*  Acanthoma - Wikipedia
An acanthoma is a skin neoplasm composed of squamous or epidermal cells. It is located in the prickle cell layer. Types of acanthoma include pilar sheath acanthoma, a benign follicular tumor usually of the upper lip; clear cell acanthoma, a benign tumor found most frequently on the legs; and Degos acanthoma, often confused with but unrelated to Degos disease. In 2005, "Acanthoma" was added to MeSH as an index term; previous indexing was "Skin Neoplasms" (1965-2004). At that time, PubMed indexed only 206 articles with the term "acanthoma" (the term usually in the title or abstract). "acanthoma" at Dorland's Medical Dictionary Medline Data Changes for 2005 NLM Technical Bulletin 2004 November-December; ...
  https://en.wikipedia.org/wiki/Acanthoma
*  Abstract 5752: Role of MicroRNA-503 in Diabetic Endotheliopathy | Circulation
Diabetes disturbs endothelial function and reparative neovascularisation, thus contributing to limb ischemia. Recently, we showed that the atypical neurotrophin receptor p75NTR mediates diabetes-determined impairment of reparative neovascularization. Diabetes induces p75NTR expression in microvascular endothelial cells (ECs) of ischemic limb muscles, thus impairing EC survival and functions. Conversely, p75NTR inhibition restores proper post-ischemic neovascularization in diabetic mice. Making a step forward into the understanding of the relevance of p75NTR in diabetic microangiopathy, here we studied whether p75NTR modulates the expression of microRNAs (miRNAs) in ECs. MiRNAs are small non-coding RNAs that act as endogenous regulators of gene expression, by controlling degradation and/or translational repression of target mRNAs. Using microarray analyses of miRNAs expression in human umbilical vein ECs (HUVECs) transduced with p75NTR or control (empty vector), we detected that miRNA-503 ...
  http://circ.ahajournals.org/content/120/Suppl_18/S1141.4
*  Lymphedema People ™ • View topic - Lymphomatoid Papulosis
In layman's terms, LyP is a rare (from a 1992 article: the overall prevalence rate of lymphomatoid papulosis is estimated at 1.2 to 1.9 cases per 1,000,000 population and may occur less frequently in black patients) lymphatic system disorder consisting of self healing nodules and papules (you or I would call them 'bumps' or 'spots') that "wax and wane". In other words, if you leave them alone, they eventually go away by themselves. Some lesions are small, round, shiny and smooth. Other are large, open to the air, gooey and have a crust in the middle. Some leave scars and some do not. Some leave flat scars and some leave keloid scars. The colors range from pinkish red to pinkish brown and purple. If you would like to see photos of LyP skin lesions please check out DermIS ...
  http://www.lymphedemapeople.com/phpBB3/viewtopic.php?t=265
*  Subacute cutaneous lupus erythematosus - Wikipedia
Subacute cutaneous lupus erythematosus (SCLE) is a clinically distinct subset of cases of lupus erythematosus that is most often present in white women aged 15 to 40, consisting of skin lesions that are scaly and evolve as polycyclic annular lesions or plaques similar to those of plaque psoriasis. Characteristically the lesions appear in sun-exposed areas such as the vee of the neckline or the forearms, but not the face. It may be brought on by sun-sensitizing medications, but is usually associated with autoimmune disorders such as rheumatoid arthritis and Sjögren's syndrome. Treatment generally involves sun avoidance and protection and topical corticosteroids. Sometimes systemic drug treatment is necessary. Besides corticosteroids other immunosuppressants such as methotrexate are also used. Lesions of SCLE may have an annular configuration, with raised red borders and central clearing. Lupus erythematosus List of cutaneous conditions List of human leukocyte antigen alleles associated with ...
  https://en.wikipedia.org/wiki/Subacute_cutaneous_lupus_erythematosus
*  Manifestations and Treatment of Cutaneous Lupus Erythematosus (Part I of II): Scientific, Peer-Reviewed Dermatology Article...
Scientific, peer-reviewed Dermatology article, indexed with MEDLINE/PubMed: Manifestations and Treatment of Cutaneous Lupus Erythematosus (Part I of II) : No abstract available
  http://jddonline.com/articles/dermatology/S1545961611P1212X/1
*  Lymphomatoid papulosis
Author(s): Werner Kempf, Katrin Pfaltz, Maarten H Vermeer, Antonio Cozzio, Pablo L Ortiz-Romero, Martine Bagot, Elise Olsen, Youn H Kim, Reinhard Dummer, Nicola Pimpinelli, Sean Whittaker, Emmilia Hodak, Lorenzo Cerroni, Emilio Berti, Steve Horwitz, H Miles Prince, Joan Guitart, Teresa Estrach, José A Sanches, Madeleine Duvic, Annamari Ranki, Brigitte Dreno, Sonja Ostheeren-Michaelis, Robert Knobler, Gary Wood, Rein Willemze. Journal: Blood. 2011 Oct;118(15):4024-35.. ...
  http://diseaseinfosearch.org/Lymphomatoid+papulosis/4377
*  Lymphomatoid Papulosis - The Clinical Advisor
Physician assistants and nurse practitioners use Clinical Advisor for updated medical guidance to diagnose and treat common medical conditions in daily practice.
  http://www.clinicaladvisor.com/dermatology/lymphomatoid-papulosis/article/589254/
*  cutaneous lupus erythematosus -Doctors Lounge(TM)
Hello,Lupus erythematosis is an auto immune disorder which is due to reaction of the body to self antigens.Discoid LE which is localized is relatively less of a problem compared with systemic LE.Excess sunlight,strong winds could precipitate the condition.Family history is seen occasionally.This condition could be chronic in a few but most would respond well to sunscreens,external steroids,and antimalarials which have immunomodulatory properties.Best wishes ...
  https://www.doctorslounge.com/dermatology/forums/backup/topic-43347.html
*  Korbel Group - Publications - EMBL
International Cancer Genome Consortium, Hudson TJ, Anderson W, Artez A, Barker AD, Bell C, Bernabé RR, Bhan MK, Calvo F, Eerola I, Gerhard DS, Guttmacher A, Guyer M, Hemsley FM, Jennings JL, Kerr D, Klatt P, Kolar P, Kusada J, Lane DP, Laplace F, Youyong L, Nettekoven G, Ozenberger B, Peterson J, Rao TS, Remacle J, Schafer AJ, Shibata T, Stratton MR, Vockley JG, Watanabe K, Yang H, Yuen MM, Knoppers BM, Bobrow M, Cambon-Thomsen A, Dressler LG, Dyke SO, Joly Y, Kato K, Kennedy KL, Nicolás P, Parker MJ, Rial-Sebbag E, Romeo-Casabona CM, Shaw KM, Wallace S, Wiesner GL, Zeps N, Lichter P, Biankin AV, Chabannon C, Chin L, Clément B, de Alava E, Degos F, Ferguson ML, Geary P, Hayes DN, Hudson TJ, Johns AL, Kasprzyk A, Nakagawa H, Penny R, Piris MA, Sarin R, Scarpa A, Shibata T, van de Vijver M, Futreal PA, Aburatani H, Bayés M, Botwell DD, Campbell PJ, Estivill X, Gerhard DS, Grimmond SM, Gut I, Hirst M, López-Otín C, Majumder P, Marra M, McPherson JD, Nakagawa H, Ning Z, Puente XS, Ruan Y, ...
  https://www.embl.de/research/units/genome_biology/korbel/publications/index.php
*  Eculizumab | Aplastic Anemia and MDS International Foundation
Eculizumab (Soliris ®) is the only drug approved by the U.S. Food and Drug Administration (FDA) and the European Medicines Evaluation Agency (EMEA) to treat PNH. It works by making your complement system less active. Eculizumab (Soliris ®) is given as an IV into a vein at the doctor's office or at a special center. The procedure usually takes about 35 minutes. You will probably get an IV once a week for the first 4 weeks. Starting in the 5th week, you will get a slightly higher dose of Soliris every 2 weeks.
  http://www.aamds.org/treatments/therapies/eculizumab
*  MEET the SPEAKERS | br.BIO.fr
Leandra Baptista Dra. Leandra Baptista is a professor at Universidade Federal do Rio de Janeiro (Campus Xerem). Her research interest are in translational biomedicine, focusing on mesenchymal stem cells, adipose tissue and obesity. Angelo MAGRO Dr. Angelo Magro is a professor at the Faculdade de Ciências Agronômicas at UNESP/Botucatu, Brazil. His expertise is on molecular biophysics,…
  https://brbiofr.wordpress.com/meet-the-speakers/
*  Discussions - Derm101
Nodular scabies and lymphomatoid papulosis have many attributes histopathologic in common. Both consist of infiltrates whose pattern is superficial and deep, perivascular, and interstitial, and whose population of cells may be mixed, i.e., small lymphocytes, large lymphocytes, plasma cells, eosinophils, and neutrophils. Some lymphocytes may be large. Infiltrates may become nodular and even diffuse, and […] ...
  http://www.derm101.com/differential/nodular-scabies-vs-lymphomatoid-papulosis/discussions/
*  Eculizumab - The Atypical HUS Foundation
Physicians wishing to explore the use of eculizumab (Soliris®) therapy for patients with atypical HUS are advised to directly contact Alexion Pharmace…
  http://atypicalhus.ning.com/page/eculizumab
*  Requena | Spain | Britannica.com
Requena: City, Valencia provincia (province) and comunidad autónoma (autonomous community), eastern Spain. Overlooking the left bank of the Magro River, the city, 2,270 feet (692 metres)...
  https://www.britannica.com/place/Requena
*  Community-Based Health Quality Improvement - RWJF
Browse resources from AF4Q, a community-based quality improvement initiative that supported 16 alliances located throughout the United States.
  https://www.rwjf.org/en/library/collections/af4q.html