*  WHO | Severe Acute Respiratory Syndrome (SARS) - multi-country outbreak - Update
Disease Outbreak Reported. As of 15 March 2003, reports of over 150 cases of Severe Acute Respiratory Syndrome (SARS), an atypical pneumonia of unknown aetiology, have been received by the World Health Organization (WHO) since 26 February 2003 ( see previous report ). WHO is co-ordinating the international investigation of this outbreak and is working closely with health authorities in the affected countries to provide epidemiological, clinical and logistical support as required.. SARS was first recognised on the 26 February 2003 in Hanoi, Viet Nam. The causative agent has yet to be identified. The main symptoms and signs include high fever (>38 degrees C), cough, shortness of breath or breathing difficulties (see Case definitions for Surveillance of Severe Acute Respiratory Syndrome). A proportion of patients with SARS develop severe pneumonia; some of whom ...
  http://who.int/csr/don/2003_03_16/en/
*  Lirias: Biosafety risk assessment of the severe acute respiratory syndrome (SARS) Coronavirus and containment measures for the...
At the end of 2002, an outbreak of a new viral respiratory illness, called SARS (Severe Acute Respiratory Syndrome virus), occurred in China. The disease spread over Asia, North America, Europe and Africa. In response to the SARS outbreak, the World Health Organization (WHO) coordinated an international collaboratorion that included clinical, epidemiologic, and laboratory investigations, and initiated efforts to control the spread of SARS. As in other countries, Belgium has been decided to establish biosafety guidelines and recommendations with particular emphasis on handling clinical specimens associated with SARS for research, production, and clinical laboratories. Taking into account that there is so far no SARS case reported in Belgium as well as in other countries in the world, and based on a scientific risk assessment related to the contained use of biological agents, the SARS-CoV was classified as a Risk Group 3 ...
  https://lirias.kuleuven.be/handle/123456789/161707
*  Dynamic Profiles of Cytokine/Chemokine in Severe Acute Respiratory Syndrome - Tabular View - ClinicalTrials.gov
Severe acute respiratory syndrome (SARS) is an emerging infectious disease caused by a novel coronavirus (SARS-CoV). The major clinical features of SARS include fever, dyspnea, lymphopenia, and a rapid progression of pulmonary infiltrates on chest radiologic images. The SARS-related deaths have resulted mainly from pulmonary complications, including progressive respiratory failure due to alveolar damage and acute respiratory distress syndrome (ARDS). Pathological changes in SARS suggest that SARS sequelae such as infiltration of PMN in lung tissue, multiple organ dysfunction and ARDS have been associated with cytokines and chemokine dysregulation. Some patients still manifested lung injury at a time when the viral load was falling also supports the immune nature of the lung damage. We ...
  https://clinicaltrials.gov/ct2/show/record/NCT00173459
*  Severe acute respiratory syndrome - Simple English Wikipedia, the free encyclopedia
Severe acute respiratory syndrome (SARS) [1] was an atypical pneumonia.[2] It started in November 2002 in Guangdong Province, in the city of Foshan, of the People's Republic of China. The disease was caused by the SARS coronavirus (SARS CoV), a new coronavirus. It was also a part-time STD, it can be spread through both sexual and casual contact.. SARS was first reported in Asia in February 2003. Over the next few months, the illness spread to more than 24 countries in Asia, North America, South America, and Europe before the SARS global outbreak of 2003 was contained. According to the World Health Organization (WHO), a total of 8098 people worldwide became sick with SARS during the 2003 outbreak; 774 of these died.. After the Chinese government suppressed news of the SARS outbreak, the disease spread rapidly, reaching Hong Kong and Vietnam in late February 2003, and then to other countries via international travellers. The last case in this ...
  https://simple.wikipedia.org/wiki/Severe_acute_respiratory_syndrome
*  Synthesis inEscherichia colicells and characterization of the active exoribonuclease of severe acute respiratory syndrome...
The nsp14 protein, an exoribonuclease of the DEDD superfamily encoded by severe acute respiratory syndrome coronavirus (SARS-CoV), was expressed in fusion with different affinity tags. The recombinant
  https://link.springer.com/article/10.1134%2FS0026893309030091
*  The interferon gamma gene polymorphism +874 A/T is associated with severe acute respiratory syndrome | BMC Infectious Diseases ...
Severe acute respiratory syndrome (SARS) is an infectious disease caused by SARS coronavirus [1] with ,8000 cases and 774 deaths reported in 2003 [2]. Much progress has been made in understanding SARS coronavirus but the pathogenesis is still unclear [3]. It was reported that old age, diabetes mellitus and heart disease were risk factors for adverse prognosis of SARS [4-6], however, little is known about the contribution of genetic factors. We have demonstrated that genetic haplotypes associated with low serum mannose-binding lectin (MBL) were associated with SARS [7] and our findings were recently replicated [8]. Recently, homozygotes for CLEC4M tandem repeats were reported to be less susceptible to SARS in Hong Kong Chinese [9].. Cytokines are known to be important in antiviral action. Interferon (IFN)-γ from T and natural killer (NK) cells is important in driving the T helper cell type 1 (Th1) responses. It also activates monocytes and ...
  https://bmcinfectdis.biomedcentral.com/articles/10.1186/1471-2334-6-82
*  NIOSHTIC-2 Publications Search - 20024103 - Cluster of severe acute respiratory syndrome cases among protected health-care...
Infections among health-care workers (HCWs) have been a common feature of severe acute respiratory syndrome (SARS) since its emergence. The majority of these infections have occurred in locations where infection-control precautions either had not been instituted or had been instituted but were not followed. Recommended infection-control precautions include the use of negative-pressure isolation ro
  https://www.cdc.gov/niosh/nioshtic-2/20024103.html
*  Outbreak of severe acute respiratory syndrome in Singapore and modifications in the anesthesia service [13] | ScholarBank@NUS
Liu, E.H., Koh, K.-F., Chen, F.-G. (2004-06). Outbreak of severe acute respiratory syndrome in Singapore and modifications in the anesthesia service [13]. Anesthesiology 100 (6) : 1629-1630. ScholarBank@NUS Repository ...
  http://scholarbank.nus.edu.sg/handle/10635/132947
*  Outbreak of severe acute respiratory syndrome in Singapore and modifications in the anesthesia service [13] | ScholarBank@NUS
Liu, E.H.,Koh, K.-F.,Chen, F.-G. (2004). Outbreak of severe acute respiratory syndrome in Singapore and modifications in the anesthesia service [13]. Anesthesiology 100 (6) : 1629-1630. ScholarBank@NUS Repository ...
  http://scholarbank.nus.edu.sg/handle/10635/30888
*  Severe Acute Respiratory Syndrome | Aventura Hospital & Medical Center | Aventura, FL
Learn more about Severe Acute Respiratory Syndrome at Aventura Hospital & Medical Center DefinitionCausesRisk FactorsSymptomsDiagnosisTreatmentPreventionrevision ...
  https://aventurahospital.com/hl/?/38008/SARS&com.dotmarketing.htmlpage.language=1
*  Severe Acute Respiratory Syndrome | Good Samaritan Hospital
Learn more about Severe Acute Respiratory Syndrome at Good Samaritan Hospital DefinitionCausesRisk FactorsSymptomsDiagnosisTreatmentPreventionrevision ...
  https://goodsamsanjose.com/hl/?/38008/sp
*  Severe Acute Respiratory Syndrome | JFK Medical Center | Atlantis, FL
Learn more about Severe Acute Respiratory Syndrome at JFK Medical Center DefinitionCausesRisk FactorsSymptomsDiagnosisTreatmentPreventionrevision ...
  https://jfkmc.com/hl/?/38008/
*  Severe Acute Respiratory Syndrome --- Singapore, 2003
Five persons with probable SARS cases have been categorized as super spreaders of SARS. These patients appear to have infected , 10 HCWs, family and social contacts, or visitors to the health-care facilities where the patients were hospitalized. Case 1. A person aged 22 years visited Hong Kong for a shopping trip and resided at Hotel M during February 20--25. On February 25, the visitor developed a fever with a dry cough and, on March 1, was hospitalized on Ward 5A of TTSH with a patchy infiltrate on chest radiograph. The patient's platelet count was 105,000/mm3 (normal: 130,000--150,000/mm3); a white blood count was 3,800/mm3 (normal: 4,000/mm3). On March 4, the patient was transferred to the intensive-care unit (ICU) because of decreased blood oxygen saturation. During March 6--11, the patient was admitted to and remained in isolation on Ward 5A. On March 11, the patient was transferred to Ward 8A. This patient was directly linked to probable SARS infection in 21 persons ...
  https://www.cdc.gov/mmwr/preview/mmwrhtml/mm5218a1.htm
*  北京大学医学部机构知识库(IR@PKUHSC): Use of clinical criteria and molecular diagnosis to more effectively monitor patients recovering after...
Fung, YWW,Lau, LT,Wong, FPF,et al. Use of clinical criteria and molecular diagnosis to more effectively monitor patients recovering after severe acute respiratory syndrome coronavirus infection[J]. CLINICAL INFECTIOUS DISEASES,2004,39(4):604-606 ...
  http://ir.bjmu.edu.cn/handle/400002259/59234
*  Toronto: City Creating 'Perfect Conditions' for TB -- Health Group - TheBody.com
While Toronto recovers from the lingering effects of its Severe Acute Respiratory Syndrome outbreak, health experts are worried the city is poised for an ...
  http://www.thebody.com/content/art28751.html
*  Deliberations and recommendations of the Pediatric Emergency... : Pediatric Critical Care Medicine
Despite difficult challenges during responses to the terrorist attacks of September 11, 2001, Hurricane Katrina, and the 2009 Pandemic Influenza A/H1N1 and severe acute respiratory syndrome outbreaks, no North American emergency to date has overwhelmed intensive care unit (ICU) services on a widespread basis since the modern development of the field of critical care. However, planners have recognized that in a future public health emergency we may not be so fortunate. To deal with very large emergencies involving many patients whose survival depends on immediate access to intensive care, an international Task Force for Mass Critical Care proposed recommendations in January 2007 to extend critical care resources for the adult population, referred to as the Emergency Mass Critical Care (EMCC) approach (1-5).. The EMCC approach triples critical care capabilities for a period of up to 10 days in a very large public health emergency by focusing ...
  http://journals.lww.com/pccmjournal/Fulltext/2011/11001/Deliberations_and_recommendations_of_the_Pediatric.1.aspx
*  NewYork-Presbyterian/Queens - Severe Acute Respiratory Syndrome (SARS)
SARS-CoV spreads from one person to another mainly through close contact with a SARS patient. When a person with SARS coughs or sneezes without covering his or her mouth, respiratory droplets containing living virus can spray up to 3 feet and invade the mucous membranes of another person. Individuals in close contact with someone with SARS are most at risk, which means they live or work with someone with SARS or have direct contact with the a person through kissing, hugging, or sharing eating utensils.. The virus also can spread when an individual touches an object with infectious droplets on it and then touches his or her mouth, nose, or eyes. It is not known whether SARS can spread more broadly through the air.. Research suggests that SARS patients are infectious only when they are experiencing symptoms, such as fever or cough. They are most infectious during their second week of illness. As a precaution, the CDC recommends that SARS patients stay in isolation at home or in the hospital to ...
  http://www.nyhq.org/diw/Content.asp?PageID=DIW007732&language=Korean
*  WHO | Cumulative Number of Reported Probable Cases of SARS
Notes:. Cumulative number of cases includes number of deaths.. As SARS is a diagnosis of exclusion, the status of a reported case may change over time. This means that previously reported cases may be discarded after further investigation and follow-up.. 1. The start of the period of surveillance has been changed to 1 November 2002 to capture cases of atypical pneumonia in China that are now recognized as being cases of SARS.. 2. A decrease in the number of cumulative cases and discrepancies in the difference between cumulative number of cases of the last and the current WHO update are attributed to the discarding of cases.. 3. Includes cases who are "discharged" or "recovered" as reported by the national public health authorities.. 4. The date of onset of the most recent probable SARS case in Canada was 12 June, the last date of isolation of a probable SARS case was also 12 June.. 5. The date of onset of the most recent probable SARS case in China was 3 June 2003. The date of isolation of this ...
  http://www.who.int/csr/sars/country/2003_07_04/en/
*  Severe acute respiratory syndrome - Wikipedia
The SARS epidemic appears to have started in Guangdong Province, China in November 2002 where the first case was reported that same month. The patient, a farmer from Shunde, Foshan, Guangdong, was treated in the First People's Hospital of Foshan. The patient died soon after, and no definite diagnosis was made on his cause of death. Despite taking some action to control it, Chinese government officials did not inform the World Health Organization of the outbreak until February 2003. This lack of openness caused delays in efforts to control the epidemic, resulting in criticism of the People's Republic of China from the international community. China has since officially apologized for early slowness in dealing with the SARS epidemic.[16]. The outbreak first appeared on 27 November 2002, when Canada's Global Public Health Intelligence Network (GPHIN), an electronic warning system that is part of the World Health Organization's Global Outbreak Alert and Response Network (GOARN), picked up reports of ...
  https://en.m.wikipedia.org/wiki/Severe_acute_respiratory_syndrome
*  Severe Acute Respiratory Syndrome (SARS) Spreads Worldwide
this news reminded me a bit different thing. recently Japanese TV reported that there's growing number of pulmonary edema like symptom spreading widely in Japan, caused by spraying anti-rain coating chemical such as ScotchGuard in closed air space like inside of cars or houses. people here often use such chemicals spray on skiwears and shoes before going to ski, then get sudden breathing problem during skiing and then hospitalized. if there's no virus or bacterium found on this SARS case, I'm curious to other type of chemicals in relation. BTW you can even make vapor that causes temporary breathing problems by just burning red pepper in oil. don't try this at home. (I accidentally did while cooking curry. it was horrible.). ...
  https://joi.ito.com/weblog/2003/03/16/severe-acute-re.html
*  U.S. GAO - Severe Acute Respiratory Syndrome: Established Infectious Disease Control Measures Helped Contain Spread, But a...
SARS is a highly contagious respiratory disease that infected more than 8,000 individuals in 29 countries principally throughout Asia, Europe, and North America and led to more than 800 deaths as of July 11, 2003. Due to the speed and volume of international travel and trade, emerging infectious diseases such as SARS are difficult to contain within geographic borders, placing numerous countries and regions at risk with a single outbreak. While SARS did not infect large numbers of individuals in the United States, the possibility that it may reemerge raises concerns about the ability of public health officials and health care workers to prevent the spread of the disease in the United States. GAO was asked to assist the Subcommittee in identifying ways in which the United States can prepare for the possibility of another SARS outbreak. Specifically, GAO was asked to determine 1) infectious disease control measures practiced within health care and community settings that helped contain the ...
  http://www.gao.gov/products/GAO-03-1058T
*  Scientists Identify SARS Receptor - Scientific American
Severe acute respiratory syndrome (SARS) originated in southern China in November 2002, and soon spread to people on six continents, killing nearly 800 people all told. For the first time, researchers have identified a crucial SARS receptor in vivo that helps explain how and why SARS infection causes lung failure. The findings should help researchers treat other diseases that compromise lung function. Previous research using cell lines had identified ACE2, a protein involved in regulating blood pressure, as a potential SARS receptor. Now Josef Penninger of the Institute of Molecular Biotechnology (IMBA) in Vienna, Austria, and his colleagues have tested the hypothesis in mice. In a paper published online yesterday by Nature Medicine, they report that SARS infection, and specifically the SARS protein known as Spike, reduces ACE2 expression. As a result, blood vessels in the lungs become damaged and the lung becomes flooded as a result. In a ...
  https://www.scientificamerican.com/article/scientists-identify-sars/
*  Longer term follow up of aerobic capacity in children affected by severe acute respiratory syndrome (SARS) | Thorax
Studies examining the sequelae of SARS are limited and most have concentrated on the early phases of rehabilitation (1-6 months).3,7,10,20,21 To the best of our knowledge, this is the first study to examine later stage recovery in children and adolescents who contracted the SARS CoV. The main findings of the current study were: (1) impairment of aerobic capacity in asymptomatic children at 6 months which persisted to 15 months after the diagnosis was made; (2) those with residual radiological abnormalities had a significantly greater reduction in aerobic capacity than those with normal HRCT scans at 6 months but this association no longer existed at 15 months; and (3) the reduction in aerobic capacity appears to be related to impaired lung function but is probably also the result of deconditioning following this acute illness.. Studies investigating aerobic capacity following viral infections are sparse and the few reported studies have focused on patients with HIV. Decreased aerobic ...
  http://thorax.bmj.com/content/61/3/240
*  Risk factors for porcine reproductive and respiratory syndrome outbreaks in Vietnamese small stock farms
AIM : To examine risk factors that could have played a role in the 2010 porcine reproductive and respiratory syndrome (PRRS) outbreak in Yenhung district, Quangninh province, North-Vietnam, with the purpose of establishing why existing control measures implemented after previous outbreaks had failed to prevent further outbreaks. METHODS : A case-control study was carried out in Yenhung district. Data were obtained by an interview-based questionnaire survey. The sampling unit was households, which equated to small-scale pig farms. A total of 150 case and 150 control households were selected at communes affected by the 2010 PRRS epidemic during April to June. Risk factors were analysed using binary logistic regression and unconditional multiple logistic regression. RESULTS : Households infected with PRRS were significantly associated with multiple variables belonging to three main groups: (1) location of the farms: i.e. farms positioned ,1,000 m from a pig abattoir or within ...
  https://repository.up.ac.za/handle/2263/40388
*  WHO | Affected Areas - Severe Acute Respiratory Syndrome (SARS)
An affected area: an area in which local chain(s) of transmission of SARS is/are occurring as reported by the national public health authorities.. ...
  http://www.who.int/csr/sarsareas/2003_04_01/en/