Protocols and Video Articles Authored by Adrian W. Moore (Translated to Russian)
Prdm Proto-oncogene Transcription Factor Family Expression and Interaction with the Notch-Hes Pathway in Mouse Neurogenesis ... Hamlet, a Binary Genetic Switch Between Single- and Multiple- Dendrite Neuron Morphology Science (New York, N.Y.). Aug, 2002 , ... These proteins were expressed in the dendritic arborization neurons of the larval peripheral nervous system and their effects ... The fate-determining signals NOTCH and PAX2 act at multiple stages of lineage elaboration and HAMLET acts to modulate their ...https://www.jove.com/author/Adrian+W._Moore?language=Russian
Distinct developmental programs require different levels of Bmp signaling during mouse retinal development | Development
By contrast, the expression of retinal anterior homeobox gene Rx and LIM domain-containing transcription factor gene Lhx2, both ... Analyses of gene and protein expression in coronal sections of embryonic retina at the indicated stages by radioactive in situ ... according to Standardized Genetic Nomenclature for Mice (www.informatics.jax.org/mgihome/nomen/gene.shtml)] was used to ... Vax and Pax2 (Koshiba-Takeuchi et al., 2000). Bmp4 signaling may be subject to negative regulation by the ventrally localized ...http://dev.biologists.org/content/132/5/913
Frontiers | The Long Adventurous Journey of Rhombic Lip Cells in Jawed Vertebrates: A Comparative Developmental Analysis |...
... summarizes vertebrate rhombic lip and early cerebellar development covering classic approaches up to modern developmental ... genetics which identifies the relevant differential gene expression domains and their progeny. Most of this information is ... summarizes vertebrate rhombic lip and early cerebellar development covering classic approaches up to modern developmental ... genetics which identifies the relevant differential gene expression domains and their progeny. Most of this information is ...https://www.frontiersin.org/articles/10.3389/fnana.2011.00027/full
PAX2 is the second member of the nine-member PAX gene family. PAX2's role begins as a developmental gene in late primitive ... The MAFB protein is a basic leucine zipper (bZIP) transcription factor that plays important roles both in development and in ... BLU/ZMYND10 is inactivated in a variety of human tumors due to genetic or epigenetic mechanisms, but the function is largely ... PAX2 (Paired box gene 2) Eccles, Michael (Jean-Loup Huret (Editor-in-Chief), 2015) ...http://documents.irevues.inist.fr/handle/2042/55196/discover?filtertype=subject&filter_relational_operator=equals&filter=Middle+Aged
Frontiers | Transcription factors define the neuroanatomical organization of the medullary reticular formation | Frontiers in...
... are derived from distinct developmental progenitor domains each of which expresses distinct patterns of transcription factors ( ... Within each lineage, distinct patterns of gene expression and organization were localized to specific hindbrain regions. Rostro ... hindbrain nuclei show a highly stereotyped pattern of localization across vertebrates suggesting a strong underlying genetic ... are derived from distinct developmental progenitor domains each of which expresses distinct patterns of transcription factors ( ...https://www.frontiersin.org/articles/10.3389/fnana.2013.00007/full
MKK7 is an essential component of the JNK signal transduction pathway activated by proinflammatory cytokines. Requirement of...
Requirement of the JIP1 scaffold protein for stress-induced JNK activation ... Science & research, Analysis, Genetic aspects, Proteins, Developmental biology, Gene expression, Morphogenesis, Cytokines, ... that JNK initiates cytokine cascade of bone morphogenetic protein-4 and sonic hedgehog which induces transcription factor Pax2 ... The need of the JIP1 scaffold protein for stress-induced c-Jun N-terminal kinase (JNK) activation is discussed. JIP1 is in the ...http://www.readabstracts.com/Biological-sciences/MKK7-is-an-essential-component-of-the-JNK-signal-transduction-pathway-activated-by-proinflammatory-c.html
Protocols and Video Articles Authored by Stefan Britsch (Translated to German)
Thus, our genetic analysis of Bcl11a reveals essential functions of this transcription factor in neuronal morphogenesis and ... the dorsal horn of Bcl11a mutants and identified dysregulated expression of the gene encoding secreted frizzled-related protein ... Developmental Biology. Ex Utero Elektroporation und Organotypischen Kultur der Maus Hippocampus-Gewebe Sathish Venkataramanappa ... Immunohistological analyses revealed that Gbx1 identifies a distinct population of late-born, Lhx1/5(+), Pax2(+) neurons. In ...https://www.jove.com/author/Stefan_Britsch?language=German
Developmental programming of hypertension and kidney disease.
Ret growth factor/receptor pair, transcription factors Six2 and Pax2, or the renin-angiotensin system components are probably ... The major players in epigenetic mechanisms of gene expression regulation are DNA or chromatin protein methylation, acetylation ... is used to designate a fetus that has not reached its growth potential because of genetic or environmental factors. The most ... The BRCT-domain containing protein PTIP links PAX2 to a histone H3, lysine 4 methyltransferase complexDevelopmental CellYear: ...http://www.biomedsearch.com/nih/Developmental-programming-hypertension-kidney-disease/23251800.html
PPT - PY4302 Developmental Neuroscience Eye Development PowerPoint presentation | free to download - id: 2e02a-NTYyO
DNA-binding transcription factors. EYA (eyes absent) Has protein-binding domains that interact with members of the following ... Gene X Gene Y. Gene X Gene Y. Gene X Gene Y. time 51. Pax6 is required for eye development in mice and flies. Pax6/. Pax6/. ... 3 proliferating RPCs with evolving genetic programme. 4 non-proliferating. 32. Transcription factor control of retinal cell ... Pax2. Pax6 20. Proximo-distal specification of the optic vesicle. The part of the optic vesicle in contact with the head ...https://www.powershow.com/view/2e02a-NTYyO/PY4302_Developmental_Neuroscience_Eye_Development_powerpoint_ppt_presentation?varnishcache=1
Enhancer evolution and animal diversity | Philosophical Transactions of the Royal Society B: Biological Sciences
2012 DNA regions bound at low occupancy by transcription factors do not drive patterned reporter gene expression in Drosophila ... 2004 Genetic and developmental basis of evolutionary pelvic reduction in threespine sticklebacks. Nature 428, 717-723. (doi: ... such that motifs for some factors may be absent and some necessary TF are rather recruited via cooperative protein-protein ... pax2 is expressed in several cell-types, whereas pax8 is expressed only in a subset of pax2-expressing tissues. Despite this ...http://rstb.royalsocietypublishing.org/content/368/1632/20130017
From placode to polarization: new tunes in inner ear development | Development
The transcription factor Pax2 is among the earliest of the `regionalized' genes in the chick inner ear. It is first expressed ... A genetic complementation assay has already demonstrated that Scrb1 (Scrib) the homolog of a tumor suppressor gene involved in ... The transcription factor Eyes absent is a protein tyrosine phosphatase. Nature 426,299 -302. ... Catch up with recent preLights selected for the developmental biology community.. Articles of interest in our sister journals. ...http://dev.biologists.org/content/131/17/4119
Requirement of Lim1 for female reproductive tract development | Development
Lim1 (also known as Lhx1) encodes a transcription factor with a DNA-binding homeodomain and two cysteine-rich LIM domains that ... Pax2+/- mice on a 129/Sv×C3H×C57BL/6J mixed genetic background (Torres et al., 1995), and the X-linked GFP mice (Hadjantonakis ... The Lim1 gene was previously mutated in the mouse and was found to be required for head and kidney formation (Shawlot and ... Chi, N. and Epstein, J. A. (2002). Getting your Pax straight: Pax proteins in development and disease. Trends Genet. 18,41 -47. ...http://dev.biologists.org/content/131/3/539
Mechanisms of impaired nephrogenesis with fetal growth restriction: altered renal transcription and growth factor expression
At this time point, mRNA and protein expression of transcription and growth factors WT1, Pax2, FGF2 (mesenchyme condensation ... Brodbeck S, Englert C. Genetic determination of nephrogenesis: the Pax/Eya/Six gene network. Pediatr Nephrol. 2004;19:249-55. [ ... Developmental programming of health and disease. Proc Nutr Soc. 2006;65:97-105. [PMC free article] [PubMed] ... WNT4 and WNT11, transcription factors that are regulated by Pax2, were decreased in mRNA; 0.2 fold, p=0.04 and 0.5 fold, p=0.01 ...http://pubmedcentralcanada.ca/pmcc/articles/PMC2932650/?lang=en-ca
Zebrafish Pronephros Development | SpringerLink
Bouchard M, Pfeffer P, Busslinger M (2000) Functional equivalence of the transcription factors Pax2 and Pax5 in mouse ... He L, Xu W, Jing Y, Wu M, Song S, Cao Y, Mei C (2015) Yes-associated protein (Yap) is necessary for ciliogenesis and ... Chen YH, Chang CF, Lai YY, Sun CY, Ding YJ, Tsai JN (2015) von Hippel-Lindau gene plays a role during zebrafish pronephros ... Sun Z, Amsterdam A, Pazour GJ, Cole DG, Miller MS, Hopkins N (2004) A genetic screen in zebrafish identifies cilia genes as a ...https://link.springer.com/chapter/10.1007/978-3-319-51436-9_2
HDAC inhibitors in kidney development and disease.
Transcription factors that promote MM induction and survival, such as Eya1, Pax2, WT1, and Emx2, are among the most sensitive, ... Terada Y,Tanaka H,Okado T,Shimamura H,Inoshita S,Kuwahara M,Sasaki S. Expression and function of the developmental gene Wnt-4 ... These enzymes are capable of targeting many non-histone proteins and, in some instances, participating directly in gene ... In a post-damage environment, regenerating proximal tubular epithelial cells proliferate and express genetic markers normally ...http://www.biomedsearch.com/nih/HDAC-inhibitors-in-kidney-development/23052657.html
Protocols and Video Articles Authored by Edwin S. Monuki (Translated to Portuguese)
We report that Lhx2 is required for the expression of transcription factor paired box gene 6, axon guidance molecule Ephrin A5 ... Genetic Ablation of the CDP/Cux Protein C Terminus Results in Hair Cycle Defects and Reduced Male Fertility Molecular and ... Lhx2(-/-) optic vesicles and lens ectoderm upregulate Pax2, Fgf15 and Sox2 in response to BMP treatments, and Lhx2 genetic ... Flash Freezing e Cryosectioning E12.5 cérebro de camundongo D. Spencer Currle1, Edwin S. Monuki1 1Department of Developmental ...https://www.jove.com/author/Edwin+S._Monuki?language=Portuguese
Activation of Wnt/β-catenin signalling affects differentiation of cells arising from the cerebellar ventricular zone.
Development of the cerebellum proceeds under the precise spatio-temporal control of several key developmental signalling ... 0/Adenomatous Polyposis Coli Protein; 0/Biological Markers; 0/SOX9 Transcription Factor; 147336-22-9/Green Fluorescent Proteins ... by examining expression of the transcription factor Pax2. Pax2 is expressed in lineage restricted interneuron progenitors that ... The appropriate reference gene for analysis was identified using a GeNorm reference gene selection kit (PrimerDesign). This ...http://www.biomedsearch.com/nih/Activation-Catenin-Signalling-Affects-Differentiation/22880037.html
Congenital Anomalies of the Kidney and Urinary Tract: A Genetic Disorder?
The journal welcomes submissions related to cell biology, developmental biology, genetics, immunology, pathology, ... Recent studies demonstrate that Pax2, a transcription factor critical for normal kidney development, is an important ... Exome represents protein-coding subset of a genome. Because exons harbor 85% of mutations in single-gene diseases , exome ... "The BRCT-domain containing protein PTIP links PAX2 to a histone H3, lysine 4 methyltransferase complex," Developmental Cell, ...https://www.hindawi.com/journals/ijn/2012/909083/
Identification of Pax2-regulated genes by expression profiling of the mid-hindbrain organizer region | Development
Pax2-dependent regulation of the En2 transcription factor gene. Pax2 also controls the expression of the transcriptional ... The transcription factor Brn1 is a member of the class III POU protein family (Ryan and Rosenfeld, 1997) and has been ... and non-coding Ncrms genes as genetic Pax2 targets that are totally dependent on Pax2 function for their expression in the mid- ... which reflects Pax2 expression at this developmental stage (Fig. 2A). At E9.5, the expression patterns of the putative Pax2- ...http://dev.biologists.org/content/132/11/2633
Dicyema Pax6 and Zic: tool-kit genes in a highly simplified bilaterian | BMC Evolutionary Biology | Full Text
... a cnidarian PaxB gene uniting Pax2 and Pax6 functions. Dev Cell. 2003, 5: 773-785. 10.1016/S1534-5807(03)00325-3.View Article ... and other developmentally critical transcription factors. Our most important finding may be the presence of both genes in the ... Pax6 is a master gene in eye development in both vertebrates and Drosophila. In contrast, Zic family proteins have diverse ... Gehring WJ: The genetic control of eye development and its implications for the evolution of the various eye-types. Int J Dev ...https://bmcevolbiol.biomedcentral.com/articles/10.1186/1471-2148-7-201
Frontiers | Wnt/β-Catenin Regulates the Activity of Epiprofin/Sp6, SHH, FGF, and BMP to Coordinate the Stages of Odontogenesis ...
Bone Morphogenetic protein 4 (Bmp4) and Dickkopf WNT signaling pathway inhibitor 1 (Dkk-1) were overexpressed in first molars ... Bone Morphogenetic protein 4 (Bmp4) and Dickkopf WNT signaling pathway inhibitor 1 (Dkk-1) were overexpressed in first molars ... Epiprofin/Specificity Protein 6 (Epfn) is a Krüppel-like family (KLF) transcription factor that is critically involved in tooth ... A genetic linkage between a 2-bp insertional mutation of Sp6 gene and the amelogenesis imperfecta phenotype in rats has been ...https://www.frontiersin.org/articles/10.3389/fcell.2016.00025/full
Studying Kidney Disease Using Tissue and Genome Engineering in Human Pluripotent Stem Cells - FullText - Nephron 2018, Vol. 138...
50] combined differentiation of hPSCs and gene editing to systematically study the role of 8 pancreatic transcription factors ... but not Pax2 and Lim1 (LHX1 in humans) . These findings would anticipate that the derivation of OSR1+ WT1+ PAX2- LHX1- ... Howden SE, Gore A, Li Z, Fung H-L, Nisler BS, Nie J, et al: Genetic correction and analysis of induced pluripotent stem cells ... The study uncovers the specific developmental step(s) affected by mutations in these genes and highlights the importance of ...https://www.karger.com/Article/FullText/480710
PAX2-Related Disorder - GeneReviews® - NCBI Bookshelf
PAX2 pathogenic variants have been identified in multiple sporadic and familial cases of nonsyndromic renal disease including ... Iris colobomas have not been reported in any individual with PAX2-related disorder. Ophthalmologic abnormalities may ... a wider range of phenotypes has been recognized in association with pathogenic variants in PAX2. Abnormal renal structure or ... PAX2-related disorder is an autosomal dominant disorder associated with renal and eye abnormalities. The disorder was ...https://www.ncbi.nlm.nih.gov/books/NBK1451/
The Pax gene eyegone facilitates repression of eye development in Tribolium | EvoDevo | Full Text
Taken together, expression and knockdown data suggest that Tribolium eyg serves as a competence factor that facilitates the ... participates in many developmental processes in Drosophila, including the Notch signaling activated postembryonic growth of the ... time point of eyg knockdown nor knocking down components of the Janus kinase/Signal Transducer and Activators of Transcription ... Pax transcription factor family genes constitute an important part of the genetic toolkit that controls the development of the ...https://evodevojournal.biomedcentral.com/articles/10.1186/2041-9139-2-8
Interactive Fly, Drosophila
This report is one of the first demonstrations of correlation between gene expression, binding of transcription factors and ... The BRCT-domain containing protein PTIP links PAX2 to a histone H3, lysine 4 methyltransferase complex. The MLL family of ... Best known as epigenetic repressors of developmental Hox gene transcription, Polycomb complexes alter chromatin structure by ... genetic analysis implicated eed and Bmi1 in parallel pathways, which converge at the level of Hox gene regulation. Whereas EED ...http://www.sdbonline.org/sites/fly/polycomb/histh3-2c.htm