UFL1 - E3 UFM1-protein ligase 1 - Homo sapiens (Human) - UFL1 gene & protein
... a post-translational modification on lysine residues of proteins that may play a crucial role in a number of cellular processes ... May play a role in the unfolded protein response, mediating the ufmylation of multiple proteins in response to endoplasmic ... the covalent attachment of the ubiquitin-like modifier UFM1 to substrate proteins, ... p>This section describes post-translational modifications (PTMs) and/or processing events.,p>,a href='/help/ptm_processing_ ...http://www.uniprot.org/uniprot/O94874
Phosphorylation is one of the most important post-translational modification. Phosphorylation is involved in multiple ... All the human protein data that had Phosphosite plus and PDB was collected. The position of phosphorylated residue was ... To assure that the predicted phosphoresidue is not biased on our experimental process, we have obtained the positions of ... In the process in creating the model, grid search was performed by using the grid.py in the LIBSVM Tools to obtain optimum C, ...http://www.kri.sfc.keio.ac.jp/report/mori/2015/b-024/
Orchestrating plant development, metabolism and plant-microbe interactions - NO problem! - Homem - 2013 - New Phytologist -...
A significant emerging theme is the regulation of these processes through post-translational protein modifications, mainly ... is chief among NO mediated post-translational modifications. An increasing number of proteins integral to a wide variety of ... this redox-based post-translational modification has begun to emerge as an important feature of signal transmission systems in ... Detection of protein S-nitrosylation with the biotin-switch technique. Free Radical Biology & Medicine 46: 119-126.. *CrossRef ...http://onlinelibrary.wiley.com/doi/10.1111/nph.12152/full
Notch-mediated post-translational control of Ngn3 protein stability regulates pancreatic patterning and cell fate commitment -...
... can be significantly enhanced upon induction of a pro-endocrine drive combined with the inhibition of Notch processing. Type: ... Notch-mediated post-translational control of Ngn3 protein stability regulates pancreatic patterning and cell fate commitment. * ... pattern of Ngn3/Hes1 proteins in the mammalian pancreas is partially controlled through Notch-mediated post-translational ... This connection involves transcriptional repression as previously shown, but also incorporates a novel post-translational ...http://www.forskningsdatabasen.dk/catalog/236769797
Post Translational Modification | China-Mainland | Sigma-Aldrich
As a result, the analysis of proteins and their post-translational modifications is particularly important for the study of ... Post-translational modifications such as glycosylation, phosphorylation, and sulfation, to name a few, serve many functions. ... Most proteins undergo some form of modification following translation. These modifications result in mass changes that are ... Glycoproteins play crucial roles in cellular processes such as protein sorting, immune recognition, receptor binding, ...https://www.sigmaaldrich.com/china-mainland/zh/life-science/proteomics/post-translational-analysis/phosphorylation/post-translational-modification.html
Ubiquitin-fold modifier 1
This post-translational modification on lysine residues of proteins may play a crucial role in a number of cellular processes. ... UFM1 is a ubiquitin-like protein that is conjugated to target proteins by E1-like activating enzyme UBA5 (UBE1DC1; MIM 610552) ... the Ufm1 system plays a critical role in vesicle trafficking, and its inhibition may lead to protein overload in the ER and UPR ... Ubiquitin-like modifier which can be covalently attached via an isopeptide bond to substrate proteins as a monomer or a lysine- ...https://pharos.nih.gov/idg/targets/P61960
Difference between revisions of "User:Karmella Haynes" - OpenWetWare
proteins. , known as 'effectors. ,. ' have the remarkable ability to discriminate and bind to specific post-translational ... and multi-input processing. I am interested in developing simple modules that can feed useful biological information into these ... proteins called 'effectors' have the remarkable ability to discriminate and bind to specific post-translational modifications ... have the remarkable ability to discriminate and bind to specific post-translational modifications of target proteins called ...https://openwetware.org/wiki/?title=User:Karmella_Haynes&diff=758069&oldid=574613
Glycosylation of closely spaced acceptor sites in human glycoproteins | Journal of Cell Science
Although N-glycosylation is often described as a post-translational protein modification reaction, most N-linked glycans are ... Stt3p is directly involved in the glycosylation process. J. Biol. Chem. 277, 47692-47700. doi:10.1074/jbc.M208136200. ... 4C) using wild-type Hp did not provide evidence for post-translational glycosylation of any sequon in Hp, unlike previously ... The murine cytoplasmic protein database had 10614 N-x≠P-T/S sites in 2256 proteins. Color-coded symbols in the inset plot ...http://jcs.biologists.org/content/126/23/5513
Cell signaling, post-translational protein modifications and NMR spectroscopy | SpringerLink
Post-translationally modified proteins make up the majority of the proteome and establish, to a large part, the impressive ... Epigenetic regulation of gene expression in physiological and pathological brain processes. Physiol Rev 91(2):603-649Google ... 3. Ligands, post-translational modifications, and diseases associated with intrinsically disordered proteins. J Proteome Res 6( ... Most eukaryotic post-translational protein modifications (PTMs) denote reversible, covalent additions of small chemical ...https://link.springer.com/article/10.1007%2Fs10858-012-9674-x
Assays for Investigating deSUMOylation Enzymes - Current Protocols
... translational modifications by the SUMO (Small Ubiquitin‐like MOdifier) family of proteins are recently discovered essential ... Post‐translational modifications by the SUMO (Small Ubiquitin‐like MOdifier) family of proteins are recently discovered ... SUMOylation and De‐SUMOylation: Wrestling with life's processes. J. Biol. Chem. 284:8223‐8227. ... All SUMO proteins are synthesized as larger precursors that are matured by SUMO‐specific proteases, known as SENPs, which ...http://www.currentprotocols.com/WileyCDA/CPUnit/refId-mb1030.html?quicktabs_cp=toc
... of post-translational protein modification will help us understand the molecular basis of life and the disease process. ... 2) Post-translational modification of protein. Post-translational protein modification is key to gene expression and regulation ... C.Post-Translational Modification Proteomics--phosphoproteome identification Protein post-translational modification (PTM) ... and the study of protein post-translational and chemical modification. Application of MRM. 1) Verification for protein ...http://alpharomics.com/Home/Service_ssr_ps
Designing and Applying Proximity‐Dependent Hybridization Chain Reaction - Current Protocols
... is a novel technique for detection of protein interaction, post‐translational modifications (PTMs), or protein expression ... post‐translational modifications (PTMs), or protein expression. The method is based upon antibodies targeting the proteins of ... Microspectroscopic imaging tracks the intracellular processing of a signal transduction protein: Fluorescent‐labeled protein ... Keywords: hybridization chain reaction; protein interaction; post‐translational modification; proxHCR; proximity ligation assay ...http://www.currentprotocols.com/WileyCDA/CPUnit/refId-ps1928.html?quicktabs_cp=abstract
Post-translational control of vegetative cell separation enzymes through a direct interaction with specific inhibitor IseA in...
A novel cell surface protein, IseA, inhibits the cell wall lytic activities of these d,l-endopeptidases in vitro, and IseA ... Membrane Proteins / metabolism. Microscopy, Fluorescence. Plasmids. Protein Processing, Post-Translational*. Chemical. Reg. No ... 0/Bacterial Proteins; 0/Carrier Proteins; 0/DNA, Bacterial; 0/Enzyme Inhibitors; 0/Membrane Proteins; 0/yoeB protein, Bacillus ... Post-translational control of vegetative cell separation enzymes through a direct interaction with specific inhibitor IseA in ...http://www.biomedsearch.com/nih/Post-translational-control-vegetative-cell/18761694.html
Expression and disposition of the murine mammary tumor virus (MuMTV) envelope gene products by murine mammary tumor cells.
Protein Precursors / metabolism. Protein Processing, Post-Translational. Viral Envelope Proteins. Viral Proteins / analysis, ... 0/Antigens, Surface; 0/Antigens, Viral; 0/Carbohydrates; 0/Protein Precursors; 0/Viral Envelope Proteins; 0/Viral Proteins ... only Pr70env is processed intracellularly to give rise to the mature MuMTV envelope proteins gp52 and gp36.. ... The envelope precursor protein (P75env) that was shed into the culture medium was found to differ from the predominant form of ...http://www.biomedsearch.com/nih/Expression-disposition-murine-mammary-tumor/6302986.html
Differential effects of garcinol and curcumin on histone and p53 modifications in tumour cells.
... of histones and other proteins are perturbed in tumours. For example, reduced levels of acetylated H4K16 and trimethylated ... Protein Processing, Post-Translational / drug effects*. RNA Interference. Terpenes / pharmacology*. Time Factors. Transfection ... BACKGROUND: Post-translational modifications (PTMs) of histones and other proteins are perturbed in tumours. For example, ... 0/Antineoplastic Agents; 0/CREBBP protein, human; 0/Enzyme Inhibitors; 0/H2AFX protein, human; 0/Histones; 0/TP53 protein, ...http://www.biomedsearch.com/nih/Differential-effects-garcinol-curcumin-histone/23356739.html
The serine/threonine kinase Pim-2 is a novel anti-apoptotic mediator in myeloma cells.
Protein Processing, Post-Translational / drug effects. Protein-Serine-Threonine Kinases / biosynthesis, genetics, physiology*. ... 0/Adaptor Proteins, Signal Transducing; 0/Apoptosis Regulatory Proteins; 0/Chromones; 0/EIF4EBP1 protein, human; 0/IL6 protein ... 0/Neoplasm Proteins; 0/PIM2 protein, human; 0/Phosphoproteins; 0/Proto-Oncogene Proteins; 0/Proto-Oncogene Proteins c-bcl-2; 0/ ... Proto-Oncogene Proteins c-bcl-2 / metabolism. Proto-Oncogene Proteins c-myc / metabolism. RNA Interference. RNA, Small ...http://www.biomedsearch.com/nih/kinase-Pim-2-novel-anti/21475253.html
"Citrullination of proteins: a common post-translational modification p" by Bashir M. Mohamed, Navin K. Verma et al.
Post-translational protein modifications catalyzed by Ca(2+)-dependent peptidylargininedeiminases have been shown to trigger ... CONCLUSION: Nanoparticle exposure facilitated post-translational citrullination of proteins. ... Protein citrullination, peptidylargininedeiminases activity and target proteins were evaluated. RESULTS: The studied ... Therefore, the aim of the study was to assess if nanoparticles are able to promote protein citrullination. MATERIALS and ...https://escholarship.umassmed.edu/thompson/34/
Wiley: Molecular Neuroendocrinology: From Genome to Physiology - David Murphy, Harold Gainer
9 Posttranslational Processing of Secretory Proteins 171. Nabil G. Seidah and Johann Guillemot ... the mechanisms that enhance peptide and protein diversity beyond what is encoded in the genome through post-translational ... expression and the mechanisms that contribute to protein, and hence biological, diversity. B) discusses ... genomic technologies in physiological and behavioural experiments that seek to better understand complex biological processes. ...http://www.wiley.com/WileyCDA/WileyTitle/productCd-1118760336.html
MUC3A | Cancer Genetics Web
O-glycan processing - post-translational protein modification Data from Gene Ontology via CGAP [Hide] ... What does this gene/protein do?. Show (10). MUC3A is implicated in:. - cellular protein metabolic process - digestion - ...http://www.cancerindex.org/geneweb/MUC3A.htm
Bioprocess Engineering: Basic Concepts, 3rd Edition | InformIT
... techniques for more consistent authentic post-translational processing of proteins; and other advanced topics. It includes new ... Cell-free processes, metabolic engineering, and protein engineering. *Biofuels and energy, including coordinated enzyme systems ... Contains expanded discussions of metabolic engineering, protein engineering, and stem cells New and updated homework and ... highly productive techniques for making heterologous proteins; new commercial applications for both animal and plant cell ...http://www.informit.com/store/bioprocess-engineering-basic-concepts-9780137062706
Surfactant protein C - Wikipedia
Solarin KO, Wang WJ, Beers MF (2002). "Synthesis and post-translational processing of surfactant protein C". Pediatric ... Surfactant protein C (SP-C), is one of the pulmonary surfactant proteins. In humans this is encoded by the SFTPC gene. It is a ... "Lipid-protein interactions of hydrophobic proteins SP-B and SP-C in lung surfactant assembly and dynamics". Pediatric pathology ... Keller A, Eistetter HR, Voss T, Schafer KP (Aug 1991). "The pulmonary surfactant protein C (SP-C) precursor is a type II ...https://en.wikipedia.org/wiki/Surfactant_protein_C
Schematic representation of a possible scenario by whic | Open-i
Protein Processing, Post-Translational. *tau Proteins/metabolism. Related in: MedlinePlus. © Copyright Policy Related In: ... Accumulation of proteins is a recurring event in many neurodegenerative diseases, including Alzheimer's disease (AD). Evidence ... Accumulation of proteins is a recurring event in many neurodegenerative diseases, including Alzheimer's disease (AD). Evidence ... Bottom Line: Evidence has suggested that protein accumulation may result from a dysfunction in the ubiquitin proteasome system ...https://openi.nlm.nih.gov/detailedresult.php?img=PMC3822529_jcmm0012-0363-f2&req=4
Binary vector constructs. Ag 7, Agrobacterium gene 7 te | Open-i
These results indicate that post-translational processing of glutelin is not necessary for trafficking and stable accumulation ... Rice glutelin is synthesized as a precursor in the endosperm endoplasmic reticulum and then deposited within the protein ... These results indicate that post-translational processing of glutelin is not necessary for trafficking and stable accumulation ... a quite different complex from the processed mature GluA2 products.These results indicate that post-translational processing of ...https://openi.nlm.nih.gov/detailedresult.php?img=PMC2724699_jexboterp187f01_ht&req=4
Quantitative analysis of synovial inflammation and join | Open-i
Protein Processing, Post-Translational. *Proteoglycans/analysis. *Proto-Oncogene Proteins c-jun/metabolism ... Among them, mitogen-activated protein kinases are thought to be of central importance. Herein, we investigate the role in vivo ... Among them, mitogen-activated protein kinases are thought to be of central importance. Herein, we investigate the role in vivo ...https://openi.nlm.nih.gov/detailedresult.php?img=PMC1064897_ar1473-3&req=4
Effect of FoxO6 loss of function on gluconeogenesis. CD | Open-i
Mutant Proteins/physiology. *Obesity/metabolism. *Organ Specificity. *Phosphorylation. *Protein Processing, Post-Translational ... C: Hepatic FoxO6 protein levels. D: Hepatic G6Pase activity. E: Hepatic G6Pase mRNA levels. F: Hepatic PEPCK mRNA levels. G: ... C: Hepatic FoxO6 protein levels. D: Hepatic G6Pase activity. E: Hepatic G6Pase mRNA levels. F: Hepatic PEPCK mRNA levels. G: ... 7F), and PEPCK protein (Fig. 7G) expression in FoxO6-siRNA vector-treated mice. Hepatic FoxO1 expression remained unchanged in ...https://openi.nlm.nih.gov/detailedresult.php?img=PMC3198083_2763fig7&req=4
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