*  Protein instability and immunogenicity: Roadblocks to clinical application of injectable protein delivery systems for sustained...
We describe the potential roles for academic research in further improving protein stability and developing new analytical ... Protein instability and immunogenicity are two main roadblocks to the clinical success of novel protein drug delivery systems. ... for using state-of-the-art analytical assays to monitor protein stability for both conventional and novel therapeutic protein ... Protein instability and immunogenicity: Roadblocks to clinical application of injectable protein delivery systems for sustained ...
  http://drugdeliverytechnology.leidenuniv.nl/publications/3304
*  Metabolic Stability Assays | Sigma-Aldrich
The metabolic stability assays provide a means to measure the rate of disappearance of a test compound over time in either ... which takes into account additional factors such as hepatic blood flow and drug/protein binding. ... The metabolic stability assays provide a means to measure the rate of disappearance of a test compound over time in either ... Our hepatocyte stability assays use a genetically modified version of the immortalized human liver cell line HepaRG™, created ...
  https://www.sigmaaldrich.com/life-science/adme-tox-assays/metabolic-stability-assays.html
*  PLOS Computational Biology: Trade-off between Positive and Negative Design of Protein Stability: From Lattice Models to Real...
Protein stability is determined by the difference between the free energies of the native and non-native states. It follows ... The stability of the native state of proteins is, therefore, of paramount importance both in vivo and for many biotechnological ... Analysis of protein sequence data shows that a higher incidence of correlated mutations is found in protein families with ... that protein stabilization can be achieved via two different strategies: (i) 'positive design' by introducing favorable ...
  http://journals.plos.org/ploscompbiol/article/metrics?id=10.1371/journal.pcbi.1000592
*  modulation of protein stability in cancer therapy - modulation of protein stability in cancer therapy prices & reviews on
Compare prices for Modulation Of Protein Stability In Cancer Therapy, find the best offer in hundreds of online stores! ... Looking for Modulation Of Protein Stability In Cancer Therapy? ... Search results for "Modulation of protein stability in cancer ...
  https://www.shopmania.com.au/shopping?q=modulation%20of%20protein%20stability%20in%20cancer%20therapy&qc=books&_from=missing_prod
*  Measuring membrane protein stability under native conditions | PNAS
1995) Protein stability as a function of denaturant concentration: The thermal stability of barnase in the presence of urea. ... It will be interesting to examine the stability of other membrane proteins to see if high thermodynamic stability is common ... Methods to measure the thermodynamic stability of membrane proteins have largely followed methods developed for soluble protein ... Measuring membrane protein stability under native conditions. Yu-Chu Chang and James U. Bowie ...
  http://www.pnas.org/content/111/1/219
*  Therapeutic Protein Stability
In particular, proteins are not very stable relative to small molecule drugs and mAbs are prone to unfolding and aggregation at ... Furthermore, their large size and numerous surface-exposed functional groups make these proteins prone to several chemical ... The development of the use of proteins, especially monoclonal antibodies (mAbs), as therapeutic molecules has provided many ... In particular, proteins are not very stable relative to small molecule drugs and mAbs are prone to unfolding and aggregation at ...
  http://www.selectscience.net/application-articles/characterization-of-monoclonal-antibody-formulations-during-long-term-storage/?artID=45501
*  The Yeast Ubiquitin Protease, Ubp3p, Promotes Protein Stability | Genetics
The levels of Stu1p are even lower in ubp3Δ stu1-5 cells, suggesting that Ubp3p plays a role in promoting protein stability. We ... The Yeast Ubiquitin Protease, Ubp3p, Promotes Protein Stability Message Subject (Your Name) has forwarded a page to you from ... The Yeast Ubiquitin Protease, Ubp3p, Promotes Protein Stability. Christine T. Brew and Tim C. Huffaker ... The Yeast Ubiquitin Protease, Ubp3p, Promotes Protein Stability. Christine T. Brew and Tim C. Huffaker ...
  http://www.genetics.org/content/162/3/1079
*  protein stability - Protein and Proteomics - BioForum
Can anyone suggest a paper or so to measure protein stability. Thanks! ... posted in Protein and Proteomics: Hello everyone, After purifying a membrane protein, how do you know if it's stable or ... Measuring protein aggregation (if ur stability problem is obnly aggregation) by lowry or bradford may not such a good idea as ... I am abit new to the field but I suggest for stability check the protein concentration after some times and see how much is ...
  http://www.protocol-online.org/forums/topic/7324-protein-stability/
*  TKS Publisher | Measuring globular protein stability
We reviewexperimental measurements of the stability of foldedconformations of proteins. Globular protein stability is ... Most proteins fold to specifi c native conformationsin order to function. Conformational stability is athermodynamic quantity ... Targeted delivery of nucleic acids via carbohydrate-protein interactions. *DNA aptamer to human lung adenocarcinoma shows ... which refl ects the populationof protein in its native, functional state. ...
  http://www.teknoscienze.com/tks_article/measuring-globular-protein-stability/
*  Recent Articles | Protein Stability And Developmental Biology | The Scientist Magazine®
In Fragile X syndrome-a genetic mishap that results in cognitive delays-the lack of a translation-repressing protein leads to ... tags: protein stability x developmental biology x The Scientist. » protein stability and developmental biology ...
  https://www.the-scientist.com/?articles.list/categoryNo/2625/category/The-Scientist/tagNo/1565,5/tags/protein-stability,developmental-biology/
*  Recent Articles | Protein Stability And Disease/Medicine | The Scientist Magazine®
The race to develop analgesic drugs that inhibit sodium channel NaV1.7 is revealing a complex sensory role for the protein. ... Infectious protein aggregates from the skin of human patients can cause disease in mice. ... tags: protein stability x disease/medicine x The Scientist. » protein stability and disease/medicine ...
  https://www.the-scientist.com/?articles.list/tagNo/1565,6/tags/protein-stability,disease-medicine/
*  Recent Articles | Protein Stability, Culture And Ecology | The Scientist Magazine®
The Nutshell Neurons Use Virus-Like Proteins to Transmit Information In mice and flies, the Arc protein forms capsids and ... Millions of measurements from 23 people who consumed extra calories every day for a month reveal changes in proteins, ... tags: protein stability x culture x ecology x The Scientist. » protein stability, culture and ecology ...
  https://www.the-scientist.com/?articles.list/categoryNo/2625/category/The-Scientist/tagNo/1565,3,7/tags/protein-stability,culture,ecology/
*  Patent US7282572 - Method and device for improving protein stability and solubility - Google Patents
Protein expression is driven by a strong bacterial promoter (TAC). The expression is induced by the addition of 1 mM IPTG that ... are cloned into the multiple cloning site of the Vector System just downstream of the p26 or alpha crystallin type protein and ... A method for expressing proteins as a fusion chimera with a domain of p26 or alpha crystallin type proteins to improve the ... protein stability and solubility when over expressed in bacteria such as E. coli is provided. Genes of interest ...
  http://www.google.com/patents/US7282572
*  Contribution of surface salt bridges to protein stability - CaltechAUTHORS
Strop, Pavel and Mayo, Stephen L. (2000) Contribution of surface salt bridges to protein stability. Biochemistry, 39 (6). pp. ... Contribution of Surface Salt Bridges to Protein Stability, Pavel Strop and Stephen L. Mayo, Biochemistry 2000 39 (6), 1251-1255 ... The role of surface salt bridges in protein stabilization has been a source of controversy. Here we present the NMR structure ... Solvents; Bacterial Proteins; Hydrogen Bonding; Solutions; Mutagenesis: Site-Directed; Pyrococcus furiosus; Crystallography: X- ...
  https://authors.library.caltech.edu/24083/
*  Transport Phenomena and Protein Stability in Downstream Processing of Biopharmaceuticals-Chemical Engineering - Carnegie Mellon...
Transport Phenomena and Protein Stability in Downstream Processing of Biopharmaceuticals. Professor Giorgio Carta ... Transport Phenomena and Protein Stability in Downstream Processing of Biopharmaceuticals. *Chemical Engineering Seminar Series ... Transport Phenomena and Protein Stability in Downstream Processing of Biopharmaceuticals-Chemical Engineering - Carnegie Mellon ... Chemical Engineering, , Upcoming Events , Recent Events , Transport Phenomena and Protein Stability in Downstream Processing of ...
  https://www.cmu.edu/cheme/upcoming-events/past-events/carta.html
*  Antagonistic Control of Disease Resistance Protein Stability in the Plant Immune System | Science
Antagonistic Control of Disease Resistance Protein Stability in the Plant Immune System ... Antagonistic Control of Disease Resistance Protein Stability in the Plant Immune System ... Antagonistic Control of Disease Resistance Protein Stability in the Plant Immune System ... Antagonistic Control of Disease Resistance Protein Stability in the Plant Immune System ...
  http://science.sciencemag.org/content/early/2005/06/23/science.1109977
*  UCLA researchers discover mechanism that regulates protein stability in cells - Healthcanal.com : Healthcanal.com
... causes an enzyme that degrades proteins to be sequestered and because of that becomes a regulator of cellular protein stability ... and it may be that cancer needs higher protein stability than other cells, which is why increased Wnt signaling if found in so ... "Protein degradation is a very important part of the life of a cell. About 10 percent of the genes in the genome are dedicated ... When cells receive Wnt, it's a signal for them to degrade their proteins more slowly, to keep them for a longer period of time ...
  https://www.healthcanal.com/cancers/13491-ucla-researchers-discover-mechanism-that-regulates-protein-stability-in-cells.html
*  PLOS ONE: Effects of Solute-Solute Interactions on Protein Stability Studied Using Various Counterions and Dendrimers
Little attention, however, has been paid to the effect of additive-additive interactions on proteins. Our group and others have ... which inhibits cooperative binding to the protein surface but at the same time, significantly suppresses nonnative aggregation. ... recently shown that such interactions can actually govern protein events, such as aggregation. Here we use dendrimers, which ... dendrimers pose an interesting case given that guanidinium can form multiple attractive hydrogen bonds with either a protein ...
  http://journals.plos.org/plosone/article/related?id=10.1371/journal.pone.0027665
*  Protein stability versus function: effects of destabilizing missense mutations on BRCA1 DNA repair activity. | Sigma-Aldrich
Protein stability versus function: effects of destabilizing missense mutations on BRCA1 DNA repair activity.. [David C A ... It is likely that both protein context (location of the BRCT domains at the C-terminus of the large BRCA1 protein) and cellular ... BRCA1 is a large protein of 1863 residues with two small structured domains at its termini: a RING domain at the N-terminus and ... how reduced thermodynamic stability of the isolated BRCT mutants translates into loss of function of the full-length protein in ...
  https://www.sigmaaldrich.com/catalog/papers/25748678
*  KAKEN - Research Projects | Thermodynamic Analysis of Protein Stability (KAKENHI-PROJECT-09044222)
In order to estimate the contribution of each factor to protein stability, the data of structure and stability changes must be ... we tried to estimate some factors that contribute to conformational stability of a protein using data base of stability/ ... A General Rule for the Relationship between hlydrophobic Effect and Conformational Stability of a Protein : Stability and ... A General Rule for the Relationship between hydrophobic Effect and Conformational Stability of a Protein : Stability and ...
  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-09044222/
*  Malvern Instruments Shares its Buyer's Guide to Protein Stability Measurement Platforms - Pharma Business review
Malvern Instruments Shares its Buyer's Guide to Protein Stability Measurement Platforms. By admin ... Protein stability and higher order structure is also used to assist with biocomparability studies. This buyer's guide discusses ... Characterizing biopharmaceutical protein stability is critical during all phases of biopharmaceutical development, including ... the available instrumentation for protein stability characterization, and what to consider when choosing stability assays. ...
  https://www.pharmaceutical-business-review.com/suppliers/malvern__instruments__particle__size__analysis__measurement__solutions/whitepapers/a-buyers-guide-to-protein-stability-measurement-platforms
*  The CSN positively regulates Ci155 protein stability in | Open-i
The CSN positively regulates Ci155 protein stability in wing discs.(a) CSN5 clones are revealed by the absence of GFP (green) ... f2: The CSN positively regulates Ci155 protein stability in wing discs.(a) CSN5 clones are revealed by the absence of GFP ( ... f2: The CSN positively regulates Ci155 protein stability in wing discs.(a) CSN5 clones are revealed by the absence of GFP ( ... Protein levels of Ci-Myc detected by the anti-Myc antibody (red) are reduced in CSN4 mutant clones (arrow). (d) The ci-lacZ ...
  https://openi.nlm.nih.gov/detailedresult.php?img=PMC3105314_ncomms1185-f2&req=4
*  RCSB PDB - 130L: STRUCTURES OF RANDOMLY GENERATED MUTANTS OF T4 LYSOZYME SHOW THAT PROTEIN STABILITY CAN BE ENHANCED BY...
STRUCTURES OF RANDOMLY GENERATED MUTANTS OF T4 LYSOZYME SHOW THAT PROTEIN STABILITY CAN BE ENHANCED BY RELAXATION OF STRAIN AND ... STRUCTURES OF RANDOMLY GENERATED MUTANTS OF T4 LYSOZYME SHOW THAT PROTEIN STABILITY CAN BE ENHANCED BY RELAXATION OF STRAIN AND ... Structures of randomly generated mutants of T4 lysozyme show that protein stability can be enhanced by relaxation of strain and ... Protein Workshop , Ligand Explorer. Global Symmetry: Asymmetric - C1 Global Stoichiometry: Monomer - A Biological assembly 1& ...
  https://www.rcsb.org/structure/130L