*  Endosomal localization and receptor dynamics determine tyrosine phosphorylation of hepatocyte growth factor-regulated tyrosine...
Hepatocyte growth factor-regulated tyrosine kinase substrate (Hrs) is a prominent substrate for activated tyrosine kinase receptors that has been proposed to play a role in endosomal membrane trafficking. The protein contains a FYVE domain, which specifically binds to the lipid phosphatidylinositol (PI) 3-phosphate (PI 3-P). We show that this interaction is required both for correct localization of the protein to endosomes that only partially coincides with early endosomal autoantigen 1 and for efficient tyrosine phosphorylation of the protein in response to epidermal growth factor stimulation. Treatment with wortmannin reveals that Hrs phosphorylation also requires PI 3-kinase activity, which is necessary to generate the PI 3-P required for localization. We have used both hypertonic media and expression of a dominant-negative form of dynamin (K44A) to inhibit endocytosis; under which conditions, receptor stimulation fails to elicit phosphorylation of Hrs. ...
*  RCSB PDB - Protein Feature View - Hepatocyte growth factor-regulated tyrosine kinase substrate - Q960X8 (HRS DROME)
The PDB archive contains information about experimentally-determined structures of proteins, nucleic acids, and complex assemblies. As a member of the wwPDB, the RCSB PDB curates and annotates PDB data according to agreed upon standards. The RCSB PDB also provides a variety of tools and resources. Users can perform simple and advanced searches based on annotations relating to sequence, structure and function. These molecules are visualized, downloaded, and analyzed by users who range from students to specialized scientists.
*  Stable association of chloroplastic precursors with protein translocation complexes that contain proteins from both envelope...
Recent identification of several members of the chloroplastic protein translocation machinery has allowed for further refinement of our understanding of the mechanism by which precursors are transported into chloroplasts. We have attempted to define the composition of complexes that form during translocation using co‐immunoprecipitation techniques with antibodies specific to translocation components. We have observed that precursors could be found in stable association with translocation complexes after solubilization with a mild detergent, decylmaltoside. Characterization of these complexes has led to two conclusions: (i) that under limiting ATP conditions, precursors associated with translocation complexes containing components of the outer and inner envelope membranes; and (ii) that the chaperone ClpC, a stromal Hsp100 homolog, was associated with precursor‐containing complexes under these limiting ATP conditions.. The data presented here suggest a new role for the ...
*  wingfield.npb101.readings.2009 - adhesion molecules gap junctions receptors transport molecules Feedback loops(negative and...
View Notes - wingfield.npb101.readings.2009 from NPB NPB 101 at UC Davis. adhesion molecules, gap junctions, receptors, transport molecules Feedback loops (negative and positive) How are chemical
*  Assembly and mechanism of bacterial twin-arginine translocation systems - WRAP: Warwick Research Archive Portal
Baglieri, J. (2012) Assembly and mechanism of bacterial twin-arginine translocation systems. PhD thesis, University of Warwick. ...
*  A gating motif in the translocation channel sets the hydrophobicity threshold for signal sequence function | JCB
An initial step in the biogenesis of most integral membrane and secreted proteins is the transport of the protein through the Sec61 protein translocation channel in the rough ER. The Sec61 complex is an evolutionarily conserved heterotrimer. Archaebacterial and eubacterial organisms transport proteins through the homologous SecYEβ and SecYEG complexes.. High-resolution structures of archaebacterial and eubacterial translocation channels have provided detailed views of the closed and partially open channel conformations (Van den Berg et al., 2004; Tsukazaki et al., 2008; Zimmer et al., 2008; Egea and Stroud, 2010). In the closed conformation, the ten transmembrane (TM) spans of SecY are arranged in two five-helix bundles (TM spans 1-5 and 6-10) to form an hourglass-shaped transport pore with a central constriction termed the pore ring (Van den Berg et al., 2004). A reentrant loop preceding ...
*  News | Department of CELL BIOLOGY
A recent paper by Li et al. (Rapoport lab, with help from Hidde Ploegh's lab at the MIT), reports a crystal structure of the active protein translocation channel, which had been a "holy grail" in the field. Previously, the Rapoport lab had reported crystal structures of the idle channel (van den Berg, B. et al. Nature 427, 36-44 (2004)) and of a complex of the channel with the translocation ATPase SecA (Zimmer et al. Nature 455, 936-943 (2008)). Structures of the idle channel show that the largest subunit, SecY, consists of two halves that form an hourglass-shaped pore and a lateral gate that faces lipid. The constriction in the middle of the membrane is formed from six pore ring residues. The cytoplasmic funnel is empty, while the extracellular funnel is filled with a plug domain. When SecA binds to the channel, it inserts a two-helix finger into the cytoplasmic opening of the channel and partially opens the lateral gate. The new structure now contains the SecY channel, SecA, and a short ...
*  A dynamic model of the mitochondrial protein import machinery
Pfanner, Nikolaus; Rassow, Joachim; Klei, Ida J. van der und Neupert, Walter (20. März 1992): A dynamic model of the mitochondrial protein import machinery. In: Cell, Vol. 68, Nr. 6: S. 999-1002 ...
*  Identification and functional analysis of NOL7 nuclear and nucleolar localization signals | BMC Cell Biology | Full Text
Active nuclear transport involves complex interactions between the transport machinery and protein cargo, mediated in part through NLSs. Typically composed of discrete patterns of basic residues, these sequences are recognized by the transport machinery and can vary in their affinity, rate, and efficiency of localization, which in turn can influence the function and biologic relevance of the cargo protein in different physiologic settings. Here, we have shown that NOL7 is targeted to the nucleus via an energy- and nucleoporin-dependent mechanism. This transport is mediated by three evolutionarily conserved but distinct NLSs. In addition, each NLS was found to be independently capable of directing the nuclear localization of the cytoplasmic protein PK or full length NOL7. Each NLS individually and additively contributed to the rate and efficiency of NOL7 nuclear targeting, suggesting that ...
*  Plus it
Trafficking of postsynaptic receptors is a means of regulating synaptic function in the dendrites, yet the details of delivery processes are not well explored. In this study, we present two general pathways for receptor transport to synaptic sites in the dendrite. Six of the seven GPCRs examined notably preferred passive diffusion from the cell body to the dendrite branches. This energy efficient transport via the plasma membrane is likely shared by most postsynaptic GPCRs. An alternate pathway, as seen with 5-HT1B, retains receptors in transport vesicles. At the cost of expending energy on active transport, 5-HT1B is maintained as a readily accessible source of mobile receptors for rapid exocytotic recruitment to the membrane throughout the dendrites. Though unique among the receptors included in our study, this active trafficking pathway may be used by yet unexamined receptors.. Previous postsynaptic GPCR studies describing intracellular ...
*  Sec31a - Protein transport protein Sec31A - Rattus norvegicus (Rat) - Sec31a gene & protein
Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules.
*  SEC61 (YLR378C) Result Summary | BioGRID
Conserved ER Protein Translocation Channel; Essential Subunit Of Sec61 Complex (Sec61p, Sbh1p, And Sss1p); Forms Channel For SRP-dependent Protein Import; With Sec63 Complex Allows SRP-independent Protein Import Into ER; Involved In Posttranslational Soluble Protein Import Into The ER, ERAD Of Soluble Substrates, And Misfolded Soluble Protein Export From The ER
*  Membrane-protein insertion: One helix and one amino acid at a time | School of Physics
Membrane proteins are critical components of all cells, controlling, e.g., signaling, nutrient exchange, and energy production, and are the target of over half of all drugs currently in production. At an early stage of their synthesis, nearly all membrane proteins are directed to a protein-conducting channel, the SecY/Sec61 complex, which permits access to the membrane via its lateral gate.
*  Anti-Rab5抗体- Early Endosome Marker参考文献
Citations for Abcam's Anti-Rab5抗体- Early Endosome Marker. References for Ms,大鼠,狗,Hu in ICC,ICC/IF,IF,IHC,IHC-Fr,IHC-P,WB.
*  Lman1 - Protein ERGIC-53 precursor - Mus musculus (Mouse) - Lman1 gene & protein
Mannose-specific lectin. May recognize sugar residues of glycoproteins, glycolipids, or glycosylphosphatidyl inositol anchors and may be involved in the sorting or recycling of proteins, lipids, or both. The LMAN1-MCFD2 complex forms a specific cargo receptor for the ER-to-Golgi transport of selected proteins (By similarity).
*  Gentaur Molecular :Cusabio \ Human Protein transport protein Sec24A(SEC24A) ELISA kit SpeciesHuman \ CSB-EL020950HU
Gentaur molecular products has all kinds of products like :search , Cusabio \ Human Protein transport protein Sec24A(SEC24A) ELISA kit SpeciesHuman \ CSB-EL020950HU for more molecular products just contact us
*  Transport route planner PTV Map&Guide: Finds you the most efficient truck route - PTV Map&Guide
Road route planner by PTV: Save transport costs and driving time with Map&Guide route planners software. Learn how to optimise your transport logistics.
*  Inhibition of Delta pH pathway protein transport by ant | Open-i
Inhibition of Delta pH pathway protein transport by antibodies to Hcf106. (A) Maize thylakoids were preincubated with 0.1 mg/ml anti-Hcf106 or preimmune (PI) Ig
*  Some Effects of Ionizing Radiation on Translocation in Plants | Science
Thank you for your interest in spreading the word about Science.. NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address.. ...
*  The Brain and the Mind, page 1
Yet there are arguments made against this view. Although memory has never been found - and may never be found - in the human brain, there are attempts nevertheless to explain it as such; a particular experience for example can be 'physically' monitored; the neuronal movements can be mapped, which will imply a technology that can see INTO neurons and all the protein movements occurring therein. Since this will involve millions of processes within a single neuron, we'll need an impressive supercomputer to do all this. But lets say we do all, and discover that "this" cluster of neurons corresponds to this memory; and show it that everytime this memory is activated, these proteins are assembled just like that. It seems almost absurd in the complexity; and even logically, we know that correlation isn't causation, and that is the real kicker about science and mind. You can't ever prove or unprove it. It just is: it stays as it is and we live as we live, and in the end, we die, and ...
*  DI-fusion Selective transport systems mediate sequestration of plant...
DI-fusion, le Dépôt institutionnel numérique de l'ULB, est l'outil de référencementde la production scientifique de l'ULB.L'interface de recherche DI-fusion permet de consulter les publications des chercheurs de l'ULB et les thèses qui y ont été défendues.
*  Anti-EEA1 抗体 - Early Endosome Marker (ab2900)
ウサギ・ポリクローナル抗体 ab2900 交差種: Ms,Rat,Chk,Hm,Cow,Dog,Hu,Xl,Zfsh,RMk,Apl 適用: WB,IP,IHC-FoFr,IHC-P,ICC,IHC (Methanol…
*  Sen3 protein localization. (A) MHY851 cells were stain | Open-i
Sen3 protein localization. (A) MHY851 cells were stained with anti-HA antibody to visualize the Sen3 protein (FITC). (B) DNA (DAPI). Bar, 5 μm.
*  Re: %files section of SPEC file
buildroot}/etc/ ...and placed in the final destination of: /etc I keep getting the entire %{buildroot} created on the destination host. TIA ...
*  1 - Agea forex online
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