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*  C3B6-Tg(APP695)3Dbo/Mmjax
These mice provide a useful model for studying the underlying mechanism of amyloid deposition, a process implicated in ... mutation and develop amyloid deposits in brain tissue by 18-20 months of age. ... These transgenic mice express the human amyloid precursor protein bearing the Swedish (K670N/M671L) ... Prn, prion protein readthrough transcript, mouse, laboratory. Expressed Gene. APP695, amyloid beta (A4) precursor protein ( ...
  https://www.jax.org/strain/003375
*  anti-Amyloid beta (A4) Precursor Protein-Binding, Family A, Member 3 (APBA3) (AA ...</span...
Murine), Rat (Rattus) Host: Rabbit Clone: Polyclonal Conjugate: Alexa Fluor 555 , Order APBA3 antibody (ABIN1389017). ... Mouse (Murine), Rat (Rattus). Alternatives 37 Human. 16 Mouse (Murine). 16 Rat (Rattus). ... Precursor Protein-Binding, Family B, Member 1 Interacting Protein Antibodies * anti-Amyloid beta (A4) Precursor Protein-Binding ... anti-Amyloid beta Precursor Protein (Cytoplasmic Tail) Binding Protein 2 Antibodies * anti-Amyloid P Component, serum ...
  https://www.antibodies-online.com/antibody/1389017/anti-Amyloid+beta+A4+Precursor+Protein-Binding,+Family+A,+Member+3+APBA3+AA+240-290+antibody+Alexa+Fluor+555/
*  Gene Expression Literature Detail
... Symbol. Name. ID App amyloid beta (A4) precursor protein. MGI:88059 ... of expression patterns between CREB family transcription factor OASIS and proteoglycan core protein genes during murine tooth ... Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc ...
  http://www.informatics.jax.org/gxdlit/key/32267
*  WikiGenes - PLP2 - proteolipid protein 2 (colonic epithelium...
... protein deposition in familial Alzheimer's disease with the mutation in codon 717 of the beta A4 amyloid precursor protein gene ... Identification of the murine coronavirus MP1 cleavage site recognized by papain-like proteinase 2. Kanjanahaluethai, A., ... Distribution of beta/A4 protein and amyloid precursor protein in hereditary cerebral hemorrhage with amyloidosis-Dutch type and ... frozen cortical tissue of HCHWA-D and AD patients to investigate the beta/A4 amyloid protein and the amyloid precursor protein ...
  https://www.wikigenes.org/e/gene/e/5355.html
*  Ceruloplasmin (Ferroxidase) (CP) ELISA Kits
Evidence supports a regulatory role of both proteins (Ceruloplasmin (CP) and beta-amyloid protein precursor (APP (zeige APP ... Two transcript variants, one protein-coding and the other not protein-coding, have been found for this gene. ... Mouse (Murine) Ceruloplasmin (Ferroxidase) (CP) Interaktionspartner * In D-galactosamine-sensitized mice CP+Cu(II) increased ... The protein encoded by this gene is a metalloprotein that binds most of the copper in plasma and is involved in the ...
  https://www.antikoerper-online.de/transition-metal-ion-homeostasis-pathway-58/cp-elisa-kit-749/
*  Protocols and Video Articles Authored by Ian Parker
Generation of Bone Marrow Derived Murine Dendritic Cells for Use in 2-photon Imaging', 'Imaging Effector Memory T cells in the ... Unaltered secretion of beta-amyloid precursor protein in gelatinase A (matrix metalloproteinase 2)-deficient mice. J. Biol. ... and subsequently expressed the myelin proteolipid protein gene, initiating remyelination. These findings indicate that NPCs ... Generation of Bone Marrow Derived Murine Dendritic Cells for Use in 2-photon Imaging Melanie P. Matheu1, Debasish Sen1, Michael ...
  https://www.jove.com/author/Ian_Parker
*  APBB1 - Wikipedia
Amyloid beta A4 precursor protein-binding family B member 1 is a protein that in humans is encoded by the APBB1 gene. The ... the murine Fe65 gene (Apbb1), and the human Fe65-like gene (APBB2): genes encoding phosphotyrosine-binding domain proteins that ... "Regulation of beta-amyloid secretion by FE65, an amyloid protein precursor-binding protein". J. Biol. Chem. 274 (12): 7952-7. ... "Entrez Gene: APBB1 amyloid beta (A4) precursor protein-binding, family B, member 1 (Fe65)". Guénette SY, Chen J, Jondro PD, ...
  https://en.wikipedia.org/wiki/APBB1
*  JoVE | Peer Reviewed Scientific Video Journal - Methods and Protocols
... peptide accumulation and by immunohistochemical staining of amyloid precursor protein, amyloid-? protein, tau, and ... We performed in vivo PET scans with (11)C-PIB, a radiolabeled ligand for amyloid imaging, to detect fibrillary amyloid beta ... Early transcriptional response in murine brain to low-dose X-rays (100 mGy) has been reported, suggesting alterations of ... and 10 cGy led to a marked upregulation of one gene (Chat) and a downregulation of three genes (Apoe, Ctsd, and Il1?), and, at ...
  https://www.jove.com/visualize?author=Yaqun+Fang
*  Method of use of serum amyloid a protein - Patent # 6004936 - PatentGenius
... native serum amyloid A (SAA) and a ligand having SAA properties thereby increasing the affinity of high density lipoprotein ( ... "Murine Tissue Amyloid Protein AA NH.sub.2 -Terminal Sequence Identity with Only One of Two Serum Amyloid Protein (ApoSAA) Gene ... Narindrasorasak et al., 1991, "High Affinity Interactions Between the Alzheimer's beta-Amyloid Precursor Proteins and the ... "Murine Tissue Amyloid Protein AA: NH2-Terminal Sequence Identity With Only One of Two Serum Amyloid Protein (ApoSAA) Gene ...
  http://www.patentgenius.com/patent/6004936.html
*  Down syndrome research - Wikipedia
APP is an Amyloid beta A4 precursor protein. It is suspected to have a major role in cognitive difficulties. Another gene, ETS2 ... December 1996). "Isolation of human and murine homologues of the Drosophila minibrain gene: human homologue maps to 21q22.2 in ... Online Mendelian Inheritance in Man (OMIM) AMYLOID BETA A4 PRECURSOR PROTEIN; APP -104760, gene located at 21q21. Retrieved on ... Down syndrome individuals to develop Alzheimer's pathology is the gene that encodes the precursor of the amyloid protein. ...
  https://en.wikipedia.org/wiki/Down_syndrome_research
*  Docagne F[au] - PubMed - NCBI
Sp1 and Smad transcription factors co-operate to mediate TGF-beta-dependent activation of amyloid-beta precursor protein gene ... Activation of cannabinoid CB2 receptor negatively regulates IL-12p40 production in murine macrophages: role of IL-10 and ERK1/2 ... Transforming growth factor-beta 1 potentiates amyloid-beta generation in astrocytes and in transgenic mice. ... Does transforming growth factor-beta (TGF-beta) act as a neuroprotective agent in cerebral ischemia?]. ...
  https://www.ncbi.nlm.nih.gov/pubmed?cmd=search&term=Docagne+F%5Bau%5D&dispmax=50
*  Amyloid beta antibody | acris-antibodies.com
... encodes a cell surface receptor and transmembrane precursor protein that is cleaved by secretases to form a… ... Amyloid beta precursor protein gene (ABPP) encodes a cell surface receptor and transmembrane precursor protein that is cleaved ... 2. Activation of nuclear factor-kappa B by beta-amyloid peptides and interferon-gamma in murine microglia. (Bonaiuto C; J ... The antibody can detect Beta amyloid ( 1-42 ), Beta amyloid ( 1-28 ), Beta amyloid ( 1-20 ) and Beta amyloid ( 1-17 ).. * ...
  https://www.acris-antibodies.com/target/amyloid-beta-antibody.htm
*  JCI - FGF-2 regulates neurogenesis and degeneration in the dentate gyrus after traumatic brain injury in mice
... amyloid beta deposition in transgenic mice overexpressing both Alzheimer mutant presenilin 1 and amyloid beta precursor protein ... FGF-2 gene transfer increases FGF-2 protein in mouse hippocampus after TBI. We next examined the effect of overexpressed FGF-2 ... Genetic approaches to neurotrauma research: opportunities and potential pitfalls of murine models. Exp. Neurol. 1999. 157:19-42 ... Regulation of basic fibroblast growth factor (bFGF) gene and protein expression following its release from sublethally injured ...
  https://www.jci.org/articles/view/16618
*  Expression profiles for macrophage alternative activation genes in AD and in mouse models of AD | Journal of Neuroinflammation ...
... of the amyloid precursor protein (APP). Numerous studies have shown that the immune cells in the vicinity of amyloid deposits ... in AD express mRNA and proteins for pro-inflammatory cytokines, leading to the hypothesis that microglia demonstrate classical ... Neuritic plaques are fibrous deposits composed of the amyloid beta-peptide fragments (Abeta) ... Walker D, Link J, Lue L, Dalsing-Hernandez J, Boyes B: Gene expression changes by amyloid beta peptide-stimulated human ...
  https://jneuroinflammation.biomedcentral.com/articles/10.1186/1742-2094-3-27
*  APBB2 - Wikipedia
The protein encoded by this gene interacts with the cytoplasmic domains of amyloid beta (A4) precursor protein and amyloid beta ... the murine Fe65 gene (Apbb1), and the human Fe65-like gene (APBB2): genes encoding phosphotyrosine-binding domain proteins that ... Amyloid beta A4 precursor protein-binding family B member 2 is a protein that in humans is encoded by the APBB2 gene. ... "Entrez Gene: APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 (Fe65-like)". Human APBB2 genome location ...
  https://en.wikipedia.org/wiki/APBB2
*  Mitochondrial Medicine for Aging and Neurodegenerative Diseases | SpringerLink
Amyloid beta Alzheimer's disease Amyotrophic lateral sclerosis Amyloid precursor protein Adenosine triphosphate Caloric ... 2004). Gene expression profiles of transcripts in amyloid precursor protein transgenic mice: Up-regulation of mitochondrial ... Mutations in amyloid precursor protein and presenilin-1 genes increase the basal oxidative stress in murine neuronal cells and ... Amyloid precursor protein and amyloid beta-peptide bind to ATP synthase and regulate its activity at the surface of neural ...
  https://link.springer.com/article/10.1007%2Fs12017-008-8044-z
*  WikiGenes - TUBB3 - tubulin, beta 3 class III
IL-1 beta decreases expression of amyloid precursor protein gene in human glioma cells. Yang, F., Jansen, L., Friedrichs, W.E ... Expression of nicotinic acetylcholine receptors on murine alveolar macrophages. Galvis, G., Lips, K.S., Kummer, W. J. Mol. ... In Alzheimer's disease a small fragment of the amyloid protein precursor (APP), called beta 4, is a characteristic component of ... wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary ...
  https://www.wikigenes.org/e/gene/e/10381.html
*  Targeting Platelets in Acute Experimental Stroke | Circulation
Age-related learning deficits in transgenic mice expressing the 751-amino acid isoform of human beta-amyloid precursor protein ... Procedural and strain-related variables significantly affect outcome in a murine model of focal cerebral ischemia. Neurosurgery ... Plasminogen activator inhibitor-1 gene-deficient mice, II: effects on hemostasis, thrombosis, and thrombolysis. J Clin Invest. ... and the preparations were then applied to an immobilized protein A column, followed by an immobilized protein G column ( ...
  http://circ.ahajournals.org/content/115/17/2323?maxtoshow=&HITS=80&hits=80&RESULTFORMAT=&fulltext=kleinschnitz&searchid=1&FIRSTINDEX=0&sortspec=date&resourcetype=HWCIT
*  Molecular neuropathology of transgenic mouse models of Down syndrome | Springer for Research & Development
For example, transgenic mice containing additional copies of the amyloid precursor protein (APP) gene, have been useful in ... cleaves the amyloid precursor protein at the beta-secretase site. Mol Cell Neurosci 16:609-619PubMedCrossRefGoogle Scholar ... Martinez-Cue C, Baamonde C, Lumbreras MA, Vallina IF, Dierssen M, Florenz J (1999) A murine model for Down syndrome shows ... Down Syndrome Amyloid Precursor Protein Transgenic Mouse Model Basal Forebrain Partial Trisomy These keywords were added by ...
  https://rd.springer.com/chapter/10.1007/978-3-7091-6262-0_24
*  SMART: Secondary literature for WW domain
... embryo cDNA library was screened for proteins that interact with the C-terminus of the human beta-amyloid precursor protein ( ... The message encodes a protein of 735 amino acids that is 95% identical to the rat Fe65 protein. The human Fe65 gene was mapped ... The formins, proteins involved in murine limb and kidney development, contain a proline-rich region that matches consensus ... This mouse protein also interacts with the homologous C-terminal domains of the mouse amyloid precursor-like proteins, APLP1 ...
  http://smart.embl-heidelberg.de/smart/show_secondary.cgi?domain=WW
*  New target for Alzheimer's: APP-C31 - Biomarker Insights
2000) A second cytotoxic proteolytic peptide derived from amyloid beta-protein precursor. Nat. Med. 6, 397-404. 10.1038/74656 ( ... We offer PCR arrays, miRNA analysis or pathway reporters for reliable gene expression and regulation studies. If you're more ... using a murine model, Poksay et al. (2017) showed that a mutation in the cleavage site of APP prevents APP-C31 generation and ... a recent study using a chemical-genetics approach to identify inhibitors of amyloid precursor protein (APP) caspase cleavage, ...
  http://biomarkerinsights.qiagen.com/2017/07/28/dgpcr-new-target-for-alzheimers-app-c31/
*  The central molecular clock is robust in the face of behavioural arrhythmia in a Drosophila model of Alzheimer's disease |...
... which are composed of amyloid beta peptide (Aβ), derived from the proteolytic cleavage of amyloid precursor protein, and ... 1993). Targeted gene expression as a means of altering cell fates and generating dominant phenotypes. Development 118, 401-415. ... As a complement to murine models of AD, we have generated a Drosophila system to study Aβ toxicity. Instead of replicating the ... 1998). Transgenic Drosophila expressing human amyloid precursor protein show γ-secretase activity and a blistered-wing ...
  http://dmm.biologists.org/content/7/4/445?utm_source=DMM&utm_campaign=Nobel2017
*  Produktübersicht anti-BNIP1 Antikörper
... amyloid beta (A4) precursor protein-binding family A member 1 binding protein , amyloid beta (A4) precursor protein-binding, ... BCL2/adenovirus E1B 19 kDa protein-interacting protein 1 , transformation-related gene 8 protein , vesicle transport protein ... Mouse (Murine) BCL2/adenovirus E1B 19kDa Interacting Protein 1 (BNIP1) Interaktionspartner * The genes for the three Necab's, ... amyloid beta (A4) precursor protein-binding, family A, member 2 binding protein , amyloid beta A4 protein-binding family A ...
  https://www.antikoerper-online.de/abstract/BCL2-adenovirus+E1B+19kDa+Interacting+Protein+1+
*  The immunology of traumatic brain injury: a prime target for Alzheimer's disease prevention | Journal of Neuroinflammation |...
amyloid beta. AD: Alzheimer 's disease. APC: antigen-presenting cell. APP: amyloid precursor protein ... induced IL-6 protein and mRNA expression by inhibiting activator protein-1 activation and phosphorylation of JNK in the murine ... and mitogen-associated protein kinase (ERK1/2, p38 and JNK) pathways are involved in modulating inflammatory gene expression. ... A lack of amyloid beta plaques despite persistent accumulation of amyloid beta in axons of long-term survivors of traumatic ...
  https://jneuroinflammation.biomedcentral.com/articles/10.1186/1742-2094-9-185
*  Advanced glycation endproducts: from precursors to RAGE: round and round we go | SpringerLink
Sturchler E, Galichet A, Weibel M, Leclerc E, Heizmann CW (2008) Site specific blockade of RAGE Vd prevents amyloid beta ... Leclerc E, Fritz G, Veter SW, Heizmann CW (2009) Binding of S100 proteins to RAGE: an update. Biochim Biophys Acta 1793:993- ... Gale CP, Grant PJ (2004) The characterization and functional analysis of the human glyoxalase 1 gene using methods of ... RAGE modulates vascular inflammation and atherosclerosis in a murine model of type 2 diabetes. Atherosclerosis 185:70-77PubMed ...
  https://link.springer.com/article/10.1007%2Fs00726-010-0773-2