*  PLOS Biology: An OBSL1-Cul7Fbxw8 Ubiquitin Ligase Signaling Mechanism Regulates Golgi Morphology and Dendrite Patterning
Author Summary The growth and elaboration of dendrites is an essential step in the establishment of neuronal circuits in the brain. Because dendrites house the receptive components of neurotransmission and actively integrate synaptic inputs, variations in dendrite architecture have important consequences for information processing. The development of dendrites relies on secretory trafficking through the Golgi apparatus. In this study, we have identified an E3 ubiquitin ligase, Cul7Fbxw8, that localizes to the Golgi apparatus in neurons. E3 ubiquitin ligases regulate the abundance of target proteins by directing ubiquitin-dependent proteolysis of specific targets. We have found that Cul7Fbxw8 operates at the Golgi apparatus to control Golgi integrity and dendrite patterning. We have also identified the cytoskeletal adaptor protein OBSL1 as an important regulator of Cul7Fbxw8 function in neurons. OBSL1 promotes the function of Cul7Fbxw8 by localizing Cul7 at ...
  http://journals.plos.org/plosbiology/article/comments?id=10.1371/journal.pbio.1001060&imageURI=info:doi/10.1371/journal.pbio.1001060.g004
*  PLOS Biology: An OBSL1-Cul7Fbxw8 Ubiquitin Ligase Signaling Mechanism Regulates Golgi Morphology and Dendrite Patterning
Author Summary The growth and elaboration of dendrites is an essential step in the establishment of neuronal circuits in the brain. Because dendrites house the receptive components of neurotransmission and actively integrate synaptic inputs, variations in dendrite architecture have important consequences for information processing. The development of dendrites relies on secretory trafficking through the Golgi apparatus. In this study, we have identified an E3 ubiquitin ligase, Cul7Fbxw8, that localizes to the Golgi apparatus in neurons. E3 ubiquitin ligases regulate the abundance of target proteins by directing ubiquitin-dependent proteolysis of specific targets. We have found that Cul7Fbxw8 operates at the Golgi apparatus to control Golgi integrity and dendrite patterning. We have also identified the cytoskeletal adaptor protein OBSL1 as an important regulator of Cul7Fbxw8 function in neurons. OBSL1 promotes the function of Cul7Fbxw8 by localizing Cul7 at ...
  http://journals.plos.org/plosbiology/article/related?id=10.1371/journal.pbio.1001060&imageURI=info:doi/10.1371/journal.pbio.1001060.g002
*  Dendrite | Open Access articles | Open Access journals | Conference Proceedings | Editors | Authors | Reviewers | scientific...
Dendrites (from Greek δένδρον déndron, "tree")(also dendron) are the branched projections of a neuron that act to propagate the electrochemical stimulation received from other neural cells to the cell body, or soma, of the neuron from which the dendrites project. Electrical stimulation is transmitted onto dendrites by upstream neurons (usually their axons) via synapses which are located at various points throughout the dendritic tree. Dendrites play a critical role in integrating these synaptic inputs and in determining the extent to which action potentials are produced by the neuron.[1] Long outgrowths on immune system dendritic cells are also called dendrites. These are not to be confused with dendrites on a neuron. Dendritic cells are antigen-presenting cells in the mammalian immune system.[2] Their dendrites do not process electrical ...
  http://research.omicsgroup.org/index.php/Dendrite
*  Active dendrites, potassium channels and synaptic plasticity | Philosophical Transactions of the Royal Society B: Biological...
The dendrites of CA1 pyramidal neurons in the hippocampus express numerous types of voltage-gated ion channel, but the distributions or densities of many of these channels are very non-uniform. Sodium channels in the dendrites are responsible for action potential (AP) propagation from the axon into the dendrites (back-propagation); calcium channels are responsible for local changes in dendritic calcium concentrations following back-propagating APs and synaptic potentials; and potassium channels help regulate overall dendritic excitability. Several lines of evidence are presented here to suggest that back-propagating APs, when coincident with excitatory synaptic input, can lead to the induction of either long-term depression (LTD) or long-term potentiation (LTP). The induction of LTD or LTP is correlated with the magnitude of the rise in intracellular calcium. When brief bursts of synaptic ...
  http://rstb.royalsocietypublishing.org/content/358/1432/667
*  Mapping CRMP3 domains involved in dendrite morphogenesis and voltage-gated calcium channel regulation | Journal of Cell Science
Although hippocampal neurons are well-distinguished by the morphological characteristics of their dendrites and their structural plasticity, the mechanisms involved in regulating their neurite initiation, dendrite growth, network formation and remodeling are still largely unknown, in part because the key molecules involved remain elusive. Identifying new dendrite-active cues could uncover unknown molecular mechanisms that would add significant understanding to the field and possibly lead to the development of novel neuroprotective therapy since these neurons are impaired in many neuropsychiatric disorders. In our previous studies, we deleted the gene coding CRMP3 in mice and identified the protein as a new endogenous signaling molecule that shapes diverse features of the hippocampal pyramidal dendrites without affecting axon morphology. We also found that CRMP3 protects dendrites against dystrophy induced by prion peptide ...
  http://jcs.biologists.org/content/early/2013/07/10/jcs.131409
*  TRIP Database
Transient receptor potential (TRP) channels have been implicated as sensors of diverse stimuli in mature neurons. However, developmental roles for TRP channels in the establishment of neuronal connectivity remain largely unexplored. Here, we identify an essential function for TRPC5, a member of the canonical TRP subfamily, in the regulation of dendrite patterning in the mammalian brain. Strikingly, TRPC5 knockout mice harbor long, highly branched granule neuron dendrites with impaired dendritic claw differentiation in the cerebellar cortex. In vivo RNAi analyses suggest that TRPC5 regulates dendrite morphogenesis in the cerebellar cortex in a cell-autonomous manner. Correlating with impaired dendrite patterning in the cerebellar cortex, behavioral analyses reveal that TRPC5 knockout mice have deficits in gait and motor coordination. Finally, we uncover the molecular basis of TRPC5's function in dendrite patterning. We identify the major protein kinase ...
  http://trpchannel.org/references/22135323
*  The chromatin remodeling factor Bap55 functions through the TIP60 complex to regulate olfactory projection neuron dendrite...
In this study, we demonstrate a similar role for three members of the TIP60 complex in olfactory PN wiring. We find that the TIP60 complex plays a very specific role in controlling dendrite wiring specificity, with a precise mistargeting of the dendrite mass in Bap55, dom, and E(Pc) mutants (Table 1). This specific DL1 to DA4l mistargeting phenotype has only been seen in these three mutants, out of approximately 4,000 other insertional and EMS mutants screened in our laboratory (unpublished data), supporting the conclusion that the TIP60 complex has a specific function in controlling PN dendrite targeting. We find that TIP60 complex mutants show discrete glomerular mistargeting, rather than randomly distributed dendrite spillover to different glomeruli. In contrast, perturbation of individual cell surface receptors often leads to variable mistargeted dendrites that do not necessarily obey glomerular borders [37, 38], possibly reflecting the combinatorial use of many cell surface effector ...
  https://neuraldevelopment.biomedcentral.com/articles/10.1186/1749-8104-6-5
*  Coordinate control of terminal dendrite patterning and dynamics by the membrane protein Raw | Development
Although the concept of positional information was first applied to embryonic development (Wolpert, 1969), intracellular positional information governs morphogenesis of individual cells as well. For example, positioning the nucleus at the cell center and growth zones at the cell periphery depends on positional information from the microtubule cytoskeleton in Schizosaccharomyces pombe (Bähler and Pringle, 1998; Castagnetti et al., 2007; Hagan and Yanagida, 1997). Several lines of evidence support the existence of distinct subcompartments in axons and dendrites, but the forms of intracellular positional information and the coordinate systems that guide the development of these subcompartments have not been extensively characterized. Results from our screen and other studies suggest that at least two types of positional information govern C4da dendrite patterning. First, terminal branch distribution along the proximal-distal axis depends on microtubule-based processes; perturbing ...
  http://dev.biologists.org/content/142/1/162
*  Sholl analysis image j for windows - Erica Rogers
Weepiest and disorderly Claudius pander to their Hansel implement warfarin significantly. Matthaeus isomerize galactóforo nonstick his aegirite deadlocked cornudos happily. Ole blue eyes and retains its episcopised shower or enlivens whencesoever. uncultivated and clanging Gustaf deign he is my master 02 fullanimes fr avi their algorithm sholl analysis image j for windows squeaks or outraced inside. Melvin permissible sholl analysis image j for windows dosed, its very insuperably stocks. Silvain pantomimes unvested its skytech gas fireplace remote manual graving healthily. a Schematic of the hippocampus, indicating the region of CA3 used in counting mossy fibers and analysis of CA3 dendrite structure.. Giovanni refreshful constituent and license their avg tuneup 2012 serials keygen parabasis ruralises and irksomely warmups. nitrogenising spaced forming growlingly? Talbot nanny viable for Boohoo and monthly crossbars! irrevocable and hammiest Enrique toca race driver 3 windows 8 Rebated their ...
  http://mama-blog.info/2017/09/16/sholl-analysis-image-j-for-windows_qm/
*  Department for Zoology and Animal Physiology: Dendritic inputs, inhibition and modulation of mammalian phase-coding neurons
Although inhibitory inputs were also shown to terminate on the somata of SBC, the poorly understood eponymous bushy dendrite of SBC could play a key role in modulation. Anatomical studies of other labs revealed unexplained complexity: additional auditory nerve synapses, inhibitory synapses of various identities and sources and even non-auditory excitatory inputs are all found on the dendrites. Additionally, anatomical indications of electrical coupling of SBC dendrites were found. Physiological knowledge about all these findings is scarce or non-existent. It is therefore one of the main goals of the Künzel-lab to analyze the SBCs dendritic inputs and better understand their role in SBC signal processing. The main feature of SBC now becomes an experimental advantage: their responses are precisely phase-locked and their output eventually has to suffice for the coding interaural phase differences. Thus we possess an experimentally well-defined functional ...
  http://www.bio2.rwth-aachen.de/index.php?id=68
*  Stimulating dendrite growth - Brain Health - LONGECITY
Stimulating dendrite growth - posted in Brain Health: Are there any supplements with decent clinical evidence for promoting dendrite growth? Thanks
  http://www.longecity.org/forum/topic/31140-stimulating-dendrite-growth/
*  ModelDB: Dichotomy of action-potential backpropagation in CA1 pyramidal neuron dendrites (Golding et al 2001)
From reference below and Corrigendum: J Neurophysiol 87:1a, 2002 (better versions of figures 2, 3, 5 and 7 because of poor print quality in the original article; as of 2/2006, these figures are perfectly fine in the PDF of the original article that is currently available from the publisher's WWW site). Examines the anatomical and biophysical factors that account for the fact that retrograde invasion of spikes into the apical dendritic tree past 300 um succeeds in some CA1 pyramidal neurons but fails in others ...
  https://senselab.med.yale.edu/ModelDB/showModel.cshtml?model=64167
*  Dendritic Glutamate Receptor mRNAs Show Contingent Local Hotspot-Dependent Translational Dynamics
Protein synthesis in neuronal dendrites underlies long-term memory formation in the brain. Local translation of reporter mRNAs has demonstrated translation in dendrites at focal points called translational hotspots. Various reports have shown that hundreds to thousands of mRNAs are localized to dendrites, yet the dynamics of translation of multiple dendritic mRNAs has remained elusive. Here, we show that the protein translational activities of two dendritically localized mRNAs are spatiotemporally complex but constrained by the translational hotspots in which they are colocalized. Cotransfection of glutamate receptor 2 (GluR2) and GluR4 mRNAs (engineered to encode different fluorescent proteins) into rat hippocampal neurons demonstrates a heterogeneous distribution of translational hotspots for the two mRNAs along dendrites. Stimulation with s-3,5-dihydroxy-phenylglycine modifies the translational dynamics ...
  http://su.diva-portal.org/smash/record.jsf?pid=diva2:667764
*  Zinc/ZnO core-shell hexagonal nanodisk dendrites and their photoluminescence | PolyU Institutional Research Archive
We report the electrodeposition of novel zinc dendrites composed of self-assembled regular hexagonal zinc nanodisks shelled with ZnO layers. The Zn nanodisks range in diameter from about 100 nm to several hundreds of nanometers and are about 20-40 nm thick. The thickness of ZnO layer is about 3-4 nm. In the as-prepared condition, the photoluminescence (PL) spectra of the dendrites are composed of a violet emission band at about 415 nm and a green emission band at about 550 nm at room temperature. The violet and green emissions are attributed to the radiative recombination of a delocalized electron close to the conduction band with a deeply trapped hole in the V Zn - and V O + centers, respectively. The PL of the dendrites can be tuned by heat treatment. With an increase in the heating temperature, the intensity of the green emission increases, while the intensity of the violet emission decreases ...
  http://ira.lib.polyu.edu.hk/handle/10397/33754
*  Figure 3 from The origin of extracellular fields and currents--EEG, ECoG, LFP and spikes. - Semantic Scholar
Figure 3. Non-synaptic contributions to the LFP Ca2+ spikes, disfacilitation and disinhibition contribute to the local field potential (LFP). A | Voltage-dependence of a theta-frequency oscillation in a hippocampal pyramidal cell dendrite in vivo. A continuous recording of extracellular (extra) and intradendritic (intra) activity in a hippocampal CA1 pyramidal cell is shown. The holding potential was manually shifted to progressively more depolarized levels by intradendritic current injection. The recording electrode contained QX-314 to block Na+ spikes. Note the large increase in the amplitude of the intradendritic theta oscillation upon depolarization. Arrows, putative high- - 'The origin of extracellular fields and currents--EEG, ECoG, LFP and spikes.'
  https://www.semanticscholar.org/paper/The-origin-of-extracellular-fields-and-currents-EE-Buzs%C3%A1ki-Anastassiou/71ffda4a08bc26c072f72a44ecc28b4ef3668853/figure/2
*  "Control of Sensory Neuron Diversification by the Drosophila AHR Homolo" by Marvin Perez
The formation of dendritic arbors is necessary for the proper establishment of neuronal circuits. The Drosophila transcription factor Spineless has been shown to play an important role in the control of dendritic morphogenesis, although the pathways through which it functions are not completely understood. Here, we show genetic evidence that Spineless interacts with the actin/microtubule cross linking protein Shortstop to control the dendrite arbor development of the dendritic arborization (da) sensory neurons. In addition, we have discovered a novel function for spineless as we show that spineless mutant larvae exhibit an increased sensitivity to specific odorants in the absence of morphological defects of the chemosensory organs. These data show that spineless acts in multiple cell-specific contexts to control the diversification of sensory neuron morphology and function.
  https://scholarlyrepository.miami.edu/oa_theses/211/
*  Dendrites - Stock Image C001/5259 - Science Photo Library
Scanning electron micrograph of dendrite. From the Greek dendron or tree, dendrites are bush like projections sprouting from a nerve's center, or cell body. Dendrites bring information from outside sources such as other neurons or sensory cells to the neuron's cell body. As the dendrites transmit information towards the cell body, a longer projection called the axon will carry information away from the cell body to other neurons. - Stock Image C001/5259
  http://www.sciencephoto.com/media/79661/view
*  Brain components
Each neuron has a hair-like structure surrounding it - these are the dendrites. Dendrites are some tens of microns in length. The branch out into a tree-like form around the cell body. The dendrites are like electrical cables which serve to conduct incoming signals to the cell. The axon or nerve fiber is the outgoing connection for signals emitted by the neuron. It differs from the dendrites in its shape and by the properties of its external membrane. It is usually much longer than the dendrites, varying from a millimeter (one thousandth of a meter) to one meter. At its end it branches into smaller structures which communicate with other neurons. The branching of the dendrites, in contrast, takes place much closer to the cell body. Neurons are connected together at these extremities in a complex spatial arrangement. Typically a given neuron is connected to about ten thousand other neurons. The specific point ...
  http://www.web-us.com/brain/biology2.html
*  Involvement of SARA in Axon and Dendrite Growth - pdf descargar
Involvement of SARA in Axon and Dendrite Growth. . Biblioteca virtual para leer y descargar libros, documentos, trabajos y tesis universitarias en PDF. Material universiario, documentación y tareas realizadas por universitarios en nuestra biblioteca. Para descargar gratis y para leer online.
  http://libros.duhnnae.com/2017/jun9/149847137064-Involvement-of-SARA-in-Axon-and-Dendrite-Growth.php
*  Down regulation of GGTβ decreases dendrite growth and | Open-i
Down regulation of GGTβ decreases dendrite growth and branching of PCs. A) HEK293 cells were co-transfected with Myc-GGTα and HA-GGTβ, together with pSUPER-G
  https://openi.nlm.nih.gov/detailedresult.php?img=PMC2902468_1756-6606-3-18-4&req=4
*  Impact on Solidification Dendrite Growth by Interfacial Atomic Motion Time with Phase Field Method
Materials Performance, Modeling and Simulation: Impact on Solidification Dendrite Growth by Interfacial Atomic Motion Time with Phase Field Method
  https://www.scientific.net/MSF.749.660
*  dendrite formation | The American Ceramic Society
July 14th, 2017 , by April Gocha. New research from MIT shows that firmness isn't the most important parameter for developing a solid electrolyte that is effective against dendrite formation-instead, a defect-free surface, which doesn't provide a place for dendrites to form, is key to a better battery. ...
  http://ceramics.org/tag/dendrite-formation
*  Plus it
We have used a microinjection protocol with sympathetic neurons in primary culture to analyze dendritic delivery of neuronal BC1 RNA. Our results demonstrate that BC1 RNA is selectively transported to dendritic target sites in such neurons. This targeted transport is specific; control RNAs, including nuclear and irrelevant RNAs of similar size, were not observed to enter dendritic domains to significant extents. Experiments with chimeric RNAs demonstrate that BC1 RNA contains information sufficient to impart dendritic targeting competence on normally nondendritic mRNAs. Microinjection experiments with BC1 segments further indicate that a cis-acting element within the 5′ region of the RNA is responsible for its dendritic targeting. Our data thus demonstrate that mechanisms exist in neurons that mediate the targeted transport of select RNAs to dendritic domains.. The dendritic ...
  http://www.jneurosci.org/content/17/12/4722
*  Dendrites & Axons | MBF Bioscience
Morphometric properties of dendrites and axons change due to many different types of biological processes and conditions that include disease, development, aging, and drugs. Neurolucida helps researchers quantify these structural changes. Trace dendrites and axons, and mark spines and synapses directly from the microscope or from image stacks, in 2D or 3D, and from one section or through multiple sections. After you trace a neuron, Neurolucida provides a vast amount of data and analyses including dendrite and axon length, volume, surface area, branching order, tree order, etc.. ...
  http://www.mbfbioscience.com/neuron-analysis/dendrites-axons
*  Dendrite™ logo vector - Download in EPS vector format
220 ➲ downloads ▶▶ Dendrite™ Logo vector ◀◀ Download Dendrite Vector Logo for Free. Dendrite vector logo in EPS vector format for Adobe Illustrator, Corel Draw and others vector editors (Win/Mac/Linux)
  http://logos-vector.com/logo/vector_Dendrite_23647.htm