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*  C-C chemokine receptor type 7 - Wikipedia
The protein encoded by this gene is a member of the G protein-coupled receptor family. This receptor was identified as a gene ... Two ligands have been identified for this receptor: the chemokines (C-C motif) ligand 19 (CCL19/ELC) and (C-C motif) ligand 21 ... C-C chemokine receptor type 7 is a protein that in humans is encoded by the CCR7 gene. ... identification of a novel chemokine receptor that binds dendritic cell- and T cell-active chemokines including ELC, SLC, and ...
  https://en.wikipedia.org/wiki/C-C_chemokine_receptor_type_7
*  CCRL1 - Wikipedia
"CCR11 is a functional receptor for the monocyte chemoattractant protein family of chemokines". J. Biol. Chem. 275 (13): 9550-6 ... 2006). "The chemokine receptor CCX-CKR mediates effective scavenging of CCL19 in vitro". Eur. J. Immunol. 36 (7): 1904-16. doi: ... The protein encoded by this gene is a member of the G protein-coupled receptor family, and is a receptor for C-C type ... "CCR11 is a functional receptor for the monocyte chemoaattractant protein family of chemokines". The Journal of Biological ...
  https://en.wikipedia.org/wiki/CCRL1
*  SLC Public Library hours [Institute of Museum and Library Services]
The protein encoded by this gene is a member of the G protein-coupled receptor family, and is a receptor for C-C type ... This receptor has been shown to bind dendritic cell- and T cell-activated chemokines including CCL19/ELC, CCL21/SLC, and... ... C-C chemokine receptor type 11 is a protein that in humans is encoded by the CCRL1 gene.. ...
  http://imlswebwise.net/LibraryServices/slc-public-library-hours
*  Notch1-induced T cell leukemia can be potentiated by microenvironmental cues in the spleen | Journal of Hematology & Oncology |...
In vitro transwell experiment further confirmed that MIP-3β recruits T-ALL cells which express a high level of MIP-3β receptor ... By screening a panel of cytokines/chemokines, a higher level of MIP-3β was found in the splenic microenvironment than BM ... MILLIPLEX® MAP Multiplex Immunoassay was performed to measure cytokine/chemokine levels in different microenvironments. ... Macrophage inflammatory protein (MIP)-3β, also known as CCL19, is a CC family chemokine that specifically binds to CC chemokine ...
  https://jhoonline.biomedcentral.com/articles/10.1186/s13045-014-0071-7
*  Chemokine Cooperativity Is Caused by Competitive Glycosaminoglycan Binding | The Journal of Immunology
Chemokines comprise a family of secreted proteins that activate G protein-coupled chemokine receptors and thereby control the ... CXCL13 enhances CCL19-mediated chemotaxis. Next, we used a transwell migration assay to test whether the enhanced receptor ... Furthermore, activated chemokine receptors bind to the scaffolding protein β-arrestin (1-3). Chemokine receptor activation ... Upon ligand binding, chemokine receptors activate G proteins of the Gαi family, leading to inhibition of adenylyl cyclases and ...
  http://www.jimmunol.org/content/192/8/3908
*  CCL19 - Wikipedia
2000). "Cutting edge: identification of a novel chemokine receptor that binds dendritic cell- and T cell-active chemokines ... Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are ... Chemokine (C-C motif) ligand 19 (CCL19) is a protein that in humans is encoded by the CCL19 gene. This gene is one of several ... This chemokine elicits its effects on its target cells by binding to the chemokine receptor chemokine receptor CCR7. It ...
  https://en.wikipedia.org/wiki/CCL19
*  Chemokine C Receptor 7 Expression and Protection of Circulating CD8+ T Lymphocytes from Apoptosis | Clinical Cancer Research
Borner C. The Bcl-2 protein family: sensors and checkpoints for life-or-death decisions. Mol Immunol 2003;39:615-47. ... 4). The protective dose of chemokines (200 ng/mL) was selected after preliminary titrations; higher concentrations of CCL19 or ... The CC chemokine receptor-7 ligands 6Ckine and macrophage inflammatory protein-3β are potent chemoattractants for in vitro- and ... Also, expression levels of apoptosis-related proteins, such as the death receptor, Fas, proapoptotic protein, Bax, or ...
  http://clincancerres.aacrjournals.org/content/11/21/7901
*  Galectin-1-Matured Human Monocyte-Derived Dendritic Cells Have Enhanced Migration through Extracellular Matrix | The Journal of...
CCL19 (MIP-3β), a lymph node homing chemokine for DCs that is the cognate ligand for CCR7, a chemokine receptor highly ... Chemokines and chemokine receptors play crucial roles in targeting DCs both to sites of inflammation and back to the secondary ... Galectin-1 effects can involve both carbohydrate binding as well as protein-protein interactions (19). Although we have shown ... Galectins are a family of highly conserved β-galactoside-binding lectins that function in cell growth regulation, cell-cell ...
  http://www.jimmunol.org/content/177/1/216
*  angiogenesis | High-Throughput Screen for the Chemical Inhibitors
As a member of chemokine receptor family, C-C chemokine receptor type 7 (CCR7) is usually mainly located on the membrane of ... Chemokines mediate their chemical effect on target cells through G-protein-coupled receptors, which are characterized ... and it could induce the homing of dendritic and T cells to the lymph node by binding with its specific ligands CCL19 WZ8040 and ... Chemokines belong to the small molecule chemo-attractive cytokine family and are grouped into CXC chemokines and CC chemokines ...
  http://acancerjourney.info/index.php/tag/angiogenesis/
*  Stimulating Lymphotoxin β Receptor on the Dendritic Cells Is Critical for Their Homeostasis and Expansion | The Journal of...
The ligands of CCR7 include secondary lymphoid tissue chemokine (CCL21) and EBV-induced molecule-1 ligand chemokine (CCL19), ... a receptor expressed by T lymphocytes; TNFSF14) is a TNF family member that also binds to LTβR and two other distinct members ... Coexpression of the chemokines ELC and SLC by T zone stromal cells and deletion of the ELC gene in the plt/plt mouse. Proc. ... Fusion proteins and in vitro proliferation assays. Generation of recombinant LIGHT was described previously (28). Stable- ...
  http://www.jimmunol.org/content/175/10/6997
*  Human CCR7 Stable Cell Line-HEK293T Gαqi5 - Creative Biogene
This receptor was identified as a gene induced by the Epstein-Barr virus (EBV), and ... The protein encoded by this gene is a member of the G protein-coupled receptor family. ... C-C chemokine receptor activity; C-C motif chemokine 19 receptor activity; C-C motif chemokine 21 receptor activity; G-protein ... The protein encoded by this gene is a member of the G protein-coupled receptor family. This receptor was identified as a gene ...
  https://www.creative-biogene.com/Human-CCR7-Stable-Cell-Line-HEK293T-G%CE%B1qi5-CSC-RG1719-1373011-11.html
*  Follicular Homing T Helper (Th) Cells and the Th1/Th2 Paradigm | JEM
1999) In vivo-activated CD4 T cells upregulate CXC chemokine receptor 5 and reprogram their response to lymphoid chemokines. J ... through actions of chemokines such as CCL19 (macrophage inflammatory protein [MIP]-3β). Naive T cell activation is dependent on ... B cell activator belonging to the TNF family (BAFF), a newly identified cytokine for B cell responses (30), is one possibility. ... Th1 cells preferentially express CC chemokine receptor (CCR)5 and CXC chemokine receptor (CXCR)3, and migrate in response to a ...
  http://jem.rupress.org/content/192/11/F31
*  Plus it
Because chemokines are major players in the promotion of inflammation and cellular migration, the chemokine receptor US28 was ... zinc finger protein (FOG-2) gene (Catusse et al., 2008). FOG-2 belongs to the family of FOG proteins that are transcriptional ... U12 from HHV-6 and HHV-7 bind the CC chemokines CCL2, CCL3, CCL4, and CCL5 (Isegawa et al., 1998) and CCL17, CCL19, CCL21, and ... LiuC, Sandford G, Fei G and Nicholas J (2004) Galpha protein selectivity determinant specified by a viral chemokine receptor- ...
  http://molpharm.aspetjournals.org/content/76/4/692
*  CC chemokine receptors - Wikipedia
The orphan chemokine receptor G protein-coupled receptor-2 (GPR-2, CCR10) binds the skin-associated chemokine CCL27 (CTACK/ALP/ ... Its ligands include the related chemokines CCL19 and CCL21, (previously called ELC and SLC). CCR8 is associated with Th2 ... They represent one subfamily of chemokine receptors, a large family of G protein-linked receptors that are known as seven ... The CC chemokine receptors all work by activating the G protein Gi. CCR1 was the first CC chemokine receptor identified and ...
  https://en.wikipedia.org/wiki/CC_chemokine_receptors
*  CCL19 - C-C motif chemokine 19 precursor - Homo sapiens (Human) - CCL19 gene & protein
Binds to chemokine receptor CCR7. Recombinant CCL19 shows potent chemotactic activity for T-cells and B-cells but not for ... Binds to atypical chemokine receptor ACKR4 and mediates the recruitment of beta-arrestin (ARRB1/2) to ACKR4. ... present in a protein.,p>,a href='/help/family_and_domains_section' target='_top'>More...,/a>,/p>Family & Domainsi. ,p>This ... R-HSA-380108 Chemokine receptors bind chemokines. R-HSA-418594 G alpha (i) signalling events. R-HSA-6783783 Interleukin-10 ...
  https://www.uniprot.org/uniprot/Q99731
*  Chemokine - Wikipedia
CCL1 for the ligand 1 of the CC-family of chemokines, and CCR1 for its respective receptor. The CC chemokine (or β-chemokine) ... G proteins are coupled to the C-terminal end of the chemokine receptor to allow intracellular signaling after receptor ... Their homeostatic function in homing is best exemplified by the chemokines CCL19 and CCL21 (expressed within lymph nodes and on ... Chemokines (Greek -kinos, movement) are a family of small cytokines, or signaling proteins secreted by cells. Their name is ...
  https://en.wikipedia.org/wiki/Chemokine
*  Choreography of Cell Motility and Interaction Dynamics Imaged by Two-Photon Microscopy in Lymphoid Organs
... by dissecting the signaling pathway that leads from chemokine to receptor (G protein-coupled receptor, or GPCR) to G protein ... FRCs secrete the chemokines CCL19, CCL21, and CXCL12 and stain most strongly for surface-bound CCL21 in the paracortex (25, 57 ... Haematopoietic cell-specific CDM family protein DOCK2 is essential for lymphocyte migration. Nature. 2001;412:826-31. [PubMed] ... Chemokines and haptokinesis Among the chemokine receptors that couple through pertussis toxin-sensitive Gi proteins, CCR7 has a ...
  http://pubmedcentralcanada.ca/pmcc/articles/PMC2732400/?lang=en-ca
*  Leukotriene B4 receptor 2 - Wikipedia
... two pro-inflammatory chemokines viz., chemokine ligand 9 (also termed chemokine ligand 10) and chemokine 19 (CCL19), and ... Leukotriene B4 receptor 2, also known as BLT2, BLT2 receptor, and BLTR2, is a Integral membrane protein that is encoded by the ... and by another member of the LTB4 family of arachidonic acid metabolites, 20-hydroxy-LTB4; the relative BLT2 receptor-binding ... LTBR1 and LTBR2 encode for proteins with 45% amino acid identity that belong to the G protein-coupled receptor superfamily. The ...
  https://en.wikipedia.org/wiki/Leukotriene_B4_receptor_2
*  JCI - Mycobacterial growth inhibition is associated with trained innate immunity
CXC chemokine receptor 3 alternative splice variants selectively activate different signaling pathways. Mol Pharmacol. 2016;90( ... although these splice variants differ only in the N-terminal part of this 7-transmembrane G protein-coupled receptor, their ... The effect of these chemokines may further depend on the balance in expression of splice variants of CXCR3, since in recently ... Intriguingly, along with CXCL9, CXCL10, and CXCL11, also IL-4, CCL8 (MCP2), CCL11 (eotaxin), CCL17 (TARC), CCL19 (MIP3β), CCL23 ...
  https://www.jci.org/articles/view/97508
*  Cancers | Free Full-Text | Loss of STAT3 in Lymphoma Relaxes NK Cell-Mediated Tumor Surveillance | HTML
... upon loss of STAT3 was accompanied by reduced NK cell infiltration and decreased levels of the cytokine IFN-γ and the chemokine ... Attraction of NK cells is mediated by chemokines, such as CCL5 (or RANTES, binding CCR5), CCL19 and CCL21 (binding CCR7), ... protein suppresses adenoma-to-carcinoma transition in Apcmin/+ mice via regulation of Snail-1 (SNAI) protein stability. J. Biol ... Receptor-receptor interactions between NK and target cells induce cytotoxicity that is either delivered through exocytosis of ...
  http://www.mdpi.com/2072-6694/6/1/193/htm
*  Chemokine‐guided cell migration and motility in zebrafish development | The EMBO Journal
This migration depends on the chemokines CCL19 and CCL21, which activate the receptor CCR7 on DCs. CCL21 gradient formation ... secreted protein ligands that bind to their cognate chemokine receptors to elicit cellular responses. The chemokine family is ... The recent sequence analysis of the zebrafish genome provided a comprehensive list of chemokine and chemokine receptor family ... Figure 1. Human and zebrafish chemokine and chemokine receptor genes. Chemokine genes are listed according to their subgroup ( ...
  http://emboj.embopress.org/content/early/2015/03/11/embj.201490105
*  Neuro-Immune Crosstalk in CNS Diseases | SpringerLink
Tsai HH, Frost E, To V, Robinson S, Ffrench-Constant C, Geertman R, Ransohoff RM, Miller RH (2002) The chemokine receptor CXCR2 ... Alt C, Laschinger M, Engelhardt B (2002) Functional expression of the lymphoid chemokines CCL19 (ELC) and CCL 21 (SLC) at the ... Cho J, Gruol DL (2008) The chemokines CCL2 activates p38 mitogen-activated protein kinase pathway in cultured rat hippocampal ... Airaksinen MS, Saarma M (2002) The GDNF family: signalling, biological functions and therapeutic value. Nat Rev Neurosci 3:383- ...
  https://link.springer.com/chapter/10.1007%2F400_2009_6
*  Recent insights into the immunopathogenesis of psoriasis provide new therapeutic opportunities
Besides these mediators, consideration of high-mobility group B1 (HMGB1) protein binding to its receptor, receptor for advanced ... numerous chemokines and chemokine receptors are present in psoriatic plaques. When chemokines bind to their respective ... 2), which is likely to involve CD28 and B7 family members including B7.1 (CD80) and B7.2 (CD86) based on in vitro and in vivo ... CCL19), and CCR6. In addition, nitric oxide is present, which may contribute to an angiogenic tissue reaction, accompanied by ...
  http://pubmedcentralcanada.ca/pmcc/articles/PMC420513/?lang=en-ca
*  Regulation of the bioavailability of CCR7 ligands - Enlighten: Theses
CCRL1, a member of the atypical chemokine receptor family, binds to CCL19, CCL21 and CCL25 and is proposed to be a scavenger of ... After their secretion, chemokines can be controlled by proteases and interactions with atypical chemokine receptors that ... If this form of CCL21 is more diffusible than the full-length protein, then it might be more available for regulation by CCRL1 ... The coordinated migration of cells into and within tissues is mediated by chemokines, a family of small chemotactic cytokines ...
  http://theses.gla.ac.uk/5904/
*  Transcriptome Analysis Reveals Human Cytomegalovirus Reprograms Monocyte Differentiation toward an M1 Macrophage | The Journal...
Chemokine (C-C motif) receptor 7. CCR7. 1097_s_at. 3.0. Interleukin 2 receptor, gamma (severe combined immunodeficiency). IL2RG ... Purine-rich element binding protein A. PURA. 35221_at. −1.5. Protein tyrosine phosphatase, receptor type, C. PTPRC. 40520_g_at ... Cell-free culture supernatants from multiple donors were assayed for 37 different chemokines by using a RayBio human chemokine ... Solute carrier family 7 (cationic amino acid transporter, y+ system), member 5. SLC7A5. 32186_at. 1.6. ...
  http://www.jimmunol.org/content/181/1/698/tab-figures-data