*  Beneficial Effect of Propofol on Arterial Adenosine Triphosphate-sensitive K+Channel Function Impaired by Thromboxane |...
... and burst suppression doses of propofol for cerebral protection are up to 6 × 10−5m.20-22 Effective concentrations of propofol ... Indeed, propofol (3 × 10−7to 10−6m) recovered vascular ATP-sensitive K+channel function via reduction of superoxide levels ... Propofol (3 × 10−7, 10−6m) augmented the vasodilator responses to levcromakalim in the aortas contracted with U46619 (3 × 10−8m ... 6). Propofol (3 × 10−7to 3 × 10−6m) concentration-dependently reduced levels of superoxide in these arteries (fig. 6). ...
  http://anesthesiology.pubs.asahq.org/article.aspx?articleid=1923713
*  'Lethal levels' of anesthetic propofol killed Michael Jackson | L.A. NOW | Los Angeles...
They also found propofol in Murray's medical bag. Murray told detectives that he was not the first doctor to administer the ... On the morning Jackson died, Murray tried to induce sleep without using propofol, according to the affidavit. He said he gave ... However, police detectives saw about eight bottles of propofol in the house along with other vials and pills that had been ... Murray said he was present at a cosmetologist's office, where Adams used propofol to sedate Jackson. Since he began treating ...
  http://latimesblogs.latimes.com/lanow/2009/08/lethal-levels-of-anesthetic-propofol-killed-michael-jackson/comments/page/7/
*  Brain Sciences | Free Full-Text | Propofol Exposure in Pregnant Rats Induces Neurotoxicity and Persistent Learning Deficit in...
In this study, propofol (0.4 mg/kg/min, IV, 2 h), saline, or intralipid solution was administered to pregnant rats on ... The offspring from propofol-treated dams showed significantly less exploratory activity in the open-field test and less spatial ... We detected increased levels of cleaved caspase-3 in fetal brain at 6 h after propofol exposure. The neuronal density of the ... Preclinical studies suggest that propofol may cause neuronal injury to the offspring of primates if it is administered during ...
  http://www.mdpi.com/2076-3425/4/2/356/htm
*  Comparison of Sedation/Analgesia: Midazolam/Morphine Vs Propofol/Remifentanil - Full Text View - ClinicalTrials.gov
Propofol is a recognised agent for sedation and remifentanil is a short acting opioid analgesic. We intend to provide sedation ... Propofol. Midazolam. Remifentanil. Morphine. Hypnotics and Sedatives. Central Nervous System Depressants. Physiological Effects ... Dunn MJ, Mitchell R, Souza CD, Drummond G. Evaluation of propofol and remifentanil for intravenous sedation for reducing ... Comparison of Sedation/Analgesia: Midazolam/Morphine Vs Propofol/Remifentanil. This study has been terminated. ...
  https://clinicaltrials.gov/ct2/show/NCT00326352
*  Pharmacokinetic Model Selection for Target Controlled Infusions of Propofol:Assessment of Three Parameter Sets | Anesthesiology...
Sear JW, Diedericks J, Foex P: Continuous infusions of propofol administered to dogs: Effects on ICG and propofol disposition. ... was used with serum propofol concentration as the dependent variable and the ratio of the areas under propofol and internal ... Propofol has been shown to decrease cardiac output in animals dose-dependently [23,24] and in humans. [25-27] A reduced cardiac ... The propofol AV differences for the Dyck, Marsh, and Tackley models were 0.9 micro gram/ml (95% CI = 0.8-1.1), 0.7 micro gram/ ...
  http://anesthesiology.pubs.asahq.org/article.aspx?articleid=1949971
*  A comparison of effects of propofol or remifentanil bolus on BIS variations during tracheal suction in mechanically ventilated...
... than for propofol (63.14 ± 30). The mean duration of returning the BIS value to baseline was for propofol 23.5 ± 7 min and for ... Propofol and remifentanil altered the BIS variation and cardiovascular response to tracheal suctioning in similar way. However ... After administration of propofol and remifentanil, BIS decreased significantly: 31.5 ± 15.9 vs 37.64 ± 9.1, respectively. ... A comparison of effects of propofol or remifentanil bolus on BIS variations during tracheal suction in mechanically ventilated ...
  https://ccforum.biomedcentral.com/articles/10.1186/cc1981
*  Propofol and the DEA
Does anyone seriously envision hooking up a dog to an unattended propofol drip with a bowl of propofol at his muzzle to imbribe ... The DEA is considering placing propofol on Schedule IV of the Controlled Substances Act. Considering how important propofol is ... Propofol and the DEA. January 18, 2011. , AVMA@Work Editor share share share ... Remember that propofol is supposed to be used the same day that it is opened because of the lack of preservatives. Keeping up ...
  http://atwork.avma.org/2011/01/18/propofol-and-the-dea/
*  Vlogboy10.Net: Michael Jackson Couldn't Kill Himself With Propofol, Expert Says!
Shafer also said Murray's improper use of propofol -- allegedly as a sleep aid -- has made his own patients afraid of the drug ... Shafer also said Murray is responsible for "every drop of propofol and lorazepam" that ended up in Jackson's room, no matter if ... Shafer, who has spent 20 years studying the effects of the surgical anesthetic propofol, informed the jury that there is no way ... Paul White, who said Jackson may have caused his own death by swallowing propofol. But Shafer said it's impossible for any ...
  http://todaspot.blogspot.com/2011/10/michael-jackson-couldnt-kill-himself.html
*  Rho and Rho Kinase are involved in the signal transduction cascade caused by propofol
Propofol and sevoflurane, but not GABA, causes actin rings to be formed in the cell, and for propofol the signal goes via rhoA ... Conclusion: Propofol, but not GABA, eauses actin ring structures in neurons. Propofol uses the rho and rho kinase pathway to ... Propofol, ett narkosmedel som ges i blodet, ökar mängden calcium inuti cellen. Detta sker inte genom att propofol binder till ... Propofol tyrosine phosphorylates another ß2 subunit in the membrane then GABA. Propofol, but not GABA, also caused a tyrosine ...
  http://liu.diva-portal.org/smash/record.jsf?pid=diva2:555471
*  Anaesthetic induction and recovery characteristics of a diazepam-ketamine combination compared with propofol in dogs
Diazepam-ketamine and propofol are associated with acceptable induction and recovery from anaesthesia. Propofol had inferior ... Anaesthetic induction and recovery characteristics of a diazepam-ketamine combination compared with propofol in dogs. Login ... High quality of induction of anaesthesia with propofol has been well described while in contrast variable induction and ... Anaesthetic induction and recovery characteristics of a diazepam-ketamine combination compared with propofol in dogs. Ferreira ...
  https://repository.up.ac.za/handle/2263/49665
*  Effects of Sevoflurane and Propofol on Frontal Electroencephalogram Power and Coherence | Anesthesiology | ASA Publications
Sevoflurane GA coherence across was higher than propofol GA at 3.41-10.7 Hz (two group test for coherence, P , 0.001). Propofol ... Sevoflurane GA coherence across was higher than propofol GA at 3.41-10.7 Hz (two group test for coherence, P , 0.001). Propofol ... Sevoflurane GA coherence across was higher than propofol GA at 3.41-10.7 Hz (two group test for coherence, P , 0.001). Propofol ... Sevoflurane GA coherence across was higher than propofol GA at 3.41-10.7 Hz (two group test for coherence, P , 0.001). Propofol ...
  http://anesthesiology.pubs.asahq.org/article.aspx?articleid=1936485
*  Propofol infusion syndrome: Difficult to recognize, difficul... : Critical Care Medicine
1354: Propofol Infusion Syndrome A Critical Care Catastrophe * Predictor of mortality in suspected propofol infusion syndrome- ... Propofol infusion syndrome: Difficult to recognize, difficult to study*. Riker, Richard R. MD; Glisic, Elizabeth K. PharmD; ... propofol, adverse drug events, sedation, intensive care unit, metabolic acidosis, bradycardia, status epilepticus. ... Home , December 2009 - Volume 37 - Issue 12 , Propofol infusion syndrome: Difficult to recognize, difficul... ...
  http://journals.lww.com/ccmjournal/Citation/2009/12000/Propofol_infusion_syndrome__Difficult_to.25.aspx
*  My Emergency Medicine (capriles-urgencias.com): Propofol Infusion Syndrome (PRIS)
"What is Propofol Infusion Syndrome (PRIS)?. Propofol (2,6-diisopropylphenol), an intravenous sedative-hypnotic approved by the ... Propofol infusion syndrome (PRIS) is a rare, but potentially fatal, adverse effect of propofol administration. First described ... Immediately discontinue propofol if there is suspicion of PRIS.. *Renal replacement therapy (RRT) and Extracorporeal Membrane ... Prevention of PRIS is best: limit the maximum dose of propofol and the duration of the infusion. ...
  http://www.capriles-urgencias.com/2016/10/propofol-infusion-syndrome-pris.html
*  Effect of Remifentanil on Electroencephalographic BAR Index During Propofol Anaesthesia - Full Text View - ClinicalTrials.gov
Effect of Remifentanil on Electroencephalographic BAR Index During Propofol Anaesthesia. The safety and scientific validity of ... Propofol. Remifentanil. Hypnotics and Sedatives. Central Nervous System Depressants. Physiological Effects of Drugs. ... Then anaesthesia will be induced with propofol. Loss of the eyelash reflex, response to command and response to electrical ...
  https://www.clinicaltrials.gov/ct2/show/NCT00455026
*  Propofol and Cellular Calcium Homeostasis | Anesthesiology | ASA Publications
Propofol and Cellular Calcium Homeostasis Francois Sztark, MD; Francois Ichas, MD; Jean-Pierre Mazat, PhD; Philippe Dabadie, MD ... Propofol and Cellular Calcium Homeostasis You will receive an email whenever this article is corrected, updated, or cited in ... Propofol has been found to inhibit transmembrane Calcium2+ current in myocytes and neurons. 2-3Nevertheless, a nonspecific ... In their study, the increase in [Ca2+]iafter addition of propofol could be due to a release from another intracellular store ...
  http://anesthesiology.pubs.asahq.org/article.aspx?articleid=2323590
*  Propofol versus Propofol/Remifentanil for Deep Sedation in Prolonged Mechanically Ventilated Rabbits: Dose Requirements and...
Propofol versus Propofol/Remifentanil for Deep Sedation in Prolonged Mechanically Ventilated Rabbits: Dose Requirements and ... Although the concurrent administration of propofol with remifentanil does not affect the ID of propofol, it reduces the rate ... After isoflurane discontinuation, the animals received either propofol (group P, n=4) or propofol plus remifentanil (group P/R ... of propofol ID in group P, 123 ± 43% of propofol ID in group P/R and 184 ± 58% of remifentanil ID. ...
  http://www.vin.com/apputil/content/defaultadv1.aspx?pId=11181&catId=30098&id=3852404&ind=116&objTypeID=17
*  Possible pathogenic mechanism of propofol infusion syndrome involves coenzyme Q - Institutional Repository University of Antwerp
Propofol impedes the electron flow through the respiratory chain and coenzyme Q is the main site of interaction with propofol. ... Background: Propofol is a short-acting intravenous anesthetic agent. In rare conditions, a life-threatening complication known ... Some studies suggested that propofol acts as uncoupling agent, others suggested that it inhibits complex I or complex IV, or ... Methods: Eight rats were ventilated and sedated with propofol up to 20 h. Sequential biopsy specimens were taken from liver and ...
  https://repository.uantwerpen.be/link/irua/125524
*  Effect of a 0.5% Dilution of Propofol on Pain on Injection during Induction of Anesthesia in Children | Anesthesiology | ASA...
Propofol-Lipuro®; B. Braun Melsungen AG) in a 10% MCT/LCT emulsion was administered. In the 0.5% propofol group, propofol was ... propofol group compared with the 1.0% propofol group 3 and 20 min after administration of propofol. Results are presented in ... MCT/LCT propofol and no difference between LCT propofol and 1.0% MCT/LCT propofol in a study including 202 adult patients. ... 1. Triglyceride values (mg/dl). * P , 0.05 for 0.5% propofol versus 1.0% propofol. Bottom symbol = 1st percentile; bottom of ...
  http://anesthesiology.pubs.asahq.org/article.aspx?articleid=1922845
*  Propofol Infusion Syndrome - ICM Case Summaries
One thought on "Propofol Infusion Syndrome" * Propofol Infusion Syndrome - ICM Case Summaries #FOAMed - Critical Care ... Propofol Infusion Syndrome. November 7, 2016. November 7, 2016. ICM Case Summaries1 Comment ... This gentleman was receiving an infusion of propofol of around 4ml/kg/hr for a number of days. He was not weighed, as he was a ... Propofol infusion syndrome (PRIS) was first described in 1992 in a case series of five children (1). Since then there have been ...
  https://icmcasesummaries.com/2016/11/07/propofol-infusion-syndrome/comment-page-1/
*  Fospropofol - Wikipedia
September 2004). "Comparative pharmacokinetics and pharmacodynamics of the new propofol prodrug GPI 15715 and propofol emulsion ... Fospropofol is a prodrug of propofol; it is metabolized by alkaline phosphatases to an active metabolite, propofol. Initial ... October 2005). "AQUAVAN injection, a water-soluble prodrug of propofol, as a bolus injection: a phase I dose-escalation ... October 2005). "AQUAVAN injection, a water-soluble prodrug of propofol, as a bolus injection: a phase I dose-escalation ...
  https://en.wikipedia.org/wiki/Fospropofol
*  Propofol - Wikipedia
Propofol is believed to work at least partly via a receptor for GABA. Propofol was discovered in 1977 and approved for use in ... Propofol is also used in veterinary medicine. Propofol is used for induction and maintenance (in some cases) of general ... Propofol is often used instead of sodium thiopental for starting anesthesia because recovery from propofol is more rapid and " ... Even so, as of 2016 propofol was not on a U.S Drug Enforcement Administration schedule. One of propofol's most frequent side ...
  https://en.wikipedia.org/wiki/Propofol
*  Propofol infusion syndrome - Wikipedia
It is associated with high doses and long-term use of propofol (> 4 mg/kg/h for more than 24 hours). It occurs more commonly in ... Propofol infusion syndrome (PRIS) is a rare syndrome which affects patients undergoing long-term treatment with high doses of ... Vasile, Vasile B; Rasulo F; Candiani A; Latronico N. (September 2003). "The pathophysiology of propofol infusion syndrome: a ... Zaccheo, Melissa M; Bucher, Donald H. (June 2008). "Propofol Infusion Syndrome: A Rare Complication With Potentially Fatal ...
  https://en.wikipedia.org/wiki/Propofol_infusion_syndrome
*  Propofol
... Matt Jones jonesmat at ohsu.edu Fri Oct 11 11:33:56 EST 1996 *Previous message: Propofol ... We are looking for the receptor type on which propofol is binding to and ,(ultimately) act through. ,Thanks in advance Hi, ... Propofol both potentiates the channel response to GABA, and directly activates the channel in the absence of GABA: Hales and ... 1993) Propofol activates GABA-A receptor-chloride ionophore complex in dissociated hippocampal pyramidal neurons of the rat. ...
  http://www.bio.net/bionet/mm/neur-sci/1996-October/025726.html
*  propofol - New York Magazine
See an archive of all propofol stories published on the New York Media network, which includes NYMag, The Cut, Vulture, and ...
  http://nymag.com/tags/propofol/
*  Urban Dictionary: Propofol
Propofolunknown. A short acting sedative hypnotic used in short procedures and minor surgeries. It is God's gift the ... Patient: 10, 9, 8, hey that b......*Goes into deep coma from propofol* ...
  https://www.urbandictionary.com/define.php?term=Propofol