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*  Proteases in angiogenesis - Wikipedia
They include serine, aspartic, and cysteine-type proteases. A highly characterized example of the serine protease family is the ... The propeptide is removed through cleavage by a furin type protease yielding the active enzyme. The propeptide of most MMPs is ... MMPs are a large multigene family of zinc-dependent endopeptidases. The collective MMP family is capable of degrading all known ... ADAMs contain a consensus sequence which has three histidine residues that bind to the catalytically essential zinc ion. ...
  https://en.wikipedia.org/wiki/Proteases_in_angiogenesis
*  Papain - Wikipedia
This cysteine then performs a nucleophilic attack on the carbonyl carbon of a peptide backbone. This forms a covalent acyl- ... and histidine-159. Aspartate-158 was thought to play a role analogous to the role of aspartate in the serine protease catalytic ... Papain-like cysteine proteinases are essentially synthesised as inactive proenzymes (zymogens) with N-terminal propeptide ... including endopeptidases, aminopeptidases, dipeptidyl peptidases and enzymes with both exo- and endo-peptidase activity. ...
  https://en.wikipedia.org/wiki/Papain
*  Proteolytic Enzymes
The third, unpaired cysteine is part of the conserved cysteine switch region in the propeptide domain. The sites of proteolysis ... 1 Peptide Thioester Substrates for Serine Peptidases and Metalloendopeptidases Tue, 29 Nov 2016 , Proteolytic Enzymes ... The three histidine residues responsible for binding the catalytic zinc as well as the three cysteine residues present in each ... 15 Pseudolysin and Other Pathogen Endopeptidases of Thermolysin Family Sun, 12 Jul 2015 , Proteolytic Enzymes ...
  http://www.europeanmedical.info/proteolytic-enzymes-2/
*  Frontiers | Cysteine Proteases: Modes of Activation and Future Prospects as Pharmacological Targets | Pharmacology
Proteases are classified according to their catalytic site, and distributed into four major classes: cysteine proteases, serine ... Proteases cleave proteins into smaller fragments by catalyzing peptide bonds hydrolysis. ... Proteases are classified according to their catalytic site, and distributed into four major classes: cysteine proteases, serine ... Cysteine protease inhibitors are available that can block the active site but no such inhibitor available yet that can be ...
  https://www.frontiersin.org/articles/10.3389/fphar.2016.00107/full
*  US5830995A - Fanphiregulins: a family of heparin-binding epithelial cell growth factors - Google Patents
... tested in an ELISA that uses mouse monoclonal antibody 6R1C generated against a partially refolded peptide from the cysteine- ... Modified and stabilized GDF propeptides and uses thereof EP0476983A1 (en) 1992-03-25. Vascular endothelial cell growth factor ... most of which was accounted for by partial alkylation of the two histidine residues resulting in the increase of 106 amu for ... The compositions indicated presence of methionine and an additional equivalent of lysine and serine compared with the sequence ...
  https://patents.google.com/patent/US5830995A/en
*  Protease Stabilized, Pegylated Insulin Analogues - Patent application
... the pro-peptide may be a synthetic pro-peptide, which is to say a pro-peptide not found in nature. Suitable synthetic pro- ... histidine (His, H), glutamine (Gln, Q), asparagine (Asn, N), serine (Ser, S), threonine (Thr, T), proline (Pro, P), glycine ( ... cysteine (Cys & C), phenylalanine (Phe & F), tyrosine (Tyr & Y), tryptophan (Trp & W), histidine (His & H), lysine (Lys & K), ... endopeptidases, etc.), the liver (Insulin degrading enzyme, cathepsin D etc), and in other tissues. [0089]A proteolytically ...
  http://www.patentsencyclopedia.com/app/20100216691
*  Structural basis of ribosomal peptide macrocyclization in plants | eLife
... which may help to explain why these enzymes have been independently recruited to perform peptide macrocyclization. ... Effect of adjacent histidine and cysteine residues on the spontaneous degradation of asparaginyl- and aspartyl-containing ... serine proteases (patellamide A/G - PatA/G, and peptide cyclase 1 - PCY1; following removal of the leader peptide by ... Asparaginyl endopeptidases (AEPs) are a group of asparagine/aspartic acid (Asx) specific proteases that have been classified as ...
  https://elifesciences.org/articles/32955