*  Beneficial Effect of Propofol on Arterial Adenosine Triphosphate-sensitive K+Channel Function Impaired by Thromboxane |...
... and burst suppression doses of propofol for cerebral protection are up to 6 × 10−5m.20-22 Effective concentrations of propofol ... Indeed, propofol (3 × 10−7to 10−6m) recovered vascular ATP-sensitive K+channel function via reduction of superoxide levels ... Propofol (3 × 10−7, 10−6m) augmented the vasodilator responses to levcromakalim in the aortas contracted with U46619 (3 × 10−8m ... 6). Propofol (3 × 10−7to 3 × 10−6m) concentration-dependently reduced levels of superoxide in these arteries (fig. 6). ...
  http://anesthesiology.pubs.asahq.org/article.aspx?articleid=1923713
*  'Lethal levels' of anesthetic propofol killed Michael Jackson | L.A. NOW | Los Angeles...
They also found propofol in Murray's medical bag. Murray told detectives that he was not the first doctor to administer the ... On the morning Jackson died, Murray tried to induce sleep without using propofol, according to the affidavit. He said he gave ... However, police detectives saw about eight bottles of propofol in the house along with other vials and pills that had been ... Murray said he was present at a cosmetologist's office, where Adams used propofol to sedate Jackson. Since he began treating ...
  http://latimesblogs.latimes.com/lanow/2009/08/lethal-levels-of-anesthetic-propofol-killed-michael-jackson/comments/page/7/
*  Brain Sciences | Free Full-Text | Propofol Exposure in Pregnant Rats Induces Neurotoxicity and Persistent Learning Deficit in...
In this study, propofol (0.4 mg/kg/min, IV, 2 h), saline, or intralipid solution was administered to pregnant rats on ... The offspring from propofol-treated dams showed significantly less exploratory activity in the open-field test and less spatial ... We detected increased levels of cleaved caspase-3 in fetal brain at 6 h after propofol exposure. The neuronal density of the ... Preclinical studies suggest that propofol may cause neuronal injury to the offspring of primates if it is administered during ...
  http://www.mdpi.com/2076-3425/4/2/356/htm
*  Comparison of Sedation/Analgesia: Midazolam/Morphine Vs Propofol/Remifentanil - Full Text View - ClinicalTrials.gov
Propofol is a recognised agent for sedation and remifentanil is a short acting opioid analgesic. We intend to provide sedation ... Propofol. Midazolam. Remifentanil. Morphine. Hypnotics and Sedatives. Central Nervous System Depressants. Physiological Effects ... Dunn MJ, Mitchell R, Souza CD, Drummond G. Evaluation of propofol and remifentanil for intravenous sedation for reducing ... Comparison of Sedation/Analgesia: Midazolam/Morphine Vs Propofol/Remifentanil. This study has been terminated. ...
  https://clinicaltrials.gov/ct2/show/NCT00326352
*  Comparison of Propofol to Precedex With Propofol for Emergence and Recovery in Patients Having Craniotomy Surgery - Full Text...
Active Comparator: Propofol Propofol for emergence from anesthesia. Drug: Propofol evaulation of propofol for emergence from ... Comparison of Propofol to Precedex With Propofol for Emergence and Recovery in Patients Having Craniotomy Surgery. This study ... Comparison of Propofol Standard Anesthetic to Precedex With Propofol for Emergence and Recovery in Patients Having Craniotomy ... A routine propofol anesthetic will be administered to subjects randomized to the control group or a Precedex infusion with ...
  https://clinicaltrials.gov/ct2/show/NCT00848991
*  Pharmacokinetic Model Selection for Target Controlled Infusions of Propofol:Assessment of Three Parameter Sets | Anesthesiology...
Sear JW, Diedericks J, Foex P: Continuous infusions of propofol administered to dogs: Effects on ICG and propofol disposition. ... was used with serum propofol concentration as the dependent variable and the ratio of the areas under propofol and internal ... Propofol has been shown to decrease cardiac output in animals dose-dependently [23,24] and in humans. [25-27] A reduced cardiac ... The propofol AV differences for the Dyck, Marsh, and Tackley models were 0.9 micro gram/ml (95% CI = 0.8-1.1), 0.7 micro gram/ ...
  http://anesthesiology.pubs.asahq.org/article.aspx?articleid=1949971
*  A comparison of effects of propofol or remifentanil bolus on BIS variations during tracheal suction in mechanically ventilated...
... than for propofol (63.14 ± 30). The mean duration of returning the BIS value to baseline was for propofol 23.5 ± 7 min and for ... Propofol and remifentanil altered the BIS variation and cardiovascular response to tracheal suctioning in similar way. However ... After administration of propofol and remifentanil, BIS decreased significantly: 31.5 ± 15.9 vs 37.64 ± 9.1, respectively. ... A comparison of effects of propofol or remifentanil bolus on BIS variations during tracheal suction in mechanically ventilated ...
  https://ccforum.biomedcentral.com/articles/10.1186/cc1981
*  Rho and Rho Kinase are involved in the signal transduction cascade caused by propofol
Propofol and sevoflurane, but not GABA, causes actin rings to be formed in the cell, and for propofol the signal goes via rhoA ... Conclusion: Propofol, but not GABA, eauses actin ring structures in neurons. Propofol uses the rho and rho kinase pathway to ... Propofol, ett narkosmedel som ges i blodet, ökar mängden calcium inuti cellen. Detta sker inte genom att propofol binder till ... Propofol tyrosine phosphorylates another ß2 subunit in the membrane then GABA. Propofol, but not GABA, also caused a tyrosine ...
  http://liu.diva-portal.org/smash/record.jsf?pid=diva2:555471
*  Population model for pharmacokinetics and bispectral index after intravenous infusion of the sedative and anesthetic AZD3043 in...
The propofol model consisted of two effect-site compartments, and could describe the effects of propofol when the rate of ... It was also shown that BIS after AZD3043 treatment is related to the probability of unconsciousness similar to propofol. ... propofol, and for a novel anesthetic, AZD3043, were developed. ...
  http://uu.diva-portal.org/smash/record.jsf?pid=diva2:630679
*  Anaesthetic induction and recovery characteristics of a diazepam-ketamine combination compared with propofol in dogs
Diazepam-ketamine and propofol are associated with acceptable induction and recovery from anaesthesia. Propofol had inferior ... Anaesthetic induction and recovery characteristics of a diazepam-ketamine combination compared with propofol in dogs. Login ... High quality of induction of anaesthesia with propofol has been well described while in contrast variable induction and ... Anaesthetic induction and recovery characteristics of a diazepam-ketamine combination compared with propofol in dogs. Ferreira ...
  https://repository.up.ac.za/handle/2263/49665
*  Effects of Sevoflurane and Propofol on Frontal Electroencephalogram Power and Coherence | Anesthesiology | ASA Publications
Sevoflurane GA coherence across was higher than propofol GA at 3.41-10.7 Hz (two group test for coherence, P , 0.001). Propofol ... Sevoflurane GA coherence across was higher than propofol GA at 3.41-10.7 Hz (two group test for coherence, P , 0.001). Propofol ... Sevoflurane GA coherence across was higher than propofol GA at 3.41-10.7 Hz (two group test for coherence, P , 0.001). Propofol ... Sevoflurane GA coherence across was higher than propofol GA at 3.41-10.7 Hz (two group test for coherence, P , 0.001). Propofol ...
  http://anesthesiology.pubs.asahq.org/article.aspx?articleid=1936485
*  My Emergency Medicine (capriles-urgencias.com): Propofol Infusion Syndrome (PRIS)
"What is Propofol Infusion Syndrome (PRIS)?. Propofol (2,6-diisopropylphenol), an intravenous sedative-hypnotic approved by the ... Propofol infusion syndrome (PRIS) is a rare, but potentially fatal, adverse effect of propofol administration. First described ... Immediately discontinue propofol if there is suspicion of PRIS.. *Renal replacement therapy (RRT) and Extracorporeal Membrane ... Prevention of PRIS is best: limit the maximum dose of propofol and the duration of the infusion. ...
  http://www.capriles-urgencias.com/2016/10/propofol-infusion-syndrome-pris.html
*  Propofol and Cellular Calcium Homeostasis | Anesthesiology | ASA Publications
Propofol and Cellular Calcium Homeostasis Francois Sztark, MD; Francois Ichas, MD; Jean-Pierre Mazat, PhD; Philippe Dabadie, MD ... Propofol and Cellular Calcium Homeostasis You will receive an email whenever this article is corrected, updated, or cited in ... Propofol has been found to inhibit transmembrane Calcium2+ current in myocytes and neurons. 2-3Nevertheless, a nonspecific ... In their study, the increase in [Ca2+]iafter addition of propofol could be due to a release from another intracellular store ...
  http://anesthesiology.pubs.asahq.org/article.aspx?articleid=2323590
*  Propofol versus Propofol/Remifentanil for Deep Sedation in Prolonged Mechanically Ventilated Rabbits: Dose Requirements and...
Propofol versus Propofol/Remifentanil for Deep Sedation in Prolonged Mechanically Ventilated Rabbits: Dose Requirements and ... Although the concurrent administration of propofol with remifentanil does not affect the ID of propofol, it reduces the rate ... After isoflurane discontinuation, the animals received either propofol (group P, n=4) or propofol plus remifentanil (group P/R ... of propofol ID in group P, 123 ± 43% of propofol ID in group P/R and 184 ± 58% of remifentanil ID. ...
  http://www.vin.com/apputil/content/defaultadv1.aspx?pId=11181&catId=30098&id=3852404&ind=116&objTypeID=17
*  Possible pathogenic mechanism of propofol infusion syndrome involves coenzyme Q - Institutional Repository University of Antwerp
Propofol impedes the electron flow through the respiratory chain and coenzyme Q is the main site of interaction with propofol. ... Background: Propofol is a short-acting intravenous anesthetic agent. In rare conditions, a life-threatening complication known ... Some studies suggested that propofol acts as uncoupling agent, others suggested that it inhibits complex I or complex IV, or ... Methods: Eight rats were ventilated and sedated with propofol up to 20 h. Sequential biopsy specimens were taken from liver and ...
  https://repository.uantwerpen.be/link/irua/125524
*  KAKEN - Research Projects | Physio-pharmacological effects of intravenous anesthetic agent ; Propofol on respiratory depression...
A propofol group (n=11) received propofol-nitrous oxide-fentanyl after induction of anesthesia by propofol while a sevoflurane ... Publications] Masuda A.: 'Pink urine during propofol anesthesia' Anesth Analg. 83. 666-667 (1996). *. Description. 「研究成果報告書概要(和 ... Publications] A.Masuda et al.: 'Mususe of infusion pump during propofol anasesthesia' Can J Anaeth. 45. 187 (1998). *. Related ... Publications] A Masuda et.al.: 'Misuse of infusion pump during propofol anaesthesia' Can J Anaeth. (in press). (1998). *. ...
  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-09671547/
*  Comparative study between the effects of desflurane sevoflurane and propofol on hepatocellular integrity for Hassan Ahmed...
Comparative study between the effects of desflurane sevoflurane and propofol on hepatocellular integrity for Hassan Ahmed ... Comparative study between the effects of desflurane sevoflurane and propofol on hepatocellular integrity for Hassan Ahmed ... Comparative study between the effects of desflurane sevoflurane and propofol on hepatocellular integrity for Hassan Ahmed ... Comparative study between the effects of desflurane sevoflurane and propofol on hepatocellular integrity for Hassan Ahmed ...
  http://www.philadelphia.edu.jo/newlibrary/eng/english-books/671-english-books/91181-engb-91181
*  Propofol Infusion Syndrome - ICM Case Summaries
One thought on "Propofol Infusion Syndrome" * Propofol Infusion Syndrome - ICM Case Summaries #FOAMed - Critical Care ... Propofol Infusion Syndrome. November 7, 2016. November 7, 2016. ICM Case Summaries1 Comment ... This gentleman was receiving an infusion of propofol of around 4ml/kg/hr for a number of days. He was not weighed, as he was a ... Propofol infusion syndrome (PRIS) was first described in 1992 in a case series of five children (1). Since then there have been ...
  https://icmcasesummaries.com/2016/11/07/propofol-infusion-syndrome/comment-page-1/
*  2021 Global Propofol Market Trend & Forecast | Medgadget
... means the sales value of Propofol This report studies Propofol in Global market, especially in Nor ... 3.2 Propofol Product Type, Application and Specification. 3.2.1 Type I. 3.2.2 Type II. 3.3 B.Braun Melsungen AG Propofol ... 2.2 Propofol Product Type, Application and Specification. 2.2.1 Type I. 2.2.2 Type II. 2.3 Fresenius Kabi Propofol Capacity, ... 5.2 Propofol Product Type, Application and Specification. 5.2.1 Type I. 5.2.2 Type II. 5.3 Xi'an Libang Propofol Capacity, ...
  https://www.medgadget.com/2016/10/2021-global-propofol-market-trend-forecast.html
*  Propofol
... Matt Jones jonesmat at ohsu.edu Fri Oct 11 11:33:56 EST 1996 *Previous message: Propofol ... We are looking for the receptor type on which propofol is binding to and ,(ultimately) act through. ,Thanks in advance Hi, ... Propofol both potentiates the channel response to GABA, and directly activates the channel in the absence of GABA: Hales and ... 1993) Propofol activates GABA-A receptor-chloride ionophore complex in dissociated hippocampal pyramidal neurons of the rat. ...
  http://www.bio.net/bionet/mm/neur-sci/1996-October/025726.html
*  propofol - New York Magazine
See an archive of all propofol stories published on the New York Media network, which includes NYMag, The Cut, Vulture, and ...
  http://nymag.com/tags/propofol/
*  Dr. Murray Propofol Pharmacy Shut Down | TMZ.com
Conrad Murray with massive amounts of Propofol for Michael Jackson has been shut down ... TMZ has… ... Murray Propofol Pharmacy Shut Down. The Las Vegas pharmacy that supplied Dr. Conrad Murray with massive amounts of Propofol for ... The pharmacy shipped multiple packages of Propofol to Murray at his girlfriend's Santa Monica address in the months before MJ ...
  http://www.tmz.com/2011/03/24/dr-murray-propofol-applied-pharmacy-michael-jackson-shut-down-las-vegas-bankruptcy/18/
*  Propofol
So it seems, according to the autopsy report, propofol did kill Michael Jackson. Surprised? Nope. What is surprising is that ...
  http://www.drfunkenberry.com/tag/propofol/
*  Jackson Died from Lethal Levels of Propofol | TMZ.com
Michael Jackson had lethal levels of Propofol in his system when he died, this according to a search warrant affidavit filed in ... Murray did not disclose that he had given Jackson Propofol.. More Michael Jackson. *Stash of Propofol at Jackson's House ... Jackson Died from Lethal Levels of Propofol. Michael Jackson had lethal levels of Propofol in his system when he died, this ... Adams gave Jackson Propofol.. Interestingly, according to the warrant, Dr. Murray refused to sign the death certificate at the ...
  http://www.tmz.com/2009/08/25/jackson-died-from-lethal-levels-of-propofol/
*  Dr. Conrad Murray Withheld Info About Propofol | TMZ.com
Conrad Murray withheld a key fact from the EMTs -- that he had administered Propofol to… ... Murray gave Jackson Propofol is no doubt something the paramedics should have known about and will almost certainly be used by ... Conrad Murray Withheld Info About Propofol. A paramedic report in the Michael Jackson case reportedly says Dr. Conrad Murray ... withheld a key fact from the EMTs -- that he had administered Propofol to the singer.. The report, published by News of the ...
  http://www.tmz.com/2010/03/21/dr-conrad-murray-michael-jackson-propofol-emt-report-death-dead-heart/5/