Protein Transport / genetics * rab GTP-Binding Proteins / metabolism* * rab GTP-Binding Proteins / physiology* ... The recycling endosome protein RAB-10 promotes autophagic flux and localization of the transmembrane protein ATG-9 Autophagy. ... As previously reported, loss of rab-10 alone resulted in an increase of GFP:LGG-1 foci. Exposure of rab-10 mutant animals to ... rab-10 dauers at the nonpermissive temperature. Intriguingly, RAB-10 was required to maintain the normal size of GFP::ATG-9- ...

Pereira-Leal JB, Seabra MC (Nov 2001). "Evolution of the Rab family of small GTP-binding proteins". J Mol Biol. 313 (4): 889- ... Ras-related protein Rab-15 is a protein that in humans is encoded by the RAB15 gene. GRCh38: Ensembl release 89: ... Fukuda M (2003). "Distinct Rab binding specificity of Rim1, Rim2, rabphilin, and Noc2. Identification of a critical determinant ... Strick DJ, Elferink LA (2006). "Rab15 effector protein: a novel protein for receptor recycling from the endocytic recycling ...

Evolution of the Rab family of small GTP-binding proteins. Pereira-Leal JB, et al. J Mol Biol, 2001 Nov 2. PMID 11697911 ... They cycle between inactive GDP-bound and activated GTP-bound states, which is controlled by GTP hydrolysis-activating proteins ... This gene encodes a small GTP-binding protein that belongs to the largest family within the Ras superfamily. These proteins ... General protein information Go to the top of the page Help Preferred Names. ras-related protein Rab-41. Names. RAB41, member ...

Evolution of the Rab family of small GTP-binding proteins. J Mol Biol 2001. 313:889-901. View this article via: PubMed CrossRef ... VPS21 encodes a rab5-like GTP binding protein that is required for the sorting of yeast vacuolar proteins. EMBO J 1994. 15:1297 ... Rab proteins are Ras-like monomeric GTPases that form a large family with 60 known genes identified in humans (1). Rabs have ... Zerial, M, McBride, H. Rab proteins as membrane organizers. Nat Rev Mol Cell Biol 2001. 2:107-117. View this article via: ...

Phosphorylation of two small GTP-binding proteins of the Rab family by p34cdc2 ... with protein-A/G-agarose beads (Santa Cruz Biotechnology) pre-linked with specific antibodies (1 h, 23°C). The bound protein-A/ ... not necessarily a Golgi protein) can occur either indirectly through the action of phosphorylation-binding proteins, as has ... Phospho-specific binding of 14-3-3 proteins to phosphatidylinositol 4-kinase III beta protects from dephosphorylation and ...

rab GTP-Binding Proteins [D08.811.277.040.330.300.400.400]. *rab2 GTP-Binding Protein [D08.811.277.040.330.300.400.400.050] ... "rab2 GTP-Binding Protein" by people in this website by year, and whether "rab2 GTP-Binding Protein" was a major or minor topic ... "rab2 GTP-Binding Protein" is a descriptor in the National Library of Medicines controlled vocabulary thesaurus, MeSH (Medical ... rab2 GTP-Binding Protein*rab2 GTP-Binding Protein. *GTP-Binding Protein, rab2 ...

... such as protein bodies (PBs) and protein storage vacuoles (PSVs), for the accumulation of storage proteins. During development ... Consequently, endomembrane-modifying proteins will influence the final grain quality and yield. However, little is known about ... Based on proteome annotation and a homology search, 94 proteins associated with the endomembrane system were identified that ... Moreover, endosomal sorting complex required for transport (ESCRT)-related proteins and their transcripts are most abundant at ...

rab GTP-Binding Proteins Medicine & Life Sciences 47% * Guanine Chemical Compounds 47% ... keywords = "ALS, C9orf72, Guanine nucleotide exchange factor, Neurodegeneration, Protein expression, Protein purification, Rab ... The C9orf72 protein is predicted to be a differentially expressed in normal and neoplastic cells domain protein implying that ... The C9orf72 protein is predicted to be a differentially expressed in normal and neoplastic cells domain protein implying that ...

Through a cycle of GTP binding and hydrolysis, rab-effector proteins are recruited to membrane sub-domains in a temporally and ... This thesis focuses on Golgi-localised rab proteins and their effector proteins. The cis-Golgi-localised rab protein, rabl, is ... binding/metabolising proteins centaurin?2 and MTMR6. A search for novel effectors of the trans-Golgi-localised rab protein, ... Several rab proteins localise to the Golgi apparatus, the organelle consisting of stacked, flattened, membrane-bound cisternae ...

Analysis of multiple guanine exchange factors shows that Rab activation can occur via a number of mechanistically distinct GDP- ... Binding to a molecule called GDP makes the Rab protein inactive, while binding to GTP makes it active. Proteins called guanine ... activate the Rab protein by promoting the release of GDP and the binding of GTP. Other proteins-known as GAPs-lead to the ... The 70 or so members of the Rab subfamily of proteins perform a wide range of important tasks inside cells. A Rab protein is ...

... rab GTP-Binding Proteins/chemistry",. author = "Pawel Lis and Sophie Burel and Martin Steger and Matthias Mann and Fiona Brown ... Development of phospho-specific Rab protein antibodies to monitor in vivo activity of the LRRK2 Parkinsons disease kinase. / ... Development of phospho-specific Rab protein antibodies to monitor in vivo activity of the LRRK2 Parkinsons disease kinase. ... Dive into the research topics of Development of phospho-specific Rab protein antibodies to monitor in vivo activity of the ...

Regulatory Rab proteins are thought to inspect the joining of the SNAREs. Rab protein is a regulatory GTP-binding protein and ... controls the binding of these complementary SNAREs for a long enough time for the Rab protein to hydrolyse its bound GTP and ... Membrane-bound and secreted proteins are made on ribosomes found in the rough endoplasmic reticulum. Most of these proteins ... Coat proteins can also function to bind to various transmembrane receptor proteins, called cargo receptors. These receptors ...

Rab11 proteins, members of the Rab GTPase family, are known to regulate vesicular recycling during embryonic development. In ... Rab proteins are GTPases responsible for intracellular vesicular trafficking regulation. ... Rab/Ypt proteins are small GTP-binding proteins of the Ras superfamily and are key players in intracellular vesicular ... We first examined Rab11 protein phylogeny in zebrafish [Rab-11A (NP_001007360); Rab-11BA (NP_999935); Rab-11BB (NP_001002555)] ...

GDP dissociation inhibitors are proteins that regulate the GDP-GTP exchange reaction of members of the rab family, small GTP- ... GDP-dissociation inhibitor activity Rab GDP-dissociation inhibitor activity GTPase activator activity protein binding ... Protein XAP-4; Rab GDI alpha; Rab GDP dissociation inhibitor alpha; rab GDP-dissociation inhibitor, alpha; RABGD RABGDIA; ... GDIs slow the rate of dissociation of GDP from rab proteins and release GDP from membrane-bound rabs. GDI1 is expressed ...

... for Rab GTPases. They act in both protein secretion and autophagy and have also been proposed to have a role in other processes ... Both complexes share a core of small subunits that form the active site for the exchange of GDP for GTP. In addition, each ... The Transport Protein Particle (TRAPP) complexes are highly conserved multisubunit complexes that act as nucleotide exchange ... TRAPP complex has distinct large subunits that determine the specificity of each complex towards its substrate Rab and are ...

rab GTP-Binding Proteins 96% * Bacterial Infections 61% * Catfishes 31% * Genes 26% ... Analysis of 52 Rab GTPases from channel catfish and their involvement in immune responses after bacterial infections. ... Dive into the research topics of Analysis of 52 Rab GTPases from channel catfish and their involvement in immune responses ...

The Rab family of small GTP-binding proteins has long been implicated in the docking and fusion of transport vesicles with ... GDP-Bound Rab21 GTPase. 1z0j. Structure of GTP-Bound Rab22Q64L GTPase in complex with the minimal Rab binding domain of ... Structure of GTP-Bound Rab4Q67L GTPase in complex with the central Rab binding domain of Rabenosyn-5. ... Crystal structure of GTP-bound Rab11 in complex with FIP3. 2iey. Crystal Structure of mouse Rab27b bound to GDP in hexagonal ...

Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form. This gene ... However, the encoded protein does not appear to be a catalytically active phosphatase because it lacks several amino acids in ... This protein contains a Guanine nucleotide exchange factor (GEF) domain which is necessary for its role in growth and ... The pocket is however sufficiently preserved to bind phosphorylated substrates, and maybe protect them from phosphatases. ...

Protein, rab GTP-Binding Rab GTPase rab G Proteins rab G-Proteins rab GTP Binding Protein rab GTP Binding Proteins rab GTP- ... rab GTP-Binding. Rab GTPase. rab G Proteins. rab G-Proteins. rab GTP Binding Protein. rab GTP Binding Proteins. rab GTP-Binding ... rab GTP-Binding Proteins Entry term(s). G-Proteins, rab GTP-Binding Protein, rab GTP-Binding Proteins, rab GTPase, Rab GTPases ... Protéines G rab Entry term(s):. G-Proteins, rab. GTP-Binding Protein, rab. GTP-Binding Proteins, rab. GTPase, Rab. GTPases, rab ...

rab GTP-Binding Proteins Medicine & Life Sciences 31% * trans-Golgi Network Medicine & Life Sciences 29% ... LRRK2 phosphorylates a group of Rab GTPase proteins, including Rab10 and Rab12, within the effector-binding switch-II motif. ... LRRK2 phosphorylates a group of Rab GTPase proteins, including Rab10 and Rab12, within the effector-binding switch-II motif. ... LRRK2 phosphorylates a group of Rab GTPase proteins, including Rab10 and Rab12, within the effector-binding switch-II motif. ...

protein kinase C zeta 75% * rab GTP-Binding Proteins 14% * rab4 GTP-Binding Proteins 20% ...

rab GTP-Binding Proteins 100% * Megalencephaly 95% * Heterozygote 72% * Phenotype 40% * Guanine 40% ... On the dependent recognition of some long zinc finger proteins. Zuo, Z., Billings, T., Walker, M., Petkov, P. M., Fordyce, P. M ... The structure of NAD+ consuming protein Acinetobacter baumannii TIR domain shows unique kinetics and conformations. Klontz, E ...

rab GTP-Binding Proteins 100% * Lipid Droplets 80% * Lipid Metabolism 65% * Ethanol 57% ... A Panel of Protein Kinase Chemosensors Distinguishes Different Types of Fatty Liver Disease. Beck, J. R., Cabral, F., Rasineni ... Ethanol Exposure to Ethanol-Oxidizing HEPG2 Cells Induces Intracellular Protein Aggregation. Thomes, P. G., Rensch, G., Casey, ... Rab GTPases Associate with Isolated Lipid Droplets (LDs) and Show Altered Content After Ethanol Administration: Potential Role ...

rab GTP-Binding Proteins 100% * Monomeric GTP-Binding Proteins 79% * Membranes 40% ... Targeting of Rab GTPases to cellular membranes. Ali, B. R. & Seabra, M. C., Aug 2005, In: Biochemical Society Transactions. 33 ... Membrane targeting of Rab GTPases is influenced by the prenylation motif. Gomes, A. Q., Ali, B. R., Ramalho, J. S., Godfrey, R ... Multiple regions contribute to membrane targeting of Rab GTPases. Ali, B. R., Wasmeier, C., Lamoreux, L., Strom, M. & Seabra, M ...

As a member of the Ras superfamily, Rab proteins are small GTP-binding proteins. In the process of endocytosis of ... Humans , Cell Movement , Endocytosis , Neurodegenerative Diseases , Protein Transport , rab GTP-Binding Proteins/metabolism ... The component-target network and protein-protein interaction （PPI） network were constructed. Furthermore， amyloid β-protein （Aβ ... This review focuses on the main functions of Rab proteins and their possible roles in the onset and progression of ...

Rab family GTPase; GTP-binding protein of the rab.... 0.05. OF. Functional Annotation. *GO ... Description : small GTP-binding protein domain;Ras family. Gene families : OG_03_0001310 (OF) Phylogenetic Tree(s): OG0001310_ ...

GTP-bound Rab proteins support vesicle trafficking. Here, we report that, unlike cellular protein cargos, retromer-mediated ... Protein-protein interaction (PPI) network analysis of STAT3 with other host transcription factors that bind LCR, highlighted ... It is observed that MiR2911 directly binds to E6 and E7 oncogenes of HPV16/18, leading to the suppression of their protein ... into the retrograde transport pathway during virus entry is inhibited by Rab9a in its GTP-bound form. Knockdown of Rab9a ...

A genetically related subfamily of RAB GTP-BINDING PROTEINS involved in transport from the cell membrane to early endosomes. ... "rab5 GTP-Binding Proteins" by people in this website by year, and whether "rab5 GTP-Binding Proteins" was a major or minor ... "rab5 GTP-Binding Proteins" is a descriptor in the National Library of Medicines controlled vocabulary thesaurus, MeSH (Medical ... rab5 GTP-Binding Proteins*rab5 GTP-Binding Proteins. *GTP-Binding Proteins, rab5 ...

GTPase activating proteins (GAPs) interact with GTP-bound Rab and accelerate the hydrolysis of GTP to GDP. Guanine nucleotide ... In Dictyostelium, GTP-bound Rab21, together with two novel LIM domain proteins, LimF and ChLim, has been shown to regulate ... Lipid binding is essential for membrane attachment, a key feature of most Rab proteins. Due to the presence of truncated ... Range on the Protein: Protein ID Protein Position. P62070. NP_001655. NP_067075. NP_114152. NP_001036000. P49703. P51159. NP_ ...

GTPase activating proteins (GAPs) interact with GTP-bound Rab and accelerate the hydrolysis of GTP to GDP. Guanine nucleotide ... Lipid binding is essential for membrane attachment, a key feature of most Rab proteins.. ... Range on the Protein: Protein ID Protein Position. P84095. NP_001655. NP_067075. P51159. NP_065120. Q6IQ22. Q9UNT1. Q9NP72. ... interact with GDP-bound Rabs to promote the formation of the GTP-bound state. Rabs are further regulated by guanine nucleotide ...